Browsing by Author "Celik, Mehmet"

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Brucellosis-Associated Hepatitis
(Springer London Ltd, 2024) Arslan, Yusuf; Baran, Ali Irfan; Celik, Mehmet
AimBrucellosis is a zoonotic infection that can affect almost every organ. A mild elevation of aminotransferase levels is usually observed in liver involvement. However, the development of clinical hepatitis is rare. In this study, we aimed to present the hospitalized cases with brucellosis hepatitis in our clinic in a 13-year period.MethodsA hundred and three patients with significant hepatobiliary involvement, diagnosed by microbiological analysis, were included in the study. For the presence of hepatitis, it was required that the aminotransferases must be >= 5 times more than the upper limit and/or the total bilirubin level must be >= 2 mg/dl and/or the local hepatic lesion must be demonstrated.ResultsOf the cases, 35.9%, 17.5%, and 46.6% had clinical hepatitis, cholestatic hepatitis, and both clinical and cholestatic hepatitis, respectively. The most frequent symptom was fever (85.4%) while the most preferred treatment options were combinations containing aminoglycosides. It was observed that the mean time-interval to decrease to normal values of ALT, AST, and bilirubin values was 15.2 +/- 7.8 days while the patients having their treatment regimens. In our study, which focused on liver involvement, it was found that a chronic liver disease did not develop in any of the cases.ConclusionOur study showed that, even in the presence of hepatitis, clinical response and laboratory improvement were high with appropriate treatment. It was observed that the improvement in aminotransferases and total bilirubin values delayed in the cases with blood culture positivity, secondary organ involvement, and alanine aminotransferase/aspartate aminotransferase > 1.
Can the Efficacy of a Medical Treatment Be Predicted Based on the Type of Idiopathic Premature Ventricular Contraction
(Churchill Livingstone inc Medical Publishers, 2024) Atici, Adem; Sahin, Irfan; Dogan, Omer; Barman, Hasan Ali; Kup, Ayhan; Celik, Mehmet; Caliskan, Mustafa
Background: Premature ventricular contractions (PVCs) are common arrhythmias with diverse clinical implications. This retrospective study aimed to evaluate the efficacy of medical treatments using various clinical, imaging, and electrocardiographic parameters in patients with idiopathic PVCs. Methods: A total of 1051 patients with idiopathic PVCs were retrospectively analyzed. Patients were categorized into three groups based on treatment response: beta-blocker (BB) responders (479 patients), calcium-channel blocker (CCB) responders (335 patients), and class 1c antiarrhythmic (AA) responders (237 patients). Clinical, imaging, and electrocardiographic data were collected and analyzed to assess the factors influencing treatment response. Results: Age, left ventricular ejection fraction (LVEF), PVC QRS duration, CI variability, and multiple PVC morphologies were identified as significant factors affecting treatment response. Older age and lower LVEF were associated with better response to BB treatment, whereas CCB responders showed narrower QRS complexes. BB responders also exhibited higher CI variability, possibly linked to automaticity mechanisms. Moreover, the BB responder group had a higher frequency of multiple PVC morphologies. Conclusion: These findings emphasize the importance of tailored treatment approaches based on individual patient characteristics.
Comparison of Carbapenem Resistance Detected by the Bd Phoenix Automated System in Enterobacteriaceae Isolates E-Test Method
(Modestum Ltd, 2022) Celik, Mehmet; Sunnetcioglu, Mahmut; Guducuoglu, Huseyin; Arslan, Yusuf; Akyuz, Sumeyye; Baran, Ali Irfan
Objective: Automatic identification and antimicrobial susceptibility systems are frequently used to identify clinical isolates in hospitalized patients, but mistakes in these systems can lead to potentially devastating treatment failures for patients. Therefore, the "Centers for Disease Control and Prevention (CDC)" recommends confirming all Carbapenem-resistant and low-susceptibility isolates with a different method. The aim of this study is to compare the Carbapenem susceptibility results of isolates reported as Carbapenem-resistant Enterobacteriaceae according to the BD Phoenix 100 automated system with the E-test method. Materials and Methods: The study included 70 strains of Carbapenem-resistant Enterobacteriaceae members which were isolated and grown from several types of clinical samples in the Medical Microbiology Laboratory. Conventional methods (Gram stain, negative oxidase test) and the BD Phoenix 100 automated system were used to identify the isolates. The susceptibility of all strains to imipenem, ertapenem and meropenem was investigated by E-test method. Automated system results and E-test results were compared. Results: The frequency distribution of all isolated bacterial strains comprised K. pneumoniae in 56 (80%) of the samples included in the study. The automated system test results were correlated with the results of the E-test at a rate of 96.1 % for the imipenem-resistant strains, 84.3% for the meropenem-resistant strains, 84.1% for the ertapenem-resistant strains Conclusions: Automated systems are frequently used in microbiology laboratories to identify isolates. However, automated systems can show a high error rate against some antimicrobials. For this reason, comparing the results of automated system test results with tests such as E-test is very important to prevent both treatment failures and inappropriate antibiotic use that may occur on a patient basis.
Evaluation of Risk Factors in Patients With Ventilator-Associated Pneumonia Caused by Acinetobacter Baumannii
(Univ Udayana, 2020) Baran, Ali Irfan; Celik, Mehmet; Arslan, Yusuf; Demirkiran, Hilmi; Sunnetcioglu, Mahmut; Sunnetcioglu, Aysel
Purpose: Ventilator-associated pneumonia is a significant disease with high mortality rates. Acinetobacter baumannii is one of the most critical pathogens leading to ventilator-associated pneumonia. This study aims to evaluate the underlying risk factors in patients diagnosed with ventilator-associated pneumonia caused by Acinetobacter baumannii, who were followed in intensive care units of our hospital. Patients and Methods: The data of 112 patients diagnosed with ventilator-associated pneumonia caused by Acinetobacter baumannii, who were followed in Intensive Care Units other than Pediatric Intensive Care Unit of our hospital from 2013 to 2017, were evaluated retrospectively. Results: Of the cases included in our study, 70.5% were male, and 29.5% were female patients. Of the cases, 875% were followed in Anaesthesiology and Reanimation Intensive Care Unit. The most common modifiable risk factors are mechanical ventilation, antacid use, and the most common non-modifiable risk factors were the presence of trauma and a history of cardiovascular disease. Conclusion: Ventilator-associated pneumonia is a clinical condition with high mortality and morbidity in intensive care units. Incidence and mortality of ventilator-associated pneumonia can be reduced through the implementation of some necessary policies for the prevention of ventilator-associated pneumonia and the practices for the reduction or elimination of modifiable risk factors.
Kandida Suşuna Bağlıidrar Yolu Enfeksiyonu: İki Olgu Sunumu
(2016) Celik, Mehmet; Baran, Ali Irfan; Karahocagil, M. Kasım; Yakan, Ümit; Sünnetçioğlu, Mahmut
Üriner sistem enfeksiyonları, en sık karşılaşılan bakteriyel enfeksiyonlardan biridir. Kadınlar erkeklerden daha sık üriner sistem enfeksiyonları geçirmektedir. Üriner sistem enfeksiyonlarında bakteriyel etkenler daha sık neden olmakla beraber, son yıllarda fungal etkenlerde artış görülmeye başlanmıştır. Son yıllarda artan fungal enfeksiyonlar ve giderek yaygınlaşan antifungal ajan kullanımı dirençli mantar suşlarının ortaya çıkmasına ve direnç oranlarının artmasına neden olmuştur. Kandida suşuna bağlı iki üriner sistem enfeksiyonları olgusu, sıklığı gittikçe artan bu olgulara dikkat çekmek amacıyla sunuldu.
Leptomeningeal Carcinomatosis Due To Gastric Adenocarcinoma Mixed With Meningitis
(Cukurova Univ, Fac Medicine, 2019) Sunnetcioglu, Mahmut; Celik, Mehmet; Unal, Murat; Tarcan, Tayyar; Erten, Remzi; Baran, Ali Irfan
Van İli Erciş İlçesi Bağlarında Asmaların ve Toprakların Bazı Bitki Besin Elementleri Bakımından İncelenmesi
(2017) Gülser, Füsun; Keskin, Nurhan; Celik, Mehmet
Bu çalışmada, Van ili, Erciş ilçesindeki bağlarda asmaların ve toprakların bazı bitki besin elementleribakımından incelenmesi amaçlanmıştır. Bu amaçla, yedi farklı bağdan bağ bozumu döneminde 0 -30 cmderinlikten toprak ve ben düşme döneminde 10 omcadan, salkımların karşılarındaki yapraklardan sapları ilebirliktebitki örnekleri alınmıştır. Toprak örneklerinde toplam N, alınabilir P, değişebilir K, Ca ve Mg ile alınabi lirFe, Mn, Zn ve Cu içerikleri belirlenmiş, yaprak örneklerinde ise N, P, K, Ca, Mg, Fe, Mn, Zn ve Cu içerikleri anal izedilmiştir. Bitki besin elementleri bakımından yapılan karşılaştırmada tek yönlü varyans analizi (ANOVA) vevaryans analizini takiben farklı grupları belirlemede Duncan çoklu karşılaştırma testi kullanılmıştır. Araştırmasonuçlarına göre, topraklarda P,Mn ve Zn içeriklerinin, yapraklarda ise Zn ve Cu içeriklerinin yeters i z düzeydeolduğu belirlenmiştir.