Browsing by Author "Cobanoglu, U."

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Chest Trauma: Analysis of 126 Cases
(2000) Yalçinkaya, I.; Sayir, F.; Kurnaz, M.; Cobanoglu, U.
To evaluate our experience in chest trauma we review the records of the patients admitted for chest trauma to our service between December 1994 and April 2000. There were 126 patients (113 males, 89.7%), with an age range of 7 to 96 years (mean 35.3). The most frequent cause of chest injury were traffic accidents 48 cases (38%) and 73 cases (57.9%) were victims of blunt trauma. In 36 cases there was a politrauma. Hemo and/or pneumothorax represented the most common thoracic injury (85.7%). Rib fractures were present in 47 cases (36.2% with more than 3 rib fractures). Four patients sustained flail chest and 5 defect of thoracic wall. Six patients were pulmonary contusion and 8 intraparenchymal hematoma. Pleural drainage was performed in 106 cases (8 cases bilateral) and thoracotomy was indicated in 11 (6 cases emergency). Mortality was 6.9% (n:8), of which 4 belonged to politrauma group. Mortality is directly related with politrauma. In the patients of the chest trauma, aggressive diagnostic and therapeutic approaches in association with intensive care follow-up remains one of the most important points to decrease mortality and morbidity rate.
Clinical Results of Four Hundred and Twenty-Four Cases With Chest Trauma
(2003) Er, M.; Işik, A.F.; Kurnaz, M.; Cobanoglu, U.; Sagay, S.; Yalçinkaya, I.
BACKGROUND: In this retrospective study, we aimed to emphasize that thoracentesis is a fast and safe method to evaluate indication for thoracotomy in patients with thoracic trauma who have preshock or shock findings, without losing time by other examinations such as X - ray studies. METHODS: File records of 424 patients who were admitted to Thoracic Surgery Deparments of Adiyaman State Hospital and Medical School of Yuzuncu Yil University between December 1994 and March 2002, were investigated. RESULTS: There were 371(87,5%) male and 53 (12,5%) female patients, aged 5 to 89 (mean, 38,35). Most of the patients (n:382, 90%) were recovered by tube drainage and conservative management. There were 30 (7.1%) cases who underwent thoracotomy or median sternotomy. Nine patients underwent thoracotomy after being diagnosed by only thoracentesis without X - ray and 8 (89,9%) of them survived. The overall mortality was 2,8% (12 cases). CONCLUSION: Diagnostic thoracentesis has to be one of the indications for emergency thoracotomy after prompt systemic physical examination in the approach to thoracic trauma patient.
Management and Treatment of Foreign Bodies Ingestion in Childhood
(2011) Melek, M.; Cobanoglu, U.; Bilici, S.; Beger, B.; Kizilyidiz, B.S.; Melek, Y.
Ingestion of foreign bodies (FBs) is a significant problem that causes morbidity and mortality in childhood. The aim of this retrospective study was to report our experience of foreign body ingestion in pediatric patients. The medical records of 165 patients who were hospitalized for foreign body (FB) ingestion in pediatric and chest surgery departments between 2005 and January 2010 were evaluated retrospectively. X-ray films and abdominal ultrasound scan were used for the diagnostic approach of the patients. The common complaints were odynophagia-dysphagia (n=107), hypersalivation (n=81), cough (n=21), vomitting (n=20) and asymptomatic in 34 patients. Radiological examinations showed that FB was located in the esophagus in 81.2% (n=134) of the patients, in the stomach of 6.74% (n=11) patients, in the intestinal segments in 10.4% (n=17), in the rectum in 1.21% (n=2) and in the liver parenchyma 0.6% (n=1) patients. Endoscopic examination performed in 134 (81.2%), FB proceeded uneventfully in 23 (13.9%) in follow up period and 8 (4.8%) patients underwent surgery. The type of ingested FB varied widely. The coins (n=54, 32.7%) and pieces of plastic toys (n=29, 17.5%) were the most frequently ingested FBs. Foreign body ingestion is a major problem in childhood. Management depends on carefully and close follow up for complications and favorable treatment choice.
A Novel Screening Test for Esophageal Squamous Cell Carcinoma: Sirtuin-3
(verduci Publisher, 2017) Cobanoglu, U.; Dulger, C.; Kemik, O.; Celik, S.; Sayir, F.
OBJECTIVE: Human sirtuin-3, a protein involved in the mediation of tumors, has been shown to be present in malignancies. The goal of this study was to measure serum sirtuin-3 levels in esophageal squamous cancer cells and to determine whether sirtuin-3 may possess predictive value in advanced cases of esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: A total of 130 ESCC patients and 50 healthy control subjects participated to the study. Serum sirtuin-3 levels for all 180 subjects were measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: Median sirtuin-3 levels were significantly higher in patients with ESCC than in the control subjects. CONCLUSIONS: The presence of considerably elevated levels of sirtuin-3, could be a powerful mediator of advanced ESCC in ESCC patients, suggests that sirtuin-3 may be a useful indicator of the disease.
Oxidative Stress and Antioxidant Enzyme Activities in Newborns With Oesophageal Atresia and Their Mothers
(Sage Publications Ltd, 2012) Melek, M.; Demir, H.; Bilici, S.; Beger, B.; Cobanoglu, U.; Meral, I.; Ozmen, E.
OBJECTIVE: To measure the oxidant/antioxidant status of newborn babies with oesophageal atresia and their mothers, compared with healthy control subjects. METHODS: This case control study included 40 participants: 10 newborns with oesophageal atresia and their mothers, and 10 healthy newborns and their mothers. Whole blood malondialdehyde (MDA) levels and the activities of antioxidant enzymes (catalase, carbonic anhydrase [CA], glucose-6-phosphate dehydrogenase [G-6-PD], and superoxide dismutase [SOD]) were measured. RESULTS: MDA levels and CA activity were significantly higher, and catalase, SOD and G-6-PD activities were significantly lower, in newborns with oesophageal atresia and their mothers than in healthy newborns and their mothers. Although CA activity was similar between the newborns and mothers in the patient group, it was significantly lower in newborns than in mothers in the healthy group. CONCLUSIONS: Increased lipid peroxidation might play an important role in the pathogenesis of oesophageal atresia. Impairment of the free radical/antioxidant balance may lead to increased free radical and decreased antioxidant levels in oesophageal atresia.
Surgical Treatment of Right Middle Lobe Syndrome in Children
(Wolters Kluwer Medknow Publications, 2012) Sehitogullari, A.; Sayir, F.; Cobanoglu, U.; Bilici, S.
Objective: Right middle lobe syndrome is a rare entity in children, causing high morbidity. Our experience of these patients including their clinical and laboratory characteristics, indications forsurgical management, postoperative courses, and follow-up results was evaluated. Methods: A retrospective analysis was performed involving 20 children with right middle lobe syndrome who were hospitalized and treated with surgical resection of the right middle lobe in Van Training and Research Hospital and Yuzuncuyil university hospital, Turkey, between January 2002 and January 2011. Results: The mean age of the patients was 10.5 years (range, 5 to 15 years). Twelve patients were boys and eight were girls. The most frequent symptom was chronic cough (75). Hemoptysis was present in two (10) patients. One patient was being treated for asthma. 25 positive cultures were identified among the patients. Streptococcus pneumoniae was the most frequently identified agent in sputum. All patients underwent chest computed tomography. There were bronchiectasis in 11 (55) patients, atelectasis and bronchiectasis in five (25) patients, and destroyed lung in four (20) patients. A narrowed middle lobe bronchus was shown in 15 (75) patients. Bronchoscopy was performed in 18 (90) patients. Stenosis due to external compression was seen in 12 (60) patients, hyperemia and bronchitis in two (10) patients, granulation tissue in two (10) patients, and dense secretions in two (10) patients. A history of doctor-diagnosed tuberculosis was present in two (10) patients. These patients had completed antituberculous treatment. The patients had been symptomatic for the last 1 to 10 years (mean, 4 years) and had received several medical treatments. All patients (totally 20 patients) underwent right middle lobe resection. In one patient, a bronchial abnormality was found intraoperatively. One patient died on postoperative day 10 due to a brain abscess. Three other patients had postoperative complications (15). Mean duration of follow-up of the patients was 4.5 years (range, 2 months to 12 years). Seventeen patients were asymptomatic, and two patients had improved. Conclusions: Children with right middle lobe syndrome unresponsive to medical treatment should undergo early lobe resection to avoid serious complications and the progression of the disease to other segments or lobes.