Browsing by Author "Cicek, Bunyamin"

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Experimental Study of In-Vitro Bioanalysis and In-Vivo Living Tissue Biocompatibility of Mg-Zn Alloys
(Springer Heidelberg, 2023) Comba, Bahat; Cicek, Bunyamin; Comba, Arzu; Sancak, Tunahan; Akveran, Gonul Arslan; Koc, Erkan; Afshar, Milad Torkamanian
In this study in-vitro bioanalysis and in-vivo living tissue biocompatibility were evaluated. Pure Mg and Mg + x Zn (x = 1 and 3 wt%) alloys have been used in the study. In vitro immersion and potentiodynamic corrosion were applied to these alloys in Hank's and artificial seawater solution. The materials were kept in living tissue (gluteus-superficial) for 7 weeks in-vivo (albino-rat). After 4 and 7 week, the control and experimental groups' urine parameters, blood mineral substance levels, and radiographic image controls were evaluated. It was observed that the bio-dissolution level decreased as the Zn-ratio increased. As a result, successful results were obtained in the biocompatible and biodegradable material class of Zn-doped Mg alloys used in the study. The dissolution amount of 1.03 mm/y (for Mg + 3Zn alloy) in Hank's solution was calculated. The % vitality was determined at the level of 117%.
Investigation of In-Vitro Biocompatibility and In-Vivo Biodegradability of Am Series Mg Alloys
(Taylor & Francis Ltd, 2022) Comba, Arzu; Cicek, Bunyamin; Comba, Bahat; Sancak, Tunahan; Akveran, Gonul Arslan; Sun, Yavuz; Afshar, Milad Torkamanian
In this study, in vitro/vivo biocompatibility experiments of Mg-Al-Mn alloy were carried out, and AM50 and AM60 alloys were used in the experiments. Immersion and potentiodynamic corrosion have been applied to these alloys in vitro. For biocompatibility, cytotoxicity test was performed. A total of 40 rats were used for the in-vivo experiment. AM series alloys were surgically placed in the femoral condyle as mini screws and monitored radiographically. AM alloys were removed together with the femur at the end of 7 weeks and further examined. After in-vivo application, the biodegradability level was successfully concluded with blood mineral analysis and urinalysis. In this study, the bioprocess of AM series Mg alloys with Al and Mn additions has been completed. As a result, the AM alloys used can be classified as biocompatible and biodegradable materials.