Browsing by Author "Caksen, H"

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Brucellosis Incidence in Subjects With Headache in Eastern Turkey
(Dr Dietrich Steinkopff verlag, 2004) Anlar, O; Tombul, T; Akdeniz, H; Kisli, M; Kocturk, F; Caksen, H
Dural Arteriovenous Malformation: a Rare Cause of Epilepsy in Childhood
(Neurol Soc india, 2001) Caksen, H; Unal, O; Tombul, T; Cesur, Y; Abuhandan, M
A 3 year and 6 month old girl with epilepsy associated with dural arteriovenous malformation (DAVM), diagnosed on the MRI, is presented to emphasise the importance of DAVM in the aetiology of childhood epilepsy.
Effects of High-Dose Methylprednisolone Therapy on Coagulation Factors in Patients With Acute Immune Thrombocytopenic Purpura
(Sage Publications inc, 2005) Oner, AF; Bay, A; Kuru, M; Uner, A; Arslan, S; Caksen, H
Autoimmune thrombocytopenic purpura (ITP) is a disease that presents with skin and mucous membrane bleeding due to thrombocytopenia. In the literature, there are a few studies about the effect of high-dose steroid therapy on coagulation tests in different diseases, but their results are still controversial. In this study, coagulation parameters were investigated that might have a role in hemostatic compensation in childhood acute ITP before and after highdose methylprednisolone (HDMP) treatment. The study includes 21 children age 1.5 to 14 years with acute ITP and 21 healthy age-matched control subjects. All patients with acute ITP received HDMP for 7 days. Before and after HDMP treatment (0 and 8 days) prothrombin time, partial thromboplastin time, fibrinogen, Protein C, Protein S, antithrombin 111, and the levels of factor II (FII), FV, FVII, FVIII, FIX, FX, FXI, and FXII were studied in all subjects. The results were compared with those of the control group. Pre-treatment Protein C and Protein S levels in the patient group were significantly lower than those in the control groups (p < 0.05). Protein S and Protein C levels were significantly improved after HDMP treatment in patient group. There were lower FV, FVII, FX values in the patient group compared to the control groups on admission. There was no difference in AT III and fibrinogen levels before and after treatment. As a result, some changes in the coagulation system associated with thrombocytopenia were observed in patients with acute ITP. These changes may be accepted as compensatory mechanisms to maintain hemostasis.
The Effects of Prednisolone and Serum Malondialdehyde Levels in Puppies With Experimentally Induced Meconium Aspiration Syndrome
(Sage Publications Ltd, 2003) Kirimi, E; Tuncer, O; Kösem, M; Ceylan, E; Tas, A; Tasal, I; Caksen, H
The aim of this study was to investigate the effect of different doses of prednisolone in puppies experimentally induced with meconium aspiration syndrome (MAS). Meconium was collected from human babies in the first day of life and was released into the trachea of 11 newborn puppies to induce MAS. Puppies were treated with 2 mg/kg prednisolone (standard dose), 30 mg/kg prednisolone (megadose) or 0.9% saline, all administered intravenously. The study ended 20 h after meconium aspiration and the lungs were then scored for histopathology. Animals not treated with prednisolone deteriorated after 8 h while respiration rate, oxygenation, pH and partial pressure of carbon dioxide values were better in the prednisolone-treated groups. Histopathology scores were better in the treatment groups compared with the control group, with megadose giving the best result. At the end of the study, serum malondialdehyde levels were significantly higher in the megadose prednisolone group compared with the other two groups. In conclusion, we determined that prednisolone reduced physiological and histological changes in puppies with MAS and that a 30 mg/kg dose was more effective than 2 mg/kg.
Epileptic Seizures in Neurobrucellosis
(Elsevier, 2005) Tornbul, T; Anlar, O; Caksen, H; Akdeniz, H
A Girl With a Giant Bladder Stone
(Elsevier Science inc, 2004) Atas, B; Caksen, H; Arslan, S; Akbayram, S; Kirimi, E; Tuncer, O; Kayan, M
Myelopathy Due To Intrathecal Chemotherapy - Report of Six Cases
(Lippincott Williams & Wilkins, 2005) Bay, A; Oner, AF; Etlik, O; Yilmaz, C; Caksen, H
Intrathecal chemotherapy and systemic chemotherapy are used for both prophylaxis and treatment of central nervous system disease in hematologic malignancies. However, intrathecal treatment has some adverse effects, such as arachnoiditis, progressive myelopathy and leukoencephalopathy. The authors describe six children in whom myelopathy and adhesive arachnoiditis developed after administration of intrathecal chemotherapy including methotrexate, cytosine arabinoside, and prednisolone. Urinary retention and incontinence, the main presenting complaints in all patients, developed within 12 hours after intrathecal therapy and spontaneously resolved within 7 days. Two patients were unable to walk. In these two, weakness in the lower extremities gradually recovered by I month but urinary incontinence did not improve. None of the children had sensory loss. On follow-up periodic recurrent urinary tract infection was noted in four patients. MRI findings corresponded to arachnoiditis. No response was recorded on tibial nerve somatosensory evoked potentials in all patients. Intrathecal chemotherapy, especially methotrexate, can cause spinal cord dysfunction in children with acute lymphoblastic leukemia and non-Hodgkin's lymphoma. Arachnoiditis should be kept in mind as a causative factor in recurrent urinary tract infection in patients receiving intrathecal chemotherapy.
Primary Leptomeningeal Astrocytoma in a Child
(Blackwell Science Asia, 2000) Cirak, B; Caksen, H; Ugras, S; Unal, O
Report of Five Children With Guillain-Barre Syndrome Following a Nationwide Oral Polio Vaccine Campaign in Turkey
(Neurol Soc india, 2003) Anlar, O; Tombul, T; Arslan, S; Akdeniz, H; Caksen, H; Gundem, A; Akbayram, S
Five children with Guillain-Barre syndrome (GBS), following a national oral polio vaccination campaign to eradicate disease, are reported. Clinical examination, cerebrospinal fluid and electromyographic findings conformed to the classical description of GBS. Four of them received therapeutic dose of intravenous immunoglobulin G. Two children succumbed to the disease. It was observed that the number of cases of,GBS in children increased during the period of the oral polio vaccination campaign in Turkey, suggesting a causal relationship.