Browsing by Author "Cetin, Eyup"

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Deneysel Omurilik Hasarı Oluşturulan Ratlarda Shilajitin Karaciğer ve Böbrek Üzerine Etkisinin Histopatolojik ve Biyokimyasal İncelenmesi
(2023) Akyol, Mehmet Edıp; Sancak, Tunahan; Okulmuş, Çağlar; Keles, Omer Faruk; Cetin, Eyup
Amaç: Bu çalışmada deneysel omurilik hasarı oluşturulan ratlarda shilajitin karaciğer ve böbrek üzerine olan etkisinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada omurilik hasarı oluşturulan ratlara 150 mg/kg ve 250 mg/kg dozlarda 1., 2., ve 3. günlerde shilajit tedavisi uygulanmıştır. Uygulama sonrasında ratlar 14. günde sakrifiye edilerek kan, karaciğer ve böbrek dokuları alınmıştır. Bulgular: Karaciğer ve böbrek histopatolojik olarak incelendiğinde shilajitin yüksek dozlarının dokularda daha iyi koruyucu etkiye sahip olduğu düşük doz shilajitin ise kısmi düzeyde koruyucu etki gösterdiği belirlenmiştir. Biyokimyasal analizde ise shilajit uygulanan grupların kontrol grubuna istinaden serum serum aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), laktat dehidrojenaz (LDH), kreatin kinaz (CK), kreatin ve üre konsantrasyonlarının daha düşük, albümin (ALB) ve total protein (TP) konsantrasyonlarının ise daha yüksek çıkmıştır (P aralığı: 0.05–0.001). Öneriler: Sonuç olarak, bu çalışmada ratlarda spinal kord hasarı sonrasında Shilajit uygulamasının antiinflamatuar özelliği ile karaciğer ve böbrekte lezyon oluşumunu önemli ölçüde baskıladığı histopatolojik ve biyokimyasal olarak ortaya konmuştur.
Effects of Blood Hemoglobin Levels on Vertebral Discal Degeneration
(2023) Cetin, Eyup; Şah, Volkan; Arslan, Mustafa; Arabacı, Ozkan; Akyol, Mehmet Edıp; Ünlü, İlker
Introduction: Vertebral discopathies are one of the most important causes of low back pain, which is very common in the community. Although there are many biochemical and mechanical causes of discogenic low back pain, the most important is discal degeneration. Many studies have been conducted suggesting that disc degeneration could be associated with various factors. In our study, we aimed to reveal a possible relationship between disc degeneration and levels of hemoglobin (HGB). Methods: We investigated the connection between discal degeneration and certain parameters, especially HGB levels, in a total of 174 patients in two separate groups; those with and without disc degeneration. Age, weight, height, body mass index, chronic diseases, mean HGB, hematocrit (HTC) level, white blood cell (WBC), high-density lipoprotein, low-density lipoprotein (LDL), and triglyceride (TG) values of the patients were recorded. Results: No significant difference was detected (p>0.05) between the groups with and without degeneration in terms of HGB, HTC, WBC, and LDL values. The TG level in the group with disc degeneration was significantly (p<0.05) higher than the group without disc degeneration. Discussion and Conclusion: Lumbar disc degeneration is a public health problem that continues to be discussed in the literature. There was no significant difference in terms of HGB levels between the groups, with and without degenerated disc.
Effects of Shunt Types Used in Idiopathic Normal Pressure Hydrocephalus on Patients’ Clinical Outcomes
(2023) Cetin, Eyup; Akyol, Mehmet Edıp
Aim: Idiopathic normal pressure hydrocephalus (iNPH) is a surgically reversible neu- rological disease in adults. It is a neurological condition characterized by ventricular enlargement detected on cranial imaging as well as gait defect, cognitive reduction, and urinary incontinence, with no other reason to explain the clinical findings. Ventricular shunting, predominantly ventriculoperitoneal (VP) shunting, has been shown to be suc- cessful in relieving symptoms in patients. In this study, we aimed to investigate the effects of two VP shunts used in the iNPH patients treated in our clinic. Materials and Methods: Clinical and laboratory records of 28 patients who under- went VP shunting due to iNPH were reviewed retrospectively via the Enlyl system. A programmable shunt was inserted in 9 (32.1%) and a medium-pressure shunt was inserted in 19 (67.9%) patients. Results: There was no significant difference between the two shunt types with regard to patient age, gender, and preoperative tests (p>0.05). However, the prevalence of ataxic gait was significantly higher in the Programmable Shunt group compared to the Medium- Pressure Shunt group (p<0.05). Conversely, no significant difference was found between the shunt types with regard to postoperative examination findings and additional neuro- logical disorders (p>0.05 for both). Conclusion: In the present study, no significant difference was observed between the shunt types with regard to clinical outcomes and thus both types of shunts were revealed as viable options.
End-To Computerized Diagnosis of Spondylolisthesis Using Only Lumbar X-Rays
(Springer, 2021) Varcin, Fatih; Erbay, Hasan; Cetin, Eyup; Cetin, Ihsan; Kultur, Turgut
Lumbar spondylolisthesis (LS) is the anterior shift of one of the lower vertebrae about the subjacent vertebrae. There are several symptoms to define LS, and these symptoms are not detected in the early stages of LS. This leads to disease progress further without being identified. Thus, advanced treatment mechanisms are required to implement for diagnosing LS, which is crucial in terms of early diagnosis, rehabilitation, and treatment planning. Herein, a transfer learning-based CNN model is developed that uses only lumbar X-rays. The model was trained with 1922 images, and 187 images were used for validation. Later, the model was tested with 598 images. During training, the model extracts the region of interests (ROIs) via Yolov3, and then the ROIs are split into training and validation sets. Later, the ROIs are fed into the fine-tuned MobileNet CNN to accomplish the training. However, during testing, the images enter the model, and then they are classified as spondylolisthesis or normal. The end-to-end transfer learning-based CNN model reached the test accuracy of 99%, whereas the test sensitivity was 98% and the test specificity 99%. The performance results are encouraging and state that the model can be used in outpatient clinics where any experts are not present.
Histopathological and Immunohistochemical Investigation of the Effect of Shilajit in Rats With Experimental Spinal Cord Injury
(Turkish Assoc Trauma Emergency Surgery, 2023) Cetin, Eyup; Sancak, Tunahan; Keles, Omer Faruk; Unlu, Ilker; Akyol, Mehmet Edip; Arabaci, Ozkan
BACKGROUND: This experimental study was designed to investigate the histopathological and immunohistochemical effects of Shilajit in rats with experimentally induced spinal cord injury (SCI). METHODS: The rats were divided into three groups: Control group: The group in which spinal cord damage was created but no drug was administered. Low-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 150 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. High-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 250 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. Thin sections taken from the spinal cord after euthanasia were sent for histopathological and immunohistochemical examination. RESULTS: Histopathological examination of the high-dose group showed lower amounts of morphological findings compared to the low-dose group and control group. While a significant CD68 immune reaction was observed in the control group of rats with spinal injury, the positive immune reaction was found to be significantly decreased in the Shilajit-applied groups. CONCLUSION: It is thought that the use of Shilajit in SCI will reduce the effects of secondary damage in SCI and that its administration to such patients will have positive effects on the results.
Schwannoma-Like Thoracic Glomangioma: Case Report
(Oxford Univ Press, 2022) Cetin, Eyup; Saricicek, Ummugulsum
In this study, we present an extremely rare case of thoracic spinal glomangioma located at the thoracic T7-8 level in the foraminal region, mimicking a schwannoma tumor, in a 65-year-old female patient who was admitted to our clinic with a 6-month history of back pain and weakness in legs.
Serum Prolidase and Ischemia-Modified Albumin Levels in Neural Tube Defects: a Comparative Study of Myelomeningocele, Meningocele, and Myeloschisis
(int Scientific information, inc, 2025) Zengin, Irfan; Akyol, Mehmet Edip; Arslan, Mustafa; Arabaci, Ozkan; Yurekturk, Eyyup; Cetin, Eyup; Demir, Halit
Background: Neural tube defects (NTDs) are congenital malformations resulting from incomplete neural tube closure, leading to severe neurological impairments. Despite advances in prenatal screening and surgical interventions, the biochemical mechanisms underlying NTDs remain unclear. Prolidase, an enzyme involved in collagen metabolism, and ischemia-modified albumin (IMA), a marker of oxidative stress, may play roles in NTD pathogenesis. This study aimed to compare serum prolidase and IMA levels in infants with NTDs and healthy controls to assess their potential contribution to NTD development. Material/Methods: A case-control study was conducted, including 45 infants diagnosed with NTDs (myelomeningocele, meningocele, and myeloschisis) and 45 age-and sex-matched healthy controls. Serum prolidase and IMA levels were measured using validated spectrophotometric methods. Statistical analyses were performed to compare biomarker levels between groups and among NTD subtypes. Results: Serum prolidase levels were significantly elevated in NTD patients (2.21 +/- 0.06 IU/L) compared to controls (1.07 +/- 0.04 IU/L, p<0.001). Similarly, serum IMA levels were higher in NTD patients (0.40 +/- 0.01 ABSU) than in controls (0.22 +/- 0.01 ABSU, p<0.001). No significant differences were observed in biomarker levels among the different NTD subtypes (p>0.05). Conclusions: Elevated prolidase and IMA levels in NTD patients suggest a potential role in NTD pathogenesis, possibly through impaired collagen metabolism and oxidative stress. Further research is needed to explore their diagnostic and therapeutic implications in neural tube defect management.