Browsing by Author "Ceylan, Kadir"
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Article Application of Ureteroscopic Pneumatic Lithortripsy in Patients With Ureter Calculi: Our Five Years Experience(Professional Medical Publications, 2012) Gecit, Ilhan; Pirincci, Necip; Taken, Kerem; Benli, Erdal; Ceylan, KadirObjectives: To evaluate the efficacy and reliability of ureteroscopic pneumatic lithoripsy (URS-PL) in patients with ureter calculi. Methodology: A total of 612 patients who were treated with URS-PL in Medical school of Yuzuncu Yil University, Van State Hospital and Bingol State Hospital in the period between April 2005-May 2010 were studied. Diagnoses of ureter stones were made with intravenous pyelography (IVP) or computerize tomography (CT). Ureteral balloon dilation was not performed on any patient. On the post-operative 1st, 7th and 21st days, control direct urinary system graphic (DUSG) was taken. The rates of stone free and complication were analyzed with the ki-kare test. P < 0.05 was accepted as significant. Results: The mean age of the patients was 39 +/- 10 (18-75). There were 417 males (68.13%) and 195 females (31.86%). The mean volume of calculi in patients was 10.1 +/- 2.3 mm. Of these patients, 121 had proximal ureter stone, 169 medial ureter stones and 322 had distal ureter stones. In the first session of URS-PL, the calculi of 96 patients in proximal ureter (80%), those of 143 patients in medial ureter (85%) and those of 305 patients (95%) in distal ureter were cracked successfully. The mean stone free rate was 92.4% (79.4% in upper ureter, 94.1% in middle ureter and 93.7% in distal ureter (P < 0.05). Overall complication rate was 7.6% (7.7% in distal ureter, 3.9% in middle ureter and 11.8% in proximal ureter) (P>0.05). Most common peroperative complications of the procedure were ureteral perforation 4,2% (n=26), infection 2.2% (n=14), and mucosal laceration 1.9% (n=12). The most common late complication was ureteral stricture in 1.3% (n=8) of patients. Conclusion: Although URS-PL is a commonly used application for the treatment of patients with proximal and middle ureter stones, its common usage could also be extended to patients with distal ureter stones in the first stage of treatment, and it could be considered as an efficient and reliable procedure.specialization-in-medicine.listelement.badge Comparison of Cystoscopy and Diffusion Weighted Magnetic Resonance Imaging(DWMRI)for Diagnosis and Follow Up of Urinary Bladder Carcinoma(2009) Taken, Kerem; Ceylan, KadirGiriş ve Amaç: Amacımız mesane tümörlü hastaların tanı ve takibinde DAMRG'yi sistoskopi ile karşılaştırıp histopatolojik korelasyonunu araştırmaktır. DAMRG'nin tanı testleri (sensitivite, spesifite, yanlış pozitif oran, yanlış negatif oran ve doğruluk) ve mesane kitlelerinde DAMRG ile ADC değerleri ölçülerek malign-benign ayırımına katkısı tesbit edildi.Gereç ve Yöntem: Çalışmaya yaşları 31-85 arasında olan primer veya seconder hematüri ile üroloji polikliniğine başvuran toplam 59 kişi (yaş ortalaması 60±13.03) alındı.Üst üriner sistem patolojisi USG ile ekarte edildikten sonra hastalara önce DAMRG çekildi (ort. 7 gün ), daha sonra KS yapıldı.İncelemeler Siemens Magnetom Symphony (Siemens, Erlangen, Germany) cihazında faz dizilimli Body koil ile alt batın MR incelemesi yapıldı.. Eko-planar difüzyon MRG için kullanılan ` trace?0?500?1000-ADC' protokoldür.Elde olunan görüntüler üzerinden, görünür difüzyon katsayısı (apparent diffusion coefficient, ADC) normal mesane mukozasına ait dokudan ve mesane kitlelerinden hesaplanmıstır. Total tarama zamanı 151 sn sürmüştür.ADC değerleri bakımından Hasta-Kontrol grupları arasında fark olup olmadığını belirlemek amacıyla; tek yönlü varyans analizi (One-way ANOVA) yapılmıştır.Ayrıca test tanı ölçüt değerleri (duyarlılık, özgüllük, yanlış pozitif oran,yanlış negatif oran, doğruluk) kullanılmıştır. Hesaplamalarda anlamlılık düzeyi olarak %5 alınmış ve hesaplamalar SPSS istatistik paket programında yürütülmüştür.Bulgular: Çalışmamıza 59 hasta alınmıştır (47/12,E/K). Sistoskopi ile 43 hastada mesanede kitle saptanırken (n:34 malign,n:9 benign) 16 hastada kitle saptanmamıştır. DAMRG ile 40 hastada kitle saptanırken 19 hastada kitle saptanmadı.Sistoskopi ile 3 hastada izlenen kitle( (n:2) benign,(n:1) malign) DAMRG'de izlenmedi. DAMRG'de malign olarak yorumlanan 1 hastanın patolojisi benign idi. Histopatolojiye göre DAMRG'nin sırasıyla sensitivite, spesifite, doğruluk değerleri %97.6, %96, %96.6 olarak saptandı.Sistoskopi'ye göre ise DAMRG'nin sırasıyla sensitivite, spesifite, doğruluk değerleri % 90, %93, %91 olarak saptandı.ADC değerleri bakımından mesane tümörü saptanan 34 olgunun ortalama ADC değerleri (1,05±0.22 x10?³mm²/s), normal mesane duvarından alınan ortalama ADC değerlerinden (1,830±0.18x10?³mm²/s ) belirgin düşük olup, aralarında istatiksel olarak anlamlı fark bulundu (p<0.001). Benign lezyon saptanan 9 hastanın 6 `sı DAMRG' de benign, 1'i ise malign idi. Bunların ortalama ADC değerleri (1,73±0.12 x10?³mm²/s), normal mesane duvarından alınan ortalama ADC değerlerinden (1.78±0.2x10?³mm²/s ) istatistiksel olarak anlamlı fark bulunmadı (p>0.05). Bu benign lezyonların ADC değerleri malign lezyonların ADC değerleriyle karşılaştırıldığında aralarında anlamlı fark bulundu (p<0.001).Sonuç:.DAMRG'nin sensitivite, spesifite, doğruluk değerleri yüksek saptandı. DAMRG'nin non invazif ve hızlı bir çekim tekniği olması, iyonizan radyasyon içermemesi, tümör selüleritesinin önemli bir belirteci olması nedeniyle gelecekte mesane tümörlerinin tanısında ve takibinde gittikçe artarak kullanılacaktır.Article Comparison of Cystoscopy With Diffusion-Weighted Magnetic Resonance Images Used in the Diagnosis and Follow-Up of Patients With Bladder Tumors(Asian Pacific Organization Cancer Prevention, 2010) Ceylan, Kadir; Taken, Kerem; Gecit, Ilhan; Pirincci, Necip; Gunes, Mustafa; Tanik, Serhat; Karaman, IhsanPurpose: To compare diffusion-weighted magnetic resonance imaging (DW-MRI) with cystoscopy in the diagnosis and follow-up of patients with bladder tumor and to investigate any histopathological correlation. Materials and Methods: Totally 59 patients, between 31-85 years (mean age 60 +/- 13) referred to our clinic due to a hematuria complaint were enrolled and evaluated by upper urinary system pathology and then DW-MRI (average 7 days) and cystoscopy. Apparent diffusion coefficients (ADCs) of images were calculated. Results: While a mass in bladder was determined with cystoscopy in 43 out of 59 patients, the mass was not deternined in 16 of the patients(n=34 malign, n=9 benign). While a mass was determined in 40 out of 59 patients with DW-MRI, the mass was not determined in 19 of the patients(n=40 malign, n=19 benign). Regarding ADC values, mean ADC values of 34 patients who were diagnosed with a bladder tumor (1.05 +/- 0.22 x 10(-3)mm(2)/s), were significantly lower than the mean ADC values obtained from the normal bladder wall (1.830 +/- 0.18 x 10(-3)mm(2)/s) whereas a statistically significant difference was found (p<0.001). ADC values in 9 patients with a benign lesion (1,73 +/- 0.12 x 10(-3)mm(2)/s), were not found statistically different from the mean ADC values obtained from the normal bladder wall (1.78 +/- 0.2x10(-3)mm(2)/s) (p>0.05). A significant difference was determined between ADC values of benign lesions and the ADC values of malign lesions (p<0.001). Conclusions: According to cystoscopy, values of DW-MRI's related with sensitivity, specificity and accuracy were found, respectively 90%, 93% and 91%. As the DW-MRI is a non-invasive and a rapid technique, and does not contain ionized radiation and because it is accepted as an important marker of tumor cellularity, it may be used as an alternative in future diagnosis and follow-up of bladder tumors.Article Comparison of the Use of Prilocaine and Lidocaine Gel During the Cystoscopy(derman Medical Publ, 2012) Cecit, Ilhan; Benifi, Erdal; Keles, Ibrahim; Kayak, Servet; Pirincci, Necip; Guiles, Mustafa; Ceylan, KadirAim: In this study, the difference of the activity between the prilocaine and lidocaine gel instillation into the urethra was investigated in order to reduce the patient's pain and to increase the comfort of the procedure during the cystoscopy which was commonly used in the practice of urology. Material and Method: 134 patients who were decided to be performed the cystoscopy for various reasons between the years of 2008 and 2011 were randomly divided into two groups2% of lidocaine gel to the first group and 20 cc of 2% of prilocaine to the second group were given from the urethral route 5 minutes before the cystoscopy. Visual Analog Scale (VAS) was used in the assessment of the pain levels of the patients during the cystoscopy. The discomforts of the patients during the process were assessed with the question like "would you have the process done again if necessary". In patients in both groups, the levels of the pain and the hemodynamic changes were recorded at the beginning of the procedure, during the procedure and after the procedure. Results: There was no significant difference in terms of the hemodynamic changes between the two groups. If it is necessary to repeat the cystoscopy, while the average score of VAS for prilocaine was 3.8 and the rate of the performance was 80%, these values for lidocaine were about 5 and 70% respectively. Cystoscopy was viewed as more comfortable both for the doctor and for the patient in the group used prilocaine. It was understood that the majority of the patients would be able to perform the cystoscopy again if necessary. Discussion: Reducing the sense of the pain in the urethra, urethral instillation of the prilocaine has provided less pain during the rigid cystoscopy especially for the outpatients and has prevented the formation of the bad memories about the process. Prilocaine has drawn its score of VAS down 1.2 points compared to lidocaine and has increased the rate of doing cystoscopy again of patient by 10% when required.Article Complete Duplication of the Bladder and Urethra in the Coronal Plane: Case Report With Review of the Literature(Karger, 2013) Pirincci, Necip; Gecit, Ilhan; Gunes, Mustafa; Tanik, Serhat; Ceylan, KadirComplete duplication of the bladder and urethra without other congenital anomalies is a very rare congenital anomaly. We report the case of an 8-year-old boy with complete duplication of the bladder and urethra in the coronal plane, without any other associated congenital anomalies and without complaint associated with the urinary tract. Copyright (C) 2012 S. Karger AG, BaselArticle Conservative Approach in the Treatment of Renal Trauma in Children(Karger, 2014) Pirincci, Necip; Kaba, Mehmet; Gecit, Ilhan; Gunes, Mustafa; Tanik, Serhat; Ceylan, KadirObjective: Our aim was to evaluate the role of a conservative approach in the treatment of renal trauma in the pediatric age group. Materials and Methods: A total of 31 pediatric patients with renal trauma (male = 25, female = 6) in whom we used a conservative approach in our clinic between the years 2002 and 2010 were included in the study. Patients were assessed according to the type of trauma, type of treatment, findings of radiological imaging, concomitant other organ injuries and complications occurring during follow-up. Results: Surgery was required in just 4 of 31 pediatric patients who were treated with the conservative approach. Of the patients who underwent surgery, only one child needed nephrectomy. No complications were detected in the clinical and radiological follow-up of the patients who received the conservative approach. Conclusions: The main objective in the treatment of renal trauma occurring in childhood is to protect the kidneys. If the hemodynannic findings are stable, a conservative approach should be the first preferred method of treatment in every grade of renal trauma that can occur in childhood. Copyright (C) 2013 S. Karger AG, BaselArticle Distal Hipospadias Onarım Deneyimlerimiz(2003) Gunes, Mustafa; Ceylan, Kadir; Can, ŞabanAmaç: Hipospadias external meanın penisin ventraline açıldığı bir patolojidir. En sık distal yerleşim gösteren ve 300 erkek doğumda bir görülen bu konjenital anomalinin tedavisi cerrahidir. Bu amaçla pek çok cerrahi yöntem tanımlanmıştır. Bu çalışmada kendi sonuçlarımız sunulmuştur. Gereç ve Yöntem: Distal hipospadias onarımı yapılan 74 hasta retrospektif olarak değerlendirildi. 11 MAGPI, 18 Mathieu, 44 TIPU ve 3 hastada Onlay ada flebi teknikleri uygulandı. Bu çalışmada olgularımızdaki komplikasyon ve başarı oranları değerlendirildi. Bulgular: MAGPI tekniği uygulanan 1 hastada darlık gelişti. Mathieu tekniği uygulanan 2 vakada tüp kaybı, 5 vakada fistül ve 1 olguda darlık gelişti. TIPU uygulanlarda ise sadece 3 olguda meatal darlık ve 1 olguda fistül gözlendi. Sonuç: Distal hipospadias onarımında pek çok değişik teknik uygulanmaktadır. Bunlar içerisinde TIPU yönteminin uygulaması kolay, daha anatomik bir yaklaşım sağlaması ve daha az komplikasyonları olması nedeni ile diğer yöntemlere tercih edilebileceğini düşünüyoruz.Article Ectopic Intrauterine Device in the Bladder of a Pregnant Woman(Hindawi Ltd, 2010) Kurdoglu, Zehra; Ceylan, Kadir; Kurdoglu, Mertihan; Guler, Ayse; Sahin, Hanim GulerBackground. Uterine perforation and transvesical migration of an intrauterine device are rare complications. Case. A 28-year-old woman who had an intrauterine device was admitted to our outpatient clinic with complaints of amenorrhea lasting 5 weeks and pelvic pain lasting a year. Transvaginal ultrasonography revealed embedding of the intrauterine device in the bladder. The misplaced device was removed by laparotomy. Conclusion. The followup of intrauterine device localization with transvaginal ultrasonography is essential for early detection of possible serious complications.Article Effects of Shock Waves on Oxidative Stress and Some Trace Element Levels of Rat Liver and Diaphragm Muscles(Wiley, 2012) Gecit, Ilhan; Kavak, Servet; Meral, Ismail; Gunes, Mustafa; Pirincci, Necip; Sayir, Fuat; Ceylan, KadirThis study was designed to investigate whether the short-term extracorporeal shockwave lithotripsy (ESWL) exposure to kidney produces an oxidative stress and a change in some trace element levels in liver and diaphragm muscles of rats. Twelve male Wistar albino rats were divided randomly into two groups, each consisting of six rats. The animals in the first group did not receive any treatment and served as control group. The right-side kidneys of animals in group 2 were treated with two-thousand 18?kV shock waves while anesthetized with 50?mg kg-1 ketamine. The localization of the right kidney was achieved after contrast medium injection through a tail vein under fluoroscopy control. The animals were killed 72 h after the ESWL treatment, and liver and diaphragm muscles were harvested for the determination of tissue oxidative stress and trace element levels. Although the malondialdehyde level increased, superoxide dismutase and glutathione peroxidase enzyme activities decreased in the livers and diaphragm muscles of ESWL-treated rats. Although glutathione level increased in liver, it decreased in diaphragm muscles of ESWL-treated animals. Fe, Mg and Mn levels decreased, and Cu and Pb levels increased in the livers of ESWL-treated animals. Fe and Cu levels increased, and Mg, Pb, Mn and Zn levels decreased in the diaphragm muscles of ESWL-treated animals. It also causes a decrease or increase in many mineral levels in liver and diaphragm muscles, which is an undesirable condition for the normal physiological function of tissues. Copyright (c) 2012 John Wiley & Sons, Ltd.Article Effects of Shock Waves on Oxidative Stress, Antioxidant Enzyme and Element Levels in Kidney of Rats(Springernature, 2011) Gecit, Ilhan; Kavak, Servet; Meral, Ismail; Pirincci, Necip; Gunes, Mustafa; Demir, Halit; Ceylan, KadirThe aim of this study was to investigate the effect of extracorporeal shock wave lithotripsy (ESWL) on kidney oxidative stress and trace element levels of adult rats. Twelve male Wistar albino rats were divided equally into two groups. First group was used as control. The right-side kidneys of animals in second group were treated with 2,000 18-kV shock waves under anesthesia. Localization of the right kidney was achieved following contrast medium injection through a tail vein under flouroscopy control. The animals were sacrificed 72 h after the ESWL treatment, and the kidneys were taken. Malondialdehyde level was higher in the ESWL group than in the control. Reduced glutathione levels, superoxide dismutase, and glutathione peroxidase activities were lower in the ESWL group than those of the control. Fe, Cu, Pb, Mn, Cd, and Ni levels were lower in the ESWL group than in the control, although Mg level was higher in the ESWL group than in the control. In conclusion, the result of the present study indicated that ESWL treatment produced oxidative stress in the kidney and caused impairments on the antioxidant and trace element levels in the kidneys of rats.Article Ekstrofi Vezika: Postoperatif 2 Dev Taş Olgusu(2006) Bayraklı, Haşmet; Kuş, Alpaslan; Yılmaz, Yüksel; Ceylan, KadirEkstrofi vezikal seyrek bir konjenital anomalidir. En erken dönemde düzeltilmelidir. Ekstrofi epispadias kompleksi olan 5 olgudan komplikasyon gelişen 2 olguyu sunuyoruz. Olgu 1: 3 günlük iken iliak osteotomi ve primer mesane kapatması uygulanan hastada 4 yıl sonra simflz pubis yaklaştırılmasında kullanılan serklaj telinin enkrustasyonuna bağlı 4x3x1.5 cm çaplı taş oluşumu. Olgu 2: 18 yaşına kadar tedavi edilmemiş ekstrofi-epispadias kompleksi olan bir hasta; total sistektomi ve Indiana Pauch uygulanması sonrasında 6. yılda poş içinde 5-6 adet dev taş oluşumu ile geldi. Sonuç: Literatüre katkı olması amacıyla sunulduArticle Hemodiyaliz Hastalarında Vasküler Giriş için Arteriyovenöz Fistül Oluşturulması ve Açıklık Oranları(2003) Ceylan, Kadir; Sahin, AdemAmaç: Hemodiyaliz hastalarında damar girişi için oluşturulan arteriyovenöz fistüllerin açıklık oranlan ve bunu etkileyen faktörlerin değerlendirilmesi. Yöntem: Mayıs 1999 ile Haziran 2002 tarihleri arasında son dönem böbrek yetmezliği gelişmiş ve arteriyovenöz fistül açılmış olan 92 hasta retrospektif olarak değerlendirildi. Enfiye çukurundan 78, stiloid proçesin proksimalinden 22 ve antekübital bölgeden 16 olmak üzere toplam 116 girişim uygulandı. Bulgular: Enfiye çukurunda oluşturulan fistüllerde ilk 24 saatte %92 açıklık varken, 36 aylık takipte bu oran %42'ye geriledi. Aynı oranlar, stiloid çıkıntının proksimali için, sırasıyla, %100 ve %70, antekübital bölgede için, sırasıyla %100 ve %66 olarak belirlendi. Diyabetik hasta grubunda açıklık oranları düşerken, yaş ve cinse göre anlamlı farklar saptanmadı. Sonuç: Kronik böbrek yetmezliği olan ve hemodiyaliz uygulanan hastaların bu ihtiyacı yaşam boyu sürebilir. Tüm hastalarda ve özellikle de diyabetli olgularda vasküler giriş bölgeleri iyi korunmalıdır. Hemodiyaliz çalışanlarının konu hakkında bilgilendirilmesi ve uygun cerrahi teknik fistülün daha uzun süre kullanılmasına yardımcı olacaktır.specialization-in-medicine.listelement.badge İnfertil Vakalarda Ureaplasma ve Mıkoplazma Sıklığı ve Kültür Pozitif Olgularda Tedavi Öncesi ve Sonrası Semen Parametrelerindeki Değişiklikler(2007) Yıldız, Abdullah; Ceylan, KadirArticle Open Prostatectomy the Results of a Series of 320 Cases in Rural Area(Modestum Ltd, 2006) Ceylan, KadirAim: Suprapubic prostatectomy is frequently performed in areas with poor socioeconomic condition due to insuficient endoscopy equipment. The aim of this retrospective study is to analyse and bring our experience about the open prostatectomy operation Methods: A retrospective study was done on 320 consecutive patients with BPH underwent open prostatectomy operation between January 1996 and December 2002. Analyzed factors were age, complaints, comorbidities (especially cardiac and respiratory), early and late complications and mortalitiy. Results: The total complication rate was 34.6 %. While early complication rate was 20.3 %, late complication rate was 14.3 %. There were no deaths. Early complications were clot retantion (6.6 %), severe intraoperative bleeding (3.2%), wound infection (4.0%) vesicocutaneous leak (4.7%), and reoperation for clot retantion (1.5%). Late complications were urinary tract infection (7.5%), epididymo-orchitis (3.1%), prolonged incontinance (0.9), and bladder neck or urethral stricture (2.2%). Conclusion: Our study demonstrated that open prostatectomy for benign prostatic hyperplasia (BPH) is an acceptable option with a high degree of safety and efficacy in areas where the TUR-P equipment is lacking or this operation is technically impossible.Article Orşiektomiye Giden Brusella Orşiti: Bir Olgu Sunumu(2007) Karahocagil, Mustafa Kasım; Ceylan, Kadir; Bayram, Yasemın; Bilici, Adnan; Karsen, Hasan; Akdeniz, Hayrettin; Bulut, GülayBruselloz endemik olarak görüldüğü bölgelerde epididimorşit yapan önemli nedenlerden birisidir. Genellikle brusella epididimorşit granülamatöz tipte tutulum yapar ve prognozu iyidir. Bununla birlikte geç veya yanlış tanı ve tedavi orşiektomiye kadar giden komplikasyonlara yol açabilir. Biz burada yanlış tanı sebebiyle geç tedavi verilen bir genç erkek hasta da orşiektomiye giden unilateral brusella epididimorşit olgusunu sunarak literatür eşliğinde tartıştık.Article Penil Fraktür(2005) Yıldız, Abdullah; Ceylan, Kadir; Gönülalan, Hasan; Yılmaz, YükselAmaç: Penil fraktür cinsel ilişki, mastürbasyon esnasında veya ereksiyonda olan penise darbe veya üzerine düşülmesi sonucu gelişebilen, tunika albugineanın yırtılmasıdır. Bu yaralanmanın tedavisi cerrahidir. Penil fraktürlü hastaların etiyolojisi ve cerrahi sonrası muhtemel komplikasyonları tartışıldı. Metod: 1995 - 2004 yılları arasında peniste ani gelişen şiddetli ağrı, şişlik, renk değişikliği şikayeti ile baş vuran ve penil fraktür tanısı alan 10 hasta retrospektif olarak değerlendirildi. Bulgular: Tüm hastalarda biri hariç sebep kunt travma idi.4 olgu cinsel ilişki sırasında, 2 olgu mastürbasyon esnasında, 2 olgu sabah ereksiyonuda iken, bir olguda eşya çarpması (Kepenk düşmesi) ve bir olguda ise kurşun ile yaralanma idi. Son iki vaka üretral yaralanma ve hematüri ile beraberdi. Olguların hepsinde yırtık cerrahi olarak düzeltildi. Ortalama 24 aylık ( 8 ay-32 ay) takiplerinde cinsel aktiviteyi engelleyen kurvatur ve (erektil disfonksiyon) ED görülmedi. Sonuç: Penil fraktürün tedavisinde, cerrahi düşük komplikasyonlu, güvenli ve başarılı bir seçenektir.Article Peripheral Mononuclear Leukocyte Dna Damage, Plasma Prolidase Activity, and Oxidative Status in Patients With Benign Prostatic Hyperplasia(Taylor & Francis Ltd, 2015) Gecit, Ilhan; Meral, Ismail; Aslan, Mehmet; Kocyigit, Abdurrahim; Celik, Hakim; Taskin, Abdullah; Ceylan, KadirObjectives: Prolidase plays a major role in collagen turnover, matrix remodeling, and cell growth. Benign prostatic hyperplasia (BPH) may be associated with an increased extracellular matrix deposition. Therefore, the present study was designed to investigate the plasma prolidase activity, oxidative status, and peripheral mononuclear leukocyte DNA damage in patients with BPH. Patients and methods: Twenty-six male patients with BPH and 24 healthy male subjects were included in this study. Blood samples were collected from antecubital vein after an overnight fasting period, and the plasma was separated. Plasma prolidase activity, total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined. The peripheral lymphocyte oxidative DNA damage was determined using an alkaline single cell gel electrophoresis assay (comet assay). Results: The plasma prolidase activity, TOS levels, OSI values, and peripheral mononuclear leukocyte DNA damage were significantly higher (P < 0.001), while the TAC levels were significantly lower (P < 0.001) in patients with BPH than controls. In BPH patients, the prolidase activity was significantly associated with TAC levels (r = -0.366, P < 0.05), TOS levels (r = 0.573, P < 0.001), and OSI (r = 0.618, P < 0.001) and peripheral mononuclear leukocyte DNA damage (r = 0.461, P < 0.001). Conclusions: Our results showed that BPH might be associated with an increased oxidative stress, and also an increased plasma prolidase activity. Increased prolidase activity might play an important role in the etiopathogenesis and/or progression of BPH.Article Plasma Human Neutrophil Proteins-1, And-3 Levels in Patients With Bladder Cancer(Springer, 2013) Gunes, Mustafa; Gecit, Ilhan; Pirincci, Necip; Kemik, Ahu Sarbay; Purisa, Sevim; Ceylan, Kadir; Aslan, MehmetHuman neutrophil proteins-1, -2, and -3 (HNPs -1, -2, and -3) are expressed in several tumor types. However, the role of HNPs 1-3 in human bladder cancer has not yet been determined. We investigated the association between the plasma levels of HNPs 1-3 and clinicopathological parameters in bladder cancer patients. The plasma levels of HNPs 1-3 were measured in 60 patients with bladder cancer and in 58 healthy controls. The plasma levels of HNPs 1-3 were determined by a solid-phase enzyme-linked immunosorbent assay (ELISA). Plasma samples were obtained before surgery. Plasma samples were permitted to clot and were then stored at -80 A degrees C until use. The levels of the HNPs increased from grade 1 to 4 tumors and this difference was statistically significant (p < 0.001). Additionally, plasma HNP levels were significantly higher in patients with metastatic bladder cancer and in patients with lymphovascular involvement, metastasis of the lymph nodes, and increased tumor burden (p < 0.001). The preoperative plasma levels of HNPs 1-3 paralleled the progression and pathological stages of the malignancies. This study suggests that HNPs 1-3 promote tumor invasion and are potential indicators of disease progression in patients with bladder cancer.Article Prevalence of Ureaplasma and Mycoplasma in Infertile Men in Van Region and Effects To Semen Parameters(derman Medical Publ, 2015) Taken, Kerem; Yildiz, Abdullah; Gunes, Mustafa; Eryilmaz, Recep; Gecit, Ilhan; Ceylan, KadirAim: The purpose of this study was to assess the prevalence of Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) in semen cultures of cases with primary infertility in the Van Province, and also to determine the effect of therapy on sperm parameters. Material and Method: The study included 106 individuals divided into three groups: The infertile group (41 cases), the group with lower urinary tract symptoms (33 cases), and the control group (32 cases). The patients in the infertile group had no history of varicocele, testicular torsion, hydrocele, undescended testis, and hormonal disorders. The control group included cases without infertility and lower urinary tract symptoms. The parameters of culture-positive cases in the infertile group were determined before and after therapy. The identification of Mycoplasma species was made using the Biomerieu (R) Mycoplasma 1ST 2 (RCS Lyon France) kit. The sperm count was carried out with the Makler counting chamber (Self Medical Industries, Haifa, Israel). Results: In the infertile group, UU was isolated from 17 and MH was isolated from 3 cases. In the group with lower urinary tract symptoms, UU was isolated from 15 (45.559) and MH was isolated from 6 (18.8%) cases. In the control group, UU was isolated from 6 (18.8%) cases, but MH was isolated from none of the cases. In the infertile group, the sperm counts in 3 culture-positive cases (15%) and in 10 culture-negative cases (50%) were <15 million each (p<0.025). Prior to therapy, the sperm motility in the culture-positive 14 cases (70%) was lower than 40%, and after therapy, 5 cases (2598) demonstrated a sperm motility of <4059, With therapy, a significant increase in sperm motility was obtained. After therapy of the 20 culture-positive cases (49%), the wives of 4 (203% patients became pregnant (p<0.025). Discussion: Antibiotherapy in culture positive cases with undetermined cause of infertility contributes to therapy by positively affecting sperm motility.specialization-in-medicine.listelement.badge Prostatektomi Yapılan Hastalarda Histopatolojik Olarak Kanıtlanmış Prostatit ve Buna Etki Eden Bazı Faktörlerin İncelenmesi(2007) Gönülalan, Hasan Nazif; Ceylan, Kadir