Browsing by Author "Canbaz, Esra Turan"

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Association of Serum Rbp-4 Level With Clinical and Biochemical Parameters in Hemodialysis Patients
(2014) Canbaz, Esra Turan; Soyoral, Yasemin Usul
Turan Canbaz E. 'Hemodiyaliz Hastalarında Serum RBP-4 Düzeyinin Klinik ve Biyokimyasal Parametrelerle İlişkisi' Yüzüncü Yıl Üniversitesi Tıp Fakültesi, İç Hastalıkları Uzmanlık Tezi, Van 2014 RBP-4, insülin direncine neden olduğu gösterilmiş olan bir adipositokindir. Serum RBP4 konsantrasyonları obezite, bozulmuş glukoz toleransı ve tip 2 diabeti olan insülin dirençli kişilerde yüksek bulunmuştur. RBP-4 renal yolla atılan bir molekül olduğundan, renal yetmezlikte serum düzeyleri artmaktadır. Hemodiyaliz hastalarında kardiyovasküler hastalıklar mortalitenin en önemli nedenidir. Kardiyovasküler mortaliteye insülin direnci, inflamasyon ve aterosklerozun katkısı bulunmaktadır. Bu çalışmada inflamasyon ve insülin direncinin sıkça bulunduğu hemodiyaliz hastalarında serum RBP-4 düzeyinin klinik ve biyokimyasal parametrelerle ilişkisinin araştırılması amaçlandı. Çalışmaya en az 6 aydır son dönem böbrek yetmezliği nedeniyle haftada 3 kez hemodiyalize giren 54 hasta dahil edildi. Hastaların yaş ortalaması 44±14,3 olup 29'u erkek ve 25'i kadındı. 18 yaşından küçük, diabeti, aktif inflamasyonu ve KBY dışında kronik inflamatuar hastalığı olanlar çalışma dışı bırakıldı. Kontrol grubu 23 sağlıklı gönüllü bireyden oluşturuldu. Kontrol grubu olarak alınan sağlıklı gönüllülerin yaş ortalaması 43±17,8 olup 15'i erkek, 8'i kadındı. Serum RBP-4 düzeyleri ELISA yöntemiyle bakıldı. Hasta ve kontrol gruplarında ayrıca hemogram, CRP, biyokimya (glukoz, kreatinin, üre, BUN,total protein, albümin, sodyum, potasyum, kalsiyum, fosfor, ALT, AST, total kolesterol, LDL-kolesterol, HDL- kolesterol, trigliserid), demir, total demir bağlama kapasitesi, ferritin, fT4, TSH, PTH, insülin çalışıldı. Ayrıca çalışmaya dahil edilen tüm bireylerin boy, kilo, VKİ, bel çevresi, kalça çevresi, bel/kalça oranı, sistolik TA ve diastolik TA değerleri ölçülerek kaydedildi. HD hastalarında RBP-4 düzeyi sağlıklı kontrol grubuna göre istatistiksel olarak anlamlı yüksek saptandı (p<0,05). HD hastalarında serum RBP-4 düzeyi ile TDBK arasında pozitif korelasyon saptandı (p < 0,05; r =0,274). Kontrol grubunda serum RBP-4 düzeyi CRP ile pozitif koreleydi. (p< 0,05; r= 0,448) Bu veriler ışığında böbreklerden elimine olan RBP-4 düzeyinin hemodiyaliz hastalarında artmış olmakla birlikte biyokimyasal ve klinik parametreler üzerine belirgin bir etkisinin olmadığı söylenebilir. Ancak insülin direnci, inflamasyonla ikişkisi daha önceki çalışmalarda belirlenmiş olan RBP-4'ün hemodiyaliz hastalarında özellikle kardiyak parametreleri de içeren daha geniş ölçekli populasyonda yapılacak çalışmalara ihtiyaç vardır.
Coexistence of the Poems Syndrome With Hepatitis B: a Rare Case Report
(Springer Wien, 2016) Celik, Yilmaz; Aslan, Mehmet; Sayin, Refah; Cifci, Adem; Canbaz, Esra Turan; Kucukoglu, Mehmet Emin; Dulger, Ahmet Cumhur
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a rare multisystemic disease of unknown pathogenesis. Proinflammatory and proangiogenic cytokines play important roles in its pathogenesis. POEMS syndrome is a rare cause of ascites. Until now, the coexistence of POEMS syndrome and hepatitis B has not been reported. In this case report, we present a 48-year-old male patient who presented with malaise, fatigue, diarrhea, and abdominal swelling. Organomegaly, endocrinopathy, ascites, skin changes, and polyneuropathy were identified, and we arrived at a diagnosis of POEMS syndrome. The patient was administered methylprednisolone 64 mg/day, lamivudine 100 mg/day, calcium 1.5 g/day, and calcitriol 0.5 A mu g/day. The patient's clinical manifestations had moderately resolved at the follow-up visits. At the end of 6 months of follow-up, his ascites was minimally reduced, and his neurologic manifestations had not lessened. The present case shows that accurate diagnosis is required for the management of patients with coexisting POEMS syndrome and hepatitis B.
Comparison of the Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Wounds
(Oxford Univ Press, 2024) Canbaz, Yasin; Karakol, Percin; Erten, Remzi; Mercantepe, Tolga; Alp, Hamit Hakan; Canbaz, Esra Turan; Yuce, Serdar
We aimed to compare the effectiveness of thymoquinone (TQ), the most important bioactive component of black cumin, St. John wort (SJW) oil, a traditional medicinal plant used in burns, and silver sulfadiazine (AgSD), a well-known antiinflammatory agent used in modern medicine, in an experimental burn rat-model. Sixty-three Wistar-Albino rats were randomly divided into 9 groups (n = 7). TQ and SJW were administered topically and systemically but AgSD was applied topically. Epithelialization, inflammatory cell response, granulation tissue, vascularization, and fibrosis were evaluated. Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), vitamin E, 8-hydroxy-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10) were analyzed in serum. Topical TQ accelerated the epithelialization, enabled granulation, vascularization, and fibrosis in wounds (P = .001). Topical and systemic TQ increased Vitamin E levels (P = .003) but reduced TOS and 8-OHdG levels (P = .001). Topical SJW reduced granulation and vascularization. Topical and systemic SJW decreased TOS, MDA, and 8-OHdG levels (P = .001) but increased TAS (P = .001) and Vitamin E levels (P = .003). Topical AgSD reduced TOS, 8-OHdG, and MDA levels (P = .001). Topical and systemic TQ demonstrated significant advantages in accelerating the wound healing process while also enhancing antioxidant defenses and reducing oxidative damage. SJW oil, particularly in topical application, improved epithelialization, and antioxidant status but showed less efficacy in systemic use. AgSD, while effective in reducing oxidative stress, was less successful in promoting wound healing and appeared to delay granulation and fibrosis. Thymoquinone offers superior protective and healing benefits, SJW is effective locally but less so systemically, and AgSD should be used cautiously, potentially combined with antioxidants to mitigate its negative impact on wound healing.
Fenofibrate-Induced Rhabdomyolysis in a Patient With Chronic Renal Failure Due To Nephrotic Syndrome: a Rare Case Report
(Pergamon-elsevier Science Ltd, 2012) Erdur, Fatih Mehmet; Soyoral, Yasemin Usul; Emre, Habib; Begenik, Huseyin; Canbaz, Esra Turan; Erkoc, Reha
Objectives: Fenofibrate is a fibric acid derivative that is used alone or combination with statins in the treatment of hyperlipidemia. These drugs have potential risks, including rhabdomyolysis and acute renal failure. Despite reports of rhabdomyolysis with the use of fenofibrate alone or with statin-fibrate combinations, there have been no cases of rhabdomyolysis described when fenofibrate was used alone to treat patients with chronic renal failure owing to nephrotic syndrome. Design and methods: We report on a 26-year-old male who presented with fenofibrate-induced rhabdomyolysis with chronic renal failure due to nephrotic syndrome. Results: After the discontinuation of fenofibrate, the patient was treated with intravenous fluid replacement and urine alkalization. Subsequently, his clinical and biochemical findings improved. Conclusions: Before starting fenofibrate therapy, the causes of secondary hyperlipidemia, especially nephrotic syndrome, should be investigated. In the presence of chronic renal failure and hypoalbuminemia, the fenofibrate dose should be adjusted. Physicians should be aware of the potential toxicities of fenofibrate, and patients should be informed about its potential side effects. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Fenofibrate-Induced Rhabdomyolysis in a Patient With Stage 4 Chronic Renal Failure Due To Diabetes Mellitus
(Pakistan Medical Assoc, 2012) Soyoral, Yasemin Usul; Canbaz, Esra Turan; Erdur, Mehmet Fatih; Emre, Habib; Begenik, Huseyin; Erkoc, Reha
Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular components into the circulation. Several factors may lead to rhabdomyolysis. Fenofibrate is a fibric acid derivative agent that is used in the treatment of hyperlipidaemia. Although several case reports of rhabdomyolysis have been reported due to the combination of statin and fenofibrate, fenofibrate alone rarely causes rhabdomyolysis. When administering fenofibrate in chronic renal failure, dose should be adjusted. Here, we report a case with fenofibrate-induced rhabdomyolysis in a patient with chronic renal failure.
Submucosal Hematoma of the Esophagus Due To Fish Bone Ingestion
(Aves, 2014) Aslan, Mehmet; Celik, Yilmaz; Dulger, Ahmet Cumhur; Canbaz, Esra Turan; Olmez, Sehmus; Kemik, Ozgur; Yavuz, Alpaslan
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Cholestasis and Pericardial Effusion Due To Brucellosis Infection: a Case Report
(Hindawi Ltd, 2010) Dulger, Ahmet Cumhur; Kemik, Ozgur; Sumer, Aziz; Akdeniz, Huseyin; Kucukoglu, Mehmet Emin; Canbaz, Esra Turan; Aytemiz, Enver
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an extremely rare complication of infectious diseases. A rare case of brucellosis complicated by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) cholestasis and pericardial involvement is reported. A 27-year-old woman was admitted for fever, abdominal pain, and scleral icterus. Hermedical history revealed no recent use of diuretic agents. In addition to cholestasis and elevated liver enzymes, euvolemic hyponatremia, hypouricemia, low plasma osmolality, and high urinary osmolality were also detected. Surrenal and thyroid tests were also within normal range. Echocardiography revealed minimal pericardial effusion with normal cardiac functions. The final diagnosis was SIADH due to Brucellosis. Hyponatremia, cholestasis, and pericardial disease were resolved with effective antibrucellar treatment with streptomycine and doxycycline. After completing treatment of brucellosis, there was not any more evidence of cholestasis and pericardial fluid.