Browsing by Author "Cim, N."

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Is There Any Association Between Fetal Nervous System Anomalies and Heavy Metal-Trace Element Levels in Amniotic Fluid
(I R O G Canada, inc, 2018) Cim, N.; Tolunay, H. E.; Boza, B.; Bilici, M.; Karaman, E.; Cetin, O.; Sahin, H. G.
Aim: In this study the authors aimed to evaluate whether there are any causal relationship between heavy metals-trace elements and fetal malformations of central nervous system (CNS). Materials and Methods: The study group consisted of pregnancies with fetal congenital nervous system anomaly (anencephaly, acrania, neural tube defects, etc.) in 16-22 weeks (n=36). Pregnancies with the same weeks of pregnancy who underwent amniocentesis due to high risk in triple test with the result of normal karyotype constituted the control group (n=30). In the both groups the authors analyzed the heavy metals and trace elements in amniotic fluid. Metals and elements were measured by using atomic absorption spectrophotometer technique with a UNICAM-929 spectrophotometer. Results: When compared, the groups were similar in terms of age, parity, BMI, and gestational week (p > 0.05). In fetal congenital anomaly group the authors detected low levels of copper (Cu) and zinc (Zn) rather than control groups (p < 0.05). In fetal congenital anomaly group they detected high levels of lead (Pb) and cadmium (Cd) rather than control groups (p < 0.05). Iron (Fe), manganese (Mn), cobalt (Co), nickel (Ni), and Cd levels were similar and there was no significantly difference between the groups (p > 0.05). Conclusion: This study can contribute benefits to the literature in terms of clarifying the pathogenesis of fetal congenital nervous system anomalies.
Management of Gastric Cancer With Liver Metastasis in a Pregnant Woman
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Cim, N.; Karaman, E.; Toktas, O.; Gunes, G.; Elci, E.; Andıc, E.; Yildizhan, R.
The complaints and symptoms of gastric cancer are non-specific and many of these symptoms are frequently masked by factors related to normal pregnancy. A 38 year-old woman with G10P8A1 and at 31 weeks of pregnancy was admitted to a maternity outpatients’ clinic complaining of nausea, vomiting and constipation during the previous 4 days. On palpation a solid lesion of 1.5 cm was palpable in the subxiphoid region. A solid nodule with largest diameter of 5 cm was observed on the liver and suspected to indicate metastasis. Under endoscopic examination, ulcerovegetan, fragile and malignant mass that surrounded and narrowed the gastric antrum and extended to an angular notch was seen. The biopsy that was taken from lesion was revealed to be the result of a malignant epithelial tumor of poorly differentiated adenocarcinoma. During the explorative laparotomy, a tumoral mass with multiple peripheral lymphadenopathies was observed in the posterior gastric antrum, pancreas and colon median entry-invasive artery. Multiple metastases were present in the omentum and liver with a large amount of acid in the abdomen. The patient was considered inoperable due to the gastric cancer being in a terminal stage and adjuvant chemotherapy was planned. Early diagnosis and treatment is important for the prognosis of gastric cancer. The complaints and symptoms of gastric cancer are non-specific and many of these symptoms are similar to those seen during a normal pregnancy. If the same symptoms recur during pregnancy or there is a failure to respond to therapy, the gastrointestinal system should be evaluated endoscopically. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Maternal and Fetal Outcomes in Caesarean Sections Repeated Fourth and Fifth Times
(Univ West indies Faculty Medical Sciences, 2021) Karaman, E.; Cim, N.; Cetin, O.; Oruc, H.; Gunes, G.; Yildizhan, R.
Objective: To evaluate the maternal and fetal outcomes associated with caesarean sections (CS) repeated fourth and fifth times. Methods: We performed a retrospective study of 110 patients undergoing CS repeated fourth and fifth times between May 2014 and May 2015. The patients were divided into two groups: group 1 had CS repeated four times (n = 90) and group 2 had CS repeated five times (n = 20), and the maternal and fetal outcomes of the groups were retrospectively evaluated. Results: There were no statistically significant differences between fourth and fifth CS groups with regard to the maternal age, gravida, body mass index, gestational age at birth, birth-weight, and Apgar scores at 5 minutes (p > 0.05). We found no significant differences between the fourth and fifth CS groups in terms of injury to peripheral organs, intra-abdominal adhesions, caesarean hysterectomy, uterine dehiscence or rupture, time during operation, length of hospital stay, and need for blood transfusions (p > 0.05). Compared with the elective cases, perioperative complications and length of hospital stay were significantly higher in the urgent group (p = 0.034 and p = 0.005). Conclusion: Women with CS repeated four or five times have increased risks for perioperative complications. Placenta previa with or without accreta and intra-abdominal adhesions seem to be the major causes of increased morbidity.
Maternal Serum Ischemia Modified Albumin Level Does Not Change in the Presence of Intrauterine Growth Restriction
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Çetin, O.; Karaman, E.; Tolunay, H.E.; Boza, B.; Cim, N.; Alisik, M.; Şahin, H.G.
Maternal vascular hypoperfusion is the most common cause of fetal growth restrict ion. Maternal oxidative status features are identifiable on placental pathology, and antepartum diagnostic methods are rapidly evolving. The current study was constructed to determine the maternal oxidative status by measuring serum ischemia modified album in (IMA) levels in pregnancies complicated with idiopathic intrauterine growth restriction (IUGR). The current study was designed as a descriptive and cohort trial. A total of 87 pregnant women; 45 healthy controls and 42 pregnancies complicated with idiopathic IUGR were included to the study population. Maternal serum IMA concentration was measured prior to the administration of any medication. The perinatal outcomes of patie nts were also recorded. Maternal serum IMA concentration in pregnancies complicated by idiopathic IUGR was higher than in healthy controls. There was no significant difference between the groups (0.54±0.04 versus 0.55±0.06 ABSU, p: 0.314). IUGR is a significant pregnancy complication. Elevated oxidative stress which leads to an ischemic microenvironment is associated with IUGR. Maternal serum IMA which is a possible marker for oxidative stress is not increase in pregnancies complicated with idiopathic IUGR. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Primary Abdominal Ectopic Pregnancy: a Case Report
(2009) Yildizhan, R.; Kolusari, A.; Adali, F.; Adali, E.; Kurdoglu, M.; Ozgokce, C.; Cim, N.
Introduction: We present a case of a 13-week abdominal pregnancy evaluated with ultrasound and magnetic resonance imaging. Case presentation: A 34-year-old woman, (gravida 2, para 1) suffering from lower abdominal pain and slight vaginal bleeding was transferred to our hospital. A transabdominal ultrasound and magnetic resonance imaging were performed. The diagnosis of primary abdominal pregnancy was confirmed according to Studdiford's criteria. A laparatomy was carried out. The placenta was attached to the mesentery of sigmoid colon and to the left abdominal sidewall. The placenta was dissected away completely and safely. No postoperative complications were observed. Conclusion: Ultrasound examination is the usual diagnostic procedure of choice. In addition magnetic resonance imaging can be useful to show the localization of the placenta preoperatively. © 2009 Yildizhan et al.; licensee Cases Network Ltd.
Two Markers in Predicting the Cardiovascular Events in Patients With Polycystic Ovary Syndrome: Increased P-Wave and Qt Dispersion
(verduci Publisher, 2015) Akdag, S.; Cim, N.; Yildizhan, R.; Akyol, A.; Ozturk, F.; Babat, N.
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a prevalent disease with many potential long-term cardiovascular risks. P-wave dispersion (Pdis) and QT dispersion (QTdis) have been shown to be noninvasive electrocardiographic predictors for development of cardiac arrhythmias. In this study we aimed to search Pdis and QTdis parameters in patients with PCOS. PATIENTS AND METHODS: The study included 82 patients with PCOS and 74 age-and sex-matched healthy controls. Baseline 12-lead electrocardiographic and transthoracic echocardiographic measurements were evaluated. P-wave maximum duration (Pmax), P-wave minimum duration (Pmin), Pdis, QT interval, heart rate-corrected QT dispersion and QTdis were calculated by two cardiologists. RESULTS: Patients wirh PCOS had significantly higher QT dispersion (49.5 +/- 14.1 vs. 37.9 +/- 12.6 ms, p < 0.001), and P wave dispersion (54.2 +/- 11.4 vs. 45.9 +/- 10.1 ms, p < 0.001) than the controls. Serum testosterone and estradiol levels was correlated with the Pdis (r = 0.677, p < 0.001 and r = 0.415, p < 0.001 respectively) and QTdis (r = 0.326, p < 0.001 and r = 0.321, p < 0.001 respectively). CONCLUSIONS: Pdis and QTdis are simple and useful electrocardiographic markers which may be used in the prediction of the risk of adverse cardiovascular events in PCOS patients.