Browsing by Author "Cetin, Tayfun"

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Cytotoxicity and Antibacterial Activity of Polyhedral Oligomeric Silsesquioxane Modified Ti3c2tx Mxene Films
(Nature Portfolio, 2025) Akinay, Yuksel; Karatas, Erkan; Ruzgar, Damla; Akbari, Ali; Baskin, Dilges; Cetin, Tayfun; Topuz, Mehmet
Bioactive antimicrobial films play important roles in various fields, such as biodegradable interfaces, tissue regeneration, and biomedical applications where preventing infection, biocompatibility, and immune rejection are important. In the present study, bioactive POSS-doped Ti3C2Tx MXene filled PLA composite film was prepared using the solution casting method for biomedical applications. The contact angle tests were investigated to reveal the usability of the thin films in biomedical applications. The angle decreased from 85.92 degrees degrees in pure PLA thin films to 72.23 degrees on POSS-doped Ti3C2Tx MXene films. The antibacterial performance, cytotoxicity and cell viability assessments of the prepared films have also been thoroughly investigated. Antibacterial tests revealed that the POSS-doped Ti3C2Tx MXene films effectively inhibited the growth of E. coli and S. aureus by 65.93% and 80.63%, respectively, within 4 h. These inhibition rates were observed as 58.32% and 54.97% for E. coli and S. aureus, respectively, after 24 h. Cytotoxicity assessments demonstrated that PMPs consistently showed higher cell viability due to the combination of POSS and Ti3C2Tx MXene. The obtained results suggest that the POSS-doped Ti3C2Tx MXene film is a promising candidate in cases where bacterial inhibition and high biocompatibility are of critical importance.
An Efficient Supported Cu(I) Catalyst for the Amination of Aryl Halides With Sodium Azide
(Wiley-v C H verlag Gmbh, 2024) Fekri, Somayeh; Mansoori, Yagoub; Akinay, Yuksel; Cetin, Tayfun; John, Michael
We present the synthesis and characterization of a new Cu(I) complex supported on SBA-15 as a catalyst for preparing anilines from the reaction of aryl halides with sodium azide. The SBA-15 support was modified by treating it sequentially with (3-aminopropyl) triethoxysilane (APTES), cyanuric chloride, and 2-aminothiazole (AT). The modified mesoporous silica, SBA-15@BAT, was then treated with a CuI solution in acetonitrile to give SBA-15@BAT-Cu(I). The catalyst underwent thorough characterization using conventional methods. X-Ray photoelectron spectroscopy (XPS) analysis corroborated the presence of copper in the +1 oxidation state in the catalyst. The supported Cu(I) complex sufficiently catalyzed the amination reaction of iodo-, bromo-, and chloroarenes with NaN3. The catalyst was centrifuged, washed, and applied in the subsequent run. We investigated the effects of various reaction components and parameters to determine the optimal conditions for the reaction. The heterogeneous catalyst exhibited noticeable stability and was reused over seven runs with slight deactivation. Supporting and characterization of a new Cu(I) catalyst catalyst based on 2-aminothiazole-Cu(I) on SBA-15. Optimization of the reaction conditions for the supported catalyst in the amination of haloarens with sodium azide. Preparation of a wide range of anilines from chloro-, bromo-, and iodoarens. image
Magnetically Retrievable 2-(2-Pyridyl)benzimidazole-Cu(I) on SBA-15@Fe3O4 for Sodium Azide-Induced Amination of Aryl Halides
(Nature Portfolio, 2025) Abbasi, Zoleikha; Mansoori, Yagoub; Fekri, Somayeh; Akinay, Yuksel; Cetin, Tayfun
This study reports the synthesis and thorough characterization of a novel copper catalyst immobilized on magnetic mesoporous silica (Fe3O4@SBA-15). The catalyst preparation involved stepwise functionalization of Fe3O4@SBA-15 through sequential treatment with (3-aminopropyl)triethoxysilane (APTES), trichlorotriazine, and 2-(2-pyridyl)benzimidazole, resulting in Fe3O4@SBA-bis(PBI). Subsequent coordination with CuI in acetonitrile produced the final catalyst complex, Fe3O4@SBA-bis(PBI)-Cu. Extensive characterization was performed using standard spectroscopic techniques. The copper content of the catalyst was determined by atomic absorption spectroscopy to be 0.866 mmol g-1 (5.5 wt%). Catalytic performance evaluation demonstrated that Fe3O4@SBA-bis(PBI)-Cu effectively catalyzes the conversion of iodo-, bromo-, and chloroarenes to their respective anilines, using NaN3 as the nitrogen source. Notably, the catalyst exhibited excellent recyclability, maintaining catalytic activity over six successive cycles with minimal deactivation, highlighting its robustness and suitability for sustainable catalytic applications in organic synthesis. The low metal leaching (0.4%) shows that the copper is firmly bound to the ligand, and the reaction was mainly carried out by a heterogeneous catalyst.
Novel G-C3n4 Nanorods/Cu3bis3 Nanocomposites: Outstanding Photocatalysts With P-N Heterojunction for Impressively Detoxification of Water Under Visible Light
(Elsevier Science Sa, 2023) Hemmati-Eslamlu, Paria; Habibi-Yangjeh, Aziz; Akinay, Yuksel; Cetin, Tayfun
Novel g-C3N4 nanorods/Cu3BiS3 (abbreviated as R-GCN/Cu3BiS3) nanocomposites were fabricated via a facile hydrothermal procedure, and they were used for the removal of tetracycline (TC), amoxicillin (AMX), methyl orange (MO), rhodamine B (RhB), and Cr (VI) upon visible light. The XRD, EDX, XPS, and FTIR analyses affirmed anchoring Cu3BiS3 nanoparticles over the R-GCN component. An utmost amount of TC removal was gained when 30 wt% of Cu3BiS3 was anchored on R-GCN. The photoactivity of R-GCN/Cu3BiS3 (30%) nanocomposite for the removal of TC was 62.5 and 5.41-folds premier than GCN and T-GCN photocatalysts, respectively. The R-GCN/ Cu3BiS3 (30%) nanocomposite demonstrated significant activity even after four cycles of application. The anchored Cu3BiS3 component not only improved the extent of visible-light absorption, but also facilitated segregation and migration of charges, which were confirmed by UV-vis DRS, PL, EIS, and photocurrent analyses. Regarding the facile fabrication procedure, and outstanding activity, this research can be a good reference for construction of GCN-based visible-light-induced photocatalysts for treatment of various contaminants in wastewaters.
Novel Ti3c2x2 Mxene Supported Bamno3 Nanoparticles as Hydrazine Electrooxidation Catalysts
(Pergamon-elsevier Science Ltd, 2024) Ulas, Berdan; Cetin, Tayfun; Kaya, Sefika; Akinay, Yuksel; Kivrak, Hilal
In this study, MXene Ti3C2X2 and BaMnO3 nanoparticle-doped MXene particles were prepared by HF etching mechanism and hydrothermal method. Scanning electron microscopy-energy dispersive X-ray analysis (SEMEDX), transmission electron microscopy (TEM), and X-ray diffraction (XRD) methods were utilized for the characterization of as-synthesized catalysts. The presence of BaMnO3 nanoparticles in the catalyst system was confirmed by XRD and EDX spectra. The catalytic activity of the BaMnO3/MXene catalyst for hydrazine electrooxidation was investigated by cyclic voltammetry (CV), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS) in a basic medium. The mass activities of bare MXene and BaMnO3/MXene for hydrazine electrooxidation were determined as 309.5 and 731.7 mA mg -1, respectively. Increasing specific activity attributed to the improvement of the kinetics for the hydrazine electrooxidation reaction on MXene with the addition of BaMnO3. BaMnO3/MXene has been found to have lower charge transfer resistance and higher electrocatalytic activity than MXene. Novel BaMnO3/MXene catalyst showed super performance for hydrazine electrooxidation.
Recent Progress of Electromagnetic Wave Absorbers: a Systematic Review and Bibliometric Approach
(Keai Publishing Ltd, 2023) Akinay, Yuksel; Gunes, Umit; Colak, Bektas; Cetin, Tayfun
The electromagnetic wave absorption capabilities of an absorber depend on its dielectric and magnetic components, which determine its interfacial polarization, conductivity loss, magnetic loss, and other such mechanisms. In this study, a comprehensive review of the electromagnetic wave and material interaction was conducted. Moreover, for a better understanding of the trends and evolutionary developments in the study of the electromagnetic wave absorber, 23300 documents dated between 1990 and 2020 were examined, which were obtained from Scopus using the keywords of "electromagnetic wave absorption " and "microwave absorption ". The data search in Scopus was conducted using the related keywords in the search bar for titles and abstracts. These results demonstrate that the majority of research regarding electromagnetic wave absorbers was conducted in China, which was followed by the United States. The number of published documents regarding the electromagnetic wave absorption field significantly increased between 1990 and 2020; these documents were mostly published as journal articles. With respect to the journal activity, the most productive journal was the "Journal of Alloys and Compounds ", with a total of 592 articles. In addition, graphene and titanium dioxide were determined to be the materials that were most studied in the field of electromagnetic wave absorption.
Review: Recent Developments in 2D Mxene-Filled Bioinspired Composites for Biomedical Applications
(Springer, 2025) Akinay, Yuksel; Topuz, Mehmet; Gunes, Umit; Gokdemir, Muhammet Enver; Cetin, Tayfun
Two-dimensional carbide- and nitride-based MXene materials have become some of the most studied materials in interdisciplinary fields due to their superior properties. This review comprehensively discusses recent advances in MXene materials such as bioinspired coating films, scaffolds, and electrochemical activities for use in biomedical fields. MXene consists of multilayer 2D nitride, carbide, or carbonitride flakes with excellent electrical conductivity, large surface area, and good mechanical properties. Bibliometric studies have revealed a sharp increase in the number of publications and citations, having reached 15,831 records as of February 2025. Notably, the number of citations surged from under 20 in 2012 to over 222,000 in 2024. Due to being two-dimensional materials with superior physicochemical and biological properties, MXenes are also being increasingly used in biomedical and engineering applications. They have been reported to be ideal for such biomedical applications as corrosion-resistant biofilms, biocompatibility, low toxicity, drug delivery, and tissue engineering. In addition, MXene-based scaffolds have emerged as a promising material for bone tissue engineering due to their extraordinary mechanical durability, biocompatibility, and adjustable surface properties. By aiding tissue regeneration and preventing infections, MXene scaffolds have also been found to exhibit enhanced drug delivery and antibacterial properties. Recent advances in materials science have focused on creating bioinspired structures with multifunctionality. Taking into account MXenes' multilayered structures and functional surfaces, unique physicochemical properties have been designed by learning from nature to produce bioinspired materials. This article comprehensively reviews biomedical applications of such 2D MXene materials as bioinspired coating films, scaffolds as biosensors, drug delivery, cancer treatments, and tissue regeneration.
Rh (0) Nanoparticles Impregnated on Two-Dimensional Transition Metal Carbides, Mxene, as an Effective Nanocatalyst for Ammonia-Borane Hydrolysis
(Wiley, 2022) Karatas, Yasar; Cetin, Tayfun; Akkus, Ihsan Nuri; Akinay, Yuksel; Gulcan, Mehmet
MXene, which are known as two-dimensional transition metal carbides have received heavy interest due to their rich elemental diversity and many fascinating physical and chemical properties. Here, Rh (0) nanoparticles deposited MXene catalysts were synthesized by an easy wet-impregnation method for hydrogen production. Rh (0) nanoparticles were conveniently loaded on the surface of MXene (Rh/MXene) were used as an effective nanocatalyst for the hydrogen production from the hydrolysis of ammonia-borane (AB). The morphological and structural characterizations of Rh/MXene catalysts show that Rh nanoparticles were successfully deposited on the surface of MXene substrates. Rh (0) nanoparticles with an average size of 2.55 nm were homogeneously dispersed and deposited on the MXene surface. The Rh/MXene displayed good catalytic performance in the hydrogen production via the hydrolysis of AB, and the turnover frequency value at 25 degrees C was 288.4 min(-1), which is comparable to most of the synthesized catalysts. The Rh/MXene catalyst displaying good activity in seven consecutive catalytic cycles can be considered a good nanocatalyst candidate for hydrogen production from the hydrolysis of AB.
Synthesis and Characterization of Pd Doped Mxene for Hydrogen Production From the Hydrolysis of Methylamine Borane: Effect of Cryogenic Treatment
(Elsevier Sci Ltd, 2023) Karatas, Yasar; Cetin, Tayfun; Akinay, Yuksel; Gulcan, Mehmet
In this study, a palladium-doped cryo-MXene catalyst was prepared by a wet impregnation method and its catalytic activity was studied using the hydrolysis of methylamine-borane. The palladium nanoparticles were doped on the surface of the MXene substrate by chemical reduction of Pd+2 and characterized by different analysis techniques. The prepared palladium-doped MXene phases were cryogenically treated with liquid ni-trogen at-160 degrees C. The morphological and structural characterization of particles was performed using a field emission scanning electron microscope, transmission electron microscope, and X-ray diffraction machine with Cu K & alpha; radiation. The surface and bonding types of particles were determined by X-ray photoelectron spectroscopy. The palladium-doped cryo-MXene catalysts exhibited excellent catalytic performance in the hydrolysis of methylamine-borane with a turnover frequency (TOF) of 45.8 for 298 K. In addition, the palladium-doped cryo- MXene displayed good stability even after the five cycles.
Ti 3 C 2 T X Mxene-Functionalized Hydroxyapatite/Halloysite Nanotube Filled Poly- (Lactic Acid) Coatings on Magnesium: in Vitro and Antibacterial Applications
(Keai Publishing Ltd, 2024) Topuz, Mehmet; Akinay, Yuksel; Karatas, Erkan; Cetin, Tayfun
Magnesium (Mg) stands out in temporary biomaterial applications due to its biocompatibility, biodegradability, and low Young's modulus. However, controlling its corrosion through next-generation polymer-based functional coatings is crucial due to the rapid degradation behavior of Mg. In this study, the function of 2D lamellar Ti3 C2 Tx (MXene) in Hydroxyapatite (HA) and Halloysite nanotube (HNT) hybrid coatings in biodegradable poly- (lactic acid) (PLA) was investigated. The morphological and structural characterizations of the coatings on Mg were revealed through HRTEM, XPS, SEM-EDX, XRD, FTIR, and contact angle analyses/tests. Electrochemical in vitro corrosion tests (OCP, PDS, and EIS-Nyquist) were conducted for evaluate corrosion resistance under simulated body fluid (SBF) conditions. The bioactivity of the coatings in SBF have been revealed in accordance with the ISO 23,317 standard. Finally, antibacterial disk diffusion tests were conducted to investigate the functional effect of MXene in coatings. It has been determined that the presence of MXene in the coating increased not only surface wettability (131 degrees, 85 degrees, 77 degrees, and 74 degrees for uncoated, pH, PHH, and PHH/MXene coatings, respectively) but also increased corrosion resistance (1857.850, 42.357, 1.593, and 0.085 x 10-6 , A/cm2 for uncoated, pH, PHH, and PHH/MXene coatings, respectively). It has been proven that the in vitro bioactivity of PLA-HA coatings is further enhanced by adding HNT and MXene, along with SEM morphologies after SBF. Finally, 2D lamellar MXene-filled coating exhibits antibacterial behavior against both E. coli and S. aureus bacteria. (c) 2024 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) Peer review under responsibility of Chongqing University
Ti2ntx Mxene Materials Derived From Ti2aln Max Phases: Their Characterization and Electrocatalytic Activity Toward Hydrazine Electrooxidation
(Pergamon-elsevier Science Ltd, 2024) Ulas, Berdan; Cetin, Tayfun; Topuz, Mehmet; Akinay, Yuksel
Nitride-based MXenes materials are promising for advancing technological developments, especially in popular scientific fields such as energy storage and conversion. This study successfully synthesized 2D lamellar Ti2NTx 2 NTx MXenes via selective etching of Al from the Ti2AlN 2 AlN MAX phase. Synthesized Ti2NTx 2 NT x MXene was characterized by field emission scanning electron microscope with energy-dispersive X-Ray spectroscopy attachment (FESEMEDX), X-ray diffraction (XRD), X-Ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy (HRTEM), and Brunauer-Emmett-Teller (BET) analyses techniques in details. 2D lamellar morphology of MXene phase was observed with FESEM, while distinctive diffraction peaks were confirmed with XRD analyses. While the BET surface area of the MAX phase was 0.5375 m2/g, 2 /g, it was measured as 2.0867 m2/g 2 /g with Ti2NTx 2 NT x MXene which increased by 3.88 times. Ti-O-N, Ti-N, and surface functional groups (Tx: x : OH, -F, -O) of Ti2NTx 2 NT x MXenes were revealed with XPS analyses. (112) crystal plane associated interplanar d-space (0.243 nm) was observed with HRTEM results. The electrocatalytic activity of synthesized Ti2NTx 2 NT x MXene was investigated by hydrazine electrooxidation. The Ti2NTx 2 NT x electrocatalyst exhibited a specific activity of 2.739 mA/cm2 2 and mass activity of 44.1 mA/mg for hydrazine electrooxidation. Ti2N 2 N also showed long-term stability compared to Ti2AlN. 2 AlN.
Ti3C2Tx Mxene/Halloysite Nanotube Functionalized Films for Antibacterial Applications
(Taylor & Francis Ltd, 2025) Topuz, Mehmet; Karatas, Erkan; Ruzgar, Damla; Akinay, Yuksel; Cetin, Tayfun
In the study, chitosan (CS)-based Ti3C2Tx MXene/Halloysite nanotube (HNT) films were successfully synthesized using the solution casting method. The prepared films were characterized morphologically and structurally. To measure the surface wettability of the films for potential biological applications, contact angles were measured in simulated body fluid. The bacterial viability and antibacterial properties on Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria were evaluated by CFU counting, and statistical analyses were performed using ANOVA. The HNT particles with a size of about 30-40 nm were homogeneously anchored onto MXene layers without partial agglomerations. The presence of micropores and functional end groups in the prepared films contributes to their antibacterial effect. The incorporation of HNT into the chitosan MXene film provided a hydrophilic character by decreasing the contact angle from 82.26 degrees to 49.47 degrees. Antibacterial evaluation revealed that the film exhibited high inhibition for E. coli (34.63%) and S. aureus (63%) due to the synergistic effect between HNT and MXene. These findings highlight the potential of the developed film as an antibacterial material for biomedical applications.