Browsing by Author "Cicek, Mutalip"

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Association of Demodicosis With Acne Rosacea
(Professional Medical Publications, 2010) Cengiz, Tas Z.; Yilmaz, Hasan; Akdeniz, Necmettin; Cicek, Mutalip; Ozkol, Halil; Calka, Oemer
Objectives: Demodex spp of humans are encountered frequently all over the world. The role of these parasites is controversial in the causation of skin diseases. This study was carried out to determine the prevalence and the association of Demodex spp with acne rosacea. Methodology: The study was conducted between the years of 2005-2008 in the output clinic of Dermatology and Parasitology Laboratory of Health Research and Training Hospital of Yuzuncu Yil University. One hundred two patients (patient group) composing of 59 females and 43 males with acne rosacea and randomly selected 50 healthy subjects (control group) were examined for Demodex spp. Twenty seven patients were under the age of 35, and 75 patients were aging 35 years old and over. Samples were plucked out from surface of nose and forehead of patients with acne rosacea and healthy subjects by standardized surface skin biopsy (SSSB) method in the Laboratory. The preparations prepared in Hoyer solution were examined under 4X and 10X objectives of light microscope. Results: The detected parasites were higher in the patient group with acne rosacea (67.65%) than the control group (6%), in females (76.27%) than males (55.81%) and in patients aging 35 years old and over (74.67%) than the patients under 35 years of age (48.15%). Significant relationships were detected between acne rosacea and demodicosis, sex and demodicosis, and age and demodicosis (p<0.001, p<0.05 and p<0.05, respectively). Conclusion: It was concluded that there is a relationship between the demodicosis and acne rosacea, and dermatologists should take into consideration the Demodex spp. in the etiology of acne rosacea.
Does Neutrophil / Lymphocyte Ratio Contribute To Diagnostics in Patients With Fascioliasis
(Carbone Editore, 2018) Cicek, Mutalip; Deveci, Ozcan; Cengiz, ZeynepTas; Bilden, Alican; Bilik, Ozge Alkan
Introduction: Fasciolia sp. is a trematode causes infection by settling in the liver bile ducts of domestic animal and human liver. Fascioliasis is a parasite disease that might have changes in liver parenchyma and in bile ducts. Many inflammatory reactions occur during the settlement of larvae and mature parasites into the liver. The neutrophil/lymphocyte ratio (NLR) has become a prominent marker of underlying inflammation. The objective of the present study is to investigate the relationship between the hematological parameters in patients with fascioliasis. Materials and methods: The diagnosis of fascioliasis was based on patient history, clinical and laboratory findings, radiological imaging (ultrasound), stool examination and IgG antibody titer determination by ELISA. Clinical and laboratory data were collected for 56 patients with fascioliasis, and diagnosed with serological and radiological imaging. 56 healthy volunteers were selected for the control group. Stool and blood samples were collected from patients with fascioliasis for serologic, biochemical, hematologic tests and ova examination. Total leukocyte, neutrophil, eosinophil and lymphocyte counts were recorded and NLR was calculated. ELISA antibody cut off titer value of patients with fascioliasis was 10> positive. Results: We compared neutrophil/lymphocyte ratio, eosinophil/lymphocyte ratio, the relation of eosinophilia and IgG antibody titers between two groups (patient and control groups). There was no statistically significant difference between patients and healthy controls neither based on age and gender nor NLR. According to these findings, NLR can not be considered as a diagnostic marker in fascioliasis. Conclusion: As a result, it was determined that NLR is not a crucial indicator of inflammation in parasitic fascioliasis. Extensive studies are need to be done to clarify the correlation between NLR and progression of other parasitic diseases.
Human Infection With Dicrocoelium Dendriticum in Turkey
(K Faisal Spec Hosp Res Centre, 2010) Cengiz, Zeynep Tas; Yilmaz, Hasan; Dulger, Ahmet Cumhur; Cicek, Mutalip
Human dicrocoeliosis is reported sporadically in various parts of the world. We report a case in a 21-year-old male, who had right upper abdominal pain, weight loss, and chronic relapsing watery diarrhea three to four times daily for four weeks. The patient had abdominal tenderness to palpation in the right upper quadrant. Alkaline phosphatase, alanine aminotransferase, and serum immunoglobulin E levels were slightly elevated; all other biochemical and hematological findings were in their normal ranges. The duodenal biopsy samples were normal and an abdominal ultrasonography showed no biliary or hepatic abnormality. Stool microscopy revealed numerous eggs of Dicrocoelium dendriticum. As pseudoparasitosis can result from eating raw, infected animal liver, the patient was given a liver-free diet for three days, to rule out that possibility. Subsequent stool examinations showed eggs in each of the samples indicating that the infection was genuine. The patient was treated with triclabendazole 10 mg/kg in a single dose. Four weeks later, no parasite eggs were detected in the microscopic examination of the stool samples. The patient got better gradually and the symptoms disappeared. Physicians should keep in mind parasitic diseases such as the rarely encountered dicrocoeliosis.
Investigation of Cryptosporidiosis by Enzyme-Linked Immunosorbent Assay and Microscopy in Children With Diarrhea
(Saudi Med J, 2008) Yilmaz, Hasan; Tas-Cengiz, Zeynep; Cicek, Mutalip
Objective: To investigate the frequency of cryptosporidiosis by enzyme-linked immunosorbent assay (ELISA) and microscopy and its relationship with diarrhea. Methods: The study was prospectively performed in the Parasitology Laboratory and Pediatric Outpatient Clinic of the Research Hospital, Yuzuncu Yil University, Van, Turkey between 2004 and 2006. Stool samples were obtained from a total of 2000 children with diarrhea, 870 females, and 1130 males aging 015 years as study group, and 100 children of the same age were randomly selected as a control group. The flotation method was firstly carried out for all stool samples in saturated zinc sulfate solution, then staining process by modified acid-fast staining. All samples were also tested for Cryptosporidium parvum antigen by ELISA. Native-Lugol and trichrome staining were used to identify other intestinal parasites. Results: The antigen was determined in 97 (4.9%) of 2000 children by ELISA, however, the oocysts were only seen in 39 children (1.95%) by microscopy. Cryptosporidium spp. were not detected in the control group either by ELISA or by microscopy. We found a significant (p<0.001) relationship between diarrhea and cryptosporidiosis. Other intestinal parasites were detected in 713 (35.7%) of 2000 diarrheic children. Conclusion: Cryptosporidium spp. antigen searching by ELISA in stool samples should be included for diagnosis of the disease in all hospitals.
Prevalence of Toxocariasis in Human and Dogs in Van Province
(Kafkas Univ, veteriner Fakultesi dergisi, 2012) Cicek, Mutalip; Yilmaz, Hasan
This investigation was performed to detect the seroprevalence of Toxocara canis in humans by ELISA and distribution of intestinal parasites in dogs in Van province. The study was carried out between 2005-2007 Septembers. Eight hundred patients with complaints such as abdominal pain, hypereosinophilia and urticaria who were inspected in various outpatients' clinics of the Research Hospital of Yuzuncu Yil University and 100 healthy individuals as control group were investigated. T. canis seropositivity by ELISA, eosinophil counts and total IgE levels were investigated in blood samples received from patients and control group individuals; stool samples of persons were also examined with native-Lugol, trichrome staining and formalin-ether sedimentation methods. Besides, the stool samples of 420 dogs were also taken for the investigation of intestinal parasites. The stools of the dogs were examined for T canis and other intestinal parasites macroscopically, by native-Lugol, modified acid-fast staining and flotation methods. It was detected toxocariasis seropositivity in 15.25% and intestinal parasites in 13.88% of human. It was determined the eosinophilia in 25% of patients and toxocariasis seropositive in 28.05% of these patients. It was detected urticaria in 32.78%, pruritus in 22.13% and abdominal pain in 9.83% of patients with toxocariasis. One or more intestinal parasites were founded in 63.10% of the dogs, and T. canis was encountered as 19.05%. Positive relationship was detected among toxocariasis and living in rural area (P<0.01), eosinophilia (P<0.001), ageing (P<0.001) and high level of IgE (P<0.001). It was concluded that, toxocariasis is frequently encountered in humans and animals in Van province, measures should be taken to prevent this disease and ELISA method should be take place between routine diagnostic tests for diagnosis of this disease in human.
The Problem of Cystic Echinococcosis in Van Province
(Kafkas Univ, veteriner Fakultesi dergisi, 2009) Yilmaz, Hasan; Cengiz, Zeynep Tas; Cicek, Mutalip
This study was carried out prospectively in Van Meat Company and Van Municipality Slaughterhouse, Eastern Anatolian Region of Turkey. In the study, liver, lungs, spleen, hearth and other internal organs of 552 cattle and 1613 sheep slaughtered were inspected for cystic echinococcosis (CE). The organs were examined carefully with hands and the organs and cysts were cut with knife for confirmation of diagnose. It has been detected that 486 cattle and 1150 sheep slaughtered were entered to Van province from the Eastern border of Turkey. and 66 cattle and 463 sheep were breed in Van. Z test was used to evaluate the relationship of the CE's prevalence between the animals entered to Van province from the Eastern border of Turkey and breed in Van. CE was found in 22.63% of 486 cattle and 67.57% of 1150 sheep entered to Van province from Eastern border of the Country. The infection was determined in 6.06% of 66 cattle and in 28.94% of 463 sheep breed in Van. CE was totally detected in 20.65% of 552 cattle and in 56.48% of 1613 sheep. A significant independent relationship was found between the animals entered from the Eastern border of Turkey and breed in Van for CE's prevalence (P < 0.001).