Browsing by Author "Celegen, Izzet"

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Association of Subclinical Markers of Inflammation With Preterm Premature Rupture of Membranes and Adverse Neonatal Results: a Case Control Study
(Springer Heidelberg, 2022) Uckan, Kazim; Baskiran, Yusuf; Celegen, Izzet
Aim The study aims to investigate the relationship between subclinical inflammatory factors, which are known to be closely related to inflammation, with preterm premature rupture of membranes (PPROM) and adverse postpartum outcomes. Materials and methods The case control type study was conducted between January 1, 2021, and January 2022. 525 pregnant women, including 272 PPROM and 253 normal patients, were added to the study. Results There was a positive relationship between PPROM and PCT (platelet crit), MPV (mean platelet volume), NLR (neutrophil-to-lymphocyte ratio), and MLR (monocytes to lymphocyte ratio) values. ROC analysis, PCT > 0.19, MPV > 8.78, NLR > 2.82, and MLR > 0.24 were significantly related to improved risk of PPROM (P < 0.05). In logistic regression analysis, a one-unit rise in PCT resulted in a 3.9-fold rise in RDS risk and a one-unit increase in NLR resulted in a 1.6-fold significant rise in sepsis risk (p < 0.05). Conclusion NLR and PCT parameters were found to be related to adverse neonatal outcomes.
Can Failure Be Predicted in Methotrexate Treatment With the Modified Parameter
(Springer Heidelberg, 2024) Baskiran, Yusuf; Uckan, Kazim; Celegen, Izzet
Objective The objective of the study was to increase the prediction of success of single-dose methotrexate therapy in ectopic pregnancy patients with modified parameters obtained from complete blood count and beta-human chorionic gonadotropin (beta-hCG) parameters. In this way, it was aimed to predict patients whose methotrexate treatment may fail and rupture, to avoid unnecessary methotrexate treatment, to shorten the duration of hospital stay and to reduce patient mortality. Materials and methods 233 patients diagnosed with ectopic pregnancy between January 1, 2017, and March 01, 2022, in the obstetrics and gynecology service of a tertiary center were included in the study. Results The mean of beta-hCG was 1976 in the methotrexate group and 2358 in the surgery group (p < 0.05). The ROC curve determined the effect of BW (beta-hCGxWBC/1000) and BP (beta-hCGx1000/PLT) markers in diagnosing patients who will need surgery in ectopic pregnancy. The areas under the ROC curve for beta-hCG, BW and BP were 0.86, 0.99 and 0.94, respectively (p < 0.05). beta-hCG > 2139.03, BW > 30.96 and BP > 10.17 values were significantly associated with the need for surgery in ectopic pregnancy patients (p < 0.05). Logistic regression analysis revealed that a 1-unit increase in BP caused a statistically significant 1.77-fold increase in surgical need in patients with ectopic pregnancy. In contrast, a 1-unit increase in BW caused a 2.34-fold increase in surgical need (p < 0.05). Conclusion The study results showed that BW and BP values together with beta-hCG are effective in predicting ectopic pregnancy patients who may undergo surgery.
Evaluation of Hbsag, Anti-Hcv, Anti-Hiv Seroprevalence and Perinatal Outcomes in Pregnant Women
(Galenos Publ House, 2021) Uckan, Kazim; Celegen, Izzet; Uckan, Taner
Objectives: Vertical transmission of hepatitis B virus, hepatitis C virus, (HBV, HCV) and human immunodeficiency viruses (HIV) infections is an important public health problem. The aim of this study was to determine the rates of hepatitis B, anti-HCV and anti HIV seropositivities in pregnant women in a city and to evaluate the infections in terms of perinatal outcomes. Materials and Methods: In this retrospective study, 8,464 patients who gave birth in obstetrics and gynecology clinic were recorded. Seropositivity rates of pregnant women were investigated according to the results of hepatitis B surface antigen (HBsAg), HCV antibody and anti-HIV antibody. The rates were determined according to years and perinatal results and statistical comparison was made. Results: HBsAg seropositivity in pregnant women included in the study was 2.8 % (n=55) in 2015, 2.2% (n=52) in 2016, 2.3% (n=47) in 2017 and 2.2% (n=49) in 2018. The 4 year average was found to be 2.3% (n=203). There was no significant difference between the years (p>0.05). Among all our patients, 4-year mean anti-HCV seropositivity was 0.57% (n=49) and there was no difference between years (p>0.05). Anti-HIV seropositivity was found to be 0.09% on average, and there was no statistically significant difference over the years (p>0.05). Conclusion: Since hepatitis B, which is a preventable viral disease, has a risk of transmission during delivery and if it is transmitted to the fetus, it may lead to fatal complications at later ages, it is necessary to screen all pregnant women in terms of HBsAg seropositivity and to include it in an antepartum planning program to protect and treat newborns from infection. Although the transmission rate of HCV is low in the society, considering its clinical course, screening of HCV together with HIV in risky groups and pregnant women antibody positivity is considered important for the health of the society and newborns.
Hormonal and Electrolyte Predictors for Methotrexate Versus Surgery in Ectopic Pregnancy
(Public Library Science, 2025) Baskiran, Yusuf; Uckan, Kazim; Celegen, Izzet; Tanoglu, Fatma Basak
This retrospective study investigates the association between maternal serum electrolyte and hormone levels and the success of methotrexate (MTX) treatment in ectopic pregnancies, aiming to identify predictive factors and improve clinical outcomes. A total of 372 patients treated with single-dose MTX between 2012 and 2023 were included, divided into two groups: those who successfully responded to MTX and those requiring surgical intervention. Significant differences were observed in beta-hCG levels, with a mean of 1376 in the MTX-successful group and 2358 in the surgical group. Electrolyte analysis showed that patients who responded successfully to MTX had higher potassium and albumin levels, whereas magnesium levels were lower compared to the surgical group. Haematological parameters also varied, with higher hemoglobin and hematocrit levels observed in the MTX-successful group. The findings suggest that serum potassium, magnesium, and albumin levels may be predictive markers for MTX efficacy. Higher potassium and albumin levels, along with lower magnesium levels, may contribute to improved treatment outcomes. These results support the potential role of dietary interventions-such as increasing potassium and albumin intake and moderating magnesium levels-in enhancing MTX success rates. This study underscores the importance of maternal biochemical profiles in guiding treatment strategies for ectopic pregnancy and highlights the value of individualized approaches to optimize outcomes and minimize the need for surgical intervention. Future research should aim to elucidate the biological mechanisms underlying these associations and validate the findings in larger and more diverse patient populations.
The Impact of Maternal Electrolyte and Albumin Levels on the Efficacy of Single-Dose Methotrexate Treatment for Ectopic Pregnancies
(Galenos Publ House, 2023) Baskiran, Yusuf; Uckan, Kazim; Karacor, Talip; Celegen, Izzet; Acar, Zuat
Objective: This study aims to investigate the impact of maternal albumin and serum electrolyte levels on the efficacy of single-dose methotrexate (SD-Mtx) therapy for ectopic pregnancies. Building on previous research, recommendations are provided to enhance the success of SD-Mtx therapy in the management of ectopic pregnancy. Materials and Methods: Conducted at a tertiary center gynecology clinic, the study included 353 patients diagnosed with ectopic pregnancy and treated with SD-Mtx from 2012 to 2023. Patients who responded positively to SD-Mtx treatment comprised Group 1 (n=313), while those requiring surgical intervention due to failed SD-Mtx therapy constituted Group 2 (n=40). Through the hospital's digital database, patient data including complete blood count, biochemistry, and hormone test results were retrospectively examined. Results: The mean beta-hCG value was 1996 IU/mL for Group 1 in contrast to 2058 IU/mL for Group 2. There was no statistically significant difference in beta-hCG levels between the two groups. Notably, Group 1 patients exhibited lower serum magnesium levels but higher potassium levels compared to Group 2 patients, with statistically significant differences. Furthermore, Group 1 patients had higher albumin levels than those in Group 2, with a statistically significant difference. Conclusion: Successful SD-Mtx treatment was associated with lower maternal serum magnesium levels and higher potassium and albumin levels. Considering electrolyte levels before administering SD-Mtx and addressing any imbalances could potentially enhance treatment success. Additionally, restoring low albumin levels might improve the efficacy of SD-Mtx treatment for ectopic pregnancies. While this study suggests these trends, further extensive studies with a larger sample size are necessary to establish more definitive evidence.
Maternal and Neonatal Consequences of Cystocele and Rectocele in the Delivery Process
(Lippincott Williams & Wilkins, 2023) Baskiran, Yusuf; Uckan, Kazim; Celegen, Izzet; Tanoglu, Fatma Basak
The study aimed to investigate the effects of cystocele and rectocele on the stages of vaginal birth and maternal and newborn outcomes. A total of 672 multiparous pregnant women between the ages of 18 to 40 who underwent normal vaginal delivery in our tertiary center between November 2022 and February 2023, were included in this prospective study. Among the participants, 348 (51.8%) had no abnormalities, 78 (11.6%) had rectocele only, 112 (16.7%) had cystocele only, and 134 (19.9) had both cystocele and rectocele. Patients with the coexistence of cystocele and rectocele experienced a notably extended duration for both the first stage and second stage of labor, although the extension in the second stage was not statistically significant. Among the maternal complications, the development of maternal laceration and chorioamnionitis was significantly more common in the patient group with cystocele and rectocele compared to the other groups. When the groups were assessed for postpartum bleeding, while the bleeding risk increased from the normal group to the rectocele + cystocele group, this increase was not statistically significant. There was no difference between the groups in terms of neonatal outcomes. The delivery time of pregnant women with cystocele and rectocele, in the absence of additional risk factors, was determined to be significantly longer than that of the control group. We think that these patients should receive more vigilant monitoring, and this criterion should be kept in mind when assessing the indication for a cesarean section.
Relationship of Hyperemesis Gravidarum With Platelet Crit, Hemoglobin-to Cell Distribution Width Ratio, and Neutrophil-to Ratio
(Assoc Medica Brasileira, 2025) Uckan, Kazim; Baskiran, Yusuf; Celegen, Izzet
OBJECTIVE: The aim of this study was to investigate the relationship between the severity of hyperemesis gravidarum disease and subclinical inflammatory factors such as platelet crit, hemoglobin-to-red cell distribution width ratio, neutrophil-to-lymphocyte ratio, which are known to be closely associated with inflammation in patients with hyperemesis gravidarum. METHODS: This retrospective case-control study was conducted between December 2020 and December 2021. A total of 215 pregnant women, 102 with hyperemesis gravidarum and 113 healthy pregnant women, were included in the study. Hyperemesis gravidarum patients were divided into three groups according to the modified Pregnancy-Unique Quantification of Emesis and nausea classification as mild (n=38), moderate (n=32), and severe (n=32). RESULTS: Platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio values were found to be statistically significantly higher in the hyperemesis gravidarum group compared to the control group (p<0.05). There was a mild-to-severe increase in platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio values in hyperemesis gravidarum patients (p<0.05). Logistic regression analysis revealed that a one-unit increase in platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio resulted in a 2.14-, 1.41-, and 2.36-fold increase in hyperemesis gravidarum risk, respectively. CONCLUSIONS: Platelet crit, hemoglobin-to-red cell distribution width ratio, and neutrophil-to-lymphocyte ratio are inflammatory markers that increase in patients with hyperemesis gravidarum and have predictive value for the development of hyperemesis gravidarum. In our study, we suggested the use of a new prognostic marker for patients with hyperemesis gravidarum. We believe that our study will be a source for future studies on hyperemesis gravidarum.
The Role of Ultrasound and Mitofusin-2 Levels To Predict Pregnancy Outcomes in Patients With Severe Preeclampsia: a Case-Control Study
(Assoc Medica Brasileira, 2024) Uckan, Kazim; Ozgokce, Cagdas; Baskiran, Yusuf; Eyisoy, Omer Gokhan; Celegen, Izzet; Akbay, Halil Ibrahim
OBJECTIVE: The aim of this study was to evaluate mitofusin-2 levels and fetal Doppler ultrasonography effects in patients with severe preeclampsia. METHODS: This single-center case-control study was conducted in the gynecology service of the university hospital in Van. A total of 90 pregnant women aged 18-40 years were included in the study. Of these, 30 are normal, 30 have mild preeclampsia, and 30 are pregnant with severe preeclampsia. In this study, especially in severe preeclampsia patients, serum mitofusin-2 levels and important fetal Doppler flows such as uterine arterial pressure, umbilical arterial pressure, and 1st and 5th minute Apgar scores, birth weight, and the relationship between postnatal outcomes such as week of birth and the number of patients in the neonatal intensive care unit were investigated. RESULTS: There was a significant difference between the three groups in terms of mitofusin-2 levels, which was the highest in the group (p<0.05). Maternal serum mitofusin-2 levels were positively correlated with uterine arterial pressure (r=0.543, p=0.007), umbilical arterial pressure (r=0.238, p=0.008), diastolic blood pressure, and systolic blood pressure (p<0.001). Receiver operating characteristic curve of mitofusin-2 in predicting preeclampsia is as follows: optimal cutoff 1.6 ng/mL; area under the curve: 0.861; 95%CI: 0.786-0.917; sensitivity: 83.9%; and specificity: 70.0%, (p <= 0.001). A one-unit increase in mitofusin-2 resulted in a statistically significant 4.21-fold increase in preeclampsia risk. CONCLUSION: This study recommends the use of mitofusin-2 together with fetal Doppler ultrasound findings as a reliable indicator of preeclampsia severity.