Browsing by Author "Cikman, O."
Now showing 1 - 3 of 3
- Results Per Page
- Sort Options
Article Investigation of Free Radical Scavenging Enzyme Activities and Lipid Peroxidation in Liver Tissue of Zinc Deficient Rats(Chemical Publishing Co., 2008) Kaya, H.; Taysi, S.; Kaya, A.; Boyuk, A.; Dursun, H.; Islamoglu, Y.; Cikman, O.The aim of this study was to evaluate the lipid peroxidation and free radical scavenging enzyme activities in liver tissue of zinc (Zn)-deficient rats and investigate relationship among these parameters in either group. 16 Male rats with a weight of 35-40 g were used for the experiment. The rats were divided into control (n = 8) and Zn-deficient groups. After 4 weeks of feeding, the rats were killed by cervical dislocation and liver tissues were removed. Biochemical measurements in liver tissue were carried out using a spectrophotometer. Catalase, glutathione peroxidase, glutathione reductase, glutathione S transferase activities, total (enzymatic plus non-enzymatic) superoxide scavenger activity, superoxide dismutase, non-enzymatic superoxide scavenger activity, superoxide dismutase activities and Zn level in the Zn-deficient group were significantly lower than those of the control group, whereas malondialdehyde level was significantly higher than those of the control group. Slightly increased non-enzymatic superoxide scavenger activity was not significantly different from the controls. The results obtained in this study demonstrate that Zn-deficiency causes a decrease in antioxidant defence system and an increase in oxidative stress in liver tissue in rats.Article L-Carnitine Has a Protective Effect on the Colonic Mucosa During Abdominopelvic Radiotherapy in Rats(Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia, 2016) Tas, S.; Ozkan, O.F.; Cikman, O.; Kiraz, A.; Akgun, Y.; Karaayvaz, M.PURPOSE: To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation. METHODS: Thirty-two rats were randomly assigned to four experimental groups: intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage. RESULTS: Average damage scores did not differ significantly between groups 1 and 2 (0.13 ± 0.35 and 0.25 ± 0.46, respectively); the group 3 score was highest (10.25 ± 0.71), and the group 4 score (3.63 ± 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p < 0.01). CONCLUSIONS: L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels. © 2016, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.Conference Object The Radio-Protective Effects of Propolis and Nigella Sativa Oil on Oxidative/Nitrosative Stress in Liver Tissue of Rats Exposed To Total Head Irradiation(Wiley-blackwell, 2016) Taysi, S.; Cikman, O.; Gulsen, M. T.; Demir, E.; Ulusal, H.
