Browsing by Author "Celik, S."

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Comparison of Icodextrin With Thymoquinone: a New Hope for Postoperative Adhesions
(Medknow Publications & Media Pvt Ltd, 2017) Yilmaz, O.; Kiziltan, R.; Celik, S.; Yildirm, S.; Alp, H. H.; Aras, A.; Kotan, C.
Objective: The purpose of this study was to compare the effects of thymoquinone and icodextrin in rats within the framework of an experimental adhesion model. Materials and Methods: Rats were separated into three groups: (1) a control group consisting of rats that had 2 ml of isotonic solution administered intraperitoneally, (2) an ICO group administered with 2 ml of 4% icodextrin, and (3) a TQ group administered thymoquinone (10 mg/kg), all following cecal abrasion. The three groups underwent a reoperation on the 7th postoperative day. Hydroxyproline levels were analyzed in the resected adhesive tissues, and histopathological investigations were conducted. Blood samples were collected for biochemical analyses. Results: Fewer postoperative adhesions were observed in the ICO and TQ groups compared with the control group. A comparison of the TQ and ICO groups revealed lowers levels of postoperative adhesions in the TQ group. Compared with the control group, malondialdehyde, 8-OH-deoxyguanosine/deoxyguanosine (8-OHdG/10dG), Coenzyme Q10 (CoQ10), and CoenzymeQ10/reduced CoenzymeQ10 (CoQ10/CoQ10H) values were found to be lower in the TQ and ICO groups. When the TQ and ICO groups were compared with respect to their biochemical parameters, the results for all of the four parameters were found to be statistically significantly lower in the TQ group (P < 0.000). The levels of hydroxyproline in the control, ICO, and TQ groups were found to be (mean +/- standard deviation) 502.25 +/- 90.39 mu g/g, 342.13 +/- 66.61 mu g/g, and 287.88 +/- 49.59 mu g/g, respectively. Conclusions: A comparison of the antiadhesive effects of thymoquinone and icodextrin revealed thymoquinone to be more effective. These results indicate that thymoquinone is an efficient and strong antiadhesive molecule.
Determination of Fermentation and Digestibility Characteristics of Corn, Sunflower and Combination of Corn and Sunflower Silages
(Medwell online, 2008) Demirel, M.; Bolat, D.; Celik, S.; Bakici, Y.; Eratak, S.
This study was conducted to determine in vivo digestibilities and fermentation property of various silages made of green herbage of Sunflower (SF), Corn (C) and corn-sunflower mixtures at different rates [75% com+25% sunflower (75C25SF), 50% corn+50% sunflower (50C50SF), 25% corn+75 sunflower (25C75SF)] ensiled in 120 1 plastic barrels for 90 days. PH values of C and mixture silages were lower than that of SF silage (p<0.05). Concentrations of lactic, acetic, propionic and butyric acids were higher in SF silage than C silage (p<0.05). Lactic and propionic acid concentrations increased in mixture silages as the sunflower ratio increased, whereas decreases in butyric acid concentration were observed as corn ratio incresed in the mixture (p<0.05). While digestibility of DM, OM, ADF and NDF were high in C silage, digestibility of CP and EE were high in SF silage. The digestibility of DM, OM, ADF and NDF in mixture silages increased with the increases in corn ratio in mixture and digestibility of CP and EE of increased as sunflower ratio increased in mixture. It can be concluded that high quality silages could be obtained from green herbage of corn or sunflower alone, however their nutritive values could be improved if they are mixed at 50% ratio.
The Dynamics of Prehospital/Hospital Care and Modes of Transport During Civil Conflict and Terrorist Incidents
(W B Saunders Co Ltd, 2017) Celik, S.; Dursun, R.; Aycan, A.; Gonullu, H.; Adanas, C.; Eryilmaz, M.; Guloglu, C.
Objective: Prehospital and hospital care during incidents of mass violence and civil conflict involve a number of aspects that distinguish it from care during times of peace. We aimed to analyze the dynamics and outcomes of prehospital and hospital care during ongoing conflicts. Study design: Multicentric prospective observational study. Method: Patients enrolled in the study, which was conducted in Turkey, were all injured in armed conflict and taken to level 1 trauma centers. On admittance, patients were requested to complete a semistructured questionnaire containing questions on patient demographics, transport type, weapons used, injury severity score (ISS), and other incident-related factors. We analyzed patient outcomes (mortality, morbidity, complications, and length of hospital stay) and transfers of patients between hospitals. The present study evaluated the cases of 390 victims enrolled over a 9-month period and followed up for 6 months. Results: The majority of patients were transported by ambulances (n = 334, 85.6%); other transport modes were helicopters (n = 32, 8.2%) and private vehicles (n = 24, 6.2%). Nearly half of patients (48.7%) did not benefit by changing hospitals. During transport to hospitals, 4.1% of the vehicles in the study were involved in accidents. Using multiple regression analysis, only ISS (odds ratio [OR]: 1.098, 95% confidence interval [CI]: 1.044-1.156) and the Glasgow Coma Scale (OR: 0.744, 95% CI: 0.639-0.866) were found to affect mortality. In Receiver-operator characteristic analysis, a cutoff value of 22.5 for ISS had a sensitivity of 100% and a specificity of 89.6% for mortality. Conclusions: Despite lower ISS values, patient outcomes were worse in terror incidents/civil conflicts. Transport modes did not significantly affect outcomes, whereas hospital transport was found to be inefficiently used. (C) 2017 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
Intraoperatively Testing the Anastomotic Integrity of Esophagojejunostomy Using Methylene Blue
(Sage Publications Ltd, 2017) Celik, S.; Almali, N.; Aras, A.; Yilmaz, O.; Kiziltan, R.
Background: Intraoperative testing of gastrointestinal anastomosis effectively ensures anastomotic integrity. This study investigated whether the routine use of methylene blue intraoperatively identified leaks to reduce the postoperative proportion of clinical leaks. Methods: This study retrospectively analyzed consecutive total gastrectomies performed from January 2007 to December 2014 in a university hospital setting by a general surgical group that exclusively used the methylene blue test. All surgeries were performed for gastric or junctional cancers (n = 198). All reconstructions (Roux-en Y esophagojejunostomy) were performed using a stapler. The methylene blue test was used in 108 cases (group 1) via a nasojejunal tube. No test was performed for the other 90 cases (group 2). Intraoperative leakage rate, postoperative clinical leakage rate, length of hospitalization, and mortality rate were the outcome measures. Results: The intraoperative leakage rate was 7.4% in group 1. The postoperative clinical leakage rate was 8.6%. The postoperative clinical leakage rate was 3.7% in group 1 and 14.4% in group 2 (p = 0.007). There were no postoperative clinical leaks when an intraoperative leak led to concomitant intraoperative repair. The median length of hospital stay was 6 days in group 1 and 8 days in group 2 (p<0.001). One death occurred in each group. No test-related complications were observed. Conclusion: The methylene blue test for esophagojejunostomy is a safe and reliable method for the assessment of anastomosis integrity, especially in cases with difficult esophagojejunostomic construction.
Mixed Type Adrenal Cyst: a Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Bulut, G.; Bulut, M.D.; Yilmaz, D.; Celik, S.; Toprak, N.
Adrenal cysts are rare lesions that usually progress asymptomatically. They are often determined postmortem. Our case was a 50-year old-male who had presented to our clinic with upper right quadrant pain. The computed tomography demonstrated a cystic mass in the adrenal gland. No abnormalities were determined in the laboratory tests. According to the histopathological and immunohistochemical examination, the cyst was evaluated as a mixed-type adrenal cyst, the wall of which was covered with endothelium, mesothelium and cubic epithelium. We believed that the case was worth presenting, since it was the first diagnosed mixed-type adrenal cyst in the literature. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Neural Networks To Understand the Physics of Oncological Medical Imaging
(World Scientific Publ Co Pte Ltd, 2022) Al-Utaibi, Khaled A.; Sohail, Ayesha; Arif, Fatima; Celik, S.; Sait, Sadiq M.; Keskin, Derya Bako
The evolving field of computational image analysis has its applications in the industry, manufacturing and biological sciences, especially in the field of medical imaging. Medical imaging and computational physics have evolved together during the past decades with the advancement in the field of artificial intelligence (AI). Deep learning is the sub-domain of AI that mostly deals with imaging data for classification, segmentation and reconstruction. The time series of medical images of different patients, with different staging are categorized based on the physical and biological consequences. The hypothesis of the current research is that the deep learning tool, if trained on several patients, can identify the stage of cancer swiftly for fresh data sets. During this research, an advance Convolutional Neural Network (CNN) strategy is adopted to classify the cancer stage for a group of patients of gastric cancer. The CNN model makes use of skipping connections for better prediction. CNNs have been quite popular in medical imaging for their ability of feature detection. CNNs are used in the recent literature for the analysis of images. During this research, we have used the state-of-the-art Matlab ResNet CNN toolbox for the analysis of the images obtained from esophageal and gastric cancer patients. It was concluded that RESNET50 is a reliable algorithm for the determination of tumor mass on CT Scans. Moreover, the performance of the model can be improved by giving a comparatively larger data set as an input to the model. Inspired from Caltech101, a logic related to RESNET50 was adopted. The data was processed and an algorithm was designed to develop a mapping, based on the mass of tumor. The algorithm designed successfully identified the images, randomly picked from different patients, based on the image features.
A Novel Screening Test for Esophageal Squamous Cell Carcinoma: Sirtuin-3
(verduci Publisher, 2017) Cobanoglu, U.; Dulger, C.; Kemik, O.; Celik, S.; Sayir, F.
OBJECTIVE: Human sirtuin-3, a protein involved in the mediation of tumors, has been shown to be present in malignancies. The goal of this study was to measure serum sirtuin-3 levels in esophageal squamous cancer cells and to determine whether sirtuin-3 may possess predictive value in advanced cases of esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: A total of 130 ESCC patients and 50 healthy control subjects participated to the study. Serum sirtuin-3 levels for all 180 subjects were measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: Median sirtuin-3 levels were significantly higher in patients with ESCC than in the control subjects. CONCLUSIONS: The presence of considerably elevated levels of sirtuin-3, could be a powerful mediator of advanced ESCC in ESCC patients, suggests that sirtuin-3 may be a useful indicator of the disease.
Real-Life Experience With Maintenance Chemotherapy Plus Biologics After the First-Line Treatment of Ras Wild-Type Metastatic Colon Cancer (Mcrc): a Multicenter Onco-Colon Turkey Study
(Elsevier, 2022) Artac, M.; Cubukcu, E.; Bozkurt, O.; Bilici, A.; Celik, S.; Ozcelik, M.; Gumus, M.
Treatment and Outcomes of Patients With Metastatic Spinal Cord Compression: a Double-Center Study
(NLM (Medline), 2023) Aycan, A.; Eren, B.; Tas, A.; Celik, S.; Karagoz Guzey, F.; Kuyumcu, F.; Aycan, N.
OBJECTIVE: Spinal metastases may only affect the bone tissue and result in spinal instability or may additionally result in epidural compression, leading to neurological deficits. Surgery has emerged as a popular method in treating metastatic epidural spinal cord compression (MESCC) due to the advances in surgical techniques and instrumentation. In this study, we evaluated patients with MESCC regarding neurological status, pain status, and survival rates, and presented our experience managing MESCC. PATIENTS AND METHODS: Clinical and radiographic records of 53 patients diagnosed with MESCC between January 2011 and March 2017 were retrospectively evaluated. The study included patients with a pathological diagnosis of primary cancer, those who complained of spinal metastasis, and those who had indications of MESCC on Magnetic Resonance Imaging (MRI). Bone structure and spinal stability were evaluated using assessed Computed Tomography (CT), and metastatic spread was considered using assessed Positron Emission Tomography (PET) in suitable cases. For each patient, the presence of a tumor compressing the spinal cord, age, gender, preoperative, and postoperative American Spinal Injury Association scores (ASIA), Tokuhashi prognostic score (TPS), affected spinal segment, pathological diagnosis, preoperative, and postoperative Visual Analog Scale (VAS), the status of spinal stability, follow-up period, and complications were evaluated. RESULTS: Forty-five patients (82.2% of them were women) underwent surgery with a mean age of 58.29 ± 15.14 years. The most frequent type of primary tumor was multiple myeloma (33.9%), followed by lung (24.6%), gastric (7.5%), and prostate (5.7%). The most common site of metastasis was the thoracic region (43.4%), followed by lumbar (24.5%), multiple (24.5%), and cervical (5.7%). The analysis indicated that a significant difference was found between the survival rates of the TPS categories. CONCLUSIONS: Common symptoms of MESCC include spinal pain and neurological deficit below the level of the injury. Prompt surgical treatment followed by oncological treatment leads to significant neurological recovery, more prolonged survival, pain relief, and improved quality of life in patients with a short survival time. Oncological treatments, including radiotherapy (RT), should be recommended after surgical treatment.