Browsing by Author "Ceylan, M.R."

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Cases of Cutaneous Anthrax in Eastern Turkey: the Reports of Three Cases
(Ondokuz Mayis Universitesi, 2015) Karadaş, S.; Gönüllü, H.; Ceylan, M.R.; Esmer, F.; Ebinç, S.
Anthrax is an acute disease caused by the bacterium Ba cillus anthracis. This bacteria can form dormant endospores. When spores are inhaled, ingested, or come into contact with a skin lesion on a host, they may become reactivated multiply and rapidly. B. anthracis bacterial spores are soil-borne. Because of their long lifespan, spores are present globally and remain at the burial sites of animals killed by anthrax for many decades. Diseased animals can spread anthrax to humans, either by direct contact or by consumption of a diseased animal's flesh. The most frequent clinical type of anthrax is cutaneous anthrax. It presents as a boil-like skin lesion that eventually forms an ulcer with a black center (eschar). Cutaneous anthrax form often within the site of spore penetration between two and five days after exposure. Until the 20th century, anthrax infections killed thousands of animals and people worldwide each year. Animal vaccination programs and antibiotic therapy were decreased the number of deaths. But, anthrax is still a problem in less developed countries. It has been reported that the incidence of disease has decreased in Turkey. However, we present here in three cases of cutaneous anthrax admitted to the emergency department of our hospital within a week. © 2015 OMU.
Characterisation of Drug Resistance of Nosocomial Esbl-Producing E. Coli Isolates Obtained From a Turkish University Hospital Between 2009 and 2012 by Pulsed Field Gel Electrophoresis and Antibiotic Resistance Tests
(EDIMES Edizioni Medico Scientifiche, 2016) Karagöz, A.; Sunnetcioglu, M.; Ceylan, M.R.; Bayram, Y.; Yalcin, G.; Kocak, N.; Andac, C.A.
In this study, drug resistance of 28 ESBL-producing Escherichia coli isolates obtained from 144 patients hospitalized at the Yüzüncüyil University Hospital at Van (YUH), Turkey, between 2009 and 2012 were characterized by pulsed field gel electrophoresis and antibiotic susceptibility tests. Antibiotic resistance profile was determined by a Phoenix automated system (BD, USA). The ratio of ESBL-producing E. coli strains was determined to be 19.4% (28 out of 144 E. coli isolates). It was determined that the anaesthesiology, paediatrics and thoracic medicine intensive care units in YUH were cross-contaminated between 2009 and 2012 by ESBL-producing E. coli strains, which is a sign of nosocomial infection in YUH. Analysis of PFGE results gave rise to two main PFGE profiles, profile-A with four subprofiles and profile-B with three subprofiles, where profile-A predominates over profile-B (14%). Comparison of the antibiotic resistance profile with the PFGE profile yielded similarities while some differences also exist due to either identical restriction enzyme cutting sites with slightly different genetic sequences in between the cutting sites or newly formed restriction enzyme cutting sites that do not affect antibiotic resistance genes. Enterobacteriaceae, particularly E. coli, have developed resistance in YUH by producing ESBLs against oxyimino and non-oxyimino cephalosporins, and penicillin-type antibiotics. Therefore, more effective antibiotics such as cefoxitin or cefoperazone- sulbactam should be used for the treatment of future nosocomial infections in YUH while hospital staff should take care with hygiene, such as hand washing. © 2016, EDIMES Edizioni Medico Scientifiche. All rights reserved.
Essential Trace Element Levels in Patients With Cutaneous Anthrax
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Binici, I.; Parlak, M.; Sunnetcioglu, M.; Baran, A.I.; Ceylan, M.R.; Kul, A.R.; Huyut, Z.
The causative microorganism in anthrax is Bacillus anthracis and this disease is more common in some regions of Türkiye. Changes in trace elements other than iron in anthrax infection have not been studied. In this study, iron, copper, lead, zi nc, manganese, magnesium, cadmium and cobalt levels were investigated in cases with cutaneous anthrax. Fifteen patients with cutaneous anthrax and 15 healthy individuals wereincluded in the study. The groups were similar to each other in terms of age and gender. Anthrax was diagnosed according to contact status with animals, symptoms, examination, and microbiological results. We performed our study with Atomic Absorption Spectrophotometer (UNICAM-929 spectrophotometer). Serum iron, lead, and cadmium levels were significantly higher in the patients than in the control subjects (p<0.05). Serum magnesium, manganese, zinc, copper, and cobalt levels were significantly lower in the patients than in the control subjects (p<0.05). The copper/zinc molar ratio was not significantly increased in the patients with cutaneous anthrax than in the control subjects. It has been reported that iron, cadmium, and lead levels are low and copper level is high in infectious diseases. But we determined the opposite situation in the patients with cutaneous anthrax. As a result, it can be said that the detection of high lead and cadmium levels in the cell in anthrax disease suppresses the immune system. Also, zinc can be used as a marker for this disease. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Rare Brucellosis Involvement: Thyroid Gland Abscess
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Sunnetcioglu, M.; Ceylan, M.R.; Atmaca, M.; Baran, A.İ.; Mentes, O.; Ücler, R.
Brucellosis is a zoonotic disease, especially in endemic regions all over the world, it is a common infectious disease. However, brucellosis borne thyroid gland infection is quite rare. The purpose of this study is to draw attention to the thyroid abscess borne due to brucella, which also show an unusual clinical graphic. Within this study we aim to represent a case with thyroid abscess dominated Brucella spp. © 2015 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Serum Adenosine Deaminase Activity in Cutaneous Anthrax
(International Scientific Literature Inc., 2014) Sunnetcioglu, M.; Karadas, S.; Aslan, M.; Ceylan, M.R.; Demir, H.; Oncu, M.R.; Aypak, C.
Background: Adenosine deaminase (ADA) activity has been discovered in several inflammatory conditions; however, there are no data associated with cutaneous anthrax. The aim of this study was to investigate serum ADA activity in patients with cutaneous anthrax. Material/Methods: Sixteen patients with cutaneous anthrax and 17 healthy controls were enrolled. We measured ADA activity; peripheral blood leukocyte, lymphocyte, neutrophil, and monocyte counts; erythrocyte sedimentation rate; and C reactive protein levels. Results: Serum ADA activity was significantly higher in patients with cutaneous anthrax than in the controls (p<0.001). A positive correlation was observed between ADA activity and lymphocyte counts (r=0.589, p=0.021) in the patient group. Conclusions: This study suggests that serum ADA could be used as a biochemical marker in cutaneous anthrax. © Med Sci Monit, 2014.