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Browsing by Author "Demir, Ali"

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    Article
    Pleural Effusion Resultant After Upper Abdominal Surgery: Analysis of 47 Cases
    (derman Medical Publ, 2011) Cobanoglu, Ufuk; Bartin, Mehmet Kadir; Mergan, Duygu; Yilmaz, Ozkan; Demir, Ali; Toktas, Osman
    Aim Postoperative pulmonary complications, following upper abdominal surgery, occur at a rate which is higher, than lower abdominal surgery. One of these complications is pleural effusion. In this study, the frequency and causes of pleural effusions and the changes of the blood gas values and pulmonary functions of the patients with pleural effusions, occured after upper abdominal surgery are discussed in the accompaniment of the literature. Material and Methods 148 patients to whom upper adominal surgery is performed and in 47 of these patients pleural effusion is developed (31.75%), were examined restrospectivitely. Preoperative and postoperative pulmonary function tests (PFT) and arterial blood gas (ABG) results and the blood proteins, albumin values were recorded. The anesthesia type, the surgery properties, involving type of surgery and the surgical incision were determined. Results Pleural effusion is detected bilaterally in 8 patients (17: 02), at the right side in 21 patients (44.69%), and at the left side in 18 patients (38.29%). The 40.42% (19 cases) of the patients who has pleural effusion in the postoperative period, had liver and gallbladder surgery, the % 23.41 (11 cases) had spleen and pancreas surgery and the % 36.17 (17 cases) had the other surgical procedures. Conclusions While the upper abdominal surgery, impairment of the integrity of the diaphragm's peritoneum that covers the abdominal cavity where there is a highliquid pressure, may cause the liquid transition to the pleural space that has a negative pressure. Hypoalbuminemia and hipoproteinemia, that will occur due to the changes of oral intake and diet regulation in the postoperative period, may cause a reason for the pleural effusion. For this reason, doctors who performed these surgery procedures, should not ignore this complication, in the period of postoperative follow-ups of the patients.
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    Article
    Serum Vascular Endothelial Growth Factor Receptor-3 Levels in Patients With Esophageal Squamous Cell Cancer
    (Edizioni Luigi Pozzi, 2017) Sumer, Aziz; Demir, Ali; Kemik, Ahu Sarbay; Yavuz, Alpaslan; Suvak, Burak; Dulger, Ahmet Cumhur; Kemik, Ozgur
    AIM: Esophageal cancer is one of the most aggressive tumors of the gastrointestinal tract. In this study, we quantified the serum vascular endothelial growth factor-3 (VEGFR-3) expression in patients with esophageal squamous cell carcinoma (ESCC) to evaluate the role of VEGFR-3 in ESCC. MATERIALS AND METHODS: Ninety five patients with ESCC were studied. Pre-therapy and preoperative samples were stored and ELISA was used to designate the concentrations of VEGFR-3. RESULTS: The serum values of VEGFR-3 were significantly higher in patients with ESCC than in healthy donors (p<0.0001). CONCLUSIONS: The results imply a very good sensitivity of VEGFR-3 in ESCC. VEGFR-3 may be a good diagnostic biomarker for ESCC.
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    Specialist Thesis
    The Importance of Vegf Receptor-3 Levels in Patients With Esophageal Cancer
    (2012) Demir, Ali; Sümer, Aziz
    Amaç: Lenf nodu metastazı malign kanserlerde görülür ve diğer sindirim sistemi kanserlerine göre özogafus kanserlerinde daha sık ortaya çıkar. Buna rağmen lenf nodu metastazı varlığını tespit edebilecek spesifik biomarkerler bulanamamıştır. Bu çalışmada, özofagus kanserinde VEGFR-3' ün rolünü değerlendirmek amacıyla özofagus kanserli hastalarda serum VEGFR-3 düzeyleri ölçülmüştür.Gereç ve Yöntem: Özofagus kanserli 95 hasta çalışıldı. Tedavi öncesi ve ameliyat öncesi numuneler alındı ve saklandı. VEGFR-3 konsantrasyonunu belirlemek için ELİSA yöntemi kullanıldıBulgular: Özofagus kanserli hastalarda serum VEGFR-3 değerleri diğer sağlıklı donörlere göre belirgin bir şekilde yüksek tespit edildi. ( p < 0.0001 )Tartışma: Özofagus kanserli hastalarda VEGFR-3 düzeyinin lenfanjiyogenetik ve anjiyogenetik marker olarak kullanılabileceğini düşünüyoruz. İleride yapılacak çalışmalar, VEGFR-3 klinik değerinin tümör anjiyogenezinde, lenfanjiiyogenetik markerler ve tümor markerlerı gibi belirlenmesini sağlayabilir.Anahtar Kelimeler: VEGFR-3; Özofagus Kanseri; Lenfanjiyogenez; Anjiyogenez