Browsing by Author "Caksen, Huseyin"

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Acquired Methemoglobinemia Due To Application of Prilocaine During Circumcision
(Elsevier Science inc, 2012) Akbayram, Sinan; Akgun, Cihangir; Dogan, Murat; Gundogdu, Mustafa; Caksen, Huseyin; Oner, Ahmet Faik
Acute Cyanide Poisoning After Eating Apricot Pits: a Case Report
(Galenos Yayincilik, 2012) Kaya, Avni; Okur, Mesut; Ustyol, Lokman; Temel, Hayrettin; Caksen, Huseyin
The stones and seeds of some plants such as apples, apricots, and peaches contain significant amounts of cyanide glycosides. Apricot pits are more toxic as they contain higher amounts of cyanogens and release hydrogen cyanide more easily. A previously healthy 27-month old male patient was admitted to our emergency department as intubated. His history revealed that he was intubated in the hospital where he was taken to with the complaint of fainting after having eaten numerous apricot pits with other family members. His general status was poor and he was unconscious. Both of his pupils were reactive. His deep tendon reflexes were increased and his plantar reflex was extensor bilaterally. The case was diagnosed as cyanide intoxication and the patient was admitted to the intensive care unit. Oxygen was constinuosly given under observation. After administration of hydroxocobalamine and sodium bicarbonate and correction of sodium deficit the patient regained consciousness and his general health improved. On the second day of admittance, he was discharged with a stable condition. This case was presented to emphasize that parents should not feed small children with apricot pits. (Turk Arch Ped 2012; 47: 141-2)
Acute Hepatotoxicity Due To Clonazepam in a Girl Using Oxcarbazepine
(Elsevier Science Bv, 2013) Akbayram, Sinan; Aktar, Fesih; Akgun, Cihangir; Caksen, Huseyin
Acute Itp Due To Insect Bite: Report of 2 Cases
(Sage Publications inc, 2011) Akbayram, Sinan; Akgun, Cihangir; Dogan, Murat; Caksen, Huseyin; Oner, Ahmet Faik
Immune thrombocytopenic purpura (ITP) of childhood is a common hematologic disorder. Immune thrombocytopenic purpura is characterized by increased destruction of antibody-coated platelets in the reticuloendothelial system. In the majority of children with acute ITP, thrombocytopenia occurs within 1 to 3 weeks after an infectious disease. Immune thrombocytopenic purpura may also occur after rubella, rubeola, chickenpox, or live virus vaccination. Here we report 2 cases with acute ITP that were developed after honeybee and insect bite.
Albuterol Intoxication in a Child
(Elsevier Science inc, 2013) Aktar, Fesih; Kostu, Murat; Unal, Muazzez; Caksen, Huseyin
Alstrom Syndrome Associated With Cerebral Involvement: an Unusual Presentation
(Modestum Ltd, 2006) Yilmaz, Cahide; Caksen, Huseyin; Yilmaz, Nebi; Guven, Ahmet Sami; Arslan, Derya; Cesur, Yasar
Alstrom syndrome (AS) is a rare autosomal recessive disorder, characterized by retinal degeneration, progressive hearing impairment, truncal obesity and non-insulin dependent diabetes mellitus. A 6-year-old girl was admitted with aphasia, deafness, strabismus, abdominal distention, and weakness on the right body side. The physical and laboratory examination revealed psychomotor retardation, right hemiparesis, sensorioneural hearing loss, aphasia, eye and teeth abnormalities, hyperpigmentation, truncal obesity, hepatosplenomegaly, severe iron deficiency anemia, delayed bone age, and cerebral hemiatrophy. Based on these abnormal findings she was diagnosed as AS. According to our knowledge this is the first case of AS with cerebral involvement. This last finding may be a component of the syndrome.
An Analysis of Children With Brucellosis Associated With Pancytopenia
(informa Healthcare, 2011) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Peker, Erdal; Parlak, Mehmet; Caksen, Huseyin; Oner, Ahmet Faik
Brucellosis produces a variety of nonspecific hematologic abnormalities. Hematologic complications of mild anemia and leukopenia have been frequently associated with acute brucellosis, but pancytopenia is less frequently seen. In this study, records of children with brucellosis aged under or equal to 16 years, admitted to Yuzuncu Yil University Hospital between 2004 and 2010, were analyzed retrospectively. Over this time period, 187 patients with brucellosis were diagnosed. Twenty-five (13.3%%) of 187 patients had pancytopenia during admission to hospital. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titers were 1:320 in 1 patient and 1:1280 in 24 patients. Blood culture was positive for Brucella melitensis in 3 patients (12%%). Fever was the most common manifestation, followed by malaise, anorexia, sweating, and weight loss. Fever and splenomegaly were the common signs in most patients. In addition, arthritis was observed in 5 patients, and epistaxis, headache, and abdominal pain were observed in 3 patients. The common bone marrow aspiration findings consisted of increased megakaryocytes and hyperplasia of erythroid series, with a shift to the left of the granulocytic series. Histiocytic hyperplasia was observed in the bone marrow smear of 2 patients. Mild hemophagocytosis was observed in the bone marrow of 3 patients. All patients recovered completely, and their peripheral blood counts returned to normal by 2 to 6 weeks after antibiotic treatment of brucellosis. In conclusion, the authors would like to emphasize that brucellosis should be considered in the differential diagnosis of children with pancytopenia.
Arachnoid Cyst Causing Subfalcine Herniation in a Child Failure To Thrive
(Nobel Ilac, 2011) Dogan, Murat; Yilmaz, Cahide; Ustyol, Lokman; Caksen, Huseyin
Arachnoid cysts represent only 1% in all intracranial masses. The signal and density of arachnoid cysts are mostly the same as cerebrospinal fluid unless be complicated. They do not have calcification and do not retain contrast material but they are benign lesions. Although they can be seen in all ages, they are mostly detected in children. Male-female ratio is In this case report., 18 months-old-boy with subfalcine herniation because of an arachnoid cyst who was brought to our hospital only with complaint of failure to thrive was presented due to its atypical and rare presentation.
Benidipine Hydrochloride Intoxication in a Child
(Elsevier Science inc, 2012) Akbayram, Sinan; Akgun, Cihangir; Dogan, Murat; Geylani, Hadi; Sari, Nesim; Taskin, Alparslan Gokmen; Caksen, Huseyin
Biotidinase Deficiency Accompanied by Diffuse Demyelination and Cerebral Atrophy
(Modestum Ltd, 2012) Okur, Mesut; Bektas, Mehmet Selcuk; Temel, Hayrettin; Caksen, Huseyin; Acikgoz, Mehmet; Sal, Ertan
Biotinidase deficiency is an inherited disorder which has autosomal recessive pattern; it occurs in approximately 1 in 60,000 live births. Usually it manifests seborrheic dermatitis, alopecia, ataxia, convulsions, hypotonia, developmental delay, hearing loss, chronic lactic acidosis and immune deficiency. Its diagnosis is made by the measurement of serum biotinidase enzyme activity and determination of the enzyme. Herein presented that a two and half-month-old boy with biotinidase enzyme deficiency which had cerebral atrophy without any skin signs. In the patients presented with refractory convulsions with unexplainable etiology without any skin lesions, as in our patient, biotinidase enzyme deficiency should be considered and the treatment should be established in early period to prevent many complications that may develop.
Brain Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Findings of Children With Kernicterus
(int Scientific information inc, 2015) Sari, Sahabettin; Yavuz, Alpaslan; Batur, Aabdussamet; Bora, Aydin; Caksen, Huseyin
Background: The term kernicterus, or bilirubin encephalopathy, is used to describe pathological bilirubin staining of the basal ganglia, brain stem, and cerebellum, and is associated with hyperbilirubinemia. Kernicterus generally occurs in untreated hyperbilirubinemia or cases where treatment is delayed. Magnetic resonance imaging (MRI)-based studies have shown characteristic findings in kernicterus. The objective of our study was to describe the role of 1H magnetic resonance spectroscopy (MRS) in demonstrating these metabolic changes and to review conventional MRI findings of kernicterus. Material/Methods: Forty-eight pediatric cases with kernicterus were included in this study. MRI and MRS examinations were performed on variable dates (10-29 days after birth). NAA, Cr, Cho, NAA/Cr, NAA/Cho, and Cho/Cr values were evaluated visually and by computer analysis. Results: There was no statistically significant difference between the NAA and Cho levels in the acute kernicterus patients and the control group (healthy patients), whereas both were significantly elevated in the chronic kernicterus patients. Both the mean NAA/Cr and Cho/Cr ratio values were significantly higher in the acute and chronic cases compared to the control group. The NAA/Cho ratio value was statistically lower in the acute cases than in the control group while it was similar in the chronic cases. Conclusions: Conventional MR imaging and 1H-MRS are important complementary tools in the diagnostics of neonatal bilirubin encephalopathy. This study provided important information for applying these MR modalities in the evaluation of neonates with bilirubin encephalopathy.
A Case of Acute Disseminated Encephalomyelitis Presented With Transvers Myelitis
(Turkish Pediatrics Assoc, 2010) Kaya, Avni; Ozkan, Mustafa; Bektas, M. Selcuk; Acikgoz, Mehmet; Temel, Hayrettin; Sal, Ertan; Caksen, Huseyin
Acute disseminated encephalomyelitis is an inflammatory and demyelinating disorder of central nervous system. A 9-year-old male was admitted with unable to walk, non-sensation of legs, urinary incontinence and encopresis for 2 days. On physical examination, muscle strength was 5/5 on upper extremities and 1/5 on lower extremities. Loss of pain, temperature and touch sensation was present on both lower extremities, reaches to T8 level. On spinal magnetic resonance imaging, diffuse hyperintensity from C3 to conus medullaris was detected. While electromyography was consistent with polyradiculoneuritis, magnetic resonance imaging findings were concordant with acute disseminated encephalomyelitis. On account of this case, we would like to emphasize that acute disseminated encephalomyelitis should be considered in patients presented with transverse myelitis; therefore, in addition to spinal magnetic resonance imaging, cranial magnetic resonance imaging should be examined in these patients. (Turk Arch Ped 2010; 45: 299-302)
A Case of Carbamazepine Intoxication in A Young Boy
(Elsevier Science inc, 2010) Dogan, Murat; Yilmaz, Cahide; Temel, Hayrettin; Caksen, Huseyin; Taskin, Gokmen
A Case of Congenital Hypothyroidism Presented With Dysmyelinization Findings
(Elsevier Science Bv, 2014) Yuca, Sevil An; Yilmaz, Cahide; Kaya, Avni; Ustyol, Lokman; Sal, Ertan; Cesur, Yasar; Caksen, Huseyin
The central nervous system is one of the most crucial targeted systems of hyphotiroidism where tissues undergo various broad developmental processes such as neuronal and glial cellular differentiation, migration and myelinization. However brain images are mainly normal. In this articlel. we present findings related to a 1-year-old girl who has been referred to our outpatient he clinic with complaints of slowing of movement and lack of interest. She was diagnosed with hypothyroidism. Her brain magnetic resonance image obtained during diagnosis displayed dysmyelinization. It showed improvement after Na-L thyroxin therapy during follow up.
A Case of Immune Thrombocytopenic Purpura Presenting With Intracranial Hemorrhage
(Elsevier Science Bv, 2013) Akbayrami, Sinan; Aktar, Fesih; Akgun, Cihangir; Bektas, Mehmet Selcuk; Caksen, Huseyin; Onert, Ahmet Faik
Immune thrombocytopenic purpura is an acute, generally considered a self-limiting benign disorder with a 60%-80% change of spontaneous recovery occurring usually within a few months after onset. Intracranial hemorrhage is a rare but life-threatening complication of childhood immune thrombocytopenic purpura. We report a 4-year-old girl who admitted with headache, vomiting, bleeding from noise and bruises on the extremities. Her neurological examination was normal. Based on laboratory finding she was diagnosed immune thrombocytopenic purpura and intracranial hemorrhage. We suggest that cranial imaging should be perform in patients with immune thrombocytopenic purpura admitted with bleeding symptoms, vomiting and headache even if they had no abnormal neurological signs.
A Case With Theophylline Intoxication
(Aves, 2013) Sal, Ertan; Kaya, Avni; Temel, Hayrettin; Basaranoglu, Murat; Caksen, Huseyin
Theophylline is an agent used in the treatment of obstructive airway diseases. It has a risk of intoxication with serum concentrations higher than 15 mu g/mL. A seven-year-old female patient presented with complaints of vomiting and headache. She had tachycardia and other physical examination findings were found to be normal. We were informed that she ingested 10 tablets named Bronkolin (R) each containing 300 mg theophylline. Her serum theophylline levels were found to be > 40 mu g/ml (normal range: 10-20 mu g/ml). She was monitorized and received charcoal, potassium supplementation and intravenous fluid. Her serum theophylline declined to 3.1 mu g/ml and she was discharged. With this case presentation we wanted to emphasize that the possibility of drug intoxication should be considered in presence of hyperglycemia, hypopotassemia and tachycardia with accompanying symptoms including acute and unexplained vomiting and headache.
Cerebral Venous Sinus Thrombosis in 2 Children With Celiac Disease
(Sage Publications inc, 2011) Dogan, Murat; Peker, Erdal; Akbayram, Sinan; Bektas, Mehmet S.; Basaranoglu, Murat; Cesur, Yasar; Caksen, Huseyin
Cerebral venous sinus thrombosis (CVST) is an uncommon disease in childhood. In the largest study carried out so far, the incidence was 0.67 case per 100 000 children per year. A number of etiologies and risk factors have been so far identified for CVST in childhood, including head trauma, local and systemic infectious diseases, malignancies, and autoimmune diseases. Celiac disease (CD) is a disease of the small intestine caused by an immune response to ingested gluten. Epilepsy, bilateral occipital calcification, cerebellar ataxia, degenerative central nervous system disease, peripheric neuropathy, myopathy, and rarely stroke were defined as neurologic disorders. In this presentation, we report 2 cases (16-year-old boy and 2-year-old boy) with CD and CVST. We emphasized that CD can be investigated in patients with CVST even with the absence of gastrointestinal symptoms. Finally, we suggest that algorithm of CVST can be involved in the investigation of CD.
Clinical Features and Prognosis With Guillain-Barre Syndrome
(Wolters Kluwer Medknow Publications, 2011) Akbayram, Sinan; Dogan, Murat; Akgun, Cihangir; Peker, Erdal; Sayin, Refah; Aktar, Fesih; Caksen, Huseyin
Background: Guillain-Barre syndrome (GBS) is an acute inflammatory polyneuropathy commonly characterized by rapidly progressive, symmetric weakness and areflexia. Materials and Methods: We retrospectively assessed the clinical manifestations, results of electrodiagnostic tests, functional status and prognosis of 36 children diagnosed with GBS. Results: Based on clinical and electrophysiological findings, the patients were classified as having acute inflammatory demyelinating polyradiculoneuropathy (AIDP) (n = 25), acute motor axonal neuropathy (AMAN) (n = 10) and acute motor-sensory axonal neuropathy (AMSAN) (n = 1). Twenty (55.5%) patients were males and 16 (44.5%) patients were females. The mean age of the 36 patients was 68.1 +/- 45.01 months (range, 6-180 months). Five (13.8%) patients were younger than 2 years. The most common initial symptoms were limb weakness, which was documented in 34 (94.4%) patients. In our study, 18 patients (51.4%) showed albuminocytological dissociation (raised protein concentration without pleocytosis) on cerebrospinal fluid (CSF) examination. Three patients (8.3%) required mechanical ventilation therapy during hospitalization. Unfortunately, three (8.3%) patients died; one patient had AIDP and two patients had axonal involvement (one case was AMAN and another case was AMSAN). When we compared the cases of residual sequel/dead and cases of complete recovery for neural involvement type including AIDP, AMAN and AMSAN, we did not find a statistically significant difference between the groups (P > 0.05). Conclusion: Our findings showed that cases of GBS was not uncommon in children younger than 2 years of age, and CSF protein level might be found high in the first week of the disease in about one half of the patients, with a higher rate of morbidity and mortality in patients with axonal involvement than in those with AIDP.
Clinical Outcome and Magnetic Resonance Imaging Findings in Infants With Hypoglycemia
(Sage Publications inc, 2011) Caksen, Huseyin; Guven, Ahmet Sami; Yilmaz, Cahide; Unal, Ozkan; Basaranoglu, Murat; Sal, Ertan; Kaya, Avni
The authors examined clinical outcome and cranial magnetic resonance imaging (MRI) findings in infants with hypoglycemia to determine the effects of hypoglycemia on the developing brain. A total of 110 infants with hypoglycemia were included in the study. Of the patients, 36 were females and 74 were males. The age of the infants was between 1 day and 22 months. Of the 110 infants, 47 were preterm neonates, 40 were term neonates, and 23 were older than 28 days. No difference in serum glucose level was noted between symptomatic and asymptomatic infants. The most common observed abnormal findings were hyperintense lesions, encephalomalacia, and cerebral atrophy. Abnormal MRI findings were found in 4% of preterm infants, in 32.5% of term infants, and in 43.5% of older infants. Abnormal MRI findings were statistically significantly more common in symptomatic infants than in asymptomatic infants. Of the infants, 45.5% of hypoglycemic infants had cerebral palsy and/or cerebral palsy plus epilepsy.
Cortical Dysplasias, and Corpus Callosum and Posterior Fossa Abnormalities Correlation of Clinical Findings With Magnetic Resonance Imaging (Mri) Characteristics
(Sage Publications inc, 2014) Caksen, Huseyin; Kizilyildiz, Baran Serdar; Avcu, Serhat
This study examined clinical findings and magnetic resonance imaging (MRI) characteristics in 114 patients with cortical dysplasia and corpus callosum and posterior fossa abnormalities to determine the clinical findings with the extent of the lesions on MRI. The age of patients was between 1 day and 15 years. Group 1 included 74 patients with corpus callosum abnormalities and/or cortical dysplasias and group 2 included 40 patients with posterior fossa abnormalities, which were isolated and/or associated with cortical dysplasia and/or corpus callosum abnormalities. Although associated congenital abnormality apart from central nervous system abnormalities, syndrome, or systemic disorder were more common in group 2 than group 1 patients (P < .05), we did not find a difference between the groups for psychomotor retardation and epilepsy (P > .05).