Browsing by Author "Cakir, Cayan"
Now showing 1 - 4 of 4
- Results Per Page
- Sort Options
Article Association of Mild Hyperbilirubinemia With Decreased Ecg-Based Ventricular Repolarization Parameters in Young Men(Oxford Univ Press, 2021) Sengul, Cihan; Sen, Ahmet; Barutcu, Suleyman; Cakir, Cayan; Sarikaya, RemziObjective: Hyperbilirubinemia is associated with protection against various oxidative stress-mediated diseases. We aimed to investigate the association between bilirubin and novel electrocardiography (ECG)-based ventricular repolarization parameters. Methods: We enrolled 201 healthy men with mild hyperbilirubinemia (group 1) and 219 healthy men with normal bilirubin levels (group 2). The Tpeak-Tend (Tp-e) interval (defined as the interval from the peak of the T wave to the end of the T wave), corrected (c) Tp-e interval, QT interval, cQT interval, and Tp-e interval/QT interval ratio were measured from leads V-5 and V-6 with 20 mm/mV amplitude and 50 mm/second rate. Results: The Tp-e interval, cTp-e interval, and Tp-e interval/QT interval ratio were significantly lower in group 1 compared with group 2. The cTp-e interval showed a significant negative correlation with total bilirubin, conjugated bilirubin, and unconjugated bilirubin. The cTp-e interval (odds ratio [OR], 0.900; P=.002) and Tp-e interval/QT interval ratio (OR, 0.922; P=.04) were significantly associated with mild hyperbilirubinemia. Conclusion: We showed the association of mild hyperbilirubinemia with decreased novel ECG-based ventricular repolarization parameters.Article Characteristics and Transcatheter Closure of Patent Ductus Arteriosus in Patients Living at Moderate To High Altitude in Eastern Anatolia(Turkish Soc Cardiology, 2019) Epcacan, Serdar; Bulut, Mustafa Orhan; Kaya, Yuksel; Yucel, Ilker Kemal; Cakir, Cayan; Sisli, Emrah; Celebi, AhmetObjective: The incidence of patent ductus arteriosus (PDA) is greater among patients living at high altitude. In this population, the ductal diameter is often larger and pulmonary hypertension is more frequent. The aim of this study was to evaluate the hemodynamic and morphological features of PDA and transcatheter closure procedures performed with various devices in a group of patients living at high altitude in Turkey. Methods: The data of 327 patients who lived at an altitude of at least 1600 m above sea level and who had undergone cardiac catheterization for isolated PDA between May 2010 and July 2018 were retrospectively analyzed. Results: The mean age was 7.33 +/- 7.67 years, and 62.4% of the patients were female. The mean ductal diameter was 3.74 +/- 2.14 mm. Pulmonary hypertension was present in 57.8%. Transcatheter closure was performed in 322 patients, with a 97.3% success rate. The Amplatzer duct occluder I (ADO I) was used most often, as well as off-label use of the Amplatzer vascular plug II (AVP) and the Amplatzer muscular ventricular septal defect occluder (AMVSDO). Pulmonary artery pressure decreased immediately in the vast majority after percutaneous closure. Transient left ventricular systolic dysfunction after ductal closure was seen only rarely. Follow-up was uneventful. Conclusion: Transcatheter PDA closure can be performed with high success rate in highlanders. Off-label devices may be required for these procedures. Pulmonary hypertension is frequent but regresses after ductal closure. Transient left ventricular dysfunction after transcatheter closure is rarely seen in these patients and resolves without any medication.Article Percutaneous Mitral Commissurotomy in Women With Asymptomatic Severe Mitral Stenosis Before Pregnancy(Taylor & Francis Ltd, 2021) Cakir, Cayan; Ceylan, Yemlihan; Karagoz, Ali; Okten, Mehmet Sefa; Kaya, YukselObjectives:Performing percutaneous mitral commissurotomy (PMC) in the women with asymptomatic severe mitral stenosis (MS) who plan a pregnancy is recommended. However the data regarding this recommendation is limited in the literature. We aimed to investigate maternal and fetal outcomes of women with asymptomatic severe MS who underwent PMC before a planned pregnancy. Methods:We retrospectively analysed the procedural, pregnancy related, and fetal outcomes of 33 consecutive women with severe asymptomatic MS, age 27.97 +/- 2.86 years, who underwent PMC before a planned pregnancy between 2014 and 2019. The control group comprised of 66 pregnant women, age 29.09 +/- 3.00 years, without a cardiac disease. Results:The PMC procedure was successful in all patients and no major complication occurred. There were no deaths, pulmonary oedema, heart failure, atrial fibrillation, and thromboembolism during pregnancy. Maternal arrhythmia (p < .001), deterioration in NYHA class (p = .08), and use of cardiovascular medication (p < .001) was significantly higher in the study group. Maternal hospitalisation (p = .435), preeclampsia (p = 1), abortus (p = 1), fetal death (p = 1), and preterm delivery (p = .746) was similar between groups. Birth weight was significantly lower in the PMC group 2890 g (229) vs 3120 g (255) <0.001, however small for gestational age newborns were similar between groups (p = .12). Conclusions:PMC is safe in asymptomatic women with severe MS planning a future pregnancy. In selected patients with favourable valve anatomy PMC may improve maternal and fetal outcomes.Article The Prevalence and Correlates of T-Wave Inversion in Lead Iii in Non-Obese Men(Churchill Livingstone inc Medical Publishers, 2020) Sengul, Cihan; Cakir, Cayan; Barutcu, Suleyman; Sarikaya, RemziBackground: T-wave inversion in lead III was linked to displacement of the base of the heart due to abdominal adipose tissue in early electrocardiography (ECG) trials. The observation of T-wave inversion in lead III in some of the pathological and physiological conditions other than obesity suggests the possibilities of different mechanisms. We aimed to investigate the prevalence and correlates of T-wave inversion in lead III in non-obese men. Method: A total of 1240 men underwent ECG, blood pressure measurement, hepatic ultrasonography, and biochemical tests from January 2019 to December 2019. We excluded 220 subjects due to predetermined criteria. The eligible 105 non-obese men with T-wave inversion in lead III and 915 non-obese men without T-wave inversion in lead III were compared with each other in terms of clinical, demographic and laboratory parameters. Results: The mean age was 27.9 years with a range of 20 to 46 years. The prevalence of T-wave inversion in lead III was 10.3%. Body mass index (BMI), blood urea nitrogen, creatinine, alanine aminotransferase, hematocrit, and the percentage of non-alcoholic fatty liver disease (NAFLD) were significantly higher in Group with T-wave inversion while alkaline phosphatase was significantly higher in Group without T-wave inversion. In multivariable analysis, NAFLD was the best independent correlate of inverted T-wave in lead III (beta = 6.215, p < 0.0001). BMI (beta = 1.448, p b 0.001) and hematocrit (beta = 1.179, p = 0.021) were the other independent correlates of T-wave inversion in lead III. Conclusion: We demonstrated the association of T-wave inversion in lead III with NAFLD, BMI, and hematocrit in non-obese men. (C) 2020 Elsevier Inc. All rights reserved.