Browsing by Author "Ceylan, Y."

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Regional Functions of the Left Ventricle in Patients With Coronary Slow Flow and the Effects of Nebivolol
(2009) Gunes, Y.; Tuncer, M.; Guntekin, U.; Ceylan, Y.; Sahin, M.; Simsek, H.
Background: Microvascular and endothelial dysfunction have been implicated for coronary slow flow (CSF). Nebivolol, besides its beta-receptor blocking activity, causes an endothelium-dependent vasodilatation through increased nitric oxide release. Methods: This study included 27 patients with CSF and 27 subjects with normal coronary arteries. Segmental functions of the left ventricle (LV) were assessed using myocardial tissue Doppler velocities before and 3 months after treatment with nebivolol 5 mg/day. Results: Compared with the control group, mitral deceleration time (DT) was significantly longer, and E/A ratio, systolic velocity of lateral mitral annulus (Sm) and regional myocardial peak systolic and early diastolic velocities (Vs, Vd) were significantly lower in patients with CSF. The reason for coronary angiography was typical angina in 21 (77.8%) and positive treadmill test in six (22.2%) CSF patients. There were significant correlations between presence of CSF in left anterior descending artery (LAD) with Sm (r =-0.404, p =0.002) and Vs in anterior (r =-0.531, p < 0.001 ) and lateral (r =-0.495, p < 0.001 ) segments and between presence of CSF in RCA and Vs in posterior segments (r =-0.501, p < 0.001). Treatment with nebivolol significantly decreased blood pressures (128.5±12.5/82.5±8.8 to 119.8± 12.6/76.4± 7.4 mmHg, p < 0.001), DT (252.3±53.6 to 222.0±41.0 ms, p < 0.001 ) and IVRT (115.7±19.9 to 103.3±17.0 ms, p <0.001), and increased exercise capacity (8.7±1.3 to 10.4±0.9 METs, p < 0.001), E/A ratio (0.87±0.26 to 1.08±0.23, p <0.001) and myocardial velocities (p < 0.001). All the patients were free of angina after treatment. Patients with CSF had impaired diastolic and regional LV functions. Conclusions: Nebivolol may therefore be useful in improving angina, exercise capacity and LV functions in patients with CSF. © 2009, SAGE Publications. All rights reserved.
Relationship Between Total Atrial Conduction Time and Epicardial Adipose Tissue in Patients With Subclinical Hypothyroidism
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Ceylan, Y.; Eker, E.
Subclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) levels with normal free thyroxine (fT4) levels. It is associated with increased cardiovascular risk, necessitating regular monitoring of cardiovascular parameters. This study investigated the relationship between total atrial conduction time (TACT) and epicardial adipose tissue (EAT) in patients diagnosed with SCH, aiming to identify potential cardiovascular risks. An observational cross-sectional study was conducted at Van Yüzüncü Yıl University from January 2024 to January 2025. Fifty-four patients with SCH (TSH levels 5.0-10 µIU/mL, normal fT4) were compared to fifty-four healthy controls. Echocardiographic measurements, including EAT thickness and TACT, were obtained. No significant differences were found between groups regarding age, gender, and various laboratory parameters. TSH levels were significantly higher in the patient group 7.39±1.29 µIU/mL compared to control s 2.33±0.93 µIU/mL, p=0.001; EAT 6.74±0.96 mm vs. 4.73±0.41 mm, p=0.001 and TACT 122±8.70 ms vs. 87.8±5.33 ms, p=0.001 were also significantly elevated in SCH patients. A strong positive correlation was observed between EAT and TACT (r=0.895, p=0.001) as w ell as between TSH and both EAT and TACT (r=0.701, p=0.001; r=0.822, p=0.001). SCH patients exhibit significantly increased EAT and TACT levels compared to healthy controls, indicating a heightened risk for adverse cardiovascular outcomes. The strong correlation between TSH, EAT, and TACT underscores the importance of monitoring TSH levels and suggests that proactive management of SCH may mitigate cardiovascular risks. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.