Browsing by Author "Cinar, Ali"

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Advanced Oxidation Protein Products (Aopp) Levels and Kidney Function in Fluorotic Sheep
(int Soc Fluoride Research, 2016) Mert, Handan; Comba, Bahat; Mert, Nihat; Cinar, Ali; Apaydin, Betul
The ingestion of excessive amounts of the fluoride ion (F) may cause chronic fluorosis with abnormalities in many organs and systems including, in addition to dental and skeletal fluorosis, impaired renal function. The aim of the present study was to investigate renal function and the levels of advanced oxidation protein products (AOPP) as oxidative stress markers in chronically fluorotic sheep with kidney disease. Fifteen healthy and 30 fluorotic sheep were studied. The plasma F levels were determined with a F-selective electrode. The plasma AOPP and the serum total protein levels were measured spectrophotometrically. The serum BUN, creatinine, potassium, sodium, and chloride levels were determined by autoanalyzer. Compared to the control group, significant increases were present in the fluorotic sheep in the levels of F (p=0.001), AOPP (p=0.001), BUN (p=0.001), creatinine (p= 0.05), and total protein (p= 0.05). A significant decrease was present in the fluorotic sheep in the level of potassium (p=0.01) while no significant changes were present in the sodium and chloride concentrations. The levels of AOPP in chronically fluorotic sheep, reported here for the first time in veterinary science, and the biochemical abnormalities can be considered in the evaluation of the effects of chronic fluorosis on kidney function.
Detection of Se, Vit. E, Vit. A, Mda, 8-Ohdg, and Coq10 Levels and Histopathological Changes in Heart Tissue in Sheep With White Muscle Disease
(Humana Press inc, 2019) Yildirim, Serkan; Ozkan, Cumali; Huyut, Zubeyir; Cinar, Ali
This study was carried out to determine vit. E, Se, vit. A, malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), and ubiquinone-10 (CoQ10) levels and histopathological changes in sheep with white muscle disease (WMD). A total of 30 sheep were used; 20 sheep with WMD were brought to our clinic for diagnosis and treatment at various times, and 10 healthy sheep were in the control group. The Se, vit. E, vit. A, MDA, 8-OHdG, and CoQ10 values of the healthy and WMD sheep were as follows: 0.917 +/- 0.037, 0.790 +/- 0.067; 1.190 +/- 0.011, 1.090 +/- 0.021; 5.400 +/- 0.275, 5.200 +/- 0.173; 1.602 +/- 0.264, 2.636 +/- 0.576; 0.656 +/- 0.197, 1.485 +/- 0.271; and 0.280 +/- 0.044, 1.753 +/- 0.551 respectively (p<0.05). According to histopathological and immunohistochemical findings in the WMD group, hyaline degeneration, Zenker's necrosis, and dystrophic calcification were observed in the muscle fibers. Immunohistochemically, 8-OHdG staining of the heart tissue determined a severe 8-OHdG expression in the WMD group. The findings of this study suggest that MDA, 8-OHdG, and CoQ10 values could be used as diagnostic and prognostic biomarkers in sheep affected with WMD.
Effects of Green Tea on Electrocardiography of Guinea Pigs Exposed To Electromagnetic Field Emitted by Mobile Phones
(Kafkas Univ, veteriner Fakultesi dergisi, 2009) Kilicalp, Dide; Deger, Yeter; Cinar, Ali
This study was carried out to determine the effects of green tea on Electrocardiography (EKG) of Guinea pigs exposed to a 900 MHz electromagnetic field emitted by mobile phones. Because green tea has a beneficial effect on endothelial function, tea consumption is associated with decreased cardiovascular risk. Twenty-eight healthy guinea pigs weighing 600-800 g were used. After one week adaptation period, animals were randomly divided into four groups. Four experimental groups labeled as controls (Group A), irradiated (Group B), irradiated receiving green tea extract (Group C) and green tea only (Group D) were formed with seven randomly chosen animals. Group A and D were housed in a separate room without exposing EMF of mobile phones. Irradiation was accomplished by exposing the animals in Group B and C to a 900 MHz electromagnetic field from a 217-Hz pulse rate, 2-W maximum peak power mobile phone placed in the cage were the animals were kept. ECG of guinea-pigs in four groups was recorded by a direct writing electrocardiograph at the end of the 30-day experimental period during exposure to mobile phone. Sinus bradycardia (lower heart beat) and prolongation of the P-R interval was observed in Group B and C after exposure to electromagnetic field (P<0.05). Whereas the heart rate in the green tea extract supplemented group was close to the control group's level, it was found to have been the lowest in the only irradiated (Group B). We found measurable effects in the heart rate and P-R interval parameters in the EM-exposed guinea pigs. It was found that EMF exposure for 30 days have some effects on ECG findings of guinea-pigs. The results suggest that exposure of guinea pigs to EM fields can cause disturbances in autonomic cardiac regulation.
Effects of Vitamin C on Anae Positivity and Blood Cells in Acth Induced Stress in Chicken
(indian veterinary Journal, 2007) Donmez, Hasan Hueseyin; Yoruk, Mecit; Cinar, Ali; Donmez, Nurcan
Animals treated with ACTH show evidence of stress and lymphatic involution (Everaus et al., 1997). Profiles of circulating leucocytes were also affected (Stevenson and Taylor, 1988). Although many researchers have investigated the effects of stress and vitamin C on some blood parameters the effects of Vitamin C on alpha naphthyl acetate esterase (ANAE) have not been adequately investigated yet. Therefore, it would be useful to establish the effects of vitamin C on ANAE activity and some blood parameters in chicken stressed by ACTH.