Browsing by Author "Delen, V."

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The Clinical Effect of Platelet-Rich Plasma Injections on Symptomatic Meniscal Tears of the Knee
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Delen, V.; Ediz, L.; Alpaycı, M.
This study aims to assess the clinical efficacy of intra-articular platelet-rich plasma injections in symptomatic meniscus tears of the knee. Forty one patients (12 males, 29 females; mean age 38.2±8.37 years; range 21 to 50 years) with meniscal tear included in the study. Lateral patellofemoral approach was used for intra-articular platelet-rich plasma injections. The platelet-rich plasma applications were performed three times one week apart. Patients were evaluated usingVisual Analogue Scale (VAS) and Lequesne Index. Baseline scores were obtained pre-first injection and compared to satisfaction scores one-and four-weeks post-last injections. Compared with pre-treatment, at post-treatment weeks 1 and 4, both VAS and Lequesne Index scores significantly decreased (p<0.001). Also, compared with post-treatment week 1, at post-treatment week 4, both VAS and Lequesne Index scores significantly decreased (p<0.001). Our study results suggest that platelet-rich plasma injections improve pain and disability in patients with meniscus tears of the knee. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Efficacies of Medicinal Leech Therapy and Platelet Rich Plasma Injection Added To Muscle Stretching Exercises in the Treatment of Myofascial Pain Syndrome
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Ediz, L.; Çağaç, A.; Delen, V.
Myofascial pain syndrome is among the most common cause of physical disability and severe chronic muscle pain and affect millions of people worldwide. So far muscle stretching exercises and some therapeutic interventions have been recommended with various effects. Sixty-six patients with myofascial pain syndrome due to trigger points in trapezius muscle were included in this study. Patients were divided randomly into 2 groups of 33 patients: group 1; medicinal leech therapy group, group 2; platelet rich plasma injection group. To the first group, 4 medicinal leech were applied to the trigger points 2 times in a 4 week interval . To the second group, a total of 2 ml platelet rich plasma was administered to each trigger point 2 times in a 4 week interval. All patients had also taught and given trapezius muscle stretching exercises for ten minutes as a daily diary schedule for 12 weeks. At the end of the study there was a significant decrease in visual analogue scale scores in both groups, while a significant increase in pain threshold values in medicinal leech therapy group (p<0.05). Significant differences were found between groups in short form-36 pain, general health and vitality scores in favor of leech therapy group (p <0.05). Although both methods were found effective in the treatment of myofascial pain syndrome, the clinical efficacy of medicinal leech therapy was greater than platelet rich plasma. Leech therapy seems to be an eff ective and reliable treatment option when added to muscle stretching exercises in myofascial pain syndrome. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Investigation of Relationship Between Lumbar Modic Changes and Serum Vitamin D Concentrations
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Ilter, S.; Delen, V.; Toprak, M.; Akçalı, R.
Introduction: There is limited and inconsistent data on the relationship between vitamin D deficiency and Modic changes (MCs). Also, which type of MCs is associated with vitamin D is not clear. Vitamin D has anti-inflammatory effects, while type 1 MCs has inflammatory nature. Accordingly, patients with type 1 may have lower vitamin D levels than those with type 2 MCs. This study aimed to com pare type 1 and type 2 MCs for serum vitamin D concentrations. Materials and Methods: Between May 2019 and July 2020, a total of 53 patients with type 1 or type 2 MCs were included in this study. Patients’ demographics were recorded, and back pain severity was assessed by using visual analog scale. Serum levels of vitamin D were measured as total 25-hydroxy vitamin D. Accordingly, serum levels of vitamin D (µg/L) are graded as deficient (<20), insufficient (20-30), and sufficient (30-80). Results: Type 1 MCs (n=26) and type 2 MCs (n=27) groups were similar in age (p=0.199), gender, BMI, work status, pain duration, vitamin D concentration, degree of vitamin D deficiency (p=0.773), and spinal levels. Type 1 MCs patients had more painful low back than type 2 MCs patients. Conclusion: Type 1 MCs are similar to type 2 MCs for serum vitamin D concentration. The more painful low back of type 1 MCs may be related to its inflammatory nature, but may not be associated with vitamin D insufficiency. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Is Gdf5 Gene Promoter Polymorphism+104t/C Associated With Osteoarthritis in the Eastern of Turkey Population
(C M B Assoc, 2017) Tuluce, Y.; Yildirim, I. H.; Ozkol, H.; EdiZ, L.; Delen, V.
Osteoarthritis (OA) is the most common form of arthritis. Genetic factors have been shown to play important roles in the etiology of OA. The gene growth differentiation factor 5 (GDF5) has been implicated in skeletal development and joint morphogenesis in human and mice. A functional single nucleotide polymorphism (SNP) +104T/C in the 5'-UTR of GDF5 (rs143383) was reported to be associated with osteoarthritis susceptibility in Han Chinese and Japanese populations. Our objective was to assess whether this SNP was also associated with OA in the Eastern Turkey population. A total of 172 cases including 95 patients with idiopathic OA and 77 control cases were recruited into the study. DNA samples were extracted from peripheral blood lymphocytes of all cases by using salting out method. The +104T/C polymorphism was genotyped by PCR-RFLP method. In terms of genotype comparison there wasn't any correlation between patient and control groups. Frequency of C allele was found to be higher in-patient group than control group and statistical analysis showed a poor correlation in allele frequencies of the +104T/C SNP of GDF5 gene between cases and controls (p< 0.05). Significant correlation between GDF5 and OA has been reported in Asian population, especially T alleles were found in higher frequencies and related to OA. Our study did not confirm this association and also in term of T allele. Interestingly, we found higher frequency of C allele in patient group than control group and our results are compatible with the study carried out in Greek population.