Browsing by Author "Cikman, O."

Now showing 1 - 5 of 5

Evaluation of the Transversus Abdominis Release Method in Large Ventral Hernias and Its Effect on Postoperative Abdominal Pressure
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Nusretoglu, R.; Cikman, O.
The aim of this study is to evaluate the effectiveness of the posterior separation technique performed by releasing the transversus abdominis in large ventral hernias (LVH) and its effect on postoperative intra-abdominal pressure (IAP). LVH patients who treated with transversus abdominis release (TAR) technique in our hospital between March 2021 and June 2022 were evaluated. The patients' age, sex, body mass index (BMI), presence of comorbidities, hernia size, IAP, postoperative complications, presence of recurrence were evaluated. IAP (day 1-3) values were compared statistically. In total, 35 patients were operated. 25.7% (9/35) of patients had previously known comorbid diseases. The cause of hernia was previous laparotomy in 21 patients (21/35; 60%), and primary ventral hernia in 14 patients (14/35; 40%). 14 patients (14/35; 40%) had a history of recurrence after hernia repair with on-lay technique. Postoperative day 1 IAP was measured as median 13.2 mmHg IQR:2.2, on day 2 median IAP was 9.5 mmHg IQR:3.6 and on day 3 median IAP was 8.6 mmHg IQR:3.5. IAP values decreased statistically significantly for three days (1st day-3rd day: p=0,001; 2nd day-3rd day: p=0,001; 1st day-3rd day: p=0,001). Wound infection was seen in one patient and hematoma was seen in one p atient (2/35; 11.4%). Total follow-up was median 12 months, IQR:9. No recurrence was observed in any patient. TAR technique provides good outcomes with no recurrence and low complication rates in LVH patients. This technique allows to safely closure of large defects without increasing intra-abdominal pressure. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Fissurectomy and Anocutaneous V-Y Flap in the Treatment of Chronic Anal Fissure: Clinical Experiences in Low Tone Cases
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Cikman, O.; Aslan, F.
Chronic anal fissure is a common condition that severely affects the quality of life. For patients who do not respond to medical and conservative treatments, alternative treatment methods such as fissurectomy and anocutaneous V-Y advancement flap application stand out. This study aims to evaluate the outcomes of 53 patients who underwent fissurectomy and anocutaneous V-Y advancement flap treatment as a sphincter-preserving method. This study includes 53 female cases conducted at the Department of General Surgery, Van University Faculty of Medicine, between 2022 and 2024. Parameters such as demographic data (age, gender), number and type of deliveries, clinical features of chronic anal fissures, complications related to wound healing in the postoperative period, recurrence rates, and incontinence were examined. The anocutaneous V-Y advancement flap was successfully applied to all 53 patients, and all patients recovered within an average of 45 days. Only six patients developed wound dehiscence, which was completely healed by the sixth month. At the end of the 12-month follow-up, no recurrence or incontinence was observed in any case. This study demonstrates that the anocutaneous V-Y advancement flap is an effective and safe method for treating chronic anal fissures in patients with low anal tone who have undergone multiple vaginal deliveries. Due to its high success rate, low complication risk, and ability to preserve anal continence, this method should be considered an important alternative in chronic anal fissure treatment. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Investigation of Free Radical Scavenging Enzyme Activities and Lipid Peroxidation in Liver Tissue of Zinc Deficient Rats
(Chemical Publishing Co., 2008) Kaya, H.; Taysi, S.; Kaya, A.; Boyuk, A.; Dursun, H.; Islamoglu, Y.; Cikman, O.
The aim of this study was to evaluate the lipid peroxidation and free radical scavenging enzyme activities in liver tissue of zinc (Zn)-deficient rats and investigate relationship among these parameters in either group. 16 Male rats with a weight of 35-40 g were used for the experiment. The rats were divided into control (n = 8) and Zn-deficient groups. After 4 weeks of feeding, the rats were killed by cervical dislocation and liver tissues were removed. Biochemical measurements in liver tissue were carried out using a spectrophotometer. Catalase, glutathione peroxidase, glutathione reductase, glutathione S transferase activities, total (enzymatic plus non-enzymatic) superoxide scavenger activity, superoxide dismutase, non-enzymatic superoxide scavenger activity, superoxide dismutase activities and Zn level in the Zn-deficient group were significantly lower than those of the control group, whereas malondialdehyde level was significantly higher than those of the control group. Slightly increased non-enzymatic superoxide scavenger activity was not significantly different from the controls. The results obtained in this study demonstrate that Zn-deficiency causes a decrease in antioxidant defence system and an increase in oxidative stress in liver tissue in rats.
L-Carnitine Has a Protective Effect on the Colonic Mucosa During Abdominopelvic Radiotherapy in Rats
(Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia, 2016) Tas, S.; Ozkan, O.F.; Cikman, O.; Kiraz, A.; Akgun, Y.; Karaayvaz, M.
PURPOSE: To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation. METHODS: Thirty-two rats were randomly assigned to four experimental groups: intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage. RESULTS: Average damage scores did not differ significantly between groups 1 and 2 (0.13 ± 0.35 and 0.25 ± 0.46, respectively); the group 3 score was highest (10.25 ± 0.71), and the group 4 score (3.63 ± 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p < 0.01). CONCLUSIONS: L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels. © 2016, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.
The Radio-Protective Effects of Propolis and Nigella Sativa Oil on Oxidative/Nitrosative Stress in Liver Tissue of Rats Exposed To Total Head Irradiation
(Wiley-blackwell, 2016) Taysi, S.; Cikman, O.; Gulsen, M. T.; Demir, E.; Ulusal, H.