Browsing by Author "Caksen, Hueseyin"

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Altered Antioxidant Status and Increased Lipid Peroxidation in Children With Acute Gastroenteritis Admitted To a Pediatric Emergency Service
(Elsevier Science inc, 2009) Bayiroglu, Fahri; Cemek, Mustafa; Caksen, Hueseyin; Cemek, Fatma; Dede, Semiha
Acute gastroenteritis is a common illness worldwide and has a great impact on children. Our aim was to examine possible alterations in the antioxidant defense in pediatric gastroenteritis. To comprehensively examine the reaction of the antioxidant system, all possible components of the system were measured. The whole blood malondialdehyde and reduced glutathione, serum beta-carotene, retinol, vitamin C, vitamin E, catalase, ceruloplasmin, albumin, total bilirubin, uric acid, erythrocyte superoxide dismutase, and glutathione peroxidase levels were studied. Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased, however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased. Catalase activity remained unchanged, whereas some of the other non-enzymatic antioxidants such as ceruloplasmin, total billirubin, and uric acid levels were increased compared to the control group. We have shown an association between antioxidant levels and gastroenteritis in children. Further study is needed to assess whether antioxidant supplementation will be beneficial as an adjunct to conventional relevant therapy of the disease. (C) 2009 Elsevier Inc.
Bilateral Brachial Plexus Palsy and Right Horner Syndrome Due To Congenital Cervicothoracal Syringomyelia
(Elsevier Science Bv, 2010) Cagan, Eren; Sayin, Refah; Dogan, Murat; Peker, Erdal; Cagan, Havva Hasret; Caksen, Hueseyin
Syringomyelia (SM) is a disorder in which a cyst forms within the spinal cord. This cyst, called a syrinx, expands and elongates over time, destroying the center of the cord. Horner syndrome is an infrequent illness caused by a lesion of the cervical sympathetic nerve fiber. Its clinical features are facial anhidrosis, ptosis, miosis, and hypochromia iridis of the affected side. A full-term male newborn infant was admitted with weakness in bilateral upper extremities and narrowing of the palpebral fissure on the right side. Ophthalmologic examination revealed a smaller right pupil. Muscle power in bilateral upper limbs was 1/5. Chest X-ray and cranial magnetic resonance imaging were normal. Magnetic resonance imaging of the cervicothoracic spine showed SM at C4-T2 level. Electromyographic examination revealed bilateral brachial plexus palsy. The diagnosis was of brachial plexus palsy and congenital Homer syndrome due to congenital cervicothoracic SM. According to our best knowledge, this association has not been reported in the literature. (C) 2009 Elsevier B.V. All rights reserved.
Brucellosis and Uveitis
(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Karahocagil, Mustafa Kasim; Demirok, Ahmet; Kilic, Adil; Cinal, Adnan; Caksen, Hueseyin; Yasar, Tekin
A 30-year-old-lady, (Case 1) was found to have brucella uveitis in her left eye. Serum agglutination (SAT) and SAT/Coombs titers were positive at 1:320 and 1:160, respectively. In Case 2, a 12-year-old-girl diagnosis of left brucellosis uveitis was made. Both SAT and SAT/Coombs titers were positive at 1:1280. This report confirms that Brucellae organisms as a cause of uveitis.
A Child With Incomplete Kluver-Bucy Syndrome Developed During Acute Encephalitis
(Elsevier Science inc, 2008) Yilmaz, Cahide; Cemak, Fatma; Guven, Ahmet Sami; Caksen, Hueseyin; Atas, Buelent; Tuncer, Oguz
Congenital Hypothyroidism With Isolated Fibula Agenesis
(Nobel Ilac, 2010) Dogan, Murat; Yilmaz, Cahide; Caksen, Hueseyin; Cesur, Yasar; Akpinar, Fuat; Gueven, Ahmet Sami
Although congenital hypothyroidism is seen often as an isolated case, it can also be seen as a part of some syndromes like Schinzel-Giedion, Aicardi-Goutieres-like, cleidocranial dysplasia and deletion of 18q. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac heart diseases, skeletal abnormalities, Central nervous system and eye malformations. In this article, 11-years-old-girl with fibula agenesis associated with congenital hypothyroidism because of thyroid gland hypoplasia is presented. In our knowledge, both congenital hypothyroidism and isolated fibula agenesis have not been published before in the literature.
A Desensitization Protocol in Children With L-Asparaginase Hypersensitivity
(Lippincott Williams & Wilkins, 2010) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Caksen, Hueseyin; Oner, Ahmet Faik
Background: L-asparaginase is effective in the treatment of malignant diseases, but it has been associated with hypersensitivity reactions in 5% to 45% of the patients. Purpose: To determine whether a desensitization protocol in children with native Escherichia coli L-asparaginase hypersensitivity allows subsequent safe administration of native E. coli L-asparaginase. Patients and Methods: A desensitization protocol was used in 9 children with leukemia (n = 8) or Langerhans cell histiocytosis (n = 1) and previous severe (n = 4) or mild/moderate (n = 5) L-asparaginase hypersensitivity. Dexamethasone (2 mg/kg intravenously) and pheniramine hydrogen maleate (1 mg/kg intravenously) were administered 1 hour before each of the following L-asparaginase administrations. Subsequently, 0.1%, 1%, 5%, 10%, and the remaining 84% of the total dose of L-asparaginase (10,000 IU/m(2)) were each prepared in 240 mL 0.9% saline and infused over 4 hours (20 h in total). Results: After desensitization, none of the patients had recurrence of hypersensitivity reactions during the subsequent 2 to 15 doses (median: 6 doses/patient; 68 doses in total) of native E. coli L-asparaginase. Conclusion: This desensitization protocol was safe and allows continued administration of native E. coli L-asparaginase administration.
Evaluation of Auditory Brainstem Potentials in Children With Acute Herpes Simplex Encephalitis
(Taylor & Francis Ltd, 2009) Caksen, Hueseyin; Yilmaz, Cahide; Tombul, Temel; Guven, Ahmet Sami; Ozen, Ozlem
Objective: In this study, auditory brainstem potentials (ABPs) were studied in children with Herpes simplex encephalitis (HSE) to determine the ABP abnormalities in HSE during childhood. We also wished to determine whether or not to use ABP in early diagnosis of HSE. Method: The study includes 28 children; eight children with acute HSE, nine with nonspecific encephalitis, and 11 healthy age-matched control subjects. The diagnosis of HSE was confirmed by the demonstration of Herpes simplex virus type 1 in CSF by polymerase chain reaction. Recordings of ABPs were performed by using Nihon Kohden Neuropack 2 device. Results: The study includes eight children (four females and four males) with acute HSE, nine children (five males and four females) with nonspecific encephalitis, and 11 healthy age-matched control subjects (six males and five females). Age ranges of the patients and controls were between six months and 12 years. There was not statistically significant difference between the groups for age and gender (p>.05). There were significant differences in the mean latencies of the wave IV on the right ear and in the mean interpeak latencies (IPLs) of the waves III-V on the right and left ears between the nonspecific encephalitis group and the control group (p<.05). However, there were no statistically significant differences between the HSV and control groups (p>.05). In addition, there was no significant difference between HSV and nonspecific groups (p>.05). Conclusions: Our findings revealed that there were mild ABP abnormalities in children with nonspecific encephalitis, but no ABP abnormality in patients with HSV encephalitis. However, we think that more extensive and detailed studies should be performed to determine whether or not there were ABP abnormalities in childhood HSV encephalitis.
Hemiplegic Migraine: a Case Report
(Galenos Yayincilik, 2010) Yilmaz, Cahide; Sonmez, Bulent; Basaranoglu, Murat; Kaya, Avni; Acikgoz, Mehmet; Caksen, Hueseyin
The girl patient aged twelve had been brought to the hospital having weakness at her left side. After having fallen from a balcony, her paroxysmal headeche accompanying nause and vomiting had began. This case was cured by valproic acid. Electroencephalography showed focal slowing and deep wave discharge. This case was presented to remind that hemiplegic migraine can seldomly begin, after minor head trauma. (Turk Arch Ped 2010; 45: 153-4)
Oxidant and Non-Enzymatic Antioxidant Status in Measles
(Oxford Univ Press, 2007) Cemek, Mustafa; Dede, Semiha; Bayiroglu, Fahri; Caksen, Hueseyin; Cemek, Fatma; Mert, Nihat
Measles is a highly contagious viral disease of childhood associated with serious complications and significant morbidity and mortality. In the present study, antioxidant and oxidant status was investigated in children with measles. Our aim was to evaluate the possible changes in non-enzymatic antioxidant levels and their relationship to the oxidative stress in measles. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA), reduced glutathione (GSH) and vitamin C in measles. We measured the whole blood MDA (as a marker of lipid peroxidation) and GSH, and serum beta-carotene, retinol, alpha-tocopherol and ascorbic acid levels in all subjects. There was a statistically significant difference between the groups for all parameters (p < 0.05). Non-enzymatic antioxidant status was found to be decreased but, lipid peroxidation was increased in the study group. As a conclusion, these findings suggested that oxidant and antioxidant defence system were altered in children with measles.
Pulmonary Tuberculosis With Nonspecific Psoas Abscess
(Nobel Ilac, 2009) Kaya, Avni; Kizilyildiz, Baran Serdar; Karaman, Kamuran; Bektas, Selcuk; Aktar, Fesih; Caksen, Hueseyin
Psoas abscess is a rare disease in childhood. Usually its diagnosis is diffucult and so delayed. A five-year-old girl was admitted with high fever, sweating, swelling and pain on tight thigh and abdominal pain for one week. On family history there was no contact with any known tuberculosis case. She had two siblings who had died clue to diarrhea and pneumonia. At physical examination, the right leg was tender with movements and in flexion posture. There was also defence and rebaund on abdomen. Ultrasonography revealed a mass lesion at 39x17 mm diameters with heterogenous echo next to the psoas muscle. In laparotomy, the abcess has been drained and Staphylococcus aureus isolated in routine culture. Acid-fast staining and culture for mycobacterium was negative. Despite of appropriate antibiotic treatment, she had fever on the tenth hospital day so we presumed a tuberculosis infection. Serum adenozine deaminase level was high (45 IU/L) and thorax high resolution computed tomography demonstrated multiple changes consisted with pulmonary tuberculosis. Antituberculosis treatment was started. We conclude that psoas abcess was secondary to pulmonary tuberculosis. The patient has been well on follow-up after four months of treatment.
Relationship Between Antioxidant Capacity and Oxidative Stress in Children With Acute Hepatitis a
(Baishideng Publishing Group inc, 2006) Cemek, Mustafa; Dede, Semiha; Bayiroglu, Fahri; Caksen, Hueseyin; Cemek, Fatma; Mert, Nihat
AIM: To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA, an indicator of oxidative stress) and nonenzymic antioxidants in children with acute hepatitis A. METHODS: Whole blood MDA and reduced glutathione (GSH), serum beta-carotene, retinol, vitamin E and vitamin C levels were studied in 19 (10 females, 9 males) children with acute hepatitis A and in 29 (13 females, 16 males) healthy control subjects. RESULTS: There was a statistically significant difference between patients and controls for all parameters (P < 0.05). Lipid peroxidation marker MDA was significantly elevated (P < 0.001), while antioxidants beta-carotene, retinol and GSH were significantly decreased (all P < 0.001) in patients compared to healthy subjects. In addition, a-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls (P < 0.05, P < 0.01, respectively). CONCLUSION: Our study shows that hepatitis A virus induces oxidative stress in childern with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A. (C) 2006 The WJG Press. All rights reserved.
Report of a Case With Narcolepsy
(Nobel Ilac, 2009) Dogan, Murat; Yilmaz, Cahide; Kaya, Avni; Caksen, Hueseyin
Narcolepsy is characterized by the excessive daytime sleepiness. In most cases, cataplexy also accompanies to narcolepsy and is called as narcolepsy-cataplexy syndrome. A-5-year-old boy was brought to our hospital due to drop attacks which had occurred two-three times in a week for one year when he was playing. It was learned that the patient had excessive daytime sleepiness while playing, and after these attacks he had continued to play again. After the reevaluation of the history and physical examination, he was diagnosed as narcolepsy. Imipramine treatment was begun. After two months of imipramine treatment, the symptoms were resolved.
Reversible Posterior Leukoencephalopathy Syndrome
(Nobel Ilac, 2010) Okur, Mesut; Yilmaz, Cahide; Kaya, Avni; Gueven, Ahmet Sami; Dogan, Murat; Caksen, Hueseyin
Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinico-radiological syndrome which includes symptoms such as headache, confusion, seizures, and visual disturbances and radiological findings of edema involving the white matter in the posterior regions of the cerebral hemispheres, and in particular bilaterally in the parietooccipital regions. RPLS was firstly described as a possible result of hypertension, eclampsia or immunsupresiye treatment. Recently reported with some other diseases that include iatrogenic and neurotoxicologycal etiologies. Usually, clinical and radiological abnormalities resolve when precipitating factors are treated with appropriate therapy. Although RPLS is reversible with early the treatment, permanent cerebral injury may occur if the treatment is delayed. In this article, we present 14 years-old-female patient who was brought with headache, fatigue, decrement at urine output complaints and at her physical examination revealed lethargy, ascite, pretibial edema and hypertension (145/ 90mmHg) and later diagnosed with chronic renal failure
Toxic Methemoglobinemia Due To Prilocaine Use
(Elsevier Science inc, 2010) Kizilyildiz, Baran Serdar; Sonmez, Buelent; Karaman, Kamuran; Caksen, Hueseyin
Two Cases of Subacute Sclerosing Panencephalitis Associated With Brainstem Involvement
(Oxford Univ Press, 2007) Yilmaz, Cahide; Caksen, Hueseyin; Yilmaz, Nebi; Gueven, Ahmed Sami; Bayram, Irfan
The most commonly involved areas in subacute sclerosing panencephalitis ( SSPE) are periventricular and subcortical white matter. The basal ganglia, cerebellum, spinal cord and corpus callosum are less commonly involved. Brainstem involvement is rare and usually accompanied by other intracranial lesions. In this article, we report two cases of SSPE associated with brainstem involvement. The first case a 9-year-old girl had the typical symptom of SSPE. Magnetic resonance imaging (MRI) of the brain revealed a focal lesion 2 x 2.5 cm a diameter in the pons. The second case was a 6-year-old girl. On admission, MRI of the brain was normal. During 6th month of follow-up, T2-weighted MRI showed a hyperintense lesion in the pons and pedincule of cerebellum. On account of these cases we would like to stress that brainstem involvement may be seen in patients with SSPE; therefore, these patients should be monitored for this disorder.