Browsing by Author "Candan, Zehra"

Now showing 1 - 4 of 4

The Effect of Disease Control on Mean Platelet Volume and Red Blood Cell Distribution in Patients With Acromegaly
(E-century Publishing Corp, 2015) Ucler, Rifki; Aslan, Mehmet; Atmaca, Murat; Alay, Murat; Ademoglu, Esra Nur; Candan, Zehra; Gulsen, Ismail
Objectives: Several studies have shown increased atherogenic risk factors and biomarkers of inflammation and atherosclerosis in association with growth hormone excess. Mean platelet volume (MPV) and red blood cell distribution (RDW) are currently gaining interest as new independent cardiovascular risk factors. The aim of this study was to evaluate the effect of disease control on MPV and RDW in acromegaly patients. Materials and methods: We retrospectively enrolled 36 acromegaly patients (23 males, 13 females; mean age 41.94 +/- 11.55). Patients were divided into two groups: disease controlled by surgical treatment alone (group A) or by somatostatin analog (SSA) therapy (group B). MPV and RDW measurements were evaluated during active and inactive disease periods in the two groups. Results: There were statistically significant increases in MPV and RDW in patients receiving SSA therapy (P = 0.012 and P = 0.020, respectively). The differences in MPV and RDW changes in patients receiving surgical treatment alone were not statistically significant (P=0.364 and P=0.339, respectively). Conclusions: This is the first report on the evaluated the effect of disease control on MPV and RDW in acromegaly patients. Our study results showed that MPV and RDW measurements are significantly increased in acromegaly patients with disease controlled by SSA therapy. Therefore, acromegalic patients treated with SSAs may have increased cardiovascular risk based on an increase in MPV and RDW.
Mediation Method in the Solution of Domestic Problems in Islamic Family Law
(2021) Candan, Zehra; Aslan, Mehmet Selim
Aile içi problemlerin çözümünde İslam hukukuna uygun, aynı zamanda medeni hukukta uygulanabilir bir yöntem geliştirmeyi amaçlayan tez çalışmamız tahkim, sulh ve arabuluculuk yöntemlerini kapsayan sentez bir yapıya sahiptir. Bu kapsamla önerdiğimiz aile içi problemlerin çözümünde arabuluculuk yöntemi; İslam aile hukukunda Kur'an-ı Kerim'e dayanan tahkim uygulamasını aile birliğini korumak amacıyla üçüncü bir şahsın desteğinin alınması ve tarafların temsil edilmesi yönüyle; İslam hukukunda sulh yöntemini yapılan müzakerelerin öncelikli olarak uzlaşma odaklı barışçıl bir şekilde sonuçlanmasını öncelemesi yönüyle; medeni hukukta arabuluculuk yöntemini ise sürecin mahkeme eliyle ve uzmanlık eğitimi almış, profesyonel bir üçüncü şahsın uzlaştırma amacıyla aracılık yapması yönüyle; kapsamakta ve bu uzlaşma yöntemlerinin birleşiminden oluşmaktadır. İslam aile hukukunda arabuluculuk yöntemi aynı zamanda mahkemeye gitmeden uzlaşma sağlaması amacıyla mahkemelerin iş yükünü azaltmayı, uzman profesyonel üçüncü bir şahsın desteğiyle taraflara manevi destek ve iletişim rehberliği sunmayı, toplumsal bir sorun haline gelen boşanma olgusunu azaltma konusunda katkı sağlamayı amaçlamaktadır. Türkiye aile yapısına uygun olarak çalıştığımız arabuluculuk yöntemi İslam hukuku, medeni hukuk ve toplumsal yapının özellikleri göz önünde bulundurularak; temel klasik kaynaklar, modern güncel kaynaklar ve disiplinler arası çalışmaların ele alınmasıyla geliştirilen bir yöntemle hazırlanmıştır. Giriş bölümüyle başlayan çalışmamızın ilk bölümünde genel olarak arabuluculuk yöntemi, kavramsal çerçevesi ve tarihsel gelişimi açısından ele alınmış, ikinci bölümde İslam hukukunda arabuluculuğun meşruiyeti değerlendirilmiştir. Sonraki bölümlerde ise İslam aile hukukunda aile içinde yaşanan problemler, nafaka, mehir, boşanma ve hıdâne özelinde ele alınarak arabuluculuk yöntemi ile bu problemlerin çözümü üzerine değerlendirmeler yapılmıştır. Sonuç olarak çalışmamızda sulh temelli arabuluculuk yönteminin uygulanabilirliği ele alınmıştır.
Ocular Findings in Sheehan's Syndrome
(Springer, 2015) Atmaca, Murat; Kizildag, Esra; Candan, Zehra; Ozbay, Mehmet Fatih; Seven, Ismet
Sheehan's syndrome (SS) is one of the most common causes of hypopituitarism. The primary effect of SS is a deficiency in production of growth hormone (GH). A number of studies have supported the association between congenital GH deficiency and ocular anomalies. However, ocular findings such as central corneal thickness (CCT), intraocular pressure (IOP), and retinal nerve fiber layer thickness (RNFLT) have not been evaluated in patients with adult GH deficiency. The objective of this study was to evaluate ocular anomalies in SS with GH deficiency under a cross-sectional design. Thirty three SS patients with GH deficiency and 28 controls with no history of thyroid, adrenal, or pituitary gland diseases or surgery underwent complete hormonal and ophthalmological evaluation, including an assessment of CCTs, IOPs, and RNFLT. The mean CCTs were significantly lower in the SS group compared with the control group (p < 0.001). There was no significant difference between patients and controls in terms of mean IOP, mean corrected IOP, and mean RNFLT (p = 0.517, p = 0.186, p = 0.965, respectively). The mean CCT was positively correlated with insulin-like growth factor 1 (IGF-1; p < 0.01) and adrenocorticotropic hormone (ACTH; p < 0.01) and negatively correlated with the corrected mean IOP (p < 0.05). In covariance analysis, IGF-1 was found to be a potential predictor of the mean CCT (p = 0.023). This study is the first investigation of ocular findings in SS and adult GH deficiency. Adult GH deficiency is characterized by lower CCT values.
Type 2 Diabetes Mellitus and Functional Hypoparathyroidism
(Aves, 2014) Atmaca, Murat; Acar, Ismail; Gonultas, Engin; Seven, Ismet; Ucler, Rifki; Ebinc, Senar; Candan, Zehra
Purpose: The present study aims to investigate the effect of blood sugar regulation and vitamin D levels on calcium metabolism and parathormone levels in patients with type 2 diabetes mellitus. Material and Method: We included 132 patients with type 2 diabetes mellitus who presented to our outpatient clinic for regular check up between August 2013 and October 2013. Fasting blood glucose, HbA1c, calcium, phosphorus, magnesium, albumin, creatinine, parathormone, 25-Hydroxy vitamin D [25(OH) D], spot urinary calcium and creatinine levels were studied for each patient. Results: Vitamin D levels were below 30 ng/mL in 96.9% (n = 128) and below 20 ng/mL in 78.7% (n = 102) of the patients included in the study. Patients with impaired blood sugar regulation (HbA1c > 10%) had lower levels of PTH, albumin and 25(OH) D levels and higher phosphorus levels compared to patients with HbA1c levels below 10% (p = 0.018, p = 0.043, p = 0.002, p = 0.01, respectively). The rates of functional hypoparathyroidism (parathormone < 65 ng/mL) in patients with vitamin D levels below 30 ng/mL and 20 ng/mL were 63.2% and 59.6%, respectively. Among the diabetic patients with vitamin D levels < 30 ng/mL, magnesium levels were significantly lower in those with functional hypoparathyroidism (parathormone < 65 ng/mL) compared to those with secondary hyperparathyroidism (p = 0.015). Comparative statistical analysis of patients with HbA1c levels above and below 10% demonstrated higher proportion of patients with functional hypoparathyroidism in the group with impaired blood sugar regulation (p = 0.035 for patients with vitamin levels below 30 ng/mL, and p = 0.031 for patients with vitamin levels below 20 ng/mL). Discussion: Impaired blood sugar regulation leads to functional hypoparathyroidism with secondary hypomagnesemia in type 2 diabetes mellitus, as was previously described for subjects with type 1 diabetes mellitus.