Browsing by Author "Cetinkaya, Nuralay"

Now showing 1 - 4 of 4

Dissociative Symptoms Secondary To Piracetam: a Case Report
(Kure Iletisim Grubu A S, 2013) Aydin, Adem; Ozdemir, Pinar Guzel; Selvi, Yavuz; Uguz, Faruk; Cetinkaya, Nuralay
Piracetam is a cyclic derivative of gamma-aminobutyric acid that is often used in neurology. Piracetam is an antithrombotic, neuroprotective agent which improves cognitive performance. Piracetam is indicated for vertigo in clinical practice. The etiology of dissociation is not precisely defined. In pharmacotherapy studies, depersonalization is the basic dissociative symptom. In this article, we have reported a case with the diagnosis of peripheral vertigo where piracetam was used as part of combination therapy. However dissociative symptoms like depersonalization and derealization occurred after piracetam use and these symptoms disappeared after discontinuation of piracetam.
Effects of Selective Serotonin Reuptake Inhibitors on Thought-Action Fusion, Metacognitions, and Thought Suppression in Obsessive-Compulsive Disorder
(W B Saunders Co-elsevier inc, 2011) Besiroglu, Lutfullah; Cetinkaya, Nuralay; Selvi, Yavuz; Atli, Abdullah
Objective: We aimed to assess whether cognitive processes change over time in patients with obsessive-compulsive disorder (OCD) receiving selective serotonin reuptake inhibitors without cognitive behavioral therapy and to investigate the factors associated with probable cognitive changes. Methods: During the 16 weeks of the study, 55 patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for OCD received open-label treatment with sertraline (100-200 mg/d) or fluoxetine (40-80 mg/d) and were assessed using the Yale-Brown Obsessive-Compulsive Scale, Beck Depression Inventory (BDI), Thought-Action Fusion Scale (TAFS), Metacognitions Questionnaire (MCQ-30), and White Bear Suppression Inventory (WBSI). Results: The Yale-Brown Obsessive-Compulsive Scale (P < .001), BDI (P < .001), TAFS morality (P < .005), MCQ-30 (P < .01), and WBSI (P < .005) scores at follow-up were significantly lower than baseline scores. When we excluded OCD patients with depressive disorder (n = 12), statistical significance in paired comparisons for MCQ and WBSI disappeared. Similarly, when OCD patients with religious obsessions (n = 16) were excluded, paired comparisons for MCQ and TAF morality were not statistically significant. Changes in BDI, TAFS morality, MCQ-30, and WBSI (P < .005) were significantly correlated with changes in severity of obsessions, but not that of compulsions. After controlling for the change in depression severity, significant correlations between changes in obsessive and cognitive scales did not continue to have statistical significance. The BDI changes (P < .05) significantly explained the changes in symptom severity in a linear regression model. Conclusions: Our findings suggest that selective serotonin reuptake inhibitors can change appraisals of obsessive intrusions via their effects on negative emotions. (C) 2011 Elsevier Inc. All rights reserved.
Latent Class Analysis of Obsessive-Compulsive Symptoms in a Clinical Sample
(W B Saunders Co-elsevier inc, 2014) Atli, Abdullah; Boysan, Murat; Cetinkaya, Nuralay; Bulut, Mahmut; Bez, Yasin
Objective: Obsessive compulsive disorder (OCD) is probably a heterogeneous condition. To date, research investigating the symptom structure of OCD has generally focused on variable-classification approaches, primarily factor analysis. Our aim was to use the latent class analysis, an advanced individual-classification method, in order to define homogeneous sub-groups based on the Yale Brown Obsessive Compulsive Scale Check List (Y-BOCS CL) assessments within 193 outpatients with OCD. Method: Latent class analysis of 13 obsessive compulsive symptom-clusters measured by the Yale Brown Obsessive Compulsive Scale Check List was performed. Associations of demographic and clinical features with latent class membership were tested by using logistic regression models. Differences in severity of obsessive compulsive symptoms, obsessive beliefs; and depressive symptomotology between latent classes were evaluated with the chi-square likelihood test. Results: Latent class analysis models of best fit yielded 3 latent classes: "autogenous obsessions", "reactive obsessive compulsive", and "reactive obsessions". Outpatients in reactive obsessive compulsive group reported significantly higher scores on the Y-BOCS global, obsessions, and compulsions scales than outpatients in other two sub-groups. Participants in reactive obsessive compulsive group were predominantly female, single, and had a history of family psychopathology; whereas autogenous and reactive obsessions groups were predominantly male. There were no differences in severity of depression and obsessive belief domains. Conclusions: The results provide support for the validity of autogenous/reactive distinction for OCD. These three classes may have important implications for research and clinical purposes. (C) 2014 Elsevier Inc. All rights reserved.
The Validity and Reliability of the Turkish Version of the Obsessive Beliefs Questionnaire-44 (obq-44)
(Galenos Yayincilik, 2010) Boysan, Murat; Besiroglu, Lutfullah; Cetinkaya, Nuralay; Atli, Abdullah; Aydin, Adem
Objective: Cognitive factors have a central place in the etiology and persistence of obsessive-compulsive disorder (OCD). The aim of the study was to evaluate psychometric properties of the Turkish version of the Obsessive Beliefs Questionnaire-44 (OBQ-44). Original factor structure of the OBQ-44 and discrimination characteristic of the instrument between OCD patients and nonclinical population were evaluated extensively in Turkish sample. Methods: Data were collected from 175 healthy subjects and 62 patients with OCD who applied to the Psychiatry Clinic at Yuzuncu Yil University. Subjects were administered the SCID-I, the Obsessive Beliefs Questionnaire-44 (OBQ-44), the Padua Inventory (PI-41), the Yale-Brown Obsessive Compulsive Scale (Y-BOKS), the Metacognitions Questionnaire-30 (MCQ-30), the Thought Action Fusion Scale (TAFS), the White Bear Suppression Inventory (WBSI), the Penn Inventory of Scrupulosity (PIOS), the Penn State Worry Questionnaire (PSWQ), and the Beck Depression Inventory (BDI). Data were analyzed in order to evaluate the reliability and validity of the OBQ-44. Results: The three-factor original structure tested using confirmatory factor analysis was observed to be highly consistent with the data obtained from the study. OCD patients reported significantly higher scores on OBQ-44 rather than controls. Correlations of the OBQ-44 scores with psychological variables were generally significant. Inner consistency coefficient for the OBQ-44 was alpha 0,95 and test-retest correlation between two points at 30-day time course was r=0.79. Conclusion: The Turkish version of the OBQ-44 has adequate validity and reliability in clinical and nonclinical Turkish sample.(Archives of Neuropsychiatry 2010;47:216-22)