Browsing by Author "Cinar, Vedat"

Now showing 1 - 4 of 4

The Acute Effects of Simulated Hypoxic Training at Different Altitudes on Oxidative Stress and Muscle Damage in Elite Long-Distance Runners
(Peerj inc, 2025) Sarikaya, Muecahit; Oge, Beyza; Embiyaoglu, Nuri Mert; Selcuk, Muzaffer; Cinar, Vedat; Oner, Salih; Batrakoulis, Alexios
Background Understanding the impact of altitude on muscle damage and oxidative stress is essential for optimizing training and recovery strategies for athletes exposed to high-altitude conditions. Therefore, this study aimed to investigate the effects of acute exercise at different altitudes on oxidative stress and muscle damage. Methods A total of twelve elite long-distance runners (mean age: 20.3 +/- 1.5 years) from different branches participated in the study. The exercise protocol was the Bruce submaximal treadmill exercise test, which was conducted under three simulated hypoxic conditions (at 1,700 m, 2,450 m, and 3,200 m) and one normoxic condition (sea level). All measurements took place at the same time of the day. After the exercise protocol, 5 ml venous blood samples were taken from the participants, while heart rate and oxygen saturation were monitored at the 3rd, 6th, 9th, and 12th minutes during the exercise. Results Significant altitude-dependent variations were observed in oxidative stress markers, with total oxidant status (TOS) (p = 0.017) and malondialdehyde (MDA) (p < 0.001) levels increasing at higher altitudes, while total antioxidant status (TAS) (p < 0.001) exhibited an elevation and oxidative stress index (OSI) (p < 0.001) demonstrated a decline as altitude increased. However, no significant difference was found in creatine kinase (CK, p = 0.059) levels. Additionally, there were significant differences in the oxygen saturation measurement taken at the 3rd (p < 0.001), 6th (p < 0.001), 9th (p < 0.001), and 12th (p < 0.001), minutes following the exercise session. There was no difference in the pulse measurement taken at the 3rd and 12th minutes, but a difference was observed at the 6th and 9th minutes post-exercise (p < 0.01). Conclusions In conclusion, the study determined that endurance exercises performed under simulated normobaric hypoxia at different altitudes increased TAS and reduced OSI in elite long-distance runners. The increase in TAS and the reduction in OSI were more pronounced at higher altitudes, particularly at 2,450 m and 3,200 m, compared to sea level. These findings highlight the need for altitude-specific training and recovery strategies to minimize oxidative stress and muscle damage in athletes.
Determination of the Role of Aerobic and Anaerobic Training at Different Altitude on Hypoxia-Induced Factor 1, Hemoglobin, Iron, Erythropoietin, Hepcidin, and Nitric Oxide
(Oxford University Press, 2025) Onturk, Ugur; Cinar, Vedat; Sarikaya, Mucahit; Alp, Hamit Hakan; Akbulut, Taner; Chaverri, Diego; Migliaccio, Gian Mario
Introduction or background Altitude training is a well-established strategy for improving athletic performance, particularly in endurance sports. Hypoxic exposure induces physiological adaptations through oxygen sensing and erythropoietic mechanisms. However, the comparative effects of aerobic and anaerobic training on hematological and biochemical markers under different altitude conditions have not yet been adequately investigated.Sources of data This prospective cohort study included 24 trained male athletes (aged 19-23) who were randomly assigned to aerobic or anaerobic training groups (n = 12 per group). Training was conducted at simulated altitudes of 0 m, 1700 m, 2450 m, and 3200 m for 8 weeks. Biomarkers such as hypoxia-induced factor 1-alpha (HIF-1 alpha), hemoglobin, erythropoietin (EPO), iron, hepcidin, and nitric oxide (NO) were measured using ELISA and standard biochemical methods.Areas of agreement Consistent with previous literature, both aerobic and anaerobic training resulted in altitude-induced increases in hemoglobin levels. Aerobic training was associated with earlier activation of hypoxia-related markers such as HIF-1 alpha and NO, supporting the role of moderate altitude exposure in stimulating adaptive molecular responses.Areas of controversy While EPO is generally expected to increase with altitude exposure, this study found a decrease in EPO levels across altitudes in the aerobic group, while a significant increase was observed only at 3200 m in the anaerobic group. Interpretation of hepcidin dynamics also differs between training modalities, highlighting the complexity of iron regulation under hypoxic stress.Growing points This study highlights the different timing and magnitude of biomarker responses to aerobic and anaerobic training at various altitudes. It suggests that aerobic exercise triggers earlier molecular responses, while anaerobic training elicits delayed or blunted adaptations.Areas timely for developing research Further research is needed to optimize altitude training protocols tailored to specific exercise modalities and targeted physiological adaptations. Future studies could examine gender differences, longer training durations, and additional markers of oxidative stress and inflammation to expand on these findings.
The Effect of 6-Week Zinc Supplement and Weight Training on the Blood Lipids of the Sedentaries and Athletes
(C M B Assoc, 2018) Cinar, Vedat; Akbulut, Taner; Kilic, Yakup; Ozdal, Mustafa; Sarikaya, Mucahit
In this study, we aimed to investigate the effect of 6 weeks of zinc supplementation and weight training on blood lipids of sedentary and athletes. Research group consists of total 40 males; 20 athletes who do regularly physical exercises and 20 sedentary volunteers. The volunteers were divided into four groups. These groups were constituted in that way: the first group is a natural sedentary group which called control group as well (S); the second group is another sedentary group which is supplied with only zinc (Z+S); the third group is training group which composing of athletes and is supplied with zinc (Z+T); the fourth group is the natural training group or athletes (T). From the beginning of the study to the end of 6-weeks of training, the participants gave blood samples before and after every application order to measure the total cholesterol, LDL cholesterol and HDL cholesterol and the levels of Triglyceride. This study identifies that the values of the total cholesterol, LDL cholesterol and Triglyceride of the groups which were supplied with zinc supplement decreased, whereas the levels of HDL cholesterol increased in these groups. Consequently, this work demonstrates that the 6-weeks zinc supplement and training can make a significant contribution to the performance by changing positively the levels of blood lipid.
Strength Development, Muscle and Tissue Damage in Different Training Models
(Sciencedomain int, 2021) Akbulut, Taner; Cinar, Vedat; Oner, Salih; Erdogan, Ramazan
Purpose: The aim of this study was to determine the effects of during six weeks core and weight lifting trainings on strength development, muscle and tissue damage which may occur. Method: The research group consisted of sixteen volunteers who participated in the same age group. Participants were divided into two groups, core training group (n: 8) and weight lifting training group (n: 8). Participants continued to the program for the group to which the belonged lasted for three days a week for six weeks. Participant's performance measures (Back and leg strength, hand grip strength, vertical jump) were taken and blood samples were taken twice at rest before and at the end of the training sessions. AST, ALT, LDH, CK and CK-MB levels were determined in the blood samples taken. SPSS 22 package program was used in the analysis of the obtained data. Paired samples t test was used for intra-group comparisons. Results: When intra-group analyses are made; there were significant differences in the leg strength, vertical jump, CK and CK-MB values of the weight lifting training group, it was determined that only differences in back and leg strength values occurred in the core training group(p<0,05). Conclusion: As a result, both core and weight lifting training have led to some improvement in strength parameters. It can be said that especially weight lifting training also causes muscle damage as well as strength development.