Browsing by Author "Cubuk, Osman"

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Development of Mof-Based Pvc Membrane Potentiometric Sensor for Determination of Imipramine Hydrochloride
(Springer int Publ Ag, 2022) Subasi, Yaver; Kanberoglu, Gulsah S.; Coldur, Fatih; Cubuk, Osman; Zahmakiran, Mehmet
Imipramine hydrochloride (IMIP) is a tricyclic antidepressant utilized in the treatment of depression and chronic pain in some certain cases together with pain medication. The side effects of anxiety, insomnia, crying attacks, personality change and tachycardia are seen in imipramine overdose; therefore, determination of imipramine is an important issue. In this study, a novel potentiometric PVC membrane ion-selective sensor (ISE) was developed for monitoring of IMIP. MIL-53(Al) metal-organic framework was utilized for the first time as an electroactive material in the construction of imipramine-selective PVC membrane sensor. The sensor membrane consisting of 3.0% MIL-53(Al), 64.0% dibutylphthalate (DBP), 32.0% polyvinylchloride (PVC) and 1.0% potassium tetrakis(4-chlorophenyl)borate (KTpClPB) exhibited the most satisfied potentiometric performance characteristics. The sensor displayed a linear response for imipramine hydrochloride in the concentration range of 1.0 x 10(-7) M-1.0 x 10(-1) M with a slope of 57.7 mV/decade and detection limit of 5.0 x 10(-8) M. The operational pH range of the sensor was determined as 3.7-8.5. The sensor showed highly reproducible and stable potentiometric responses with the response time of less than 5 s. The IMIP content of a pharmaceutical used in the treatment of depression was successfully determined with the proposed imipramine-selective sensor. Additionally, the analytical applicability of the sensor in real biological samples was demonstrated by performing imipramine determinations in spiked human blood serum and urine samples. [GRAPHICS] .
Flow Injection Potentiometric Determination of Silver(I) in Photographic Film Developing Solution Samples by Polyvinylchloride Membrane Silver(I) Selective Electrode
(Chem Soc Pakistan, 2016) Topcu, Cihan; Coldur, Fatih; Andac, Muberra; Cubuk, Osman; Kanberoglu, Gulsah Saydan; Caglar, Bulent; Isildak, Ibrahim
A polyvinylchloride (PVC) membrane silver(I) selective electrode was developed for the determination of silver(I) ions in photographic film developing solutions. The electrode was embedded into a home-made flow cell and successfully used as a potentiometric detector in a flow injection potentiometric (FIP) system. Under the optimized flow injection conditions, the electrode exhibited a non-Nernstian slope of 67.20 +/- 0.80 mV in the linear range from 1.0x10(-5) to 1.0x10(-1) mol/L (R-2 = 0.9961) and the lowest value for limit of detection (LOD) was calculated as 7.1x10(-6) mol/L. The electrode displayed good sensitivity, selectivity, repeatable and rapid response towards silver(I) ions. Lifetime of the electrode was determined as at least two months in FIP system. The electrode was also successfully applied for the potentiometric determination of silver(I) ions in photographic film developing solution samples in FIP system. The results attained from FIP system were compared with the atomic absorption spectrophotometry (AAS) results by using student's t-test at 95 % confidence level and relative deviation (RD) between the two methods was < 8 %.
Pvc-Membrane Potentiometric Sensor for the Determination of Tamoxifen in Pharmaceutical Formulations
(Ieee-inst Electrical Electronics Engineers inc, 2015) Kanberoglu, Gulsah Saydan; Coldur, Fatih; Topcu, Cihan; Cubuk, Osman
Novel tamoxifen-selective potentiometric electrodes based on various ion associations of tamoxifen were developed. The most suitable membrane composition, which has the best potentiometric characteristics, was examined under steady-state conditions. The membrane composed of (w/w) 3% tamoxifen-phosphomolibdate ion pair, 32% poly(vinylchloride), and 65% 2-nitrophenyloctylether was determined as the membrane with the best analytical properties. On the condition of pH = 2-6, the fabricated electrode exhibited linear responses over the concentration range of 9.1 x 10(-6) -1 x 10(-3) M tamoxifen solutions (R-2 = 0.9989) with a sensitivity of 42.9 +/- 0.3 mV/decade, detection limit of 7.3 +/- 0.4 x 10(-6) M and short response time of approximate to 25 s. The influences of some alkaline, alkaline earth metals, biologically significant molecules, and some pharmaceutical species over electrode responses were studied. The proposed electrode was applied for the determination of tamoxifen contents of some pharmaceutical formulations by using standard addition method. The potentiometric analysis results obtained for the pharmaceutical formulations were in good harmony with the results obtained by high performance liquid chromatography at 95% confidence level.