Browsing by Author "Coldur, Fatih"

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Development of a Pvc Membrane Potentiometric Sensor With Low Detection Limit and Wide Linear Range for the Determination of Maprotiline in Pharmaceutical Formulations
(Wiley-v C H verlag Gmbh, 2022) Tekce, Serkan; Subasi, Yaver; Coldur, Fatih; Kanberoglu, Gulsah Saydan; Zahmakiran, Mehmet
Maprotiline (MAP), is an active ingredient of some antidepressants which has been broadly used for the therapy of depression. The overdose of MAP in the treatment of patients with depression can lead to significant side effects, even lethal intoxication. Therefore, it is very important to develop simple, inexpensive, fast and reliable detection methods for MAP in interested samples. In our present study, we have offered a novel poly(vinylchloride) (PVC) membrane maprotiline-selective potentiometric sensor based on a type of MOFs, known as MIL-53(Al), as electroactive ionophore substance. The sensor prepared at the optimum membrane composition exhibited a linear response for maprotiline hydrochloride in the concentration range of 1,0x10(-9) M-1,0x10(-2) M with a slope of 59,1 mV/decade and detection limit of 9,0x10(-10) M. The pH working range of the sensor was determined as 2,0-9,5. The response time of the sensor was very fast and less than 5 s. With these performance features, it has been shown that the current sensor has quite superior features compared to the potentiometric MAP-selective sensor available in the literature. The potentiometric application of the sensor was successfully carried out with the detection of MAP in pharmaceutical tablets containing MAP-HCl.
Development of Mof-Based Pvc Membrane Potentiometric Sensor for Determination of Imipramine Hydrochloride
(Springer int Publ Ag, 2022) Subasi, Yaver; Kanberoglu, Gulsah S.; Coldur, Fatih; Cubuk, Osman; Zahmakiran, Mehmet
Imipramine hydrochloride (IMIP) is a tricyclic antidepressant utilized in the treatment of depression and chronic pain in some certain cases together with pain medication. The side effects of anxiety, insomnia, crying attacks, personality change and tachycardia are seen in imipramine overdose; therefore, determination of imipramine is an important issue. In this study, a novel potentiometric PVC membrane ion-selective sensor (ISE) was developed for monitoring of IMIP. MIL-53(Al) metal-organic framework was utilized for the first time as an electroactive material in the construction of imipramine-selective PVC membrane sensor. The sensor membrane consisting of 3.0% MIL-53(Al), 64.0% dibutylphthalate (DBP), 32.0% polyvinylchloride (PVC) and 1.0% potassium tetrakis(4-chlorophenyl)borate (KTpClPB) exhibited the most satisfied potentiometric performance characteristics. The sensor displayed a linear response for imipramine hydrochloride in the concentration range of 1.0 x 10(-7) M-1.0 x 10(-1) M with a slope of 57.7 mV/decade and detection limit of 5.0 x 10(-8) M. The operational pH range of the sensor was determined as 3.7-8.5. The sensor showed highly reproducible and stable potentiometric responses with the response time of less than 5 s. The IMIP content of a pharmaceutical used in the treatment of depression was successfully determined with the proposed imipramine-selective sensor. Additionally, the analytical applicability of the sensor in real biological samples was demonstrated by performing imipramine determinations in spiked human blood serum and urine samples. [GRAPHICS] .
Flow Injection Potentiometric Determination of Silver(I) in Photographic Film Developing Solution Samples by Polyvinylchloride Membrane Silver(I) Selective Electrode
(Chem Soc Pakistan, 2016) Topcu, Cihan; Coldur, Fatih; Andac, Muberra; Cubuk, Osman; Kanberoglu, Gulsah Saydan; Caglar, Bulent; Isildak, Ibrahim
A polyvinylchloride (PVC) membrane silver(I) selective electrode was developed for the determination of silver(I) ions in photographic film developing solutions. The electrode was embedded into a home-made flow cell and successfully used as a potentiometric detector in a flow injection potentiometric (FIP) system. Under the optimized flow injection conditions, the electrode exhibited a non-Nernstian slope of 67.20 +/- 0.80 mV in the linear range from 1.0x10(-5) to 1.0x10(-1) mol/L (R-2 = 0.9961) and the lowest value for limit of detection (LOD) was calculated as 7.1x10(-6) mol/L. The electrode displayed good sensitivity, selectivity, repeatable and rapid response towards silver(I) ions. Lifetime of the electrode was determined as at least two months in FIP system. The electrode was also successfully applied for the potentiometric determination of silver(I) ions in photographic film developing solution samples in FIP system. The results attained from FIP system were compared with the atomic absorption spectrophotometry (AAS) results by using student's t-test at 95 % confidence level and relative deviation (RD) between the two methods was < 8 %.
A Novel Potentiometric Pvc-Membrane Cysteamine-Selective Electrode Based on Cysteamine-Phosphomolybdate Ion-Pair
(Bentham Science Publ Ltd, 2020) Tumur, Merve; Kanberoglu, Gulsah Saydan; Coldur, Fatih
Background: Cysteamine is used as an orphan drug in the treatment of cystinosis to prevent long-term cystine accumulation in lysosomes. Dosing in cysteamine treatment is extremely important and overdose may cause some side effects. Up to now, various analytical methods have been used for cysteamine determination. Many of these methods require sophisticated instniments, expert operators, time-consuming measurement procedures and manipulation steps, expensive supplies and long analysis time. Aims and Objective: The present study deals with the development of a potentiometric PVC-membrane cysteamine-selective electrode based on an ion-pair of cysteamine and its application in a pharmaceutical formulation. Methods: Cysteamine (Cys)-Phosphomolybdate (PM) ion-pair was synthesized by mixing the equal volumes of 10-2 M Cysteamine HC1 and sodium phosphomolybdate aqueous solutions. The obtained precipitate was used as ionophore in the structure of PVC-membrane. Results and Discussion: The electrode exhibited a linear response in the concentration range of 1.0x10(-1).0 10(-5) M cysteamine with a slope of 51,7 mV per decade and detection limit of 1.0x10-5 M. The potentiometric response of the electrode Was very rapid (5 s), adequately repeatable, stable and selective. pH working range and life-time of the electrode were also determined as 3.0-7.0 and 25 days, respectively. Conclusion: A PVC-membrane cysteamine selective electrode was easily prepared. Cysteatnine determination in a pharmaceutical formulation was performed. Analysis results indicated that it can be successfully used in dnig quality control laboratories for routine analysis of cysteamine in pharmaceutical preparations alternative to more sophisticated, expensive and time-consuming analytical methods.
Pvc-Membrane Potentiometric Sensor for the Determination of Tamoxifen in Pharmaceutical Formulations
(Ieee-inst Electrical Electronics Engineers inc, 2015) Kanberoglu, Gulsah Saydan; Coldur, Fatih; Topcu, Cihan; Cubuk, Osman
Novel tamoxifen-selective potentiometric electrodes based on various ion associations of tamoxifen were developed. The most suitable membrane composition, which has the best potentiometric characteristics, was examined under steady-state conditions. The membrane composed of (w/w) 3% tamoxifen-phosphomolibdate ion pair, 32% poly(vinylchloride), and 65% 2-nitrophenyloctylether was determined as the membrane with the best analytical properties. On the condition of pH = 2-6, the fabricated electrode exhibited linear responses over the concentration range of 9.1 x 10(-6) -1 x 10(-3) M tamoxifen solutions (R-2 = 0.9989) with a sensitivity of 42.9 +/- 0.3 mV/decade, detection limit of 7.3 +/- 0.4 x 10(-6) M and short response time of approximate to 25 s. The influences of some alkaline, alkaline earth metals, biologically significant molecules, and some pharmaceutical species over electrode responses were studied. The proposed electrode was applied for the determination of tamoxifen contents of some pharmaceutical formulations by using standard addition method. The potentiometric analysis results obtained for the pharmaceutical formulations were in good harmony with the results obtained by high performance liquid chromatography at 95% confidence level.