Browsing by Author "Ceylan, N."

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Assessing of Term Newborns Hospitalized in Our Neonatal Unit With the Diagnosis of Indirect Hyperbilirubinemia
(Anatolian Journal of Clinical Investigation, 2015) Demir, N.; Peker, E.; Aslan, O.; Ceylan, N.; Tuncer, O.
The one of most common problems of the newborn baby is indirect hyperbilirubinemia. In this retrospective study; the etiology, clinical and demographic features, treatment methods, and the complications in pathological indirect hyperbilirubinemia and prolonged jaundice were evaluated. 237 cases of pathological indirect hyperbilirubinemia and prolonged jaundice that were viewed in Yüzüncü Yıl University Hospital Neonatology Unit between January 2013 - December 2014 were included in this study. All neonates in the study with following characteristics: 57.8% of patients were male, the mean gestational age of 38.4 ± 1 weeks, mean birth weight of 2870 ± 505 g , mean bilirubin level on admission of 21.6 ± 5.6 mg/dL (13–49), vaginal delivery ratio of 55.7%, first time mother ratio of 34.2%, breastfeeding ratio of 98%. While in 95 (40.1 %) neonates the etiology of hyperbilirubinemia could not be found, urinary tract infection in 34 (14.3%), ABO incompatability in 72 (30.4%) and Rh incompatability in 24 (% 10.1) patients were found. The average length of stay in the hospital and duration of phototherapy were 4 ± 2.9 days and 37.2 ± 14.2 hours, respectively. All of the cases were given phototherapy, but 44 infants were done exchange transfusions. We found that bilurubin induced neurological disorder in 23 newborn had undergone exchange transfusion, and its the most important risk factorwas ABO incompatability (43.2 %). Urinary tract infection (30.8%), and idiopathic causes (42.3 %) were found as the most important risk factors for prolonged jaundice.Pathological indirect hyperbilirubinemia is a major cause of morbidity and mortality in the newborn period. We think that newborns with jaundice should be diagnosis, treatment, and close follow-up in order to prevent development of bilirubin-induced neurologic dysfunction. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.
Evaluation of Antimicrobial Resistance in Staphylococcus Aureus Isolates by Years
(Hindawi Limited, 2016) Raǧbetli, C.; Parlak, M.; Bayram, Y.; Guducuoglu, H.; Ceylan, N.
Objective. Recently, community and hospital-acquired infections with Staphylococcus aureus have increased and raised antibiotic resistant isolates. In this study, we aimed to evaluate the antibiotic resistance profile of S. aureus isolates over several years in various clinical specimens from our hospital. Materials and Methods. S. aureus strains from 2009 to 2014 were isolated from various clinical samples at Yuzuncu Yil University, Dursun Odabas Medical Center, Microbiology Laboratory, and their antibiotic susceptibility test results were retrospectively investigated. The isolates were identified by conventional methods, and antibiotic susceptibility tests were performed by the Phoenix (Becton Dickinson, USA) automated system method according to Clinical and Laboratory Standards Institute (CLSI) standards. Results. A total of 1,116 S. aureus isolates were produced and methicillin-resistant S. aureus (MRSA) to 21% of all S. aureus isolates between 2009 and 2014. According to the results of susceptibility tests of all isolates of S. aureus, they have been identified as sensitive to vancomycin, daptomycin, linezolid, and levofloxacin. While the resistance rates to nitrofurantoin, quinupristin-dalfopristin, and trimethoprim-sulfamethoxazole were determined as 0.3%, 2.4%, and 6%, respectively, resistance rates to penicillin, erythromycin, rifampicin, gentamicin, and clindamycin were determined as 100%, 18%, 14%, 14%, and 11%, respectively. The highest percentage of methicillin resistance was determined as 30% in 2009, and the resistance was determined to have decreased in subsequent years (20%, 16%, 13%, 19%, and 21%) (p < 0.001). Conclusion. Currently, retrospective evaluations of causes of nosocomial infection should be done periodically. We think that any alteration of resistance over the years has to be identified, and all centers must determine their own resistance profiles, in order to guide empirical therapies. Reducing the rate of antibiotic resistance will contribute to reducing the cost of treatment. © 2016 Cennet Raǧbetli et al.
Hyperlipidemia in Infant Case of Acute Monoblastic Leukemia
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Ece, İ.; Dogan, M.; Akbayram, S.; Ceylan, N.; Demir, N.; Demirören, K.
Severe hyperlipidemia is a rare presentation usually associated with acute myeloid leukemia. 2-month-old girl complaining of discomfort. Her skin and conjunctivae were pale, abdominal distention and 5 cm hepatosplenomegaly were determined. Blood count revealed anemia (10 g/dL) and thrombocytopenia (41x109/L). Total leukocyte count was 24x109/L, and on blood smear, 58% blast and 42% lymphocytes were seen. Bone marrow aspirate revealed diffuse infiltration with blast cells consistent with acute monoblastic leukemia. Her plasma had a milky appearance. In the laboratory examination, triglyceride level was 1428 mg/dl, cholesterol level was 1291 mg/dl. This case report illustrate that the hematological malignancies may present with severe hypertriglyceridemia. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Rare Case That Can Be Diagnosed With Prenatal Ultrasound: Fryns Syndrome
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Çeliker, F.B.; Ceylan, N.; Turan, A.; Beyazal, M.
Fryns syndrome is a syndrome that is accompanied by multiple congenital anomalies, with extremely high mortality, showing autosomal recessive inheritance and often leaves severe mental retardation on those who survive. Abnormal facial appearance, distant faded nipples, small rib cage, distal extremity and nail hypoplasia, pulmonary hypoplasia and diaphragmatic hernia are among major criteria for the diagnosis. Later, cardiovascular, genitourinary, central nervous system and skeletal system anomalies have been identified. Here, we presented Fryns syndrome case which has been diagnosed by prenatal ultrasound, and of which the diagnosis has been confirmed by physical examination and ultrasound at the postnatal period. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Rare Cause of Metabolic Acidosis; Hypoplastic Left Heart Syndrome
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Demir, N.; Ece, İ.; Demirören, K.; Ceylan, N.; Peker, E.; Tuncer, O.
Metabolic acidosis is a common problem especially in newborns. Metabolic acidosis develops due to acid deposition rather than HCO3 loss in body fluids. It separates into two groups as anion gap normal and anion gap increased depending on anion gap level. Metabolic diseases, neonatal sepsis, congenital adrenal hyperplasia and congenital heart diseases should be thought with the observation of metabolic acidosis in a previously healthy infants. NaHCO3 infusion, renal replacement treatment and tamps like karbicarb, dichlora acetate, tromethamine are used for treatment of congenital heart diseases or lactic acidosis secondary to hypoxia. In this article we want to emphasize there are not only congenital metabolic illnesses under this non-response acidosis table but also there are congenital heart diseases which are in substantial rate. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Role of Circulating Nesfatin-1 in the Underweight Children With Poor Appetite
(verduci Publisher, 2015) Kaba, S.; Karaman, K.; Komuroglu, U.; Bala, K. A.; Demir, N.; Kocaman, S.; Ceylan, N.
OBJECTIVE: To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition. PATIENTS AND METHODS: We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age-and sex-matched controls were also included in the study. Fasting serum nesfatin-1 concentrations were measured by using Enzyme-Linked Immunosorbent Assay (ELISA) technique. RESULTS: Mean nesfatin-1 level was significantly higher in underweight children when compared to controls (p < 0.001). There was no correlation between serum nesfatin-1 levels and anthropometrics markers. CONCLUSIONS: Our results suggest that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children.
Rubella Seroprevalence in Adolescent Girls in the Eastern Region of Turkey
(2002) Çaksen, H.; Ceylan, A.; Ceylan, N.; Arslan, S.; Öner, A.F.; Kirimi, E.; Gölbasi, C.
Tooth Eruption and Symptomatology: Are the Symptoms Assumed To Be Related To the Tooth Eruption Really Associated With Teeth
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Erdoğan, F.; Eliaçık, B.K.; Paçal, Y.; Kartal, V.; Ceylan, N.; İpek, İ.
Despite little evidence, many various complaints might be associated with teething in children. Symptoms related with teething mostly result in delay diagnosis of underlying disease. In this study we explore the relationship between teething and symptoms commonly seen in pediatric clinics. Children less than 36 months of age, who came to Medipol University Faculty of Medicine, between October 2013 and May 2014 for routine well-child visit, were recruited in the study. At visit time 318 infants (60.5%) had one or more visible tooth eruption. Participants were divided in five subgroups according to their age. Parents of infants (mean age 11.5 months) completed questionnaires. The most commonly reported symptom was irritability in 12-18 months (74%), 24-30 months (57%) and 30-36 (44%) months’ periods, drooling in 6-12 months (87%), loss of appetite in 18-24 months (64%). Irritability was statistically significant in all groups except 18-24 month. (p=0.54). Febrile fever was only statistically significant in 6-12 and 12-18 months groups. Increase in biting was become statistically significant after 12 months. Although rates vary according to age group, many mild symptoms previously thought to be associated with teething were found temporally correlated with teething. Before parents/caregivers attribute these symptoms to tooth eruption other possible causes must be ruled out. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Two Novel Associations in a Case With Walker Warburg Syndrome; Enophthalmia, Interhemispheric Cyst and Cerebral Hematoma
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Kaba, S.; Doğan, M.; Bulut, M.D.; Bulan, K.; Demir, N.; Üstyol, L.; Ceylan, N.
There were severe brain malformations, hydrocephaly, myopathy and congenital cataract in a 5-month old girl presented with seizure. Walker Warburg syndrome is the most severe form of congenital muscular dystrophy accompanied by brain and eye anomalies. The findings in this case fulfilling diagnostic criteria of Walker Warburg syndrome other than type 2 lissencephaly suggest an intermediate form between Walker Warburg syndrome and muscle-eye-brain disease. In this manuscript, we intended to present this case presenting features (enophthalmia, interhemispheric cyst and cerebral hematoma) not reported previously in the spectrum of congenital muscular dystrophy-dystroglycanopathy with brain and eye anomalies. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.