Browsing by Author "Ceylan, Mehmet Resat"

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Brucella-Induced Sublingual Abscess Causes Acute Shortness of Breath
(W B Saunders Co-elsevier inc, 2016) Bozan, Nazim; Parlak, Mehmet; Ceylan, Mehmet Resat; Yalinkilic, Abdulzaziz; Cankaya, Hakan; Garca, Mehmet Fatih
Brucellosis may cause various clinical conditions. However, to our knowledge, there is no case report on the sublingual abscess caused by Brucella in the medical literature. In this case report, we present a 45-year-old male patient who presented with acute shortness of breath. A sublingual abscess was identified, and brucellosis was diagnosed based on Brucella species. The patient achieved full recovery after the lesion was drained with a catheter, and he was treated with rifampicin and doxycycline for 6 weeks. In regions where brucellosis is endemic, this rare disorder should be considered.
A Case of Salmonella Typhi Mesenteric Lymphadenitis Accompanied by Acute Abdomen and Pancytopenia
(Aves, 2013) Bilici, Adnan; Cabalak, Mehmet; Sunnetcioglu, Mahmut; Ceylan, Mehmet Resat; Karahocagil, Mustafa Kasim
Presenting with abdominal pain in the right lower quadrant and mimicking acute appendicitis, mesenteric lymphadenitis can lead to unnecessary surgical interventions, especially in children. We present a case of a 16-year-old female with Salmonella typhi mesenteric lymphadenopathy, who was admitted to the hospital with symptoms of acute abdomen, including severe abdominal pain, fever, nausea and vomiting. In addition, because of the pancytopenia, the prolongation of the prothrombin time and the hypofibrinogenemia, the clinical picture was similar to disseminated intravascular coagulation. After the growth of S. typhi in blood cultures, she was successfully treated with ciprofloxacin.
The Evaluation of Clinical and Laboratory Findings of 63 Inpatient With Cutaneous Anthrax: Characteristics of Cutaneous Anthrax in Turkey
(deri Zuhrevi Hastaliklar dernegi, 2014) Ozkol, Hatice Uce; Karadas, Sevdegul; Sunnetcioglu, Mahmut; Ceylan, Mehmet Resat; Calka, Omer; Guducuoglu, Huseyin
Background and Design: Despite a very uncommon disease in developed countries, cutaneous anthrax (CA) is currently endemic in our countries. In this study, we aimed to bring out characteristic of anthrax of Turkey by comparing our results and the other CA reports in Turkey. Materials and Methods: Sixty three inpatients with CA between October 2009 and December 2012 were investigated retrospectively. All patients were diagnosed CA by clinical finding and/or microbiological examination. The demographic characteristics patient, routine tests, wound culture and gram staining results were recorded. Results were recorded on statistical program of SPSS 13.0 and were written using percent (%). Results: There were 63 inpatients (41 female (65.1%), 22 male (34.9%), mean age 35.9 years range10-83). Forty nine patients (77.8%) had a history of contact with animals or animal product. Thirty-eight (60.3%) and twenty-one (33.3%) patients were found in the summer and fall season, respectively. Gram staining and culture were performed in 51 patients. Gram-positive bacilli were detected in 17 patients (33.3%) by gram smear. Bacillus anthracis bacilli were produced in 11 patients (21.5%) in cultures test. The lesions were mostly seen on the left hand (30.2%). Penicillin was most frequently preferred in treatment of CA (87.3%). Conclusion: CA is still endemic in Eastern Anatolia and continues to increase in recent years. Women living in the villages in which income is obtained from buying and selling of animals constitute the most important risk group. Preventive actions such as training of the risky society, vaccination of animals, and obstructing of illegal animal entries across the border, will reduce the incidence of CA.
Evaluation of Colistin-ampicillin/Sulbactam Combination Efficacy in Imipenem-Resistant Acinetobacter Baumannii Strains
(Ankara Microbiology Soc, 2013) Cikman, Aytekin; Ceylan, Mehmet Resat; Parlak, Mehmet; Karahocagil, Mustafa Kasim; Berktas, Mustafa
The increasing emergence of multi-drug resistant Acinetobacter baumannii strains as nosocomial pathogens lead to the use of antimicrobial combinations in the treatment of infections due to these bacteria. The aim of this study was to determine the MIC values of colistin and ampicillin/sulbactam and their in vitro synergistic activities by E-test in order to evaluate the effect of this combination against imipenem-resistant A.baumannii isolates. A total of 33 A.baumannii strains isolated from clinical specimens as etiologic agents of nosocomial infections and identified as imipenem-resistant were included in the study. Identification of the isolates was performed by conventional methods and their imipenem resistance was detected with BD Phoenix automated system (Becton Dickinson, USA). MIC values and in vitro synergistic activity of colistin and ampicillin/sulbactam combination were analyzed by E-test (AB Biodisk, Sweden) on Mueller-Hinton agar medium. Synergistic, additive, indifferent and antagonist effects of A.baumannii strains were evaluated by fractional inhibitory concentration (FIC) index. The combination was considered to be synergistic when the FIC index was <= 0.5, additive when it was 1- > 0.5 and antagonistic when >= 2. Of the 33 strains included in the study, 21 were resistant to colistin; 30 were resistant and 3 were moderately susceptible to ampicillin/sulbactam. MIC50 and MIC90 values and MIC range of A.baumannfi strains for colistin were 8, 32 and 0.13-128 mu g/ml; for ampicillin/sulbactam those values were 48, 256 and 12-256 mu g/ml, respectively. According to the FIC indices, 15 strains showed synergistic, four additive, five indifferent and nine antagonistic activity to colistin and ampicillin/sulbactam combination. Among the 12 colistin-susceptible strains, nine showed antagonistic, two indifferent and one synergistic activity to the tested combination while among the 21 colistin-resistant strains 14 showed synergistic, four additive and three indifferent activity. As a result, the combination of colistin with ampicillin/sulbactam, demonstrated high synergistic activity in vitro. While the synergistic effect of this combination was more significant in colistin-resistant strains, antagonistic effect of colistin-susceptible strains was found to be notable. Therefore, colistin resistance should be primarily determined before using colistin and ampicillin/sulbactam combination in A.baumannfi infections since this combination seemed to be more effective in case of colistin resistance. However, these data should be supported by further advanced clinical studies.
High Asymmetric Dimethylarginine (Adma) Levels in Patients With Brucellosis
(Springer/plenum Publishers, 2014) Mengeloglu, Zafer; Sunnetcioglu, Mahmut; Tosun, Mehmet; Kucukbayrak, Abdulkadir; Ceylan, Mehmet Resat; Baran, Ali Irfan; Akdeniz, Hayrettin
Asymmetric dimethylarginine (ADMA) is the main endogenous inhibitor of nitric oxide synthase and is considered to be associated with endothelial dysfunction. Brucellosis, a zoonotic disease caused by Brucella spp., can manifest as vasculopathy. The present study was performed to investigate the relationship between ADMA and brucellosis. Serum samples from 39 patients with an accurate diagnosis of brucellosis and from 18 healthy control individuals were included in this study. ADMA levels were significantly higher in the patient group than the controls (P < 0.001). Receiver operating characteristic (ROC) curve analysis indicated that ADMA level a parts per thousand yen0.61 had a sensitivity of 79.5 %, specificity of 88.9 %, positive predictive value of 93.9 %, and negative predictive value of 66.7 %. This is the first report of an association between brucellosis and high levels of ADMA. In conclusion, ADMA levels should be tested in brucellosis cases and that further studies to clarify the mechanism underlying the association between ADMA and brucellosis are required.
In Vitro Activity of Colistin in Combination With Tigecycline Against Carbapenem-Resistant Acinetobacter Baumannii Strains Isolated From Patients With Ventilator-Associated Pneumonia
(Ivyspring int Publ, 2015) Cikman, Aytekin; Gulhan, Baris; Aydin, Merve; Ceylan, Mehmet Resat; Parlak, Mehmet; Karakecili, Faruk; Karagoz, Alper
Objective: This study investigated the minimum inhibitory concentration (MIC) values and in vitro activity of colistin in combination with tigecycline against carbapenem-resistant Acinetobacter baumannii strains isolated from patients with ventilator-associated pneumonia (VAP) using the E-test method. Methods: A total of 40 A. baumannii strains, identified using the Phoenix Automated Microbiology System (Becton, Dickinson and Co., Franklin Lakes, NJ, USA) by conventional methods, were included in this study. Pulsed-field gel electrophoresis was performed to examine the clonal relationships between isolates. The carbapenem resistance of the strains to colistin and tigecycline was assessed using the E-test method (Liofilchem, Roseto Degli Abruzzi, Italy). The in vitro activity of colistin in combination with tigecycline was evaluated using the fractional inhibitor concentration (FIC) index. Results: While only 1 of 40 A. baumannii strains was determined to be colistin resistant, 6 were tigecycline resistant. The MIC50, MIC90, and MIC intervals of the A. baumannii strains were 0.19, 1.5, and 0.064-4 mu g/ml for colistin and 1, 8, and 0.094-256 mu g/ml for tigecycline, respectively. No synergistic effect was observed using the FIC index; 8 strains exhibited an indifferent effect and 32 exhibited an antagonist effect. Three of the six strains that were resistant to tigecycline were indifferent; the remaining three were antagonistic. The colistin-resistant strain also exhibited an antagonist effect. Conclusion: In contrast to their synergistic effect against carbapenem-resistant A. baumannii isolates, colistin and tigecycline were highly antagonistic to carbapenem-resistant A. baumannii strains isolated from patients with VAP when the drugs were administered together. Therefore, alternative treatment options should be used during the treatment of VAP attributed to A. baumannii.
Serum Myeloperoxidase Activity and Oxidative Stress in Patients With Acute Brucellosis
(Pergamon-elsevier Science Ltd, 2012) Karahocagil, Mustafa Kasim; Aslan, Mehmet; Ceylan, Mehmet Resat; Cikman, Aytekin; Sunnetcioglu, Mahmut; Kucukoglu, Mehmet Emin; Taskin, Abdullah
Objectives: The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis. Design and methods: Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined. Results: Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p<0.05, p<0.001), while catalase activity were significantly lower (p<0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r = 0.297, p = 0.016) in patients. Conclusions: These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Serum Paraoxonase and Arylesterase Activities and Oxidant Status in Patients With Brucellosis
(Academic Journals, 2011) Karsen, Hasan; Karahocagil, Mustafa Kasim; Akdeniz, Hayrettin; Ceylan, Mehmet Resat; Binici, Irfan; Selek, Sahbettin; Celik, Hakim
The aim of this study was to the investigate the effect of brucellosis infection on paraoxonase-1 (PON1) activity and oxidative status in patients with brucellosis. Sixty patients with brucellosis (47 acute, 13 subacute) and the 67 healthy controls were used in the study. Serum PON1 and arylesterase activities, total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), total free sulfhydryl (-SH), and lipid hydroperoxide (LOOH) groups were determined. In addition, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) were measured. Serum PON1 and arylesterase activities, total -SH group levels and TAC were significantly lower in brucellosis patients than controls (P<0.001). TOS, OSI and LOOH levels were significantly higher in brucellosis patients than controls (P<0.001). There were no significant differences between of serum LDL-C, TG and TC levels of patients subjects compared to controls (P > 0.05). Patients with brucellosis are exposed to potent oxidative stress and they have decreased PON1 activity. These predisposal factors might play a role in the pathogenesis for atherosclerosis in patients with brucellosis.
The Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Patients With Brucellosis
(Wiley, 2015) Dulger, Ahmet Cumhur; Aslan, Mehmet; Ceylan, Mehmet Resat; Olmez, Sehmus; Karadas, Sevdegul; Akdeniz, Hayrettin
Objective: Various studies have shown that a number of infectious disease causes syndrome of inappropriate antidiuretic hormone (SIADH). However, the relationship between infectious disease and SIADH is not yet fully known. In this prospective study, we aimed to assess the presence of SIADH in patients with brucellosis. Patients and methods: Thirty-five patients with acute brucellosis were retrospectively reviewed. The diagnosis of brucellosis was performed using the Wright test in connection with blood culture. SIADH was defined by euvolemic hyponatremia (serum sodium level lower than 135 mEq/l) with increased urinary sodium excretion (urinary sodium higher than 40 mmol/l). Results: Of the 35 patients, 19 (54%) had SIADH; 20 (57%) also had hypouricemia (uric acid level lower than 4 mg/dl). Additionally, all of the studied patients had a high mean urinary sodium excretion rate (mean 132 mmol/l; range 40-224). Most importantly, the hyponatremic patients were more likely to have a lower albumin level (P < 0.01). Conclusions: SIADH is a major complication of brucellosis. The presence of SIADH could be a diagnostic tool for diagnosing brucellosis. Further larger randomized studies may confirm these findings. (C) 2014 Wiley Periodicals, Inc.