Browsing by Author "Can, Alper"

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Esophageal Lymphoepithelioma-Like Carcinoma With Unique Daisy-Like Appearance
(Korean Soc Gastrointestinal Endoscopy, 2015) Olmez, Sehmus; Can, Alper; Yavuz, Alpaslan; Iliklerden, Umit Haluk; Bulut, Gulay
Due to differences in prognosis and management, it is important to subclassify esophageal carcinoma. Esophageal lymphoepithelioma-like carcinoma (LELC) is extremely rare, with only a few cases reported to date. Review of the literature revealed case reports describing lesions with similar histology. We present a 69-year-old man with a giant pedunculated-polypoid lesion of the esophagus shrinking the lumen. Endoscopic excision of the tumor was performed and final histopathological diagnosis was confirmed to be LELC. In contrast to a previous case with a more aggressive course and a recurrent lesion, our patient died of his disease within 8 months of diagnosis. Here we discuss the endoscopic and radiologic findings of the case and a review of the literature.
Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey
(Asian Pacific Organization Cancer Prevention, 2014) Can, Alper; Dogan, Erkan; Bayoglu, Ibrahim Vedat; Tatli, Ali Murat; Besiroglu, Mehmet; Kocer, Murat; Alacacioglu, Ahmet
Background: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials and Methods: Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Results: Only 205 (21%) of the 963 patients were women, with a male: female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.
Özefagus Kanserinde Torakoskopik-laparoskopik Özofajektomi: Yüksek Volümlü Merkezden İlk 7 Olgu
(2016) Pekşen, Çağhan; İlilkerden, Ümit; Can, Alper; Göy, Burhan; Kotan, M. Çetin; Toktas, Osman; Yerlikaya, Baran
Amaç: Yıllardır özefagus kanseri için konvansiyonel özefajektomi tekniğini kullandık. Son yıllarda yaygın olarak kullanılan minimal invaziv özefajektomi tekniğini kliniğimizde uyguladığımız ilk yedi olguyu literatür eşliğinde sunmayı amaçladık. Gereç ve Yöntem: Aralık 2013- Nisan 2014 yılları arasında kliniğimize başvuran özefagus SCC tanılı erken evre 7 hasta çalışmaya alındı. Hastalara 3 aşamalı ameliyat yapıldı. Sağ torakoskopik 4 trokar yöntemi ile torakal özefagus tamamen serbeştleştirildi. Batına 4 port girilerek laparoskopik olarak mide endo GIA ile tüp haline getirildi. Sol servikal insizyonla proksimal özefagus bulunup piyes yukarı çekildi. Özefagogastrostomi tek kat anastomoz yapıldı. Bulgular: Hastaların ortalama yaşı 58.57 ± 7.1 olup hastaların 5'i kadın, 2'si erkek idi. 5 hastada ameliyat torakoskopik-laparoskopik yaklaşımla gerçekleştirildi ve servikal anastomoz ile tamamlanabildi. 1 hastada batına laparotomi, 1 hastaya da mini laparotomi yapıldı. 2 hastada açık cerrahide çok nadir karşılaştığımız şilotoraks komplikasyonu gelişti. Bu hastalardan biri ex oldu. Sonuç: Minimal invaziv teknikler diğer alanlarda olduğu gibi, özofagus cerrahisinde de giderek artan oranda kabul görmektedir. Temel eğitim ve öğrenme peryodu sonrasında minimal invaziv özofajektomi yüksek hasta potansiyeline sahip merkezlerde uygulanabilecek, teknik olarak açık cerrahiden daha zor olmayan bir yöntem olarak görülse de işlem tecrübesi ve olası komplikasyonlara zamanında ve doğru yaklaşımın tekniğin başarı oranına önemli ölçüde etki ettiği kanaatindeyiz
Whole Brain Radiotherapy Results of Patients With Brain Metastases and Investigation of Their Prognostic Factors
(Kare Publ, 2014) Yilmazer, Gokhan; Nart, Maruf; Izmirli, Mustafa; Yavuz, Alpaslan; Can, Alper
OBJECTIVES To assess the survival ratios of patients with brain metastasis after whole brain radiotherapy according to recursive partitioning analysis (RPA) classification and other prognostic factors. METHODS Whole brain radiotherapy results and prognostic factors of 62 patients with brain metastasis were studied retrospectively. RESULTS The median survival rate in our study was 6.9 months. Single variation analysis demonstrated statistically significant survival results independently in female patients, with Karnofsky performance scale value of 70 and over, patients with controlled primary disease, RPA class I, and diagnosed with breast cancer (p<0.05). The results obtained from multi-variation analysis demonstrated statistically significant survival results among female patients, patients with an age of 65 years old and below as well as patients with solitary metastasis and who had undergone surgery (p<0.05). CONCLUSION Prognostic factors of patients must be considered in the treatment of brain metastases by selecting the most suitable process through radiosurgical, surgical resection, and/or whole brain radiotherapy.