Browsing by Author "Cobanoglu, Ufuk"

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Algorithmic Approach To the Diagnosis and Management of Solitary Pulmonary Nodules
(derman Medical Publ, 2015) Cobanoglu, Ufuk
The solitary pulmonary nodule is a common radiologic abnormality that is often detected incidentally. It is important to differentiate malignant nodules from benign nodules in the least invasive way and to make as specific and an accurate diagnosis as possible. In patients with a high probability of malignancy, surgery is the preferred strategy. Diagnostic algorithm for approaching the solitary pulmonary nodule, stratifying clinical risk factors in a standardized manner and blending this information with radiologic clues, would point the physician toward a benign or malignant cause. Such an approach would be expected to spare patients with benign causes the morbidity and cost associated with invasive tissue sampling and, at the same time, guide the physician toward recommending invasive tests for the nodules likely to be malignant.
The Analysis of Cardiologic Alterations in 70 Patients With Chest Trauma
(Bilimsel Tip Publishing House, 2007) Cobanoglu, Ufuk
We here in present a prospective analysis of 70 patients with chest trauma (blunt or penetrating) admitted to the emergency service of Yuzuncu Yil University Hospitals from 9 March 2002 to 12 October 2003. The age range was 10 and 71 years, and 60 patients (% 86) were male. The control group consisted 16 healthy individuals (10 male, 6 female) aged from 15 to 69 years. Arterial blood gas analysis, pulmonary function tests, electrocardiography, echocardiography, blood hormone levels and blood biochemistry were evaluated for all patients at the time of their admission. Statistical comparison of the groups was performed. Physiological changes caused by chest trauma were evaluated.
Are Serum Mac 2-Binding Protein Levels Elevated in Esophageal Cancer? a Control Study of Esophageal Squamous Cell Carcinoma Patients
(Hindawi Ltd, 2018) Cobanoglu, Ufuk; Mergan, Duygu; Dulger, Ahmet Cumhur; Celik, Sebahattin; Kemik, Ozgur; Sayir, Fuat
Objective. Elevated serum Mac 2-binding protein (M2BP) levels have been observed in some cancers. As far as we know, its importance has not been investigated in esophageal squamous cell carcinoma (ESCC). The investigated problem of this study was to evaluate whether there was a difference between ESCC patients and the control group in terms of M2BP. Also, we evaluated the diagnostic performance of serum M2BP alone or in combination with the CEA for patients with ESCC. Material and Methods. Blood serum samples were collected from 50 healthy donors and 150 patients with ESCC. M2BP levels of all 200 samples were quantified by ELISA (enzyme-linked immunosorbent assay). Patients who had been diagnosed with ESCC and did not have any other malignancies were enrolled to study. Results. The two groups did not significantly differ in terms of age (p > 0 05). In the control group, the mean serum M2BP level was 14.97 coproduct 3.46 ng/mL. The mean serum M2BP level of the ESCC patients was 176.65 +/- 22.14 ng/mL. The serum M2BP level was significantly higher in patients with ESCC than in the control group (p < 0 001). Gender was also comparable in both groups (p = 0 695). Conclusions. Our analysis demonstrated that this marker may be associated with the mechanism of the disease. Despite that serum M2BP is not a specific marker for ESCC, it can be used as an adjuvant biomarker for the diagnosis of ESCC.
An Asymptomatic Schwannoma Originating From an Intercostal Nerve: a Case Report
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2012) Akgul, Asli Gul; Cobanoglu, Ufuk; Yurt, Ziya Kurban
Schwannomas are usually solitary, encapsulated, and asymptomatic lesions which mostly originate from the nerve sheath or schwann cells. The majority of these lesions of the thoracic cavity are located in the mediastinum. In this article, we report a rare case of an intercostal nerve schwannoma.
Autologous Blood Pleurodesis: a Good Choice in Patients With Persistent Air Leak
(Wolters Kluwer Medknow Publications, 2009) Cobanoglu, Ufuk; Melek, Mehmet; Edirne, Yesim
Aim: The study compares the efficiency, side effects and complications of autologous blood pleurodesis with talcum powder and tetracycline. Materials and Methods: This prospective study evaluated 50 patients with persistent air leak resulting from primary and secssondary spontaneous pneumothorax between February 2004 and March 2009. The patients inclussded 32 (64.0) males and 18 (36.0) females with a median age of 39 years (range 14-69 years). All cases had persistent air leak of more than seven days. Pleurodesis was performed using autologous blood in 20 (40.0) patients, talc powder in 19 (38.0) patients and tetracycline in 11 (22.0) patients through a chest tube. Air leak cessation times after pleurodesis, side effects and pulmonary function tests (PFT) in the first and third months were measured. Results: Recurrent primary spontaneous pneumothorax was the cause of persistent air leak in all cases. Air leaks were expiratory only in 54.0 of cases. We obtained a success rate of 75.0 using autologous blood, 84.2 using talc powder and 63.6 using tetracycline. Mean air leak termination interval was significantly (P < 0.001) shorter in patients treated with autologous blood in comparison to talc powder and tetracycline. We observed a significant (P < 0.05) decline in PFT in patients treated with talc powder compared with tetracycline and autologous blood. Vital capacity, FVC and FEV1 were significantly lower in patients treated with tetracycline compared with autologous blood. Conclusion: This study shows that autologous blood pleurodesis compared to talc powder and tetracycline is related with shorter leak cessation time and less pulmonary function decline in patients with persistent air leak. We think further randomized clinical trials of pleurodesis as treatment could increase its use in thorax surgery by demonstrating the safety and the efficacy of this procedure.
Bifid Rib; Report of Two Cases and the Efficacy of 3-Dimensional Computed Tomography
(derman Medical Publ, 2010) Kara, Hasan Volkan; Agladioglu, Kadir; Bulut, Mehmet Deniz; Cobanoglu, Ufuk; Oguz, Serhat
Congenital anomalies of ribs exist between 0.15% to 30%. These patients have minor symptoms or totally symptom-free. They are generally diagnosed accidentally. There are case report of bifid (forked) ribs in the literature. Bifid rib should be differenciated from other pathological situation of lung and chest wall including malignancies. 3-dimensional(3-D) computed tomography (CT) is a very effective diagnostic tool in differencial diagnosis of bifid rib. We present 2 cases of bifid rib that had the diagnosis by f 3 dimentional (3-D) computed tomography (CT) with the demonstrative images
Chest Radiography Diagnosis of Pulmonary Contusion Is Associated With Increased Morbidity and Mortality
(Springer india, 2010) Cobanoglu, Ufuk; Melek, Mehmet; Edirne, Yesim
Background: The aim of this study is to compare morbidity and mortality rates of patients with Chest Radiography (CXR) proven pulmonary contusion and normal CXR but pulmonary contusion on contrast Computed Tomography (CT). Methods: Cases were divided into two groups according to diagnosing method: CXR-proven (CXR-group) and CT-only diagnosed pulmonary contusion group (CT-group). Groups were compared for Injury Severity Score (ISS), Length Of Stay in Hospital (LOSH), length of stay in Intensive Care Unit (ICU), Arterial Blood Gas (ABG) changes, andmorbidity and mortality rates. Results: Mean LOSH and LOSI were significantly longer (23.09 +/- 4.01 and 13.42 +/- 3.47) in CXR group than in the CT group (10.97 +/- 3.27 and 3.59 +/- 1.54). Mean ISS score was significantly higher in the CXR group (38.63 +/- 9.37) than in the CT group (22.74 +/- 18.00). Mean ABG results were significantly poorer in the CXR group than in the CT group. The percentage of the cases requiring mechanic ventilation was 54.5% in the CXR group. Morbidity and mortality rates were 45.4% and 27.7% in the CXR group and 10.8% and 4.3% in the CT group, respectively. Conclusion: Diagnosis of pulmonary contusion by CXR is associated with higher morbidity and mortality rates.
Chest Traumas Due To Bicycle Accident in Childhood
(derman Medical Publ, 2011) Cobanoglu, Ufuk; Melek, Mehmet; Sayir, Fuat; Mergan, Duygu
Aim Childhood injuries are the leading cause of death in children and result in significant healthcare utilization. Trauma is the second most common cause of mortality in children aged 1-4 years and leading cause of death in children older than 4 years. Thoracic injury is the second most leading cause of death in traumatized children. Multisystemic injury is found in more than 50% of children with thoracic injuries most of which are secondary to blunt traumas. We planned this study to evaluate thorax trauma cases secondary to bicycle driving in childhood and to draw attention to the importance of the regulation of traffic rules, the education of bicycle drivers. Material and Methods A retrospective evaluation was performed in 17 pediatric patients admitted to the Department of Thoracic Surgery during 2006-2010 with a diagnosis of chest trauma due to bicycle driving. For every patient, a pediatric trauma score (PTS) was calculated. Descriptive statistics were performed for PTS. Results Eleven (64.70%) cases were injured due to the tricycle accidents and six cases 6 (35.29%) were injured due to the two-wheeled bicycle accidents. The most frequent thoracic pathologies included pulmonary contusion (41.2%) and chest wall contusion (29.41%). Extrathoracic injuries were seen in 35.29%, the extremities (17.64%) and abdomino pelvic (11.76%) being the most commonly involved. Treatment consisted of symptomatic treatment in 12 patients (70.58%), tube thoracostomy in 2 patients (11.76%), and thoracotomy in 1 patient (5.9%). The morbidity was seen in 3 patients (17.64%). The mortality rate was 5.9% (n:1). The mean PTS of the cases who had additional system injuries were significantly worse than the cases who had isolated chest traumas. Conclusions The pediatric thorax has a greater cartilage content and incomplete ossification of the ribs. Due to the pliability of the pediatric rib cage and mediastinal mobility, significant intrathoracic injury may exist in the absence of external signs of trauma. Pulmonary contusion and pneumothorax are frequently present without rib fractures. Pulmonary contusion, pneumothorax, and rib fractures are the most common injuries. In order to prevent bicycle accidents; bicycle drivers should have specific education, helmet use must become widespread and special traffic regulations have to be settled. Increasing the education level if family will contribute to the prevention of childhood trauma.
Chest Traumas Due To Fall in Childhood
(derman Medical Publ, 2011) Cobanoglu, Ufuk; Melek, Mehmet
Aim Falls are the most common reason for childhood traumas. The aim of this study is to investigate the causes, types, monthly frequencies and results of injuries due to fall of children in our region and to recommend some precautions for preventing these injuries. Material and Methods A retrospective evaluation was performed in 47 pediatric patients admitted to the Department of Thoracic Surgery during 2006-2009 with a diagnosis of chest trauma due to fall. For every patient, a pediatric trauma score (PTS) was calculated. Descriptive statistics were performed for PTS and the duration of hospital stay. Results The mean PTS of the cases who had additional system injuries were significantly worse than the cases who had isolated chest traumas. Similarly, the length of hospital stay was also much longer in the cases with associated system injuries. Conclusions Injuries occur mostly in summer season. It may be due to the fact that the children do not go to the school and usually spend their times outside in this period. The children and their parents should be educated about the prevention of these accidents. Additionally, the accident and injury rates may also be reduced by constructing safer games and sports grounds with robust infrastructure.
Clinical Analysis of Pneumonectomy for Destroyed Lung: a Retrospective Study of 32 Patients
(Springer Japan Kk, 2019) Sayir, Fuat; Ocakcioglu, Ilhan; Sehitogullari, Abidin; Cobanoglu, Ufuk
ObjectiveDestroyed lung is whole lung destruction secondary to chronic or recurrent lung infections. This clinical condition can result in irreversible changes in the lung parenchyma. In this study, we aimed to evaluate patients undergoing pneumonectomy with a diagnosis of lung destruction in terms of surgical technique, post-operative morbidity and mortality, and long-term outcomes.MethodsA total of 32 patients that underwent pneumonectomy due to a destroyed lung between 2005 and 2017 were retrospectively reviewed. Age, gender, presenting symptoms, etiologies, localization of the destruction, pre-operative medical history, pre- and post-operative respiratory function tests, intraoperative complications and bleeding volume, morbidity and mortality, length of hospital stay, and long-term follow-up outcomes were reviewed for each patient.ResultsThe study included 32 patients with a mean age of 31.710.8years. All the patients presented with persistent cough, whereas sputum production was presented by 25, hemoptysis by 18, and chest pain by 11 patients. The underlying primary diseases included nonspecific bronchiectasis in 20 (62.5%), tuberculosis in 9 (28.1%), left pulmonary hypoplasia accompanied by Bochdalek hernia in 2 (6.2%), and aspiration of a foreign body lodged in the left main bronchus in 1 (3.1%) patient. Mean operative time was 220.6 +/- 40.2min and mean perioperative bleeding was 450.9 +/- 225.7ml. Post-operative complications occurred in 14.2% of the patients, most commonly including atelectasis associated with stasis of secretions and wound site infection. Mean post-operative hospital stay was 11.8 +/- 2.8days and mean follow-up period was 35.5 +/- 28.3months. A significant clinical improvement was observed in 81.2% of the patients post-operatively.Conclusions Favorable long-term outcomes were obtained in our patients through careful patient selection and appropriate pre-operative work-up and surgical technique.
Clinical Profile of Thorax and Lung Injuries Associated With the 2011 Van Earthquake in Turkey
(Modestum Ltd, 2013) Sehitogullari, Abidin; Kahraman, Ali; Sayir, Fuat; Akin, Oral; Sevilgen, Gokcen; Cobanoglu, Ufuk; Aktas, Serdar
The 7.2 and 5.6 magnitude earthquake that struck Turkey on October 23 and November 9, 2011, was one of the deadliest earthquakes in recent decade. Our aim is to determine the clinical profile of crush thoracic traumas resulting from the massive Van earthquake. A retrospective review was undertaken of 39 intervention for chest traumas. Sex distrubition was 21 female and 18 male patients. Thoracic cage, pulmonary parenchyma, and pleura traumas were included in the study. Among the total of 425 hospitalized patients, 39 (9.1%) were thorax and lung injuries. Pneumothorax and rib fractures were the two most frequent pathologies. There were pneumothorax or hemothorax in 31 (79%) patients, bronch ruptures in 2 (5.1%) patients, diaphragmatic ruptures in 2 (5.1%) patients, flail chest in 2 (5.1%) patients and sternal fracture was detected in 2 (5.1%) patients. Totally, 76 ribs fractures were found in 27 (69%) patients, There were 36 (92%) patients with pulmonary parenchymal injuries and 31 (79%) with pleural injuries. Thoracotomy was performed in 4 (10%) patients, while 37 (95%) patients underwent tube thoracostomy. Carinal reconstruction was performed in a patient with bronchus and trachea injuries. Four patients (10%) with severe trauma developed Acute Respiratory Distres Syndrome (ARDS) and two of them died because of developing ARDS. After the patients are admitted to the hospital, we should use an individualized treatment according to the patients recent clinical history and examination. At the same time, traumatic chest injury should be considered in planning the medical response strategies.
Comparison of the Methods of Fibrinolysis by Tube Thoracostomy and Thoracoscopic Decortication in Children With Stage Ii and Iii Empyema: a Prospective Randomized Study
(Pagepress Publ, 2011) Cobanoglu, Ufuk; Sayir, Fuat; Bilici, Salim; Melek, Mehmet
Today, in spite of the developments in imaging methods and antibiotherapy childhood pleural empyema is a prominent cause of morbidity and mortality. In recent years it has been shown that there has been an increase in the frequency of pleural empyema in children, and antibiotic resistance in microorganisms causing pleural empyema has made treatment difficult. Despite the many studies investigating thoracoscopic debridement and fibrinolytic treatment separately in the management of this disease, there is are not enough studies comparing these two treatments. The aim of this study was to prospectively compare the efficacy of two different treatment methods in stage II and III empyema cases and to present a perspective for treatment options. We excluded from the study cases with: i) thoracoscopic intervention and fibrinolytic agent were contraindicated; ii) immunosup pression or additional infection focus; iii) concomitant diseases, those with bronchopleural fistula diagnosed radiologically, and Stage I cases. This gave a total of 54 cases: 23 (42.6%) in stage II, and 31 (574%) cases in stage III. These patients were randomized into two groups of 27 cases each for debridement or fibrinolytic agent application by video-assisted thoracoscopic decortication (VATS). The continuity of symptoms after the operation, duration of thoracic tube in situ, and the length of hospital stay, in the VATS group were of significantly, shorter duration than in the streptokinase applications (P=0.0001). In 19 of 27 cases (70.37%) in which fibrinolytic treatment was applied and in 21 cases of 27 (77.77%) in which VATS was applied, the lung was fully expanded and the procedure was considered successful. There was no significant difference with respect to success rates between the two groups (P-0.533). The complication rate in our cases was 12.96% and no mortality was observed. Similar success rates in thoracoscopic drainage and enzymatic debridement, and the low cost of enzymatic drainage both served to highlight intrapleural streptokinase treatment as a reliable method in reducing the need for surgery in complicated empyema.
Conventional Osteosarcoma of the Rib: a Case Report
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2012) Sehitogullari, Abidin; Bulut, Gulay; Cobanoglu, Ufuk; Bayram, Irfan
Primary tumors of the rib are relatively uncommon in adults and rare in children. In this article, we present a case who was operated due to conventional osteosarcoma of the rib in the light of the literature review. A 17-year-old female patient had been operated due to a rib tumor 54 months ago. There was no local recurrence or metastatic disease. Chest wall tumors, particularly those arising from bones, require histologic assessment to be considered benign; the differential diagnosis of malignant neoplasms should not be based on clinical and radiographic features, only.
Costa Originated Giant Aneurysmal Bone Cyst
(Erciyes Univ Sch Medicine, 2010) Cobanoglu, Ufuk; Kosem, Mustafa; Altindal, Ebru; Arslan, Harun
A 56-years-old female patient who had a traffic accident 10 years ago applied to our outpatient clinic with complaints of dyspnea for 2 years, chest pain and an enlarging mass on her right chest side wall. There was a mass lesion sized 14 x 10 cm beginning from the 715 level with chest x-ray. Mass was resected totally to cover the relevant costas and thorax front wall muscular structure which was encompassed and diaphragm region. Aneurysmal Bone Cyst having solid and cystic components was reported at the pathologic examination.
Diagnostic Dilemma in Hydatid Cysts: Tumor-Mimicking Hydatid Cysts
(Aves, 2015) Cobanoglu, Ufuk; Asker, Selvi; Mergan, Duygu; Sayir, Fuat; Bilici, Salim; Melek, Mehmet
OBJECTIVES: Hydatid cysts are sometimes confused with different pathologies, and problems arise in their diagnosis and treatment. In this study, cases that are followed up with a diagnosis of lung malignancy and that are detected to have hydatid cysts were retrospectively examined. MATERIAL AND METHODS: Seven patients with hydatid cysts whose clinical and radiological features were consistent with lung malignancy were retrospectively examined between 2010 and 2014 regarding sex, age, symptoms, diagnostic methods, surgical procedures performed, and postoperative complications. In the diagnosis of the patients, radiological diagnostic methods such as chest radiography, thoracic computed tomography (TCT), and positron emission tomography+computed tomography (PET-CT) as well as invasive diagnostic methods such as bronchoscopy, fine-needle aspiration biopsy, thoracentesis, and video-assisted thoracoscopic surgery were used. RESULTS: The average diameter of the lesions was determined as 4.14 +/- 1.57 cm in TCT. Maximum standardized uptake value (SUV max) was measured as 8.77 +/- 3.41 (5.4-15.1) in the PET-CT analysis. Bronchoscopy, fine-needle aspiration biopsy, and thoracentesis yielded no results. Definitive diagnosis was established by performing thoracotomy and video-assisted thoracoscopic surgery. CONCLUSION: Pulmonary hydatid cysts can appear as malignant diseases such as lung cancer as well as infectious pathologies such as tuberculosis or benign pathologies. Radiologically, it should be kept in mind that pulmonary hydatid cysts can mimic many pulmonary pathologies, particularly malignancies. Necessary examinations towards its differential diagnosis must be performed in the preoperative period.
Diaphragmatic Herniation Diagnosed at a Late Stage: an Evaluation of Eight Cases
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2012) Sayir, Fuat; Cobanoglu, Ufuk; Bilici, Salim; Melek, Mehmet; Mergan, Duygu
Background: In this study, we aimed to analyze patients with diaphragmatic hernias who had specific clinical features and interesting clinical, radiologic presentations, and had operated following late diagnosis. Methods: A total of eight diaphragmatic hernia cases, of whom three were adults and five were children (4 males, 4 females; mean age 12.4 +/- 24 years; range 9 months to 28 years), who were diagnosed in the late period and who were operated on in our clinic between January 2006 and August 2010 were evaluated retrospectively. In all patients, primary repair of the diaphragm was performed following laparotomy and thoracotomy. Results: The children were diagnosed following the neonatal period. Three patients were diagnosed in adulthood. Five patients had right-sided congenital Morgagni hernias, one patient had a hiatal hernia, and two patients had left-sided Bochdalek hernia. All patients were discharged between the 5th and 19th postoperative days. The average duration of hospital stay was 9.8 days (range 7 to 23 days). The follow-up time were between six months and two years, and no significant respiratory and gastrointestinal complaints were recorded. No morbidity was detected in three cases with Morgagni hernia. Conclusion: Congenital diaphragmatic hernias are pathologies which are seen in the neonatal period, and the diagnosis of these hernias can be difficult after this period. Mortality and morbidity rates are low in cases who are followed and treated in clinics by dedicated thoracic surgeon.
Ductus Thoracicus Injury: a Case Reports
(Aves, 2008) Cobanoglu, Ufuk
Chylothorax usually results from trauma or it is developed iatrogenicaly during chest surgery procedures. Treatment should be started as soon as diagnosed and surgical treatment should be planned unless drainage is not decreased by conservative treatment for 10-14 days. Primary repair, ductal ligation and anastomosis are prefered during surgical treatment. We presented a case of 27 years old male with ductus thoracicus injury as a result of gunshot. In this case, injury was determined during thoracotomy and ligation was performed. There was not any complication during postoperative following and patient was discharged from hospital as wclmpfarc.
Effect of Crush and Axotomy of Phrenic Nerves on Oxidative Stress in Diaphragm Muscle of Rats
(Wiley, 2012) Sayir, Fuat; Kavak, Servet; Meral, Ismail; Demir, Halit; Cengiz, Nurettin; Cobanoglu, Ufuk
Introduction: In this study we investigated the effect of crush and axotomy of phrenic nerves on oxidative stress and antioxidant enzyme activities in rat diaphragm muscle. Methods: The animals in the first group were not crushed or axotomized and served as controls. Phrenic nerves of the rats in the second and third groups were crushed or axotomized in the diaphragm muscle. Results: The malondialdehyde level increased in diaphragm muscles after both crush and axotomy. The antioxidant enzymes, such as superoxide dismutase, glutathione peroxidase, carbonic anhydrase, and catalase, decreased in diaphragm muscles after both crush and axotomy. Conclusions: Crushing or axotomizing the phrenic nerves may produce oxidative stress in the diaphragm muscle of the rat by increasing lipid peroxidation and decreasing antioxidant enzyme activities. Muscle Nerve, 2012
The Effect of Diaphragmatic Plication on Pulmonary Function Test, Dyspnea Score and Arterial Blood Gases: Analysis 11 Patients With Diaphragmatic Elevation
(derman Medical Publ, 2011) Cobanoglu, Ufuk; Sayir, Fuat; Mergan, Duygu; Toktas, Osman
Aim Diaphragmatic evantration or paralysis in adults is associated with respiratory distress. In this study, we aimed to compare preoperative and postoperative pulmonary function tests, arterial blood gas analyses and dyspnea scores of the cases in whom plication had been performed for diaphragmatic elevation. Material and Methods Between January 2004 and March 2010 eleven adult patients who had undergone diaphragmatic plication due to diaphragmatic paralysis and eventration were analyzed. There were 7 (63.63%) men and 4 (36.37%) women aged 28-65 (mean 38 +/- 2.9). Diaphragmatic plication was performed. Pulmonary function test, dyspnea scores, and arterial blood gases in the preoperative and postoperative period were studied. Results Dyspnea was present in all of the cases and a decrease in both FVC, FEV1, FEV1/FVC values of pulmonary function test and partial pressure of oxygen in the arterial blood were observed. In chest x-ray and thorax computed tomography, it was detected that right or left diaphragm was elevated. Diaphragmatic paralysis was detected by fluoroscopy in 6 patients. Transthoracally, diaphragmatic plication was performed to the cases. There were no postoperative complications or deaths. In postoperative six and twelve months, significant improvements in the symptoms, the values of pulmonary function tests, partial pressure of oxygen in the arterial blood and dyspnea scores of the patients were observed. Conclusions Diaphragmatic plication is a safe and effective procedure for adult patients with dyspnea due to unilateral diaphragmatic elevation. Lung expansion is easily achieved by performing diaphragm plication.
Effects of Crush and Axotomy on Oxidative Stress and Some Trace Element Levels in Phrenic Nerve of Rats
(Pergamon-elsevier Science Ltd, 2013) Sayir, Fuat; Kavak, Servet; Meral, Ismail; Demir, Halit; Cengiz, Nurettin; Cobanoglu, Ufuk
This study was designed to investigate the effect of crush and axotomy on oxidative stress and some trace element levels in phrenic nerve of rats. Eighteen male Wistar-albino rats were divided randomly into three groups, each consisting of 6 rats. The animals in the first group were not crushed or axotomized and served as control. Phrenic nerves of the animals in the second and third groups were crushed and axotomized, respectively. Animals in all groups were sacrificed one week after the crush or axotomy, and degenerated phrenic nerves were harvested for the determination of tissue oxidative stress and trace element levels. Lipid peroxidation product malondialdehyde and antioxidant glutathione levels increased in both crushed and axotomized phrenic nerves. The activities of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase were lower in crushed and axotomized phrenic nerves than in controls. The levels of Fe, Pb, Mn, Cd and Co increased, and Mg and Cu levels decreased in crushed phrenic nerves. The levels of Fe and Mg decreased, Pb and Co levels increased in axotomized phrenic nerves. It was concluded that crushing or axotomizing the phrenic nerves may produce oxidative stress by increasing lipid peroxidation and decresing antioxidant enzyme activities. It was also concluded that while crush to phrenic nerves causes accumulation of minerals, axotomizing phrenic nerves causes depletion of minerals in the tissues. (C) 2011 Elsevier Inc. All rights reserved.