Browsing by Author "Dagistan, Ozlem Akbal"

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Knowledge, Attitude and Practice of Community Pharmacy Personnel About Implementation of the Pharmaceutical Track and Trace System, in Turkey
(Soc Stiinte Farmaceutice Romania, 2021) Erdocan, Ozlem Nazan; Dagistan, Ozlem Akbal; Arslan, Miray; Cig, Gulnaz; Sayar, Ali; Erdogan, Mehmet Sarper
Pharmaceutical Track and Trace System (PTTS) is a successful implementation of Track and Trace approach which has been applied since 2010 in Turkey. Briefly, it defines the infrastructure framework for all units belonging to each product and works by using the Datamatrix code, which provides the sureness of the uniqueness. The aim of this study was to evaluate the community pharmacy personnel's attitudes and knowledge about the PTTS, in order to reveal their expectations and identify problems thereof. 56 community pharmacies located in Beyoglu district of Istanbul, Turkey (n = 120) were included. The data were collected from 15th - 30th of April 2017 by a structured questionnaire. Besides evaluating descriptive statistics, chi(2) test was conducted to analyse relationship between demographics and knowledge, attitudes, and practices of the pharmacy personnel, respectively. This study shows that PTTS is found useful especially for providing drug safety and facilitating and accelerating the recall of the drugs.
Selection of the Polymers Used in Oral Dispersible Films Via Analytical Hierarchy Process
(Marmara Univ, 2024) Dagistan, Ozlem Akbal; Arslan, Miray
Many different active ingredients and excipients are used in the production of pharmaceutical products. Selection of the most suitable active ingredients and excipients is one of the most important stages of pharmaceutical production. When choosing the active ingredients and excipients, several factors and alternatives should be considered. In this instance, it is thought that one of the multi-criteria decision-making techniques, an operational research model, the Analytical Hierarchy Process, can assist in identifying the excipients during the pre-formulation stage. Using the Analytical Hierarchy Process, the current study seeks to identify the polymers most suitable for producing oral dispersible film formulations. The problem's criteria and potential solutions were determined before establishing the goal. Then, pairwise comparison matrices were generated, and the generated matrices were sent to the Super Decisions Version 3.2 software to reach a solution/result. The study's findings showed that the forming capacity is the most crucial factor affecting the choice of polymer to be used in the pre-formulation of oral dispersible films. Hydroxypropyl methylcellulose (14.89%) was found to be the best alternative among the polymers, followed by hydroxyethyl cellulose (12.04%) and carboxymethyl cellulose (11.58%). It was revealed that the least preferred polymers were sodium alginate (5.6%) and pectin (6.8%), which are natural polymers. It is clear from the outcomes of the various pre-formulation investigations that polymer selection in oral dispersible film formulations is one of the most critical points. This study provides a new approach to selecting the most appropriate polymers in oral dispersible film formulations.