Browsing by Author "Ceylan, E"

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The Assessment of Effects of Atracurium and Mivacurium Using Tof Guard Device in Dogs
(indian veterinary Journal, 2003) Tas, A; Aslan, L; Atasoy, N; Ceylan, E; Altug, ME; Ozbek, H
Blood Biochemicals and Gaseous Changes in Lactic Acidosis in Sheep
(indian veterinary Journal, 2003) Karaca, M; Ceylan, E; Akkan, HA; Keles, I
The Comparison of Effects of Atracurium and Mivacurium With Tof Guard Device in Cats
(indian veterinary Journal, 2003) Tas, T; Genccelep, M; Atasoy, N; Ozbek, H; Ceylan, E
The Effects of Laminitis on Milk Yield and Milk Composition of Sheep
(indian veterinary Journal, 2004) Tas, A; Isleyici, O; Baytok, E; Cak, B; Savran, A; Demirel, E; Ceylan, E
The Effects of Prednisolone and Serum Malondialdehyde Levels in Puppies With Experimentally Induced Meconium Aspiration Syndrome
(Sage Publications Ltd, 2003) Kirimi, E; Tuncer, O; Kösem, M; Ceylan, E; Tas, A; Tasal, I; Caksen, H
The aim of this study was to investigate the effect of different doses of prednisolone in puppies experimentally induced with meconium aspiration syndrome (MAS). Meconium was collected from human babies in the first day of life and was released into the trachea of 11 newborn puppies to induce MAS. Puppies were treated with 2 mg/kg prednisolone (standard dose), 30 mg/kg prednisolone (megadose) or 0.9% saline, all administered intravenously. The study ended 20 h after meconium aspiration and the lungs were then scored for histopathology. Animals not treated with prednisolone deteriorated after 8 h while respiration rate, oxygenation, pH and partial pressure of carbon dioxide values were better in the prednisolone-treated groups. Histopathology scores were better in the treatment groups compared with the control group, with megadose giving the best result. At the end of the study, serum malondialdehyde levels were significantly higher in the megadose prednisolone group compared with the other two groups. In conclusion, we determined that prednisolone reduced physiological and histological changes in puppies with MAS and that a 30 mg/kg dose was more effective than 2 mg/kg.
The Effects of Sildenafil Citrate (Viagra) in the Early Phase of Healing Process in Open Wounds in Dogs
(Vysoka Skola veterinarni Farmaceuticka, 2003) Tas, A; Atasoy, N; Özbek, H; Aslan, L; Yüksel, H; Ceylan, E; Dagoglu, G
In vivo (n = 16) and in vitro (n = 16) experiments were conducted in dogs to describe the effects of sildenafil citrate (viagra) on histopathological changes during the healing process with respect to angiogenesis and compare vasodilatative effects of sildenafil citrate, acetylcholine and sodium nitroprusside. General anaesthesia was performed with 0.2% ketamine HCl by intravenous drip after premedication with xylazine (5 mg.kg(-1)) and atropine sulphate (0.05 mg.kg(-1)). Round open wounds were created in all skin layers on anterior brachial region in all animals. On days 1, 3, 5 and 7 following the operation sildenafil citrate (25 mg) (n = 8) and saline (n = 8) were orally administered. Wound tissues were dissected for histological observation on days 3, 6, and 9. Animals receiving sildenafil citrate had greater granulosa tissue more apparent capillary network and greather fibroblast proliferation than control group on day 6. Vasorelaxant effects of sildenafil citrate, acetylcholine and sodium nitroprusside on a. brachialis were investigated in vitro. In this study, relative vasorelaxant effects of sildenafil citrate, acetylcholine and sodium nitroprusside were 4.91, 5.75 and 6.70, respectively. Results of this study suggest that sildenafil citrate does enhance the healing process by stimulating angiogenesis.
The Effects of Succinlycholine on Some Clinical, Haematological and Biochemical Parameters in Dogs
(indian veterinary Journal, 2004) Akkan, HA; Genccelep, M; Karaca, M; Ceylan, E; Tutuncu, M; Agaoglu, Z; Aytekin, I
Due to increasing population of street dogs the health and life style of human beings are affected. Some methods require chemicals to capture and regulate the stray animals. Succinylcholine is a short-acting depolarising, neuromuscular blocking agent used for capturing animals (Hicks and Bailey, 1978) in the present study the effects of succinyl choline in street dogs have been evaluated.
Erythropoietin Level and Some Blood Parameters in Cattle With Tropical Theileriosis
(indian veterinary Journal, 2004) Ceylan, E; Agaoglu, Z; Gul, Y; Meral, I; Dabak, M
Hypoglycemic Effect of Rheum Ribes Roots in Alloxan Induced Diabetic and Normal Mice
(Scandinavian Federation Laboratory Animal Science, 2004) Özbek, H; Ceylan, E; Kara, M; Özgökçe, F; Koyuncu, M
A decoction extract of Rheum ribes roots was given orally and tested for hypoglycemic effect in healthy and in alloxan-diabetic mice. The results were compared with glibenclamide, a standard hypoglycemic agent, and control groups. It was found that the extract possesses a hypoglycemic effect in diabetic animals.
Levels of Some Vitamins, Trace Elements and Electrolytes in Rams With Rumen Acidosis and Laminitis
(indian veterinary Journal, 2003) Ceylan, E; Dede, S; Tas, A; Donmez, N; Atasoy, N; Keles, I
Feeding lambs with high grain rations (80-95% concentrate) generally increases the incidence of digestive disturbances related with rumen acidosis (Britton and Stock, 1986). Rumen acidosis varies from subacute to acute from, and is associated with various secondary disordes such as laminitis, polioencephalomalacia, rumenitis, and liver abscesses (Brent, 1976; Nocek, 1988). The present study was aimed to investigate the levels of some vitamins, trace elements and electrolytes in rams with laminitis.
Nephrotoxic Effect of Amphotericin B Administered in Different Doses and Infusion Mode in Dogs
(Vysoka Skola veterinarni Farmaceuticka, 2003) Ceylan, E; Akkan, HA; Tutuncu, M; Agaoglu, Z
In this study, nephrotoxic effect of Amphotericin B (AmB) was investigated together with clinical, biochemical, and histopathological findings in dogs intoxicated with different doses and methods of administration. 18 healthy cross-bred dogs were allocated to three groups. Amphotericin B diluted with sterile water was used. Dogs in group A (n = 6) were treated with 0.5 mg/kg AmB in 25 ml 5% dextrose as a rapid bolus (4-5 min). Dogs in group B (n = 6) were treated with 1 mg/kg AmB in 50 ml 5% dextrose as a rapid bolus (4-5 min). Dogs in group C (n = 6) were treated with 2 mg/kg AmB in 1000 ml 5% dextrose as a slow infusion (4-5 h). Clinical, haematological and biochemical analyses were made in all dogs before the experiment as well as on the 5(th) and 12(th) days. Haematological and biochemical values recorded before the experiment were compared with those on the 5(th) and 12(th) day. After the third day of the experiment, vomiting, diarrhoea, anorexia, fever, phlebitis, irritability and tachycardia were recorded in all dogs (Groups A, B and C). However, the symptoms recognised were minimum in Group C, moderate in Group A and severe in Group B. There were differences in biochemical values among groups (p < 0.001). Group B was different from Group A and C in haematological parameters (p < 0.05). The most severe histopathologic changes were observed in Group B animals. These results suggest that the toxicity of AmB on kidney could be decreased when it is administered in a long period and more diluted form.
Prevalence and Antibiotic Sensitivity of Motile Aeromonas in Dogs
(veterinarni A Farmaceuticka Univerzita Brno, 2003) Ceylan, E; Berktas, M; Korkoca, H; Keles, I; Bozkurt, H; Kurtoglu, MG
The present study was carried out to assess the prevalence of motile Aeromonas sp. in the faeces of healthy dogs and to evaluate its susceptibility to some anti-microbial agents. Rectal swabs from 55 domestic dogs were examined for Aeromonas species using alkaline peptone water (pH 8.4) as the enrichment medium and Aeromonas Selective Agar containing 5 mg/l ampicillin as the plating medium. Identification and antibiotic resistance of motile Aeromonas strains was performed using Gram Negative Breakpoint ID panel. After examining these samples, aeromonads were isolated from three (5.45%) dogs. Of those, one was A. sobria, and two were A. caviae. While all isolated strains were sensitive to amikacin, cefoperazone, cefotaxime, cefotetan, ceftazidime, ceftriaxone, cefuroxime, ciprofloxacin, gentamicin, imipenem, piperacillin, tetracycline, ticarcillin, ticarcillin/clavulanate, tobramycin, and trimethoprim/sulfamethoxazole, they were resistant to ampicillin, and ampicillin/sulbactam. In addition, a strain of A. caviae was also resistant to aztreonam. As a result, in the present study, information about the prevalence of Aeromonas in dogs, susceptibility to antibiotics of these microorganisms and its importance for both animal and public health were discussed.
Prevalence of Cryptosporidium Infection in Van Cats
(indian veterinary Journal, 2005) Goz, YR; Yuksek, N; Altug, N; Ceylan, E; Deger, S
Cryptosporidium infection is a zoonotic disease caused by Cryptosporidium spp. and transmitted by faecal-oral cycle. Young animals are most likely to develop symptomatic infections and shed high quantities of infective oocysts. But infection in adult animals is asymptomatic and number of oocysts shed is usually very fewer than from young animals. (Bukhari and Smith, 1999). The aim of present study was to investigate the prevalence of Cryptosporidium spp. in Turkish Van Cats. Materials and Methods Forty six cats 96 kitten and 40 adult Van cats) from Van Cat House, aged between 16 weeks and 7 years were used in this study. Direct smear method and then formalin-ether sedimentation method were carried out to detect intestinal parasites from faecal samples of cats (n=46). The smears were stained by Modified Ziehl-Neelsen Method for identifying the red-pink oocyst of cryptosporidium. Results and Discussion Cryptosporidium sop. are coccidial protozoon belonging to the phylum Apicomplexa which inhabit the intestinal and respiratory surface epithelium of mammals, birds and reptiles. The first species of this genus was recognized in gastric glands of the laboratory mice in 1907 and was named Cryptosporidium muris (Tyzzer, 1907). In Cryptosporidium spp. has been reported from the faeces of 13 non-feral Japanese cats (Iseki,- 1979). Cryptosporidium prevalence was found to be 3.8% (Arai et al., 1990; Spain et al., 2001), 5.4% (Hill et al., 2000) and 8.1% (Mtambo etal., 1991) in other studies. In the present study, it was detected that all kittens (n=6) were infected by Cryptosporidium spp. (13.0%). No cryptosporidium oocysts were found in adult cats. Similarly, previous reports indicate that more young animals are infected with Cryptosporidium spp. Than old animals (Bukhari and Smith, 1999). Pets and farm animals with Cryptosporidium and other parasitic infections may be important sources and great risk factor for immunocompromised adults and children, especially those with AIDS (Lewis et al., 1985). In the present study, in addition to Cryptosporidium spp. Other gastrointestinal parasites including Toxocara cati (15.2%), Taenia taeniaeformis 4.3%), Giardia spp. (6.5%) and Isospora felis (2.17%) were detected. Infection incidence with only one species of parasite was more common than infection with multiple parasite species. One kitten was infected with one helminth (Toxocara cati) and two protozoa (Giardia spp. and Isospora felis). Toxocara cati was the most prevelant helminth (15.2%), followed by Taenia taeniaeformis (4.3%). Giardia spp. was detected in one adult and two kittens. Isospora felis was detected in only one kitten. Cryptosporidium infection in kittens and healthy or immunodepressed. cats can cause a spectrum of diseases from an asymptomatic state to mild, transient diarrhoea and cholera-like illness; or prolonged and life threatening malabsorption syndrome. In young animals with cryptosporidium infection, there is dehydrating diarrhoea caused by development of the parasites within the epithelial cells of the intestinal. mucosa (Tzipori et al., 1983). In the present study, no clinical symptoms including diarrhoea were found in young cats with cryptosporidium oocysts in their faecal smears. These results agree with the result of Iseki (loc. cit.). There have been reports linking feline cryptosporidiosis to human infection. (Bukhari and Smith, loc. cit.; Mtambo et al., loc. cit.). But many cat owners and breeders are not aware of feline zoonotic parsites and their mode of transmission to humans. Thus, the veterinarians have a great role in educating the cat owners and breeders regarding the transmission of zoonotic parasites such as cryptosporidium.
Report of Three Children With Leptospirosis in Rural Area of the East of Turkey
(Tohoku Univ Medical Press, 2003) Kurtoglu, MG; Tuncer, O; Bozkurt, H; Çaksen, H; Berktas, M; Ceylan, E; Kirimi, E
Leptospirosis is a systemic infection usually producing fever with hepatorenal involvement, meningoencephalitis, and hemorrhage. In this article, we present three children between 10 and 13 years of age with leptospirosis. The purpose of this paper is to emphasize that leptospirosis is a problem in our country with farmers/cattle and that leptospirosis should be considered in certain ill children. The main symptoms were headache, fever, fatigue, abdominal pain and unconsciousness. Two patients had hepatic and renal involvement. The other had hepatic, pulmonary and probably pericardial. involvement. In all children spirochetes were demonstrated in blood and urine smears by dark-field microscopy and they were also isolated from urine and blood cultures by using Flecher medium. All patients were treated with penicillin; however, one subsequently required additional antibiotics due to Klebsiella pneumoniae septicemia. While one patient was discharged in a good health, the others were taken to their home by parents without completing treatment. In conclusion, we would like to emphasize that leptospirosis is still a public health problem in our region (Eastern Turkey) in where the majority of population are farmers and raise domestic animals such as cattle in rural areas. Additionally, leptospirosis should be considered in children admitted with headache, unconsciousness, fever and abdominal pain. (C) 2003 Tohoku University Medical Press.
The Role of Urtica Dioica and Nigella Sativa in the Prevention of Carbon Tetrachloride-Induced Hepatotoxicity in Rats
(Wiley, 2003) Türkdogan, MK; Ozbek, H; Yener, Z; Tuncer, I; Uygan, I; Ceylan, E
The role of Nigella sativa L. (Ranunculaceae) (NS) and Urtica dioica L. was investigated (UD) in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis and cirrhosis. Fifty Sprague-Dawley rats were allocated into five groups (I, IIA and B, IIIA and B) and CCl4 was injected biweekly to all groups. Group I (control, CCl4 only), group IIA and B (NS fixed oil and volatile oil), group IIIA and B (UD fixed oil and UD decoction extract) rats were killed at the end of week 12 and histopathological and immunohistochemical examinations of liver tissues were performed. In the control group, coagulation necrosis and hydropic degeneration were marked in the periacinar regions (zone 3) associated with fibrosis in the periacinar regions and in the portal tracts. In groups IIA-B and IIIA-B (NS and UD), none of the serious histopathological findings were detected except for sparse coagulation necrosis in the periacinar regions. ASMA-positive perisinusoidal cells with myofibroblastic transformation and lysosomal enzyme activity suggesting fibrogenesis were also significantly more common in the control group than in the NS and UD groups. UD and NS seem to be significantly effective in the prevention of carbon tetrachloride induced hepatotoxicity in rats. Copyright (C) 2003 John Wiley Sons, Ltd.
Seronegativity of Equine Infectious Anemia in the East Border of Turkey
(indian veterinary Journal, 2004) Tutuncu, M; Akkan, HA; Karaca, M; Ceylan, E; Berktas, M; Agaoglu, Z
Equine infectious anemia (EIA), colloquially known as swamp fever, mountain fever, slow fever, equine malarial fever and Coggins disease, is a viral disease infecting all members of the Equidae including, horses, ponies, mules, and donkeys. (Sellon, 1993; Nakajima and Sugiura, 1994; Burki et al., 1992). Transmission of the virus requires direct blood transfusion, either by biting insects or other mechanical vectors such as contaminated needles. EIA usually is clinically diagnosed as a chronic disease with a high percentage of affected horses demonstrating weight loss, depression, dependent edema, and reduced haematocrit values, platelet counts, and haemoglobin. The majority of horses infected with EIA virus, however, appear to demonstrate none of the clinical abnormalities (Sellon, loc. cit.; Issel and Foil, 1984; Coggins, 1984). Turkey has a large horse population and, these horses are used for working, racing and breeding. The aim of this study was first to determine whether or not EIA is present in the east border of Turkey. There is no study on EIA in this region at present.
Seroprevalance of Toxoplasivia Gondii Infection in Goats
(indian veterinary Journal, 2005) Goz, Y; Aydin, A; Ceylan, E
Venous Blood Gases, Ph and Bicarbonate Values in Oestrus-Synchronised Cows
(British veterinary Assoc, 2005) Tasal, I; Ceylan, E; Keles, I; Gülyüz, F