Browsing by Author "Ceylan, K"

Now showing 1 - 6 of 6

Effect of Indapamide on Urinary Calcium Excretion in Patients With and Without Urinary Stone Disease
(Sage Publications inc, 2005) Ceylan, K; Topal, C; Erkoc, R; Sayarlioglu, H; Can, S; Yilmaz, Y; Gonulalan, H
Background: Indapamide is an anti hypertensive agent similar to thiazides, but with some different effects. Thiazide and thiazide-like diuretics are useful in preventing recurrent urinary stone formation due to their hypocalciuric effects. OBJECTIVE: To determine the hypocalciuric and other effects on certain laboratory parameters of indapamide 1.5 mg in different patient groups. METHODS: Four groups of patients recruited from urology and nephrology outpatient departments were experiencing non-hypercalciuric urinary stone disease (group 1), idiopathic hypercalciuria (group 2), urinary stone disease with hypercalciuria (group 3), and essential hypertension (group 4). In all patients, fasting serum uric acid, calcium, sodium, potassium, cholesterol, triglyceride, parathyroid hormone (PTH) values, and morning second-spot urine calcium and creatinine levels were assessed before and 8 weeks after treatment with indapamide. RESULTS: Urinary calcium excretion was reduced significantly in all groups: group 1 from 0.10 +/- 0.02 to 0.07 +/- 0.03 (mean +/- SD; 30% reduction; p < 0.001), group 2 from 0.30 +/- 0.15 to 0.15 +/- 0.10 (50% reduction; p < 0.001), group 3 from 0.35 +/- 0.15 to 0.20 +/- 0.10 (43% reduction; p < 0.001), and group 4 from 0.10 +/- 0.03 to 0.08 +/- 0.02 (20% reduction; p < 0.0010). These results should be interpreted with caution since no control group was included in this study. Mean serum uric acid and triglyceride levels were significantly increased, and mean PTH and potassium levels and diastolic and systolic blood pressure were significantly decreased in all groups. Few temporary adverse effects, such as dizziness and fatigue, were noticed and none of them caused discontinuation of treatment. CONCLUSIONS: Indapamide 1.5 mg/day is effective in decreasing calciuria in patients with non-hypercalciuric urinary stone disease, idiopathic hypercalciuria, urinary stone disease with hypercalciuria, and essential hypertension. This could be achieved with few adverse effects similar to those of thiazides and indapamide 2.5 mg. Indapamide decreased the PTH levels in all groups. Long-term clinical benefits of these effects should be evaluated prospectively with further randomized studies.
Gas-Forming Infection in a Renal Cyst of a Patient With Autosomal Dominant Polycystic Kidney Disease
(Oxford Univ Press, 2006) Erkoc, R; Sayarlioglu, H; Ceylan, K; Dogan, E; Kara, PS
Incidence of Renal Insufficiency in Cancer Patients
(Health Communications inc, 2005) Dogan, E; Izmirli, M; Ceylan, K; Erkoc, R; Sayarlioglu, H; Begenik, H; Alici, S
The frequency of chronic renal insufficiency among cancer patients is unclear. The aim of this study was to determine the frequency of impaired renal function within a population of cancer patients. One thousand two hundred seventeen patients (563 women, 654 men) with cancer underwent serum creatinine concentration and glomerular filtration rate (GFR) evaluations. The Cockcroft-Gault formula was used to estimate the GFR from the creatinine clearance (Cl-cr). Renal insufficiency was defined as a GFR <= 90 mL/min. Among this population, 72 (5.9%) demonstrated an abnormal serum creatinine concentration (>1.2 mg/dL). According to the Cockcroft-Gault formula evaluations, however, 330 (27.1%) of the patients had an estimated GFR <90 mL/min. Among these, the Cl-cr was between 60 and 89 mL/min in 241 patients (19.8%); 30 and 59 mL/min in 75 patients (6.2%); and 15 and 29 mL/min in 7 patients (0.6%); 7 patients (6%) had a Cl-cr <15 mL/min. As a result, 21.2% of patients demonstrating a normal serum creatinine level had abnormal renal function. Renal function should be evaluated in all cancer patients, regardless of their serum creatinine level, before any drug regimen is administered. The Cockcroft-Gault formula appears to be more accurate than serum creatinine concentration for diagnosing renal insufficiency in patients with cancer, but more prospective studies in this population will be necessary to confirm this finding.
Incidence of Retro-Aortic Left Renal Vein and Its Relationship With Varicocele
(Springer, 2005) Arslan, H; Etlik, Ö; Ceylan, K; Temizoz, O; Harman, M; Kavan, M
The retro-aortic left renal vein (RLRV) is a malformation characterized by the presence of a vessel that drains the left renal blood up to the inferior vena cava crossing behind the aortic artery. Varicocele is defined as venous dilation of the pampiniform plexus, and the left side is the most commonly affected. Several theories concerning the possible aetiology of varicocele are reviewed in the literature, but RLRV was not mentioned as an aetiologic factor of varicocele. in this study we investigated the percentage of RLRVs and their relation with varicocele. A total of 1,125 contrast-enhanced abdominal CT scans was examined to identify RLRVs. RLRVs were found in nine women (1.6%) and ten men (1.7%). We performed scrotal Doppler ultrasonography (US) for all affected men except one. Varicocele of varying degrees was found in seven of the nine male patients with RLRV (77%). RLRV could be one of the aetiological factors in the development of varicocele, and the cases with RLRV should be examined by scrotal Doppler US for the presence of varicocele.
Inguinal Approach in Adult Hydrocele Surgery
(Health Communications inc, 2006) Ceylan, K; Yüksel, Y; Hasan, G; Alpaslan, K
This prospective study compared the effects of scrotal and inguinal approaches in hydrocele repair. Thirty-two adult patients, enrolled between January 1994 and May 2000, were randomly assigned to an inguinal (n=17) or a scrotal (n=15) approach. Scrotal size (at the surgical site) was measured preoperatively and postoperatively. Edema, infection, and hematoma formation were evaluated on the first, second, and third days after operation. Hematoma occurred in 4 patients in the scrotal approach group and in I patient in the inguinal approach group. Scrotal size was significantly smaller in the scrotal approach group on all postoperative evaluation days. Three months after surgery, all patients in both groups were free of hydrocele. The inguinal approach is a feasible option in the surgical treatment of adults with hydrocele; it results in less edema than is noted with the scrotal approach. Larger studies are needed to confirm these results.
Ureteroscopic Treatment of Ureteral Lithiasis With Pneumatic Lithotripsy
(Springer, 2005) Ceylan, K; Sünbül, O; Sahin, A; Günes, M
Ureteroscopes and different lithotripsy methods have greatly improved the urologist's ability to treat ureteral stones, regardless of their location in the ureter. We retrospectively reviewed our experience with ureteroscopic pneumatic lithotriptor in 287 patients with ureteral calculi. Ureteroscopic stone treatment was performed between October 1999 and May 2004. Of 221 patients with distal ureteral calculi, 209 (group 1), and 58 of 66 patients with upper ureteral calculi (group 2) were treated successfully by ureteroscopy alone. In group 1, seven migrated stones (to the upper urinary tract) were successfully treated by ESWL later. There were five-treatment failures due to ureteral perforation which consequently required open ureterolithotomy. In group 2, there were five patients with migrated stones; two of them were sent to a percutaneous nephrolithotomy center because of previously unsuccessful ESWL attempts. Three of these with migrated stones were treated by ESWL later. In three patients, we switched to open ureterolithotomy because of ureteral rupture that required surgical repair. Ureteroscopic pneumatic lithotripsy is a safe and effective treatment modality for ureteral calculi.