Browsing by Author "Demir, Ismail"

Now showing 1 - 19 of 19

Activity of Mannitol and Hypertonic Saline Therapy on the Oxidant and Antioxidant System During the Acute Term After Traumatic Brain Injury in the Rats
(Elsevier Science Bv, 2007) Yilmaz, Nebi; Dulger, Haluk; Kiymaz, Nejmi; Yilmaz, Cahide; Gudu, Burhan O.; Demir, Ismail
In this study, our objective is to investigate the effects of mannitol and 7.5% hypertonic saline (HS) therapy on the levels of malondialdehyde (MDA), catalase and glutathione peroxidase (GSH-Px) in the early stages of experimental head traumas in rats. Rats included in the study were divided into four groups: Group I Control, Group II Trauma, Group III Mannitol, and Group IV 7.5% Hypertonic Saline. Rats in Group 11 were subject to head trauma only. Mannitol was injected intraperitoneally to rats in Group III after head trauma and 7.5% HS was injected intraperitoneally to rats in Group IV after head trauma. Rats were sacrificed 4 h after administration of mannitol. or 7.5% HS, and the levels of MDA catalase and GSH-Px in brain tissues extracted from rats were determined. MDA levels in the trauma group were significantly increased compared with the control group (p<0.01), whereas there was a reduction in catalase and GSH-Px levels, although these differences were not significant. By contrast, in the mannitol group, MDA, catalase and GSH-Px levels were lower than the levels in the trauma group, and these reductions were statistically significant (p<0.05). The MDA, catalase and GSH-Px levels of the 7.5% HS group were lower than those of the trauma group; however, this reduction was not statistically significant. It was concluded that mannitol and 7.5% HS therapies that are used to reduce intracranial pressure and to increase the use of catalase, an antioxidant enzyme, and GSH-Px, are likely to reduce cellular damage by reducing the formation of MDA, the levels of which are known to be indicative of cellular level oxidant damage. (c) 2007 Elsevier B.V. All rights reserved.
Bowel Perforation at the Delayed Stage After Shunt Surgery: Case Report
(derman Medical Publ, 2012) Arslan, Mehmet; Yazici, Taner; Gudu, Burhan Oral; Demir, Ismail
Ventriculoperitoneal shunt surgery is common used procedure in the treatment of hydrocephalus. This invasive procedure has been associated with several abdominal complications. Bowel perforation from peritoneal catheter is rare, but is an important complication; if early diagnosis is established severe ventriculitis and sepsis may develop ascending infection from gasrointestinal flora migrating thorough catheter. A 7.5-year-old, ventriculoperitoneal shunted girl with hydrocephalus was admitted for recurrent meningitis. Computed tomographic scan revealed peritoneal catheter perforating the sigmoid colon. Bowel perforation should be considered definitely if there is recurrent meningitis without the rectal extrusion of peritoneal catheter in patients with shunt.
Cavernous Hemangioma Presenting as a Giant Cervical Mass: a Case Report
(Turkish Neurosurgical Soc, 2010) Kiymaz, Nejmi; Yilmaz, Nebi; Ozen, Suleyman; Demir, Ismail; Gudu, Burhan Oral; Kozan, Abdulbaki
Intramuscular hemangiomas of the head and, neck are rare congenital vascular tumors and are sparsely reported. Hemangiomas account for approximately 7% of benign tumors and usually present as a mass that suddenly enlarges. Hemangiomas are mostly seen on the trunk and extremities, but can also appear on the head and neck region. A 10-year-old boy was referred to our clinic for puffiness and swelling on the right side of his neck. Neurological examination was normal, but we observed an advanced degree of restriction in neck movement. An MRI study showed a soft tissue mass 9x8x5 in size. The mass was totally extracted by surgical intervention and pathological analysis revealed that it was a cavernous hemangioma. The patient's neck movement returned to normal after surgery. No relapse occurred during 1-year follow-up.
Cervical Spinal Dysraphism
(Karger, 2010) Kiymaz, Nejmi; Yilmaz, Nebi; Gudu, Burhan Oral; Demir, Ismail; Kozan, Abdulbaki
Objective: Cervical spinal dysraphism is a rare congenital spinal pathology. The results obtained from our series are compared with the results obtained from other series of studies in the literature. Methods: Seven patients with cervical myelomeningocele and meningocele who underwent surgery between January 1996 and March 2009 at the YYU Faculty of Medicine in the Department of Neurosurgery were retrospectively studied. Results: The referral ages of the patients (6 females and 1 male) varied between 4 days and 4 months (median 1 month). A stalk lesion covered with a dysplastic skin formed as a sac and located at the cervical midline was demonstrated in all of the patients. Cervical myelomeningocele was present in 4 patients, while cervical meningocele was present in 3 patients; however, Chiari type II malformation and hydrocephaly were present in 3 patients with myelomeningoceles. Diastematomyelia and a filum terminal lipoma were present in 1 of the patients. Conclusion: In this series, in contrast to the literature, we noted that the number of girls with spinal dysraphism with a cervical myelomeningocele and meningocele was greater than the number of boys. Chiari type II malformation, hydrocephaly and motor weakness in patients with cervical spinal dysraphism are less frequent when compared to patients with caudal spinal dysraphism. The structure of the sac is also more durable and, accordingly, a cerebrospinal fluid leakage is uncommon. Copyright (C) 2011 S. Karger AG, Basel
Comparison of Simultaneous Shunting To Delayed Shunting in Infants With Myelomeningocele in Terms of Shunt Infection Rate
(Turkish Neurosurgical Soc, 2011) Arslan, Mehmet; Eseoglu, Metehan; Gudu, Burhan Oral; Demir, Ismail; Kozan, Abdulbaki; Gokalp, Abdulsemat; Kiymaz, Nejmi
AIM: Timing of shunt insertion in infants with myelomeningocele (MM) and hydrocephalus (HCP) has been debated. Many authors have suggested to perform the repair of MM and shunt insertion during same operation. However, there is also an opposite view. MATERIAL and METHODS: We analyzed retrospectively 166 patients who underwent MM Sac repair to evaluate whether there are difference between these two methods in terms of shunt infection rate. RESULTS: In the same session,V-P (ventriculoperitoneal) shunt placement was performed onto 65 infants within the first 48 hours of postnatal and 36 infants were operated 48 hours after birth. In separate sessions, repair of MM were performed onto 29 infants within the first 48 hours of postnatal and shunting was peformed 7 days after sac repair. 14 infants were performed MM sac repair 48 hours after birth, then shunt was applied 7 days after closure of MM. Shunt infection rate in concurrently operated groups was markedly high (12.3 % in early surgery, 33.3% in late surgery); in separatedly operated groups' shunt infection rate was lower (3.44% in early surgery, 14.29% in late surgery). CONCLUSION: We propose to perform V-P shunt placement and MM repair in separate sessions.
A Craniocervical Teratoma With an Encephalocele-Like Appearance
(Turkish Neurosurgical Soc, 2012) Kiymaz, Nejmi; Demir, Ismail; Gudu, Burhan Oral
Teratomas are rare congenital tumors. Teratomas frequently occur in adult ovaries, but can be located primarily in the sacrococcygeal zone and intracranial compartment in newborns. Teratomas are rare in the head and neck region. Teratomas arise following a sequence of cells derived from more than one germ layer at different regions of the body due to a change in location of germ cells, and contain ectodermic, endodermic, and mesodermic tissues. Herein we detail the follow-up and treatment of a newborn with a mass that was located at the back of the head and was referred to our Neurosurgery Clinic with a pathologic diagnosis of a grade II-III immature teratoma resembling an encephalocele.
The Effects of Levosimendan Exposure on Oxidant/Antioxidant Status and Trace Element Levels in the Pulmonary Artery of Rats
(Springer, 2013) Ay, Yasin; Aydin, Cemalettin; Basel, Halil; Bektas, Hava; Bulut, Gulay; Inan, Bekir; Demir, Ismail
We investigated both the effect of levosimendan and the role of oxidant/antioxidant status and trace element levels in the pulmonary artery of rats. Fourteen male Wistar albino rats were randomly divided into two groups of seven animals each. Group 1 was not exposed to levosimendan and served as a control. Levosimendan (12 mu g/kg) diluted in 10 ml 0.9 % NaCl was administered intraperitoneally to group 2. Animals of both groups were killed after 3 days, and their pulmonary arteries were harvested to determine changes in tissue oxidant/antioxidant status and trace element levels. The animals in both groups were killed 72 h after the levosimendan exposure treatment, and pulmonary arteries were harvested to determine levels of the lipid peroxidation product MDA and the antioxidant GSH as well as the decreased activity of antioxidant enzymes such as SOD, GSH-Px and CAT. It was found that MDA levels increased in pulmonary artery tissues of rats after levosimendan administration. The GSH level decreased in the pulmonary artery of rats after levosimendan treatment. Co, Mn, Fe, Cd and Pb levels were significantly higher (P < 0.001) and Mg, Zn and Cu levels significantly lower (P < 0.001) in the levosimendan group compared to the control group. These results suggest that levosimendan treatment caused an increase in free radical production and a decrease in antioxidant enzyme activity in the pulmonary artery of levosimendan-treated rats. It also caused a decrease or increase in the levels of many minerals in the pulmonary artery, which is an undesirable condition for normal pharmacological function.
The Effects of Membranous Abnormalities on Mortality and Morbidity in Chronic Subdural Hematomas
(Journal Neurological Sciences, 2015) Ak, Hakan; Gulsen, Ismail; Yaycioglu, Soner; Atalay, Tugay; Demir, Ismail; Sosuncu, Enver; Arslan, Mehmet
Objective: Our aim was to evaluate the effects of membranous abnormalities on morbidity and mortality in chronic subdural hematomas (CSDH). Methodology: This retrospective study included 116 patients operated in three different hospitals during last three years. Patients were analyzed for the presence of trauma, operation type, recurrence, complication/s, presence of membranous abnormalities like thick outer membrane and septa formation, and mortality. Results: The mean age of the patients 62,06 +/- 11.4 ranging between 42 and 87. 78 (67.2%) of them were male and 38 (32.8%) were female The most common predisposing factor was the trauma especially in male gender. The presence of membranous abnormalities played significant effects on recurrence and complication rates. However, it didn't have significant effect on mortality. Conclusion: Trauma is still the most common etiological factor in chronic subdural hematomas. The presence of membranous abnormality in CSDH increases the recurrence and complication rates.
Indications of Brain Computed Tomography Scan in Children Younger Than 3 Years of Age With Minor Head Trauma
(Hindawi Ltd, 2014) Gulsen, Ismail; Ak, Hakan; Karadas, Sevdegul; Demir, Ismail; Bulut, Mehmet Deniz; Yaycioglu, Soner
Objective. To investigate the indications to receive brain computed tomography (CT) scan and to define the pathological findings in children younger than three years of age with minor head trauma in emergency departments. Methods. In this study, hospital case notes of 1350 children attending the emergency department of Bitlis State Hospital between January 2011 and June 2013 were retrospectively reviewed. 508 children under 3 years of age with minor head trauma were included in this study. We also asked 37 physicians about the indications for requiring CT in these children. Results. This study included 508 children, 233 (45,9%) of whom were female and 275 were male. In 476 (93,7%) children, the brain CT was completely normal. 89,2% of physicians asked in the emergency department during that time interval reported that they requested CT scan to protect themselves against malpractice litigation. Conclusion. In infants and children with minor head trauma, most CT scans were unnecessary and the fear of malpractice litigation of physicians was the most common reason for requesting a CT.
Metastatic Myxoid Liposarcoma of the Scalp: Case Report
(Ortadogu Ad Pres & Publ Co, 2012) Kiymaz, Nejmi; Yilmaz, Nebi; Gudu, Burhan Oral; Demir, Ismail; Gokalp, Abdulsemat
Liposarcomas are the second most frequent soft tissue sarcomas occurring in adults after malignant fibrous histiocytomas; however, liposarcomas rarely occur on the scalp. A mass was detected on the hairy skin of a 38-year-old male patient who had undergone surgery for a mass on the posterior aspect of the right thigh and had been diagnosed with a myxoid liposarcoma 3 years earlier. The patient had undergone total bulk excision and the histopathologic examination of the mass lesion revealed liposarcoma metastasis. Chemotherapy was initiated. Relapse or metastasis did not develop during 3 years of follow-up. Here we present a patient with a myxoid liposarcoma, which metastasized from the posterior side of the right thigh to the scalp.
Neuroprotective Effects of Thymoquinone on the Hippocampus in a Rat Model of Traumatic Brain Injury
(Elsevier Science inc, 2016) Gulsen, Ismail; Ak, Hakan; Colcimen, Nese; Alp, Hamit H.; Akyol, Mehmet E.; Demir, Ismail; Ragbetli, Murat C.
BACKGROUND: Traumatic brain injury is a leading cause of morbidity and mortality worldwide. We evaluated the neuroprotective effects of thymoquinone (TQ) in a rat model of traumatic brain injury by using biochemical and histopathologic methods for the first time. MATERIALS AND METHODS: Twenty-four rats were divided into sham (n = 8), trauma (n = 8), and TQ-treated (n = 8) groups. A moderate degree of head trauma was induced with the use of Feeney's falling weight technique, and TQ (5 mg/kg/day) was administered to the TQ-treated group for 7 days. All animals were killed after cardiac perfusion. Brain tissues were extracted immediately after perfusion without damaging the tissues. Biochemical procedures were performed with the serum, and a histopathologic evaluation was performed on the brain tissues. Biochemical experiments included malondialdehyde (MDA), reduced and oxidized coenzyme Q10 analysis, DNA isolation and hydroylazation, and glutathione peroxidase, and superoxide dismutase analyses. RESULTS: Neuron density in contralateral hippocampal regions (CA1, CA2-3, and CA4) 7 days after the trauma decreased significantly in the trauma and TQ-treated groups, compared with that in the control group. Neuron densities in contralateral hippocampal regions (CA1, CA2-3, and CA4) were greater in the TQ-treated group than in the trauma group. TQ did not increase superoxide dismutase or glutathione peroxidase antioxidant levels. However, TQ decreased the MDA levels. CONCLUSIONS: These results indicate that TQ has a healing effect on neural cells after head injury and this effect is mediated by decreasing MDA levels in the nuclei and mitochondrial membrane of neurons.
Obesity-Related Disorders in Turkiye: a Multi Center, Retrospective, Cross-Sectional Analysis From the Obredi-Tr Study
(Mdpi, 2025) Oral, Alihan; Solmaz, Ihsan; Koca, Nizameddin; Topaloglu, Ulas Serkan; Demir, Ismail; Dundar, Ahmet; Uyar, Seyit
Objectives: Obesity is a significant public health concern, as it is associated with the development of numerous chronic diseases. The prevalence of obesity and attendant diseases has been increasing over recent years. This study attempted to ascertain the frequency of chronic diseases in obese patients in Turkiye for the first time on this scale. Methods: A retrospective study was conducted, with patients admitted to the internal medicine outpatient clinics or obesity centers between December 2023 and December 2024 included in this study. Participants were recruited from seven regions, 20 provinces, and 28 centers, and the inclusion criteria were met by those aged 18 years and over with a body mass index (BMI) of 30 kg per square meter (kg/m(2)) or above. Their status, with respect to chronic diseases, and their anthropometric parameters were documented. Results: The total number of patients was 10,121, with a mean age of 45.2 +/- 13.92. Of these, 7222 (71.35%) were female. The prevalence of type 2 diabetes mellitus (T2DM), hypertension (HT), dyslipidemia (DL), coronary artery disease (CAD), obstructive pulmonary disease (OPD), obstructive sleep apnea syndrome (OSAS), and fatty liver disease (FLD) was found to be 35.01%, 78.19%, 12.37%, 10.32%, 5.88%, and 75.12%, respectively. A subsequent analysis of the prevalence of these diseases by region revealed a statistically significant variation between regions (p < 0.001 for all regions). Conclusions: This study represents a substantial contribution to the existing body of knowledge in this field, particularly with regard to the identification of the current chronic disease rate of obese patients in Turkiye.
Penetrating Spinal Injury: Reports of Two Cases
(Turkish Assoc Trauma Emergency Surgery, 2009) Yilmaz, Nebi; Kiymaz, Nejmi; Mumcu, Cigdem; Demir, Ismail
Penetrating spinal cord injuries caused by stab wounds are rare. Such injuries may result from a direct lesion of the neural elements of the spinal cord, cord infarcts or, more rarely, intradural or epidural hematoma. In the present study, two cases with spinal cord and L4 root injuries caused by a knife are presented. The first case, a 22-year-old male, referred to our emergency outpatient clinic with a stab wound injury at the mid-section of his back. Neurological examination of this patient showed paraplegia, and spinal MRI displayed a total spinal cord lesion at the T7-T8 level. The wound was primarily sutured; however, during follow-up, CSF (cerebrospinal fluid) leakage continued and the patient was operated. The ruptured dura mater was primarily sutured in a surgical intervention that involved T7-T8 total laminectomy. The second patient referred to our emergency outpatient clinic with a torso injury caused by a sharp knife. The knife was embedded 2-3 cm deep at the wound site at the L3 level and the handle was broken. The patient was immediately operated and the broken and embedded metallic part of the knife was extracted.
Prognostic Factors in Patients With Occipital Encephalocele
(Karger, 2010) Kiymaz, Nejmi; Yilmaz, Nebi; Demir, Ismail; Keskin, Siddik
Background: An encephalocele is a herniation of the brain and the meninges through a skull defect protruding towards the exterior. The condition is not rare when compared to spinal dysraphisms, but the worldwide incidence is not precisely known. The cases involving occipital encephaloceles which we have diagnosed in our clinic and the surgical approaches for this rare condition are presented herein. Methods: Thirty patients who were diagnosed with occipital encephaloceles and referred to our Neurosurgery Clinic at the Yuzuncu Yil University, Faculty of Medicine Research Hospital between 2000 and 2009 were enrolled in this study. The age of the patient, size of the sac, pathologies that accompanied the condition, and treatments applied were assessed. Results: In the present study, 30 patients (22 girls and 8 boys), whose ages varied between newborn and 14 months, were evaluated. The encephalocele sac was located in the occipital region in 27 patients (90%) and in the occipitocervical region in 3 patients (3%). Nine (30%) of the 30 patients died; 2 in the preoperative period, 2 in the postoperative early period (0-7 days) and 5 in the late postoperative period first week to 3 months). With the exception of the 2 patients who died preoperatively, surgery was performed on all of the patients. The mortality rate in our study was 29%. Conclusions: Our study demonstrated that factors which determine the prognosis of patients diagnosed with occipital encephaloceles include the size of the sac, the contents of the neural tissue, hydrocephaly, infections, and pathologies that accompany the condition. An occipital encephalocele is a congenital neurologic condition with an extremely high morbidity and mortality in spite of the treatments rendered pre- and postoperatively. Copyright (C) 2010 S. Karger AG, Basel
Relationship of Antioxidant Enzyme Activities With Myelomeningocele
(Turkish Neurosurgical Soc, 2012) Arslan, Mehmet; Melek, Mehmet; Demir, Halit; Eseoglu, Metehan; Gudu, Burhan Oral; Demir, Ismail; Cetin, Cigdem
AIM: To investigate the role of erythrocyte free radical scavenging enzyme activities (FRSE), carbonic anhydrase (CA) activity and malondialdehyde (MDA) in infants with myelomeningocele (MM). MATERIAL and METHODS: We compared antioxidant enzyme activities and MDA level in 40 individuals (10 infants with MM, 10 healthy infants; and mothers of these two groups) with age-matched subjects. Erythrocyte FRSE included catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S- transferase (GST). RESULTS: CA, CAT, SOD, GPX and GST concentrations were lower in all of the infants with MM compared to healthy infants. The mothers of infants with MM also had lower CA, CAT, SOD, GPX and GST activities than healthy mothers. It was also found out that the MDA level as a marker of oxidative damage was higher in infants with MM and their mothers than in healthy infants and their mothers. CONCLUSION: Lower FRSE activities indicate an increased frequency of MM. Free radicals (FRs) such as MDA may play a significant role in the etiology of MM.
Spontaneous Migration of a Retained Bullet Within the Brain: a Case Report
(Turkish Assoc Trauma Emergency Surgery, 2012) Arslan, Mehmet; Eseoglu, Metehan; Gudu, Burhan Oral; Demir, Ismail; Kozan, Abdul Baki
Gunshot injury to the head is usually mortal, and spontaneous migration of a retained bullet is rare. We report the case of a 23-year-old man with a spontaneously migrated bullet within the brain. Cranial computerized tomography (CT) indicated that the bullet was lodged deeply in the left parietal region. The patient was conscious and had right homonymous hemianopsia. The bullet was close to the vital structures and deep-seated; therefore, surgical intervention was not considered. Two months after the injury, repeat CT revealed that the bullet had migrated posteriorly and caudally due to gravitational factors. Management of the retained bullet was controversial. Removal of a deep-seated bullet may cause additional neurological deficit, but migration of a retained bullet may cause damage to vital structures, producing significant neurological damage. We proposed that the bullet in the brain should be removed if it could be reasonably accessed without causing additional neurological damage.
Study of the Neuroprotective Effect of Ginseng on Superoxide Dismutase (Sod) and Glutathione Peroxidase (gsh-Px) Levels in Experimental Diffuse Head Trauma
(Springer Wien, 2013) Demir, Ismail; Kiymaz, Nejmi; Gudu, Burhan Oral; Turkoz, Yusuf; Gul, Mehmet; Dogan, Zumrut; Demirtas, Sezin
The purpose of our study was to investigate the effect of ginseng on antioxidant enzyme levels in brain damage following experimental diffuse head trauma in rats. The neuroprotective effect of ginseng was also studied. In this study, rats were divided into four groups, and the rats in group 1 received no intervention. In group 2, the rats were administered 50 mg/kg ginseng, injected intraperitoneally at 1, 24 and 48 h, and the effect of ginseng on normal tissues was studied. No drugs were administered to the rats in group 3 who had previously experienced diffuse head trauma using Feeney's falling weight method. In group 4, rats underwent Feeney's falling weight method, leading to diffuse head trauma, and they were given 50 mg/kg ginseng intraperitoneally 1, 24 and 48 h after head trauma. Rats were killed 72 h after head trauma and their brain tissues extracted for histopathological and biochemical studies. Histopathological study of brain cross sections in the trauma group demonstrated neurons in the trauma region and surrounding area, which generally had a dark-colored eosinophilic cytoplasm and a pyknotic nucleus, while the nuclei of neurons were located peripherally. However, brain cross sections in group 4 from rats given ginseng after head trauma showed fewer neurons with eosinophilic cytoplasm, pyknotic and peripheral nuclei in the trauma region and surrounding area. No statistically significant difference in the tissue SOD level was observed; however, the GSH Px level in group 4 was significantly reduced compared to that in group 3. After affecting the GSH Px level and reducing histopathological scores, ginseng was found to display antioxidant and neuroprotective activity.
Transorbital Orbitocranial Penetrating Injury Caused by a Metal Bar
(Medknow Publications & Media Pvt Ltd, 2012) Arslan, Mehmet; Eseoglu, Metehan; Gudu, Burhan Oral; Demir, Ismail
Transorbital intracranial injury is uncommon, representing 0.04% of penetrating head trauma with a high mortality rate. Orbital penetrating injuries may cause severe brain injury if the cranium is entered, typically via the orbital roof, the superior orbital fissure, or the optic canal. A 13-year-old male sustained a severe brain injury due to penetration of the right orbit with an iron bar. The bar entered the inferiomedial aspect of the orbit and emerged from the left occipital bone. Neurological examination revealed deep coma (GCS: E1M2V1) with fixed, dilated, and non-reactive pupils. The bar followed an intracranial trajectory, through the third ventricle and suprasellar cistern. The patient underwent an immediate exploration with removal of the bar. Unfortunately, he died 10 days postoperatively due to severe diencephalic injury with brainstem herniation. In this case report, we discuss the radiologic diagnosis and surgical management of transorbital orbitocranial injury by foreign body penetration.
Vancomycin-Resistant Enterococcus Ventriculitis in a Child
(Modestum Ltd, 2014) Kiymaz, Nejmi; Gudu, Burhan Oral; Eseoglu, Metehan; Demir, Ismail
One of the most frequently encountered problems associated with ventriculoperitoneal (VP) shunts which are used in the treatment of hydrocephaly is infection. Staphylococcus is considered the most prominent factor in VP shunt infections; Enterococcus is less likely to cause ventriculitis in such patients. A shunt ventriculitis was demonstrated in a 1.5-year-old boy. The VP shunts was removed and an external ventricular drainage system was inserted. Subsequently empiric vancomycin and cephotaxime treatment was started. Vancomycin-resistant Enterococcus faecium (VREF) began to proliferate in the cerebrospinal fluid culture, and therefore we initiated linezolid and imipenem therapy by the intravenous route. The patient underwent a VP shunt operation 45 days after. In this study, successful therapy with linezolid in VP shunt ventriculitis due to VREF is presented.