Browsing by Author "Caliskan, Umran"

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Clinical and Laboratory Data of Primary Hemophagocytic Lymphohistiocytosis: a Retrospective Review of the Turkish Histiocyte Study Group
(Galenos Yayincilik, 2010) Fisgin, Tunc; Patiroglu, Turkan; Ozdemir, Akif; Celkan, Tiraje; Caliskan, Umran; Ertem, Mehmet; Karapinar, Deniz Yilmaz
Objective: This study analyzes the clinical and laboratory findings of children with primary hemophagocytic lymphohistiocytosis (HLH) followed in various referral centers of Turkey. Materials and Methods: A simple three-page questionnaire prepared by the Turkish Histiocyte Study Group was used for documentation of patient data. Results: Age at diagnosis varied from 0.6 to 78 months (median +/- SD, 16.5 +/- 26.1). Sex distribution was almost equal (F/M= 10/12). The frequencies of parental consanguinity and sibling death in the family history were 100% and 81.1%, respectively. The most common clinical findings were hepatomegaly (100%) and fever (95%). The most common laboratory findings were anemia (100%), hyperferritinemia (100%) and thrombocytopenia (90.9%). Triglyceride and total bilirubin levels in the deceased versus surviving group appear to be high (triglyceride: 394 +/- 183 mg/dl, 289 +/- 7 mg/dl; total bilirubin: 2.7 +/- 6.9 mg/dl, 0.5 +/- 1.2 mg/dl, respectively). Conclusion: We concluded that fever, hepatosplenomegaly, anemia, thrombocytopenia, and hyperferritinemia are the most common clinical and laboratory findings in primary HLH. Increased triglyceride and total bilirubin level at the time of diagnosis might be an indicator of poor prognosis in HLH. (Turk J Hematol 2010; 27: 157-62)
Familial Hemophagocytic Lymphohistiocytosis Type Iv: Possible Founder Effect in Syntaxin 11 Gene Common Mutation Endemic To Turkish Population
(Amer Soc Hematology, 2008) Caliskan, Umran; Guler, Elif; Patiroglu, Turkan; Oner, Ahmet F.; Gurgey, Aytemiz
Melanotic Neuroectodermal Tumor of Infancy in the Maxilla: a Case Report
(Elsevier Ireland Ltd, 2011) Yildirim, Gulsun; Caliskan, Umran; Akca, C. Neslihan; Dolanmaz, Dogan; Toy, Hatice
Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, fast-growing, pigmented neoplasm of neural crest origin; it primarily affects the maxilla of the infants during the first year of life, but it may also occur in the mandible, skull, brain, epididymis, and other rare locations. In this case, a 5-months old male infant with MNTI on the right anterior maxillary alveolar ridge and its treatment was presented. The patient underwent complete surgical resection without maxillectomy. There has been no recurrence in a follow-up period of 21 months. (C) 2011 Elsevier Ireland Ltd. All rights reserved.