Browsing by Author "Dasdag, Suleyman"

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3.5 Ghz Radiofrequency Radiation May Affect Biomechanics of Bone and Muscle of Diabetics
(Taylor & Francis Ltd, 2023) Bektas, Hava; Dasdag, Suleyman; Nalbant, Asrin; Akdag, Mahmut Berat; Demir, Canan; Kavak, Servet
With the developments in wireless technologies, living beings are increasingly exposed to electromagnetic fields (EMFs). EMFs are known to affect bone metabolism and muscle tissue. However, their effects on bones and skeletal muscles are controversial, as some studies have reported positive effects while others have reported adverse effects. In this study, the effects of radiofrequency radiation (RFR) on bone biomechanics and skeletal muscle tissues were investigated in diabetic and healthy rats. Rats were exposed to 3.5 GHz RFR for 2 h per day for 30 days. Bone biomechanics measurements were taken to evaluate the effects of RFR on bone quality, flexibility and durability. The whole-body specific absorption rate (SAR) was found to be 37 mW/kg. The results showed that RFR exposure had adverse effects on bone biomechanics, including decreased elasticity coefficient and Young's modulus, increased maximum displacement and decreased maximum force. However, oxidative stress parameters in diabetics were also altered by 3.5 GHz RFR to a greater extent than in healthy rats. In conclusion, 3.5 GHz RFR may have potential to alter bone quality and structural integrity including muscle oxidative stress parameters in rats. It should be emphasized that the observed changes were more obvious in diabetic rats. In addition, the changes observed in healthy and diabetic rats exposed to RFR showed a statistically significant difference according to the sham groups.
Adverse Effects of 900, 1800 and 2100 Mhz Radiofrequency Radiation Emitted From Mobile Phones on Bone and Skeletal Muscle
(Taylor & Francis inc, 2023) Bektas, Hava; Nalbant, Asrin; Akdag, Mahmut Berat; Demir, Canan; Kavak, Servet; Dasdag, Suleyman
The goal of this study was to biomechanically and morphologically research both the impact of mobile phone like radiofrequency radiations (RFR) on the tibia and the effects on skeletal muscle through oxidative stress parameters. Fifty-six rats (200-250 g) were put into groups: healthy sham (n = 7), healthy RFR (900, 1800, 2100 MHz) (n = 21), diabetic sham (n = 7) and diabetic RFR (900, 1800, 2100 MHz) (n = 21). Over a month, each group spent two hours/day in a Plexiglas carousel. The rats in the experimental group were exposed to RFR, but the sham groups were not. At the end of the experiment, the right tibia bones and skeletal muscle tissue were removed. The three-point bending test and radiological evaluations were performed on the bones, and CAT, GSH, MDA, and IMA in muscles were measured. There were differences in biomechanics properties and radiological evaluations between the groups (p < .05). In the measurements in the muscle tissues, significant differences were statistically found (p < .05). The average whole-body SAR values for GSM 900, 1800 and 2100 MHz were 0.026, 0.164, and 0.173 W/kg. RFRs emitted from mobile phone may cause adverse effects on tibia and skeletal muscle health, though further studies are needed.
Çok Düşük Frekanslı Manyetik Alan, Glioblastomda İrinotekan Sitotoksisitesini Değiştirir: Bir Ön Gözlem
(2021) Dasdag, Suleyman; Bektas, Hava
Amaç: Günlük hayatta kullanılan elektrikli cihazlardan yayılan çok düşük frekanslı elektromanyetik alanlara (ELF-EMF)maruz kalınması, hücresel düzeyde çeşitli değişikliklere neden olabilmektedir. Glioblastoma multiform (GBM), yüksekmortalite ile sonuçlanan agresif bir beyin kanseridir. Tedavi yöntemlerindeki ilerlemelere rağmen, GBM tedaviedilemeyen bir hastalık olarak kalmıştır. Diğer taraftan, GBM hastalarında kullanılan antineoplastik ajanların etkinliğiniazaltabilecek faktörlere karşı önlem alınması da önem kazanmıştır. Antineoplastik bir ajan olan irinotekan, GBM hastalarıiçin kullanılan ilaçlardan biridir. Bu ön çalışmanın amacı, ELF-EMF'nin GBM hücreleri üzerinde irinotekan sitotoksisitesiüzerindeki etkisini incelemektir. Yöntemler: Kontrol grubundaki GBM hücrelerine (U87), farklı konsantrasyonlarda irinotekan (0, 1, 2, 10, 25, 50, 75 ve150 µM) uygulandı. Çalışma grubundaki hücrelere ise, ELF-EMF (50 Hz, 1 mT) ve irinotekan, 1 saat süreyle eş zamanlıuygulandı. Sitotoksisite, XTT testi ile belirlendi. Bulgular: IC50 (yarı-maksimum inhibisyon konsantrasyon) değeri, kontrol grubunda 14,31 µM iken, çalışma grubunda20,51 µM olarak bulundu.Sonuç: Çalışmanın sonuçları, ELF-EMF'nin irinotekanın U87 hücreleri üzerindeki etkinliğini tam olarak bilinmeyen birmekanizma ile azalttığını gösterdi. Bu nedenle, irinotekan ile kemoterapi alan hastaların ELF-EMF'lerden kaçınmak içindaha fazla dikkat göstermeleri gerekmektedir. ELF-EMF'lerin irinotekan sitotoksisitesi üzerindeki etkinliğini hangimekanizmalar aracılığı ortaya koyduğunu göstermek için daha ileri çalışmalara ihtiyaç vardır.
Comparison of Effects of 2.4 Ghz Wi-Fi and Mobile Phone Exposure on Human Placenta and Cord Blood
(Taylor & Francis Ltd, 2020) Bektas, Hava; Dasdag, Suleyman; Bektas, Mehmet Selcuk
The aim of this study was to investigate the effects of radiofrequency radiation emitted from Wi-Fi systems and mobile phones on cord blood and placenta. The study included 149 pregnant women who were divided in subgroups: unexposed (control), mobile phone exposed, Wi-Fi exposed and mobile phone plus Wi-Fi exposed groups. Immediately after birth, placenta and cord blood samples were collected and protein carbonyl (PCO), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status, 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels and DNA single strand breaks were analysed. The results of the study showed an increase in 8-OHdG, MDA, PCO and TOS in cord blood and placenta in the group exposed to mobile phones during gestation. However, the group exposed to Wi-Fi did not show alterations in the studied oxidative stress parameters. On the other hand, tail intensity and tail moment of DNA in the mobile phone exposure groups were higher than those in the control and Wi-Fi exposure groups. In conclusion, the results of this study indicated that mobile phone exposure during pregnancy could have an important potential to cause oxidative stress and DNA damage in cord blood and placenta. The results of this study also indicated that combined effects of Wi-Fi plus mobile phone exposure have a higher potential to cause synergistic harmful effects.
Effect of Mobile Phone Usage Duration During Pregnancy on the General Motor Movements of Infants
(Taylor & Francis Ltd, 2022) Bektas, Hava; Bektas, Mehmet Selcuk; Dasdag, Suleyman
Radiofrequency radiation (RFR) emitted from wireless devices increases rapidly and the most sensitive groups are pregnant women and children. Therefore, we aimed to evaluate the fidgety movements (FMs) and motor repertoires of the infants of pregnant women with different durations of mobile phone usage (DOMFU) in the prenatal period by performing a general movement assessment (GMA) using the Prechtl method. Infants suitable for the study were divided into 4 groups according to their mothers' duration of mobile phone usage during pregnancy, comprising those who did not talk on a mobile phone (Control Group, n: 31), those with mobile phone usage (MFU) of similar to 20 min a day (Group 1, n: 33), those with MFU of similar to 40 min a day (Group 2, n: 31), and those with MFU of similar to 2 h a day (Group 3, n: 28). The analysis showed that the abnormal fidgety (AF) and absent fidgety (F-), suboptimal motor optimality score (MOS) and reduced motor repertoire were statistically higher in Group 3 compared to the other groups. Normal posture and the quality of other movements were statistically higher in the Control, and Groups 1 and 2 compared to Group 3. According to the findings, infants of mothers with different DOMFU during pregnancy differed with regard to the quality of FMs, MOS, repertoire, posture and other movements. In conclusion, the findings suggested that there may be a relationship between prenatal RFR exposure and motor development in infants. More long-term studies are needed to determine whether these changes are temporary or permanent.
Effects of 3.5 Ghz Radiofrequency Radiation on Ghrelin, Nesfatin-1, and Irisin Level in Diabetic and Healthy Brains
(Elsevier, 2022) Bektas, Hava; Algul, Sermin; Altindag, Fikret; Yegin, Korkut; Akdag, Mehmet Zulkuf; Dasdag, Suleyman
Diabetes, mobile phone use, and obesity have increased simultaneously in recent years. The radiofrequency radiation (RFR) emitted from mobile phones is largely absorbed in the heads of users. With 5 G, which has started to be used in some countries without the necessary precautions being taken, the amount of RFR to which living things are exposed will increase. In this study, the changes in energy homeostasis and redox balance caused by 5 G (3.5 GHz, GSM-modulated) were explored. The effects of RFR on the brains of diabetic and healthy rats were investigated and histopathological analysis was performed. Twenty-eight Wistar albino rats weighing 200-250 g were divided into 4 groups as sham, RFR, diabetes, and RFR+diabetes groups (n = 7). The rats in each group were kept in a plexiglass carousel for 2 h a day for 30 days. While the rats in the experimental groups were exposed to RFR for 2 h a day, the rats in the sham group were kept under the same experimental conditions but with the radiofrequency generator turned off. At the end of the experiment, brain tissues were collected from euthanized rats. Total antioxidant (TAS), total oxidant (TOS), hydrogen peroxide (H2O2), ghrelin, nesfatin-1, and irisin levels were determined. In addition, histopathological analyses of the brain tissues were performed. The specific absorption rate in the gray matter of the brain was calculated as 323 mW/kg and 195 mW/kg for 1 g and 10 g averaging, respectively. After RFR exposure among diabetic and healthy rats, decreased TAS levels and increased TOS and H2O2 levels were observed in brain tissues. RFR caused increases in ghrelin and irisin and a decrease in nesfatin-1 in the brain. It was also observed that RFR increased the number of degenerated neurons in the hippocampus. Our results indicate that 3.5 GHz RFR causes changes in the energy metabolism and appetite of both healthy and diabetic rats. Thus, 5 G may not be innocent in terms of its biological effects, especially in the presence of diabetes.
Effects of 3.5-Ghz Radiofrequency Radiation on Energy-Regulatory Hormone Levels in the Blood and Adipose Tissue
(Wiley, 2024) Bektas, Hava; Dasdag, Suleyman; Altindag, Fikret; Akdag, Mehmet Z.; Yegin, Korkut; Algul, Sermin
In recent years exposure of living beings to radiofrequency radiation (RFR) emitted from wireless equipment has increased. In this study, we investigated the effects of 3.5-GHz RFR on hormones that regulate energy metabolism in the body. Twenty-eight rats were divided into four groups: healthy sham (n = 7), healthy RFR (n = 7), diabetic sham (n = 7), and diabetic RFR (n = 7). Over a month, each group spent 2 h/day in a Plexiglas carousel. The rats in the experimental group were exposed to RFR, but the sham groups were not. At the end of the experiment, blood and adipose tissues were collected from euthanized rats. Total antioxidant, total oxidant, hydrogen peroxide, ghrelin, nesfatin-1, and irisin were determined. Insulin expression in pancreatic tissues was examined by immunohistochemical analysis. Whole body specific absorption rate was 37 mW/kg. For the parameters analyzed in blood and fat, the estimated effect size varied within the ranges of 0.215-0.929 and 0.503-0.839, respectively. The blood and adipose nesfatin-1 (p = 0.002), blood and pancreatic insulin are decreased, (p = 0.001), gherelin (p = 0.020), irisin (p = 0.020), and blood glucose (p = 0.040) are increased in healthy and diabetic rats exposed to RFR. While nesfatin-1 are negatively correlated with oxidative stress, hyperglycemia and insulin, ghrelin and irisin are positively correlated with oxidative stress and hyperglycemia. Thus, RFR may have deleterious effects on energy metabolism, particularly in the presence of diabetes. 3.5 GHz radiofrequency radiation (RFR) may induce alterations in hormones regulating energy metabolism. 3.5 GHz RFR may lead to alterations in total antioxidant, total oxidant, and hydrogen peroxide levels. Particularly in conjunction with diabetes, 3.5 GHz RFR may result in adverse effects on energy metabolism. Although there were changes of the hormone levels in the exposed group, the actual values remained for both sham and exposed groups within the normal range.
Effects of Mobile Phone Exposure on Biochemical Parameters of Cord Blood: a Preliminary Study
(Taylor & Francis inc, 2018) Bektas, Hava; Bektas, Mehmet Selcuk; Dasdag, Suleyman
The purpose of this study is to investigate foetal impact of radiofrequencies (RFs) emitted from mobile phones in postnatal cord blood. The study carried on 149 pregnant women divided into four groups such as nonusers of mobile phone (n: 37; control group), 2-15min/d (n: 39; group 1), 15-60min/d (n: 37; group 2) and participants using mobile phone for more than 60min/d (n: 36; group 3). Cord blood of the infants was taken in all groups for biochemical analyses immediately after birth. The results of the study showed that the biggest foetal impact was observed in the third study group which was pregnant exposed RFRs (RF radiation) more than 1h/d (1hour per day). AST (aspartat aminotransferaz), ALT (alanine aminotransferase), LDH (lactate dehydrogenase), CK (creatine kinase), CK-MB (creatine kinase-miyocardial band), CRP (c-reactive protein), PCT (procalcitonin), TnT (troponin T), uric acid and lactate levels of third group were found higher than the other groups (p<0.001). However, Mean platelet volume values of third group were found lower than the other groups (p<0.001). Finally, this is the first human study which was performed on pregnant and infants because there is no previous work in this area. However, the results of this study revealed that long-term RFR exposure of pregnant may result in some biochemical changes in the infants. Therefore, our suggestion to pregnant is to avoid from RFR exposure emitted from mobile phones at least during pregnancy.
The Effects of Radiofrequency Radiation on Male Reproductive Health and Potential Mechanisms
(Taylor & Francis inc, 2025) Bektas, Hava; Dasdag, Suleyman
Recent studies have demonstrated that radiofrequency (RF) radiation emanating from devices such as mobile phones and Wi-Fi may have adverse effects on male reproductive health. This radiation can elevate testicular temperature, potentially compromising sperm quality and DNA integrity, and influence the specific absorption rate (SAR) across different body regions, leading to detrimental reproductive outcomes. Furthermore, exposure to RF radiation has been linked to conditions that could affect male reproductive function, such as oxidative stress, alterations in ion transitions across cell membranes, and inflammation. The article reviews research conducted on both humans and animal models regarding the effects of electromagnetic radiation on sperm quality, DNA damage, oxidative stress, hormone levels, and testicular function, suggesting that exposure to electromagnetic radiation could have harmful implications for male reproductive health. However, further research is necessary to fully understand the mechanisms and implications of non-ionizing electromagnetic radiation on male infertility.
Kadınların Gebelik Esnasında Cep Telefonu Kullanımı Bebeklerde İşitme Sorunlarına Sebep Oluyor Mu? Ön Gözlem
(2020) Dasdag, Suleyman; Bektas, Hava; Bektaş, Mehmet Selçuk
AmaçBazı çalışmalarda, cep telefonları ile uzun süreli görüşme yapmanın işitme kaybına neden olabileceği ileri sürülmektedir. Ancak gebelik esnasında cep telefonu kullanımının anne karnındaki bebeklerin işitme yetileri üzerinde etkileri olup olmadığı araştırılmamıştır. Bu nedenle, insan popülasyonu üzerindeki bu çalışmamızdaki amacımız cep telefonlarından yayılan intrauterin radyofrekans radyasyonuna (RFR) maruz kalmanın yenidoğanların işitme yetileri üzerindeki etkilerini araştırmaktı.YöntemÇalışma popülasyonu 149 yenidoğandan oluşmaktadır. Çalışmadaki gebeler, RFR maruziyet süresine göre 4 gruba ayrılmış olup bunlar, RFR’ye maruz kalmama, RFR’ye 2–15 dakika/gün maruziyet, RFR’ye 15–60 dakika/gün maruziyet ve RFR’ye 60 dakika/gün’den fazla maruziyet gruplarıdır. Yenidoğanlarda geçici uyarılmış otoakustik emisyon ve oto-işitsel beyin sapı yanıtı şeklinde gerçekleştirilen işitme taraması analizlerinin sonuçları retrospektif olarak araştırılmıştır.BulgularBulgular, gebelik esnasında 900 ve 1800 MHz RFR maruziyetinin yenidoğanlarda işitme kaybına yol açmadığını göstermiştir.SonuçSonuç olarak, yenidoğanlarda işitme hassasiyetinin ve çevre sesi algısının intrauterin dönemde cep telefonlarının yaydığı RFR maruziyetinden etkilenmediğini gözlemledik. Konuyu açıklığa kavuşturmak için ek çalışmalar yapılmalıdır.
Radiofrequency Radiation and Alzheimer's Disease: Harmful and Therapeutic Implications
(Taylor & Francis Ltd, 2025) Bektas, Hava; Dasdag, Suleyman
PurposeAlzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. The relationship between AD and radiofrequency (RF) radiation emitted by wireless devices remains under investigation. The aim of this review is to comprehensively explore the effects of RF radiation on AD by evaluating existing literature. This review used Web of Science, Scopus, and PubMed to find relevant studies on AD and RF radiation. This review evaluates a total of 81 studies, including animal models, human studies, and in vitro experiments, with results summarized in tables for clarity. ConclusionSome studies suggest RF aggravates AD by increasing oxidative stress, impairing blood-brain barrier integrity, and promoting amyloid-beta deposition. Conversely, other studies indicate RF may have protective benefits, such as enhancing brain mitochondrial functions and reducing amyloid-beta levels. Understanding the RF-AD relationship, including parameters like frequency and exposure time, is crucial for therapeutic strategies. The studies reviewed highlight RF radiation's dual effects on AD, underscoring the need for a detailed approach. Further studies are required to clarify these effects and inform preventive and therapeutic measures.