Browsing by Author "Dagoglu, G"

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Bioavailability and Pharmacokinetics of Oxytetracycline in Cultured Rainbow Trout Following Intramusicular Administration
(indian veterinary Journal, 2004) Dagoglu, G; Turel, L; Yilmaz, O; Yarsan, E; Oto, G; Kankaya, E
Aquaculture production of rainbow trout has increased in Turkey in the recent years. There is great concern over the use of drugs for fish production. Bacterial diseases, if untreated, may lead to great economic losses in the form of fish mortality and reduced growth. Thus aquafarming uses a wide variety of drugs for prevention and treatment of disease in cultured fish. Among these drugs, oxytetracycline (OTC) is a broad-spectrum antibiotic used for the treatment of a variety diseases including vibriosis, furunculosis, enteric redmouth, bacterial haemorrhagic septicemia, fin rot, gill disease columnaris and edwardsiellosis (Black et al., 1991; Unb, 1996). There is a paucity of information on the pharmacokinetics of OTC in farmed fish. The pharmacokinetics of OTC may be changed by parameters such as fish species, age, water temperature and salinity, route of administration and other conditions. Therefore the present study was performed to investigate the pharmacokinetics, i.e. absorption, distribution and elimination, of OTC in rainbow trout (Oncorhynchus mykiss) after intra-muscular administration.
The Effect of Nigella Sativa (Black Seed) and Vit. E Plus Selenium in the Prevention of Liver Necrosis Experimentally Induced With Carbon Tetrachloride (Ccl4) in Rats
(Tubitak Scientific & Technological Research Council Turkey, 2003) Sahin, A; Yener, Z; Dagoglu, G; Dede, S; Oto, G; Alkan, M
The preventive effect of Nigella sativa (black seed) was investigated in rats with hepatic necrosis experimentally induced by carbon tetrachloride (CCl4). To compare the antioxidant effect of black seed, well-known antioxidants, vitamin E and selenium mineral, were used. This study was conducted on 40 rats that were divided into five groups of eight. Group A was separated as a control group and treated intraperitoneally (i.p.) with only liquid paraffin. Group B was administered i.p CCl4 in liquid paraffin. Group C was administered i.p. CCl4 in liquid paraffin and intramuscularly (i.m.) treated with vitamin E + selenium. Group D was administered i.p. CCl4 in liquid paraffin, i.m. treated with vitamin E + Se and fed ad libitum with standard rat pellets containing 10% black seed. Group E was administered i.p. CCl4 in liquid paraffin and fed ad libitum with standard rat pellets containing 10% black seed. Blood samples were drawn from the heart of the rats four times for the experimental groups and five times for the control group, one of which was at the beginning of the experiment. In blood samples, malondialdehyde (MDA), glutathione peroxidase (GSH-px), superoxide dismutase (SOD), alanine transaminase (ALT), aspartic transaminase (AST), intracellular glutathione (GSH) and ceruloplasmin analyses were performed. In group B blood samples, lipid peroxidation and antioxidant enzymes were significantly increased. The closest enzyme activities to those of the control group were found in group E. The least weight loss percentages were in group E. The least necrosis was detected in the liver samples of group D. Histopathological results were consistent with biochemical results. In conclusion, a liver necrosis preventive effect of vitamin E + selenium and black seed was observed.
Effects of Scorpion Envenomation on Blood Constituents in Rats
(indian veterinary Journal, 2004) Sahin, A; Ozbek, H; Dulger, H; Ozturk, G; Dagoglu, G
The Effects of Sildenafil Citrate (Viagra) in the Early Phase of Healing Process in Open Wounds in Dogs
(Vysoka Skola veterinarni Farmaceuticka, 2003) Tas, A; Atasoy, N; Özbek, H; Aslan, L; Yüksel, H; Ceylan, E; Dagoglu, G
In vivo (n = 16) and in vitro (n = 16) experiments were conducted in dogs to describe the effects of sildenafil citrate (viagra) on histopathological changes during the healing process with respect to angiogenesis and compare vasodilatative effects of sildenafil citrate, acetylcholine and sodium nitroprusside. General anaesthesia was performed with 0.2% ketamine HCl by intravenous drip after premedication with xylazine (5 mg.kg(-1)) and atropine sulphate (0.05 mg.kg(-1)). Round open wounds were created in all skin layers on anterior brachial region in all animals. On days 1, 3, 5 and 7 following the operation sildenafil citrate (25 mg) (n = 8) and saline (n = 8) were orally administered. Wound tissues were dissected for histological observation on days 3, 6, and 9. Animals receiving sildenafil citrate had greater granulosa tissue more apparent capillary network and greather fibroblast proliferation than control group on day 6. Vasorelaxant effects of sildenafil citrate, acetylcholine and sodium nitroprusside on a. brachialis were investigated in vitro. In this study, relative vasorelaxant effects of sildenafil citrate, acetylcholine and sodium nitroprusside were 4.91, 5.75 and 6.70, respectively. Results of this study suggest that sildenafil citrate does enhance the healing process by stimulating angiogenesis.
Pharmacokinetics and Tissue Levels of Tilmicosin in Fowls
(Scientific Technical Research Council Turkey, 2001) Keles, O; Bakirel, T; Sener, S; Baktir, G; Dagoglu, G; Özkan, O
Tilmicosin is a long-acting macrolide antibiotic used in the treatment of respiratory disease. It was administered once (SO mg/kg b.wt) to fowls via the oral route for determination of kinetic properties and tissue levels. After oral administration, tilmicosin's pharmacokinetics conformed to a two compartment open model. Tilmicosin was slowly eliminated from the serum and lung with mean half-lives of 30.18 +/- 2.38 and 75.74 +/- 3.67 hours, respectively The mean maximum concentration of the drug in the lungs was found to be 6.2 times greater that of serum. Serum and lung tilmicosin concentrations reached peak Values 4.66 +/- 2 and 17.78 +/- 7.51 hours, respectively, after oral administration. In fowls, the apparent volume of distribution was found to be more than 1 L/kg, indicating extensive tissue distribution. The clearance Values were calculated to be 1.33 +/- 0.06 for serum and 0.11 +/- 0.004 Vh for lung. After oral administration, tilmicosin appeared to be retained at higher concentrations and for longer times in the edible tissue than in serum. The mean peak concentrations of tilmicosin were obtained in kidney 8 hours after dosing and in liver, heart and muscles 12 hours after dosing. Then, tissue concentrations decreased slowly over time and tilmicosin residues were only detected in the liver and kidney.
Pharmacokinetics of Long Acting and Conventional Formulations of Oxytetracycline in Goats
(indian veterinary Journal, 2005) Turel, I; Dagoglu, G; Yilmaz, O; Yarsan, E; Irak, K
Oxytetracycline (OTC) is a broadspectrum antibiotic extensively used for the treatment of a variety disease and is active not only against a variety of gram (+) and gram (-) organisms, but also against mycoplasma, ehrlichia, rickettsiae, clarnydia and anaplasma. The pharmacokinetics of OTC may be changed by parameters such as species, age, health, route of administration and other conditions. There is a paucity of information on the pharmacokinetics of OTC in goats. Therefore the present study was performed to investigate the pharmacokinetics of OTC after intravenous and intramuscular administrations of both conventional (CF) and long-acting (LA) formulations in Colored Mohair goats of Turkey.
Pharmacokinetics of Oxytetracycline in Rainbow Trout (Oncorhynchus Mykiss) Following Administration of Medicated Feed
(Scientific Technical Research Council Turkey, 2003) Türel, I; Dagoglu, G; Yilmaz, O; Kankaya, E; Sen, F
The pharmacokinetics of oxytetracycline (OTC) were investigated in rainbow trout in freshwater at 10.5 degreesC. A group of 70 fish received OTC, an intravascular injection (i.v.) of 5 mg/kg body weight. Another group of 105 fish were fed medicated feed containing a dose of 100 mg/kg body weight. OTC. plasma concentrations were determined by high performance liquid chromatography. The pharmacokinetic parameters were described by a two-compartment open model giving distribution half-lives of 0.907 h and 16.058 h, and elimination half-lives of 33.5 h and 27 h for Lv. and oral administration of OTC, respectively. After i.v. administration of OTC, other pharmacokinetic parameters estimated were the area under the curve (AUC: 145.078 +/- 4.45 mug.ml(-1).h(-1)) and mean residence time (MRT: 40.604 +/- 1.150 h). Following oral administration, AUC was 34.46 +/- 1.189 mug.ml(-1).h(-1); MRT was 59.272 +/- 1.541 h; C-max was 0.577 mug/ml and T-max was 36 h. The oral bioavailability (F) of OTC in rainbow trout was found to be only 1.187%.