Browsing by Author "Citoglu, Gulcin Saltan"

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Analgesic and Hepatotoxic Effects of Ononis Spinosa
(Wiley, 2006) Yilmaz, Betul Sever; Ozbek, Hanefi; Citoglu, Gulcin Saltan; Ugras, Serdar; Bayram, Irfan; Erdogan, Ender
The present study investigated the analgesic and hepatoprotective activities of a water extract of Ononis spinosa L. (OS) in mice. Analgesic activity was based on the pain thresholds measured with the tail-flick test before administration at 30, 90 and 150 min. The results were analysed with one-way variance analysis. The extract of Ononis spinosa showed analgesic activity equivalent to aspirin at 30 and 90 min and even higher than aspirin with the 50 mg/kg dose. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to aspirin at all time points. The hepatoprotective influence of OS on carbon tetrachloride (CCl4)-induced acute liver toxicity was also studied. The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCI4 treated animals (p > 0.05). Thus, the results reveal that the extract of OS had no hepatoprotective effect on CCI4-induced acute liver toxicity. Copyright (c) 2006 John Wiley & Sons, Ltd.
Hepatoprotective and Tnf-Α Inhibitory Activity of Zosima Absinthifolia Extracts and Coumarins
(Elsevier, 2011) Bahadir, Ozlem; Citoglu, Gulcin Saltan; Ozbek, Hanefi; Dall'Acqua, Stefano; Hosek, Jan; Smejkal, Karel
Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl4-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (c) 2011 Elsevier B.V. All rights reserved.
Prospective Neurobiological Effects of the Aerial and Root Extracts and Some Pure Compounds of Randomly Selected Scorzonera Species
(Taylor & Francis Ltd, 2014) Senol, F. Sezer; Acikara, Ozlem Bahadir; Citoglu, Gulcin Saltan; Orhan, Ilkay Erdogan; Acqua, Stefano Dall'; Ozgokce, Fevzi
Context: Scorzonera L. species (Asteraceae) are edible and as medicinal plants are used for various purposed in folk medicine. Objective: The methanol extracts of the aerial parts and roots from 27 Scorzonera taxa were investigated for their possible neurobiological effects. Materials and methods: Inhibitory potential of the Scorzonera species was tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYRO) at 100 mu gmL(-1) using ELISA microtiter assay. Antioxidant activity of the extracts was tested with radical scavenging activity, metal-chelation capacity, ferric-(FRAP), and phosphomolibdenum-reducing antioxidant power (PRAP) assays. Chlorogenic acid, hyperoside, rutin, and scorzotomentosin-4-O-beta-glucoside were also screened in the same manner. Total phenol and flavonoid quantification in the extracts were determined spectrophotometrically. Results: The aerial parts of Scorzonera pisidica (40.25 +/- 0.74%) and chlorogenic acid (46.97 +/- 0.82%) displayed the highest TYRO inhibition, while the remaining samples showed only trivial inhibition against cholinesterases (2.08 +/- 1.35% -25.32 +/- 1.37%). The same extract of S. pisidica was revealed to be the most potent in scavenging of all three radicals and FRAP assay. Discussion and conclusion: Out of 27 taxa, S. pisidica, in particular, may deserve further investigation for its neuroprotective potential.