Browsing by Author "Delen, Veysel"

Now showing 1 - 10 of 10

Anti-Ccp Antibody Levels Are Not Associated With Ms: Results From a Case-Control Study
(Hindawi Ltd, 2015) Alpayci, Mahmut; Milanlioglu, Aysel; Delen, Veysel; Aydin, Mehmet Nuri; Guducuoglu, Huseyin; Bayram, Yasemin
Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 +/- 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 +/- 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 +/- 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls (P < 0.001). Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores (r = -0.250). In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.
A Case of X-Linked Recessive Spondyloepiphyseal Dysplasia Tarda
(derman Medical Publ, 2013) Alpayci, Mahmut; Delen, Veysel
X-Linked recessive spondyloepiphyseal dysplasia tarda (SEDT) is a very rare disorder that mostly affects males and is characterized by short stature, arm span typically exceeding height, and barrel chest deformity. In affected patients, the center of the vertebral epiphysis is involved, the formation of the epiphysis is delayed, and platyspondyly (flattened vertebral bodies) occurs over time. In addition, progressive joint and back pain with degenerative process due to early onset of osteoarthritis and osteoporosis may ensue. Motor and cognitive functions are normal in such patients. The diagnosis of X-linked recessive SEDT is still based on a combination of clinical and radiographic features, and pedigree analysis. Molecular analysis is only needed for the confirmatory diagnosis, especially in suspected cases. This article is a case report focusing on the diagnostic findings of X-linked recessive SEDT.
Comparative Effects of Focused and Radial Extracorporeal Shock Wave Therapies on Lateral Epicondylitis: a Randomised Sham-Controlled Trial
(Coll Physicians & Surgeons Pakistan, 2023) Kaplan, Seyhmus; Sah, Volkan; Ozkan, Sezai; Adanas, Cihan; Delen, Veysel
Objective: To evaluate and compare the effects of radial and focused types of extracorporeal shock wave therapy (ESWT) on lateral epicondylitis.Study Design: A randomised sham-controlled trial. Place and Duration of the Study: Department of Sports Medicine, Yuzuncu Yil University Hospital, Van, Turkiye, from August 2019 to April 2020. Methodology: Patients with acute lateral epicondylitis were randomised into focused, radial, and sham ESWT groups. The ESWT was applied for three sessions at 2-4 days intervals. All the subjects were evaluated at baseline (week 0), week 5, and 13. Patient-rated tennis elbow evaluation (PRTEE) scores were used as outcome measures. Results: At weeks 5 and 13, all PRTEE scores (pain, function, and total) were remarkably improved in the focused and radial groups (p<0.001), but not in the sham group (p>0.05). Focused ESWT was superior to radial ESWT for the change of pain scores from baseline to week 5 (18.8 +/- 13.9 vs. 11.8 +/- 9.1; p=0.026) and week 13 (17.8 +/- 13.1 vs. 11.7 +/- 10.5, p=0.084). Focused ESWT was more effective than radial ESWT for the change of function scores from baseline to weak 5 (17.9 +/- 12.5 vs. 11.2 +/- 9.5; p=0.025) and week 13 (16.9 +/- 11.6 vs. 10.7 +/- 10.1; p=0.032). Focused ESWT was superior to radial ESWT for the change of total scores from baseline to week 5 (36.7 +/- 25.9 vs. 23.0 +/- 17.2; p=0.021) and week 13 (34.7 +/- 24.3 vs. 22.4 +/- 18.5; p=0.044). Conclusion: Focused and radial ESWT are effective in lateral epicondylitis. The focused ESWT is superior to the radial ESWT. Thus, focused ESWT should be preferred in lateral epicondylitis.
Decreased Neck Muscle Strength in Patients With the Loss of Cervical Lordosis
(Elsevier Sci Ltd, 2016) Alpayci, Mahmut; Senkoy, Emre; Delen, Veysel; Sah, Volkan; Yazmalar, Levent; Erden, Metin; Kaplan, Seyhmus
Background: The loss of cervical lordosis is associated with some negative clinical outcomes. No previous study has examined cervical muscle strength, specifically in patients with the loss of cervical lordosis. This study aims to investigate whether there is weakness of the cervical muscles or an imbalance between cervical flexor and extensor muscle strength in patients with the loss of cervical lordosis compared with healthy controls matched by age, gender, body mass index (BMI), and employment status. Methods: Thirty-two patients with the loss of cervical lordosis (23 F, 9 M) and 31 healthy volunteers (23 F, 8 M) were included in the study. Maximal isometric neck extension and flexion strength, and the strength ratio between extension and flexion were used as evaluation parameters. All measurements were conducted by a blinded assessor using a digital force gauge. The participants were positioned on a chair in a neutral cervical position and without the trunk inclined during measurements. Findings: Maximal isometric neck extension and flexion strength values were significantly lower in the patients versus healthy controls (P<0.001 and P = 0.040, respectively). The mean (SD) values of the extension/flexion ratio were 1.21 (0.34) in the patients and 1.46 +/- 0.33 in the controls (P = 0.004). Interpretation: According to our results, patients with the loss of cervical lordosis have reduced neck muscle strength, especially in the extensors. These findings may be beneficial for optimizing cervical exercise prescriptions. (C) 2016 Elsevier Ltd. All rights reserved.
Evaluation of Effectiveness of Prp Application With Clinical Parameters on Patients Diagnosed With Knee Meniscal Tear
(2014) Delen, Veysel; Ediz, Levent
Amaç: Bu çalışmada hastanemiz Fiziksel Tıp ve Rehabilitasyon polikliniğinde grade 2 ile grade 3 diz menisküs yırtığı tanısı konmuş olan hastalarda trombositten zengin plazma (PRP) uygulamasını diz eklem bölgesine tedavi amacıyla uygulayıp, PRP uygulamasının hastanın diz ağrısı ve klinik parametreleri üzerindeki etkinliğini ortaya koymak amaçlanmıştır. Gereç ve Yöntem: Bu çalışmaya Ekim 2013-Mayıs 2014 tarihleri arasında Y.Y.Ü. Tıp Fakültesi Dursun Odabaş Tıp Merkezi Fiziksel Tıp ve Rehabilitasyon polikliniğine başvuran ve diz MR sonucunda grade 2 ile grade 3 diz menisküs yırtığı tanısı almış olan ve araştırmaya alınma kriterlerine uyan 41 hasta alındı. Sonuç değişkenleri olarak da Vizüel Analog Skala (VAS) skoruna göre ağrı ve Lequesne fonksiyonel skalası değerlendirildi. Çalışmada elde edilen bulgular değerlendirilirken, istatistiksel analizler için SPSS (Statistical Package for Social Sciences) for Windows 13,0 istatistik paket programı kullanıldı. Bulgular: Çalışma, diz menisküs yırtığı tanısı almış olan 12'si erkek (% 29.26) ve 29'u bayan ( % 70.74) olmak üzere toplam 41 olgu üzerinde yapıldı. Olguların yaşları 21 ile 50 arasında değişmekte olup ortalama yaş 38,20 yıl olarak saptandı. Olguların diz menisküs yırtığında hangi tarafın ne kadar sıklıkta tutulumuna bakıldığında menisküs yırtığı lezyonunun; erkeklerde sağ dizde 4 (% 33) sol dizde 8 (% 77), bayanlarda sağ dizde 11 (% 38) sol dizde 18 (% 62) ve toplamda sağ dizde 15 (% 36,5) sol dizde 26 (% 63,5) olduğu saptandı. Olgularda VAS'a göre ağrının değerlendirilmesinde, olguların tedavi öncesi (VAS 0) ağrı düzeyi hem tedavi sonrası 1.hafta (VAS 1) hemde tedaviden sonraki 4. haftadaki takip bulgularıyla (VAS 4) karşılaştırıldığında düzelme istatistiksel olarak anlamlı bulunmuştur (p<0,001). Hastaların VAS 1 düzeyi VAS 0'dan daha düşük ve VAS 4 düzeyi hem VAS 0 hemde VAS 1'den daha düşük bulunmuştur. Olgularda Lequesne Fonksiyonel İndeks skoru değerlendirilmesinde, olguların tedavi öncesi (Lequesne 0) fonksiyonel düzeyi hem tedavi sonrası 1.hafta (Lequesne 1) hemde tedaviden sonraki 4. haftadaki takip bulgularıyla (Lequesne 4) karşılaştırıldığında düzelme istatistiksel olarak anlamlı bulunmuştur (p<0,001). Hastaların Lequesne 1 düzeyi Lequesne 0'dan daha düşük ve Lequesne 4 düzeyi hem Lequesne 0 hemde Lequesne 1'den daha düşük bulunmuştur. Sonuç: Hastaların toplamda 1,5 ay süresince takip edildiği çalışmamızda diz menisküs yırtığı olan hastalarda intraartiküler PRP tedavi uygulamasının etkin ve güvenilir bir yöntem olduğu düşünüldü. Anahtar Sözcükler: Diz menisküs yırtığı, Trombositten zengin plazma (PRP), Menisküs yırtığında PRP uygulaması
Gebelikte Kalçanın Geçici Osteoporozu ve Sakral Yetersizlik Kırığı: Bir Olgu Sunumu
(2016) Alpaycı, Mahmut; Ediz, Levent; Hız, Özcan; Delen, Veysel
Kalçanın geçici osteoporozu spontan olarak başlayankalça ağrısının bir süre sonra ortadan kalkması ve femurbaşında geç ortaya çıkan osteoporoz görünümü ilekarakterize olan nadir rastlanan klinik bir durumdur. Bizbu makalede, gebeliğin 3. trimesterinde bel ağrısışikayeti ile başvurup normal doğum sonrasındaağrılarında artış olan hastanın magnetik rezonansgörüntülemesinde femur başında ödem, sakroiliakeklemin sakral bölgesinde ödem ve sakrum fraktürütespit edilen, kalçanın geçici osteoporozu ve osteomalazitanısı alan bir olguyu sunduk
Headache Characteristics in Chronic Neck Pain Patients With Loss of Cervical Lordosis: a Cross- Sectional Study Considering Cervicogenic Headache
(int Scientific information, inc, 2023) Delen, Veysel; Ilter, Server
Background: Loss of cervical lordosis and cervicogenic headache have similar tissue abnormalities, including weakness and atrophy in the neck muscles. Cervicogenic headache is mainly unilateral and is perceived in the occipito-tem-poro-frontal regions. However, it is not clear whether loss of cervical lordosis is a sign of headache with cervi-cal origin. Herein, we aimed to assess and compare headache characteristics in patients with and without loss of cervical lordosis. Material/Methods: This was a cross-sectional study conducted on chronic neck pain patients with (n=38; F/M: 28/10; mean age 33.34 +/- 7.73 yrs; range 18 to 45 yrs) and without loss of cervical lordosis (n=38; F/M: 29/9; mean age 33.13 +/- 6.41 years; range 20 to 45 years), between May 2019 and November 2019. The 2 groups were assessed and com-pared for headache characteristics such as frequency, severity, localization, lateralization, duration, and spread scores. Cervical lordosis was assessed on the lateral cervical radiographs by using posterior tangent technique measuring the C2-C7 total cervical spine angle. Results: The 2 groups were similar for individual features, including age, sex, employment status, and duration of neck pain (P>0.05). The duration of headache attack was longer in patients with loss of cervical lordosis (5.72 +/- 8.12) than in those with normal cervical lordosis (3.29 +/- 3.92) (P=0.009). However, there were no significant differ-ences between the 2 groups for headache characteristics, including frequency, severity, localization, lateraliza-tion, and spread scores (P>0.05). Conclusions: Patients with loss of cervical lordosis have longer duration of headache attack than those without. Loss of cer-vical lordosis may be a specific finding associated with longer cervicogenic headache attacks.
Loss of Cervical Lordosis in Chronic Neck Pain Patients With Fibromyalgia: a Cross-Sectional Study
(Ios Press, 2023) Delen, Veysel; Ilter, Server
BACKGROUND: Some interrelationships among fibromyalgia (FM), loss of cervical lordosis (LCL), and headache have been reported. Thus, it is sensible to examine LCL as a factor underlying FM and headache. OBJECTIVE: In this study we aimed to assess LCL in chronic neck pain patients (CNPP) with FM and its association with headache features and FM severity. METHODS: CNPP with (n = 55; mean age 40.0 +/- 8.5; range 20 to 55 years) and without FM (n = 55; mean age 38.5 +/- 8.9; range 20 to 55 years) were included in the study. Cervical lordosis was assessed by measuring the Cobb angle on the lateral cervical radiographs. The patients were asked about headache features within the last month. In addition, the CNPP with FM were evaluated by the Turkish version of the Revised Fibromyalgia Impact Questionnaire. RESULTS: There were no statistically significant differences between the groups in terms of age, weight, height, body mass index, working status, and neck pain duration (p > 0.05 for each). The CNPP with FM had significantly reduced cervical lordosis angle compared with those without. The CNPP with FM had significantly higher headache frequency than those without (p = 0.008). There was statistically significant negative correlation between cervical lordosis angle and headache frequency in the CNPP with FM (r: 0.336; p = 0.012). CONCLUSION: According to the results of this study, LCL may be associated with FM and headache frequency in the CNPP with FM.
The Prevalence of "mefv" Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2014) Ozkol, Halil; Yildirim, Ibrahim Halil; Tuluce, Yasin; Ediz, Levent; Delen, Veysel; Gulcu, Elif
Objective: An inhibitory protein of inflammation pyrin/marenostrin is encoded by the Mediterranean fever (MEFV) gene. Mutations of this gene are known to cause familial Mediterranean fever (FMF) disease. A relation between mutations of the MEFV gene and rheumatic diseases was also suggested. The aim of the present study was to investigate the frequency of four common mutations of the MEFV gene in 110 rheumatoid arthritis (RA) patients and 98 healthy controls (HC) inhabiting a region of eastern Turkey. Material and Methods: DNA extraction was realized by salting out method from peripheral blood lymphocytes of all subjects included in the study. Polymerase chain reactions (PCR) amplification of exon 10 was performed by the appropriate primers, and single-nucleotide polymorphisms (SNPs) were detected by specific restriction endonucleases recognizing the mutational DNA or wild-type DNA regions. Results: Mutation frequency of RA patients was higher than in HC, but this result was not statistically significant (p>0.05). Conclusion: The MEFV mutation rate of RA patients living in eastern Turkey was not significantly different from HC. Further studies are needed to investigate other gene mutations that may affect RA etiopathogenesis.
Vertigo ve Tinnitusun Servikal Lordoz Kaybı ile İlişkisi
(2023) Delen, Veysel; Bozan, Nazım
Giriş: Servikal lordoz kaybı, servikojenik somatik tinnitus ve servikojenik vertigo bazı benzerliklere sahiptir. Servikojenik somatik tinnitus ve servikojenik vertigo için spesifik bir laboratuvar veya radyolojik bulgu yoktur. Çalışmada, servikal lordoz kaybı olan hastalarda tinnitus ve vertigo prevalanslarının değerlendirilmesi amaçlandı. Gereç ve Yöntem: Ocak 2022 ile Aralık 2022 arasında kronik boyun ağrılı toplam 70 hasta, servikal lordoz kaybı dikkate alınarak iki gruba ayrıldı. Bu hastalarda bireysel özellikler ve son bir ay içinde tinnitus ve vertigo varlığı sorgulandı. Servikal lordoz açısı posterior tanjant adı verilen bir yöntemle ölçüldü. Bulgular: İki grup bireysel özellikler açısından benzerlik gösterdi. Tinnitus prevalansı, servikal lordoz kaybı olanlarda (n=24) olmayanlara (n=46) göre daha yüksekti (%25'e karşı %17.4), ancak istatistik anlamlılık düzeyinde değildi (p=0.534). Vertigo prevalansı servikal lordoz kaybı olan hastalarda normal servikal lordozu olanlara göre artmıştı (%29.2'ye karşı %8.7) (p=0.038). Ayrıca servikal lordoz kaybı olan hastalarda tinnitus+vertigo prevalansı olmayanlara göre daha yüksekti (%25'e karşı %4.3) (p=0.017). Sonuç: Tinnitus için istatistik anlamlılık olmasa da, tinnitus ve vertigo servikal lordoz kaybı bulunan kronik boyun ağrılı hastalarda bulunmayanlara göre artmıştır. Servikal lordoz kaybı bu durumların tanı ve tedavi süreçlerinde kolaylaştırıcı bir bulgu olabilir.