Browsing by Author "Calka, Omer"

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Acrodermatitis Enteropathica in Three Siblings
(Medknow Publications & Media Pvt Ltd, 2013) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer
Angiokeratoma of Fordyce in a Children
(Turkish Soc dermatology venerology, 2014) Calka, Omer; Bilgili, Serap Gunes; Karadag, Ayse Serap; Bayram, Irfan; Ozdemir, Serhat
Angiokeratomas are benign tumors characterized by epidermal hyperkeratosis, acanthosis and multiple dilated blood vessels in the papillary dermis. Angiokeratoma of Fordyce is one of five types in the group of the angiokeratomas, which occurs on the scrotum, penis or vulva. It is usually observed in young adults or elderly men. A 6-year-old boy presented to the dermatology department because of papular and erythematous lesions on his scrotum and penis. These lesions were found at birth and were asymptomatic. There was a history of occasional bleeding on trauma from the lesions. Histological evaluation of a skin biopsy specimen showed hyperkeratosis and acanthosis of the epidermis and multiple dilated thin-walled vessels in the papillary dermis. Based on the clinical, histopathological and dermoscopic findings, the patient was diagnosed with Fordyce angiokeratoma. Herein, we report a case of angiokeratomas of Fordyce, which is very rare in childhood and the dermoscopic findings.
A Case of Generalized Lichen Nitidus Successfully Treated With Narrow-Band Ultraviolet B Treatment
(Wiley-blackwell, 2013) Bilgili, Serap Gunes; Karadag, Ayse Serap; Calka, Omer; Ozdemir, Serhat; Kosem, Mustafa
Lichen nitidus (LN) is a rare skin disorder presenting with multiple, small and bright papules located on the chest, abdomen, penis glans and upper extremities. It usually presents with limited involvement; however, it can present as generalized involvement. There is no consensus on treatment. Corticosteroid, astemizole, phototherapy has been used; however, the results are controversial. A 15-year-old male with clinical and histopathological diagnosis of LN was treated with narrow-band ultraviolet B (NB-UVB). The lesions completely regressed with post-inflammatory hypopigmentation on the second month of the therapy (25 sessions). We believe that NB-UVB is an effective treatment on generalized LN.
A Case of Irritant Contact Dermatitis With Leech
(informa Healthcare, 2011) Karadag, Ayse Serap; Calka, Omer; Akdeniz, Necmettin; Cecen, Ilhan
Medicinal leeches are invertebrated parasites that have been used for medical purposes for centuries as one of the traditional treatment methods. Medicinal leeches are used for wound and flap healing in the plastic and reconstructive surgery, in the treatment of venous insufficiency, varicosities, hemorrhoids, and in many other diseases. However, due to medicinal leech therapy (hirudotherapy) complications such as anaphylaxis, local allergic reactions, anemia, and mucosal synechiae can occur. In this article, we report a case of an irritant contact dermatitis in a patient who experienced severe redness and itching after applying leeches for the relief of head and neck pain. Leeches are being used widely in some regions in the world and if people are informed about the leeches, it may be helpful in preventing complications that may occur.
A Case of Levetiracetam Induced Bullous Pemphigoid
(informa Healthcare, 2013) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer; Onder, Sevda; Kosem, Mustafa; Burakgazi-Dalkilic, Evren
Bullous pemphigoid is a chronic, acquired autoimmune skin disease. Certain drugs such as furosemide, penicillins, sulfonamides, ciprofloxacins, penicillamines, angiotensin converting enzyme inhibitors, chloroquine, and phenacetin were reported to cause bullous pemphigoid. This is a case report of a 70-year-old female, who presented with the formation of diffuse cutaneous blister in month after starting to use levetiracetam. Dermatological exam and histopathological findings were consistent with bullous pemphigoid. To the best of our knowledge this is the first case of bullous pemphigoid in the literature associated with levetiracetam use.
A Case of Spider Bite Localized To the Eyelid
(informa Healthcare, 2013) Bilgili, Serap Gunes; Karadag, Ayse Serap; Karadag, Remzi; Cecen, Ilhan; Calka, Omer
Loxosceles Spiders have a worldwide distribution and are considered one of the most medically important groups of Spiders. The venom from Spiders of the genus Loxosceles, the most famous being Loxosceles reclusa (brown recluse Spider), can promote severe local and systemic damages. This report describes a girl presenting with a Spider bite over her right upper eyelid.
A Case of Tinea Capitis Favosa Which Persists Up To Adulthood
(Galenos Yayincilik, 2012) Bilgili, Serap Gunes; Calka, Omer; Karadag, Ayse Serap; Akdeniz, Necmettin
Tinea capitis favosa is a dermatophyte infection characterized by scutulum formation, and the causative agent is usually Trichophyton schoenleinii. It is seen most commonly in children, but may follow a lifelong course if remain untreated. The incidence has decreased considerably in recent years in Turkey. We report an 18-year-old female patient diagnosed with tinea capitis favosa. The disease had been present for 10 years owing to misdiagnosis and unsuccessful treatments. She was successfully treated with terbinafine. Since it is a rare condition we present this case.
Chemotherapy-Induced Acral Erythema With Involvement of the Face and Neck: a Case Report
(Sage Publications inc, 2016) Ozkol, Hatice Uce; Calka, Omer; Bulut, Gulay
Chemotherapy-induced acral erythema (CIAE) is a cutaneous response to diverse chemotherapeutic drug administration. These drugs cause symmetrical and painful erythema of palmoplantar surfaces. Bulla formation, desquamation, and subsequent reepithelialization may occur. Commonly, the lesions slowly resolve over 7-15 days, through desquamation, followed by regeneration of the skin. Here, we described a case of CIAE, with involvement of face and neck in a patient treated for breast cancer using a number of chemotherapeutic agents. Face involvement in CIAE has not been previously reported in the literature.
Childhood Traumatic Experiences, Dissociation and Thought Suppression in Patients With 'psychosomatic Skin Diseases
(Wiley, 2009) Besiroglu, Lutfullah; Akdeniz, Necmettin; Agargun, Mehmet Yucel; Calka, Omer; Ozdemir, Osman; Bilgili, Serap Genes
In this study, patients with what were considered 'psychosomatic' skin diseases were compared with patients with skin conditions that are thought to be 'non-psychosomatic' diseases in terms of their reported history of childhood traumatic experiences, dissociative experiences and thought suppression. Ninety-six patients with 'psychosomatic' skin disease were included in the study. The comparison subjects (n = 54) were patients with skin conditions believed to have a negligible psychosomatic component and the subjects without skin disease (n = 77). Subjects were administered with the Childhood Trauma Questionnaire (CTQ), the Dissociative Experiences Scale (DES) and the White Bear Suppression Inventory (WBSI). While the 'emotional neglect' scores of the psychosomatic' group were significantly higher than that of both 'non-psychosomatic' and healthy subjects, there were no significant differences for the other subscales of the CTQ. The 'psychosomatic' group scored significantly higher on the DES absorption scale, DES total and WBSI scores than the other groups. Significantly more patients in the 'psychosomatic' group reported a stressful life event as related to the onset of skin complaints compared with the 'non-psychosomatic' group. Our results suggest that the effect of subjective perception of emotional neglect, mediated by stressful life events, increases the vulnerability to psychosomatic disease. Copyright (C) 2008 John Wiley & Sons, Ltd.
Clinical Evaluation of Inpatients With Acute Urticaria
(deri Zuhrevi Hastaliklar dernegi, 2011) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer; Akdeniz, Necmettin; Ozkol, Hatice Uce; Aktar, Sirac
Background and Design: To determine the clinical and etiological features of inpatients with acute urticaria and angioedema and to assess the need for laboratory tests. Material and Methods: We recruited 105 patients with acute urticaria and angioedema who were admitted to our inpatient unit. The lesions and the characteristics of the patients were analyzed. Routine diagnostic tests including complete blood count, thyroid function tests, hepatitis panel, stool parasite, total IgE levels, cultures, erythrocyte sedimentation rate, C-reactive protein, anti-nuclear antibody, and posterior anterior lung X-ray were ordered. A psychiatric consultation was obtained, when needed. The results were analyzed with SPSS 15.0 statistical software. Results: Among 105 patients, 28 (26.7%) had urticaria, 7 (6.7%) had angioedema, and 70 (66.70/0) suffered from both urticaria and angioedema. The most common accompanying symptoms were itching (91.40%) and burning (34.3%). The most common systemic symptoms were fatigue (15.2%) and headache (12.4%). The lesions usually appeared in the evening hours (24.8%). Twenty-five patients were waking up due to itching during the night. Some lesions were associated with physical activities. Systemic diseases accompanied the lesions in 12 patients (11%). In terms of etiological factors, 33 patients (22.5%) had infections. Food- related lesions were encountered in 14 (13%) patients. Thirty patients (28.5%) had history of medication use. Stress was detected in 37.1% of the patients; anxiety was diagnosed in 3% of patients. The stool was positive for parasites in 10 (9%) patients. Conclusion: Acute urticaria is a benign disorder. Although the underlying cause of urticaria can not always be identified, infections and medications are the most common causes. A comprehensive and detailed history is very important to discover the underlying cause. The diagnostic tests should be ordered according to the patient's history. Conducting diagnostic tests without considering the medical history of the patient leads to waste of time and resources. (Turkderm 2011; 45:179-83)
Comparison of Argon Laser Photocoagulation-Induced Cutaneous Inflammation and Skin Pathergy Test in Behcet's Disease
(Springer, 2010) Sayarlioglu, Mehmet; Calka, Omer; Cinal, Adnan; Sayarlioglu, Hayriye; Akdeniz, Necmeddin; Topcu, Nazan; Gul, Ahmet
Nonspecific increased inflammatory response is an important feature of Behcet's disease (BD). The skin pathergy reaction (SPR) which tests this hyperreactivity in the skin is frequently used as a diagnostic tool. This study aims to investigate the argon laser photocoagulation (ALP)-induced cutaneous inflammation in BD patients and controls and also to compare the results with the skin pathergy test (SPT). The study group consisted of 35 patients with BD and 28 healthy volunteers. The ALP was applied to the left forearms of all cases from 20-cm distance (2,000 mW, 100 A mu m) with exposure times ranging from 0.2 to 0.7 s with 0.1-s increments. Also, a SPT with three prics was performed to both forearms of all cases. The ALP-induced cutaneous inflammation and SPT were evaluated and scored with the same method at 48 h, and the SPR scores of 2+ and above was accepted as positive. Positive results as defined above were found in eight cases (23%) with the ALP and in nine (26%) with the SPT in patients with BD. There was no clear correlation between the ALP and SPT results and also between the exposure time to laser beam and SPR scores. The preliminary results of this study reveal that ALP can induce a skin hyperreactivity similar to the needle prick-induced SPR in patients with BD. We, herein, showed that ALP can induce skin inflammation with its thermal effect and without any inoculation of antigen in BD. This method would help to develop another experimental method to investigate the cutaneous inflammation in BD.
Comparison of Cutaneous Mastocytosis With Onset in Children and Adults
(Tubitak Scientific & Technological Research Council Turkey, 2014) Bilgili, Serap Gunes; Karadag, Ayse Serap; Takci, Zennure; Calka, Omer; Kosem, Mustafa
Background/aim: Mastocytosis is a heterogeneous group of diseases characterized by the abnormal infiltration of mast cells in the skin and sometimes other organs. This study aimed to compare the demographic, clinical, and histopathological findings of cutaneous mastocytosis with onset in children and in adults. Materials and methods: Patients diagnosed with cutaneous mastocytosis in 2 different dermatology clinics between 2007 and 2011 were included in the study. Demographic characteristics of the patients as well as localization and type of the cutaneous lesions, presence of symptoms, Darier's sign, family history, systemic involvement, and histopathological evaluations were retrospectively examined. Results: Out of the 30 cases of cutaneous mastocytosis, 60% of patients were male (n = 18) and 40% were female (n = 12). Twenty-two patients had childhood-onset mastocytosis (= 15 years) and 8 patients had adult-onset mastocytosis. The onset of the disease occurred before the age of 2 years in all cases of childhood onset. Patients with adult-onset mastocytosis had statistically significantly more systemic involvement than those with childhood-onset mastocytosis (P < 0.05). Conclusion: Cutaneous mastocytosis is a benign disease in children without systemic involvement and is usually sporadic.
Comparison of Efficacy of Narrow Band Uvb Therapies With Uvb Alone, in Combination With Calcipotriol, and With Betamethasoneand Calcipotriol in Vitiligo
(Taylor & Francis Ltd, 2014) Akdeniz, Necmettin; Yavuz, Ibrahim Halil; Bilgili, Serap Gunes; Yavuz, Goknur Ozaydin; Calka, Omer
Objective: The purpose of this study is to compare the efficacy of three therapies in the treatment of non-segmental vitiligo: a combination of topical calcipotriol, narrowband-ultraviolet B (NB-UVB), and betamethasone therapies; a combination of NB-UVB and topical calcipotriol; and NB-UVB alone. Material and methods: Forty-five patients with non-segmental vitiligo presenting to our Dermatology clinic were recruited to participate in the study. Patients were randomly divided into three groups. For each patient the size of the depigmented areas was assessed according to the rule of nines. The first group was treated with a combination of topical calcipotriol, NB-UVB, and betamethasone therapies. The second group was treated with a combination of NB-UVB and topical calcipotriol and third group was treated with NB-UVB alone. Since the patients' vitiligo lesions had similar phototypes, all patients were started with 0.1 j/cm(2), regardless of their skin phototype. The dose of NB-UVB was increased 10% in each session and no further increment was done after reaching 2.5 j/cm(2). Treatment effectiveness was evaluated according to the percentage improvement in repigmentation. The quality of life of the patients was measured by the Dermatology Life Quality Index (DLQI). Results: The patients were aged from 13 to 55 years (mean: 25.29). The duration of disease ranged from 3 months to 20 years. Family history was positive for vitiligo in 10 patients (22.2%). The percentage of recovery after treatment was 63.33% +/- 7.55 in group 1, 60.67% +/- 5.75 in group 2, and 46.67% +/- 7.98 in group 3. There was no statistically significant difference between groups 1 and 2, and groups 2 and 3, but there was a statistically significant difference between groups 1 and 3 (p = 0.0048). Conclusions: In conclusion, NB-UVB-alone therapy and the combined therapies are effective treatment options in the treatment of vitiligo. Future studies with larger groups are warranted to confirm our results.
Cutaneous Anthrax Resulting in Renal Failure With Generalized Tissue Damage
(Taylor & Francis Ltd, 2013) Akdeniz, Necmettin; Calka, Omer; Ozkol, Hatice Uce; Akdeniz, Hayrettin
Anthrax is a zoonotic infection caused by Bacillus anthracis which can be clinically present in a cutaneous, gastrointestinal or inhalational form depending on the entry site of the agent. The most frequent clinical type with the mildest clinical course is cutaneous anthrax. In this report, a patient with cutaneous anthrax which begins at the dorsal hand and progresses up to the proximal forearm resulting in massive tissue damage is presented. Prerenal azotemia developed due to massive tissue damage and patient was sent to hemodialysis twice.
Dermatofibroma on Upper Extremity in Childhood Period
(Professional Medical Publications, 2011) Ceylan, Mehmet Fethi; Karadag, Ayse Serap; Bulut, Gulay; Calka, Omer; Onder, Haci
Dermatofibroma is a common benign mesenchymal tumor composed of fibroblastic and histiocytic cells. It is also known as cutaneous benign fibrous histiocytoma. Although it may occur in any age, it is mostly common at twenties and thirties. It is more common in women than men and it is most seen at lower extremity. Herein, we report a 6-month-old female infant, who had dermatofibroma on her upper extremity.
The Development of Giant Lipoma on the Bcg Vaccine Caused Scar
(informa Healthcare, 2012) Bilgili, Serap Gunes; Karadag, Ayse Serap; Ceylan, Mehmet Fethi; Calka, Omer; Turktas, Ugur; Bulut, Gulay
Lipoma is the most common mesenchymal tumors that accounts for about 6% of all soft-tissue tumors in children. The lesion size is usually around 1-2 cm that rarely reaches the bigger diameter. A 14-month-old baby girl was brought to our clinic for a progressively growing lesion on the left shoulder. The lesion started 4 months ago, and then was rapidly growing that caused pain and movement restriction. On the same site, there was a scar of BCG vaccination. The clinical and histopathological findings of the lesion were consistent with lipoma. The lesion was totally resected with no recurrence within 12 months. There are several complications related to BCG vaccination. However, the occurrence of lipoma on BCG vaccine caused scar has not been reported in literature. We reported this case because of its rarity and to emphasize that lipoma can present as a giant lesion in child.
Development of Phytophotodermatitis in Two Cases Related To Plantago Lanceolata
(Taylor & Francis Ltd, 2012) Ozkol, Hatice Uce; Akdeniz, Necmettin; Ozkol, Halil; Bilgili, Serap Gunes; Calka, Omer
Plantago lanceolata, also known as snake's tongue, is a perennial herbaceous plant from the family Plantaginaceae. It is a species widely distributed both in Turkey and all over the world. Today, its fresh leaves are still used to soothe and suppress cough, externally for wound healing and draining abscesses. Phytophotodermatitis (PPD) is a dermal photosensitive reaction induced by the contact to or oral intake of a plant and subsequent exposure to sunlight. Its acute course is called phototoxic. In this paper, two cases developed phototoxic reaction with the consumption of Plantago lanceolata and subsequent exposure to the sunlight. These cases were presented since such effect of the plant has not been known previously and there is no resembling case in the literature.
Diffused Erythema Nodosum Leprosum Reaction With Necrotic Ulcers: Case Report
(Galenos Yayincilik, 2018) Ozkol, Hatice Uce; Calka, Omer; Bayram, Irfan
Erythema nodosum leprosum (ENL) is characterized by inflammatory nodules. It is an immune reaction that develops in patients receiving lepromatous leprosy treatment. In extreme severe cases, sometimes these nodules may ulcerate. In this article, we present a case of ENL with diffuse necrotic ulcer arising in a male patient using triple therapy (dapsone, clofazimine and rifampicin) because of lepromatous leprosy. A 39-year-old male patient had papules and nodules commonly found in the upper extremity and body, lividly erythematous, ranging size changes from 2-3 mm to 2 cm, some of them opened and ulcerated. Skin biopsy of the patient was evaluated as ENL. Necrosis and ulceration are rarely seen in ENL, therefore this case was presented.
Does Isotretinoin Therapy Have Any Effects on Electrocardiography, Heart Rate and Blood Pressure
(Taylor & Francis Ltd, 2012) Karadag, Ayse Serap; Gumrukcuoglu, Hasan Ali; Bilgili, Serap Gunes; Ozkol, Hatice Uce; Ertugrul, Derun Taner; Simsek, Hakki; Calka, Omer
Background: Isotretinoin therapy is associated with numerous adverse effects of various systems. Although some cases have been reported, cardiac side effects are rare following isotretinoin treatment. Objective: To investigate the effects of isotretinoin on the cardiovascular system. Methods: Seventy patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.5-1.0 mg/kg per day of isotretinoin. Screening for biochemical and hematologic parameters, heart rate, blood pressure and electrocardiographic parameters were done before treatment and after 3 months of isotretinoin treatment. Results: Heart rate, systolic/diastolic tension and electrocardiographic parameters (P-wave duration and QTc duration) were not statistically different before compared with after treatment. Conclusion: As far as we know, there is no study researching the effect of isotretinoin on P- and QT-wave measurements in the literature. We found that isotretinoin did not affect P- and QT-wave measurement. Further studies with longer periods of follow-up are needed to understand the effect of isotretinoin on the cardiovascular system.
The Effect of Acitretin Treatment on Insulin Resistance, Retinol-Binding Protein-4, Leptin, and Adiponectin in Psoriasis Vulgaris: a Noncontrolled Study
(Karger, 2013) Karadag, Ayse Serap; Ertugrul, Derun Taner; Kalkan, Goknur; Bilgili, Serap Gunes; Celik, Huseyin Tugrul; Takci, Zennure; Calka, Omer
Background/Aim: To investigate the effects of acitretin treatment on insulin resistance (IR) and adipokines, particularly retinol-binding protein (RBP)-4. Methods: Thirty-four patients with chronic plaque psoriasis and a control group of 34 healthy volunteers were recruited in the study. Screening for the parameters was performed before starting and after 3 months of acitretin treatment in the psoriasis group. The control group was only evaluated at the beginning of the study and did not receive placebo. We could not compare our results with a placebo control group because of ethical reasons. Results: Basal adiponectin (p = 0.01), insulin (p < 0.0001) levels and homeostasis model assessment (HOMA) IR (p < 0.0001) were significantly higher in psoriasis patients. After the treatment, insulin (p = 0.014), C peptide (p = 0.011), RBP-4 (p < 0.0001) levels and HOMA-IR (p = 0.008) decreased significantly. Posttreatment leptin (p = 0.036)levels were significantly lower than those of the controls. Posttreatment adiponectin (p = 0.005) and insulin (p = 0.048) levels were higher than those of the controls. Conclusions:This study showed for the first time that RBP-4 levels and IR are decreased significantly with acitretin treatment. This finding is very important in psoriasis patients because psoriasis may cause insulin resistance and diabetes. Further experimental and clinical studies are needed to clarify the effect of acitretin on adipocyte structure and behavior. (C) 2013 S. Karger AG, Basel