Browsing by Author "Demir, Yusuf"

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Accurately Localizing the Thyroid Tissue in Mature Cystic Teratoma of Ovary by Single-Photon Emission Computerized Tomography/Computerized Tomography
(Wolters Kluwer Medknow Publications, 2015) Demir, Yusuf; Ucler, Rifki; Alkis, Ismet; Bulut, Gulay
A 30-year-old woman with hyperthyroidism was admitted to hospital. Although increased thyroid function was found, the gland was normal in ultrasonography (USG). Additionally, thyroid iodine uptake and Tc-99m pertechnetate scintigraphy was normal. Abdomen USG detected a cystic pelvic mass in left ovary. A whole-body scan was performed 48 hours after oral ingestion of 29.6 MBq (0.8 mCi) 1-131 (iodine-131) revealed a round structure located to the left lower abdomen. Iodine uptake was detected in this cyst which was compatible with functional thyroid tissue demonstrated by SPECT/CT. The patient was underwent surgical operation and histopathology confirmed mature cystic teratoma. Accurate localization and depiction of thyroid tissue in ovary mass was provided with SPECT/CT.
Assessment of Yttrium-90 Citrate Radiosynovectomy Treatment With Bone Scintigraphy in Lipoma Arborescens
(Medknow Publications & Media Pvt Ltd, 2016) Vatankulu, Betul; Nemetyazar, Jamal; Demir, Yusuf; Samanci, Cesur; Sager, Sait
A 37-year-old male patient presented with right knee pain and swelling. The patient had a 6-year history of rheumatoid arthritis. Physical examination was notable for swelling and tenderness of the right knee. The diagnosis of lipoma arborescens (LA) was confirmed from the magnetic resonance imaging of the right knee. Herein, we report the use of bone scintigraphy in a case of LA treated with yttrium-90 radiosynovectomy.
Associations Between the Standardized Uptake Value of 18f-Fdg Pet/Ct and Demographic, Clinical, Pathological, Radiological Factors in Lung Cancer
(E-century Publishing Corp, 2015) Sunnetcioglu, Aysel; Arisoy, Ahmet; Demir, Yusuf; Ekin, Selami; Dogan, Erkan
Objectives: F-18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is extensively used to diagnose and stage of lung cancer. The aim of the current study was to investigate the correlation of demographic, clinical, pathological and radiological factors with primer tumor FDG Uptake in patients with lung cancer. Materials and methods: This cross-sectional, clinical study was performed on a total of 57 lung cancer patients newly diagnosed that underwent FDG PET/CT. In addition to descriptive variables, histopathological diagnosis, tumor site and size, hemoglobin level, red cell distribution width, neutrophil to lymphocyte ratio were noted for each patient. The correlation of these variables to SUVmax values in FDG PET/CT was investigated. Results: A total of 57 patients (4 women, 53 men) with an average age of 60.8 +/- 9.4 (range: 33-89) participated in the study. Histopathological diagnoses were consistent with squamous cell carcinoma (28, 49.1%), adenocarcinoma (15, 26.3%) and small cell cancer (14, 24.6%). The SUVmax of primary tumor was positively correlated with tumor size (P<0.001). The tumor SUVmax of squamous cell carcinoma (SqCC) (17.49 +/- 8.37) was higher than that of adenocarcinoma (AC) (12.80 +/- 4.77) and small cell carcinoma (SCC) (12.40 +/- 5.80) (P=0.038). Conclusion: SUVmax value was significantly higher for squamous cell carcinoma and it SUVmax values in PET scans was found to be positively correlated with tumor size. This study suggests that, tumor size and histologic subtype had influences upon FDG uptake in lung cancer.
The Comparison of Three Different Malignacy Evaluation Criteria of Cervical Lymph Nodes in Oral Cavity Cancer Using F-18 Fdg Pet-Ct
(Carbone Editore, 2015) Surucu, Erdem; Demir, Yusuf; Polack, Berna Degirmenci
Aims: Our aim was to evaluate the diagnostic role of Fluorine-18 fluorodeoxyglucose Positron emission tomography-computed tomography (F-18 FDG PET-CT) using three different criteria published in the literature and to compare the diagnostic value of these three parameters in patients with oral cavity cancers (OCC). Materials and methods: 16 patients (4 female; 12 male, 29-81 years) were included in this study. Malignancy in the lymph nodes was evaluated according to these 3 criteria: 1: Visual assessment 2: The ratio of maximum standard uptake value (SUVmax) in tumor/ adjacent muscle tissue (T/M), 3: SUVmax adjusting to the size of lymph nodes. The histopathological evaluation of the surgery was recorded according to the neck levels. The sensitivity, specificity, negative predictive values (NPV) and positive predictive values (PPV) of F-18 FDG PET-CT for each malignancy criteria and receiver operating characteristic (ROC) curves were obtained for SUVmax and T/M. Results: Histopathological evaluations revealed 5 patients had metastatic lymph nodes (N+) whereas 11 patients had benign lymph nodes (N-). 14 of 43 lymph nodes that were visualized in CT of F-18 FDG PET-CT were evaluated as malignant whereas 29 of 43 lymph nodes were evaluated as benign. The average of SUVmax and T/M ratios of visually malignant lymph nodes were 7.67 +/- 4.95 and 7.10 +/- 3.18, respectively. The average of SUVmax and T/M ratios of visually benign lymph nodes were 1.69 +/- 0.43 and 1.49 +/- 0.48, respectively. The highest sensitivity, specificity, NPV and PPV were obtained in the criteria of T/M ratios with the threshold value of SUVmax (regardless from the size) as 3.4 and T/M ratio as 3.2 which is obtained from our population using ROC curve, 93% sensitivity, 96% specificity were calculated. Conclusion: This study indicates that F-18 FDG PET-CT is a reliable method for the correct evaluation of primary tumor and N staging in OCC. This study showed that T/M ratios in the lymph nodes could be used to evaluate malignancy with a highest diagnostic accuracy.
The Correlation Between the Metabolic Tumor Volume and Hematological Parameters in Patients With Esophageal Cancer
(Springer, 2015) Surucu, Erdem; Demir, Yusuf; Sengoz, Tarik
The aim of this study is to evaluate the correlation of the serum neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV), with the standardized uptake value (SUVmax), and metabolic tumor volume (MTV) in F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patient with esophageal squamous cell cancer at baseline. PET/CTs were performed in 52 patients with esophageal squamous cell cancer, making up the patient group. An additional 52 patients who underwent endoscopy due to dyspepsia with normal esophagus (as a control group) were included in the study to compare the hematological parameters between the patient groups. The median age was 60.0 +/- A 12.8 years (range 39-84 years) for the patients with esophageal cancer, and 56.9 +/- A 12.3 years for the control group. Statistical differences were found in terms of the neutrophils, lymphocytes, NLR, PLT, PLR, and MPV between the patients with esophageal cancer and the control group. In the correlation analysis, only the NLR was correlated with the MTV for all of the patients (p = 0.013, r = 0.344). The SUVmax was not correlated with these hematological parameters. At baseline neutrophil-to-lymphocyte ratio is associated with the metabolic tumor volume, which was assessed using the PET/CT in patients with esophageal squamous cell cancer. The SUVmax values were not related to these parameters.
Detection of Pulmonary Artery Atherosclerosis by Fdg-pet/Ct: a New Observation
(E-century Publishing Corp, 2020) Al-Zaghal, Abdullah; Aras, Mustafa; Borja, Austin J.; Moghbel, Mateen; Demir, Yusuf; Houshmand, Sina; Alavi, Abass
The aim of this study was to investigate the feasibility of FDG-PET/CT imaging to detect pulmonary artery atherosclerosis and to assess the correlation between pulmonary function testing (PFT) results and the overall pulmonary artery metabolic activity. Twenty-nine subjects between the ages of 57-75, with a history of clinical suspicion of lung cancer, underwent PET/CT imaging at 3 hours following the administration of FDG. Global FDG uptake in the central pulmonary artery branches was determined. Average SUVmax, SUVmean, and tissue-to-background (TBR) mean and maximum were calculated within each vessel. The degree of FDG uptake in non-COPD and COPD patients and its correlation with PFT were examined in this population. Furthermore, the results from patients were compared with those of 10 age-matched controls. Based on these data, the number of lesions with varying degrees of FDG uptake among patients was higher than that in the normal control group. However, there was no statistically significant difference in average SUVmax, average SUVmean, average TBRmax, or average TBRmean between non-COPD and COPD patients. This indicates that the atherosclerotic process is focal and is not diffuse in nature. Although the global quantitative data generated did not reveal evidence for diffuse artery inflammation in patients with COPD, qualitative examination showed clear-cut evidence for focally increased FDG uptake in the pulmonary arteries. This observation indicates the presence of atherosclerotic plaques which are prevalent in patients with COPD. Future prospective studies with larger numbers of subjects are needed to confirm this important observation.
Development of Agranulocytosis After Discontinuation of Methimazole: an Unusual Case
(Hindawi Ltd, 2015) Ucler, Rifki; Atmaca, Murat; Candar, Omer; Alay, Murat; Goy, Burhan; Kara, Erdal; Demir, Yusuf
Agranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. We herein describe a case of a 41-year-old woman who was previously administered methimazole (MMI) for ten days and developed ATD-induced agranulocytosis and symptoms of an upper respiratory tract infection after three weeks following discontinuation of MMI treatment. A thorough hematologic and serological evaluation did not disclose an alternative cause for the agranulocytosis. After receiving empirical antibiotic treatment, she responded successfully with clinical improvement of her symptoms and resolved neutropenia on the seventh day. This case is atypical because agranulocytosis developed after discontinuation of MMI, which strengthens the importance of remaining alert for signs of agranulocytosis even after discontinuation of ATD treatment.
The Diagnostic Role of Dual-Phase 18f-Fdg Pet/Ct in the Characterization of Solitary Pulmonary Nodules
(Lippincott Williams & Wilkins, 2014) Demir, Yusuf; Polack, Berna D.; Karaman, Canan; Ozdogan, Ozhan; Surucu, Erdem; Ayhan, Sadet; Ozdemir, Nezih
Objective Our objective was to evaluate the diagnostic role of dual-phase F-18-fluorodeoxyglucose (F-18-FDG) PET/computed tomography (CT) in the characterization of solitary pulmonary nodules (SPNs).Patients and methodsA total of 48 SPNs in 48 patients were included in this retrospective study. The final diagnosis was confirmed histopathologically or by follow-up CT. Two PET/CT scans were performed: the first (early scan) was performed 1 h after injection and the second (delayed scan) was performed 2 h later. Standardized uptake values (SUVs) [early and delayed SUVmax and SUVmean adjusted to body weight, body surface area (BSA), lean body mass (LBM) and blood glucose level (Glc)], retention index and nodule-to-mediastinum (nodule activity/subcarinal region of interest activity) ratios were calculated, along with the receiver operating characteristic curve. Intraobserver and interobserver variabilities among nuclear medicine physicians were analysed for the two phases.ResultsEighteen patients had malignant tumour, whereas 30 had benign lesions. The median (min-max) SUVmax was 1.5 (0.5-4.1) in the benign group and 3.6 (1.3-38) in the malignant group. With the threshold value of early SUVmax as 2.5 and 2.75 using the receiver operating characteristic curve, a sensitivity of 94-75%, specificity of 75-80% and an accuracy of 83-78% were calculated. With the same threshold values for delayed images, 94-100% sensitivity, 77-80% specificity and 83-88% accuracy were obtained. BSA-SUVmax, LBM-SUVmax and Glc-SUVmax did not show any advantage over other quantitative parameters in the SPN characterization. There was no variability in the results obtained between the two nuclear medicine physicians.ConclusionDual-phase PET/CT may increase the diagnostic potential of PET/CT in the characterization of SPNs. In this particular study group, a threshold value could not be determined for the retention index, but higher retention indices may show higher malignant potential in SPNs. (C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Dual-Phase F-18 Fdg Pet-Ct in Staging and Lymphoscintigraphy for Detection of Sentinel Lymph Nodes in Oral Cavity Cancers
(Elsevier Science inc, 2015) Surucu, Erdem; Polack, Berna Degirmenci; Demir, Yusuf; Durmusoglu, Mehmet; Ekmekci, Sumeyye; Sarioglu, Alien; Ikiz, Ahmet Omer
Aim: Our objective was to evaluate the diagnostic role of dual-phase fluor-18 fluorodeoxyglucose (F-18 FOG) positron emission tomography-computed tomography (PET-CT) and planar lymphoscintigraphy in patients with oral cavity cancer (OCC). We also investigated the combined impact of F-18 FOG PET-CT and sentinel lymph node biopsy (SLNB) in decision making for patients with OCC. Methods: Sixteen patients (4 female, 12 male; age range, 29-81 years) were included in this prospective study. F-18 FDG PET-CT [1 (early) and 2 h (delayed) after injection] and planar lymphoscintigraphy (2 h before the surgery) were performed for all the patients before surgery. The sensitivity, specificity, and negative and positive predictive values in F-18 FOG PET-CT for the early and the delayed scans and tumor/liver uptake (T/L) in the lymph nodes were calculated. Receiver operating characteristic curves were obtained for standardized uptake value (SUV)max and T/L. Results: Histopathological evaluations revealed that 5 patients had metastatic lymph nodes (pN+) whereas 11 patients had benign lymph nodes (pN). Out of 43 lymph nodes visualized as cN(+) in F-18 FDG PET-CT, 14 were pathologically positive for malignancy, whereas 29 were pathologically benign. There was no statistical difference between the N(+) and N(-) patients in terms of age, depth of primary tumor, and the number of mitoses. However, there was a significant difference between the N(+) and N(-) patients (P=.011) in terms of early and delayed F-18 FOG uptake of primary tumors. There was a statistically significant difference in the value of SUVmax between the early and the delayed scans for the malignant lymph nodes (P=.00). Conclusion: This study indicates that F-18 FOG PET-CT is a reliable method for the correct evaluation of primary tumor and N staging in OCCs. Delayed phase of F-18 FOG imaging may increase primary lesion detectability due to higher FDG uptake in primary tumors compared to the early phase of imaging. F-18 FOG PET-CF might demonstrate skip metastasis in lymph nodes which can be missed with SLNB. Although SUV values increased in the delayed phase of F-18 PET-CF imaging in detecting lymph node metastases, the specificity and positive predictive value did not increase. (C) 2015 Elsevier Inc. All rights reserved.
The Effect of Radioiodine on the Intima Media Thickness of the Carotid Artery
(Galenos Publ House, 2013) Surucu, Erdem; Bekis, Recep; Sengoz, Tarik; Demir, Yusuf; Celik, Ahmet Orhan; Aslan, Ozge; Durak, Hatice
Aim: The radiation can induce vessel injury. The result of this injury can be severe and life-threatening. There are a few studies demonstrating an increase in intima-media thickness (IMT) of the common carotid artery (CCA) after radiotherapy, especially in head and neck cancers. We evaluated the effect of I-131 to the IMT of the CCA in the patients who were treated for hyperthyroidism. Methods: 38 patients (25M, 13W) referred to our department for radioiodine treatment with the diagnosis of nodular goitre (25 patients) and diffuse hyperplasia (Graves disease (GD), 13 patients) were included to the prospective study. An USG was performed for all the patients before therapy, 3, 6 and 12 months after radioiodine therapy in order to measure IMT of CCA and the femoral artery (FA). The IMT was measured at the level of proximal part of bulbus anteriorly on the left and right side. The IMT of FA was measured just before the bifurcation. Results: There was a statistically significant increase in IMT of both CCA and FA bilaterally in nodular hyperthyroid patients. However, in the patients with Graves disease, there was only statistically significant increase in the left IMT of CCA at 0-3rd, 0-6th month measurements and in the right IMT of FA at 0-3rd month measurements. Conclusion: Though the limitation of the study is the interobserver and intraobserver variability, it was seen that I-131 therapy might affect the IMT of CCA in the patients with NG. I-131 effect on the IMT of CCA in patients with nodular goitre was higher than the IMT of CCA in patients with GD. I-131 effect on the IMT of CCA might be due to administered dose and adjacency. The interesting point of our study was the increased thickness of IMT in FA. We think that the increase in IMT is due to the systemic effect of radioactivity circulating in the blood vessel. I-131 effect on the IMT of FA in patients with nodular goitre was higher than the IMT of FA in the patients with GD due to I-131 uptake of thyroid gland. Because I-131 uptake was lower in patients with nodular goitre, I-131 in systemic circulation was higher.
The Effects of the Factors Related To the Patient and the Disease on the Performance of Ablation Therapy in Patients With Differentiated Thyroid Cancer Who Have Received I-131 Ablation Therapy
(Galenos Yayincilik, 2012) Sengoz, Tarik; Surucu, Erdem; Demir, Yusuf; Derebek, Erkan
Objective: To investigate whether the factors related to the patient and the disease have any effect on the success of ablation therapy in patients with differentiated thyroid cancer who have received I-131 ablation therapy. Material and Methods: All the patients with differentiated thyroid cancer were referred for I-131 ablation therapy after thyroidectomy between July 2007 and September 2009. The patients had at least six months of follow-up. Age, gender, type of tumor, presence of capsule invasion, size of tumor, number of the tumors, localization of the tumor, invasion of thyroid capsule, lymph/vessel invasion, presence of metastatic lymph nodes, type of surgery, preablation values of thyroglobulin (Tg), AntiTg, TSH, surveys for the evaluation of metastatic disease, (thyroid and bone scintigraphy, neck and abdominal ultrasonography, chest and brain computerized tomography), administered dose, postablation I-131 whole body scan (WBS) and diagnostic I-131 WBS, neck USG, values of Tg and AntiTg at the 6th month were recorded. The presence of residual thyroid activity on the 6th month diagnostic I-131 WBS image was accepted as the criterion for ablation success. Results: 191 patients with differentiated thyroid cancer were assessed in this study. The overall success rate of the first ablation therapy was 74.3%. The success rate of the ablation therapy was 66% and 75% in metastatic group and non-metastatic group, respectively. Except the significant correlation between the number of pathologic lymph nodes and the success of ablation (p=0.025), there was no other significant correlation between the patient/disease related factors and the success of ablation therapy. Conclusion: Significant correlation between the number of the pathologic lymph nodes and the ablation therapy performance can also be due to statistical error because of the limited sample size. There was no significant correlation between other patient/disease related prognostic factors and the success of ablation therapy.
Enteropathy-Associated T-Cell Lymphoma: Involvement of the Gastrointestinal Tract From the Duodenum To the Rectum
(Georg Thieme verlag Kg, 2015) Demir, Yusuf; Olmez, Sehmus; Surucu, Erdem; Demir, Cengiz; Senkoy, Funda Caliskan; Bayram, Irfan
Fasciola Hepatica Mimicking Malignancy on 18f-Fluorodeoxyglucose Emission Tomography/Computed Tomography
(Galenos Yayincilik, 2016) Surucu, Erdem; Demir, Yusuf; Dulger, Ahmet C.; Batur, Abdussamed; Olmez, Sehmus; Kitapci, Mehmet T.
A 48-year-old female with complaints of gastrointestinal symptoms such as abdominal pain, fatigue, vomiting, nausea, and weight loss was diagnosed with neuroendocrine tumor after removal of a 2 mm lesion from the stomach with endoscopic biopsy. Her magnetic resonance imaging that was performed due to on-going symptoms showed multiple linear hypointense lesions in the liver. Positron emission tomography/computed tomography (PET/CT) scan was performed for differential diagnosis, which showed high fluorodeoxyglucose (FDG) uptake in these lesions. Clinical and laboratory findings revealed the final diagnosis as Fasciola hepatica. The imaging features of this case is presented to aid in differentiating this infectious disease from malignancy and avoid misdiagnosis on FDG-PET/CT.
Hakkâri İli Küçükbaş Hayvancılık İşletmelerinin Yapısal Özellikleri
(2023) Demir, Yusuf; Tuncer, Selçuk Seçkin
Amaç: Bu çalışmada, Hakkâri ili Merkez, Çukurca, Yüksekova, Şemdinli ve Derecik ilçelerinde küçükbaş hayvancılık yapan işletmelerin ahır özellikleri ve işletme sahiplerinin sosyo-demografik özelliklerini de içeren yapısal özelliklerinin belirlenmesi amaçlanmıştır. Materyal ve Metot: Araştırma materyali 96 yetiştirici ile yüz yüze yapılan anketlerden alınan verilerden elde edilmiştir. İşletmelerin belirlenmesinde tabakalı örnekleme yöntemi kullanılmıştır. Bulgular: İşletme sahiplerinin tamamına yakını (%97.9) erkek olarak belirlenmiştir. Yetiştiricilerin çoğunluğu (%52.1) 41-60 yaş arasındadır. Hane halkı 4-6 ve 7-9 olan ailelerin çoğunlukta olduğu görüldü. Yetiştiricilerin üçte biri (%33.3) ilkokul mezunudur. Yetiştiricilerin %41.7’sinin 26 yıl ve üzerinde tecrübeye sahip olduğu bulunmuştur. Küçükbaş hayvan barınaklarının %46.9’unda taş, %26’sında briket malzemesi kullanılmıştır. Yetiştiricilerin önemli bir kısmı (%74) ücretli çoban temini yöntemini kullanmaktadır. Anket yapılan işletme sahiplerinin çoğunluğu (%95.8) yetiştirici örgütlerine üye olduğunu bildirmiştir. Yetiştiricilik bilgi kaynağı olarak çoğunlukla aile büyükleri (%59.4) ve Tarım ve Orman Bakanlığı il ya da ilçe müdürlükleri (%34.4) kullanılmaktadır. Sonuç: Küçükbaş hayvan yetiştiriciliğinin sürdürülebilirliği bakımından; sektördeki genç nüfus istihdamının daha cazip hale getirilmesi, yetiştiricilerin eğitim seviyesinin yükseltilmesi ve hayvancılık işletmelerine yapılan devlet desteklerinin artırılması önemlidir.
Hakkâri İlindeki Küçükbaş Hayvancılık İşletmelerinin Mevcut Durumu ve Genel Sorunları
(2022) Demir, Yusuf; Tuncer, Selçuk Seçkin
Bu çalışma, Hakkâri ilindeki küçükbaş hayvancılık işletmelerinin (96 işletme) mevcut durumunun ortaya konulması amacıyla yapılmıştır. İşletmeler için hazırlanan anket verileri 129 sorudan oluşturulmuştur. Anket verileri SPSS istatistik yazılım programı ile değerlendirilmiştir. Hakkâri ili küçükbaş hayvan işletmelerinin %59.4’ünün Akkaraman koyunu ve Kıl keçisi yetiştiriciliğini birlikte yaptığı tespit edilmiştir (p˂0.01). İşletmelerin %59.4’ünün yem ihtiyacının temininde satın alma yoluna gitmek zorunda kaldığı (p˂0.05) ve yem bitkisi olarak en fazla yonca ekimini (%37.5) tercih ettikleri bulunmuştur. Küçükbaş hayvan yetiştiricilerinin %40.6’sı hayvancılık desteği almadığını ifade etmiştir. Yetiştiricilerin %87.5’i desteklerin yetersiz olduğunu bildirmiştir (p˂0.01). Yetiştiricilerin sadece %28.1'i mera ot kalitesini iyi olarak ifade etmiştir (p˂0.05). Yetiştiricilerin %52.1’i yayla olanağı olduğunu bildirirken yaylaya en çok (%30.2) mayıs ayında çıktıkları (p˂0.05) ve 6 ay (%40.6) kaldıkları saptanmıştır (p˂0.01). Koç/teke katımının aşım döneminde yapılma oranı %55.8 bulunurken geri kalanında (%44.2) bütün yıl boyunca sürüde tutulmaktadır. Doğumların başlangıcı en fazla şubat (%52.1) ayında olmakta ve çoğunlukla (%41.7) nisan ayında tümüyle bitmektedir. Damızlık seçiminde en önemli kriterler olarak, sağlık/yaş (%35.4) ve cüsse (%33.3) bulunmuştur. Küçükbaş hayvan yetiştiricilerinin en önemli sorunlarının yem maliyetinin yüksek olması, mera kalitesinin yetersiz olması, yayla faaliyetlerindeki sorunlar ve ileri yaşlardaki erkeklerin damızlıkta kullanılması olduğu tespit edilmiştir
Liver Metabolic Activity Changes Over Time With Neoadjuvant Therapy in Locally Advanced Rectal Cancer
(Lippincott Williams & Wilkins, 2016) Demir, Yusuf; Surucu, Erdem; Sengoz, Tarik; Koc, Murat; Kaya, Gamze C.
Objective The aim of this study was to evaluate, using PET/computed tomography (CT), changes in liver metabolic activity in patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT). Patients and methods A total of 29 biopsy-proven LARC patients between 2009 and 2012 were studied. Liver standardized uptake values (SUVs) and SUVs adjusted for lean body mass (SULs) were obtained from PET/CT images obtained at 1 h (early) and 2 h (late) after F-18-fluorodeoxyglucose (F-18-FDG) administration both before and after neoadjuvant CRT. Age, sex, BMI, lean body mass, blood glucose level, and F-18-FDG dose, which can influence liver SUVs and SULs, were also analyzed. Results Fourteen (48%) men and 15 (52%) women with a mean age of 62 +/- 11 years (range 34-80 years) were included in the study. The mean SUVs and SULs were significantly decreased in the late scans. Sex was significantly correlated with the mean liver SUV in early and late scans. The mean SUV differed significantly between male and female patients in early and late images (P < 0.05). In a multivariate stepwise regression analysis, only liver SUVs (maximum and mean) were significantly associated with BMI before and after therapy. SUVs were significantly higher in the high (>= 25) BMI group after but not before therapy. Mean SUL was not influenced by BMI. Conclusion Liver F-18-FDG uptake is consistent before and after neoadjuvant CRT therapy in patients with LARC. When assessing response to therapy and using liver metabolic activity to indicate background activity, BMI should be considered as it can influence liver metabolic activity.
Quantitative Assessment of Pulmonary Atherosclerosis With Fdg Pet/Ct
(Soc Nuclear Medicine inc, 2019) Al-Zaghal, Abdullah; Aras, Mustafa; Demir, Yusuf; Houshmand, Sina; Werner, Thomas; Alavi, Abass
Rest Myocardial Perfusion Scintigraphy Showing the Invasion of the Hydatid Cyst in the Myocardium
(Lippincott Williams & Wilkins, 2013) Bozkurt, Hasan; Aydin, Murat; Talas, Zeki; Demir, Yusuf; Surucu, Erdem
A cardiac hydatid cyst is a rare complication of the Echinococcus infection, and it is seen in just 0.5% to 2% of all cases. Because it can cause sudden death, removing the cyst is recommended. It is important to determinate the relationship between the cyst and the intra/extracardiac structures before the operation because it is of vital importance during the operation. In our case, we showed that rest myocardial perfusion scintigraphy provided an additional contribution to anatomic imaging in that it showed the invasion of the cyst in the myocardium, which was effectively directing the course of the operation.
Structural Characteristics and Socio-Economic Status of Small Ruminant Husbandry in Hakkâri Province
(2022) Demir, Yusuf; Tuncer, Selçuk Seçkin
Bu çalışmada, Hakkâri ili Merkez, Çukurca, Yüksekova, Şemdinli ve Derecik ilçelerindeki küçükbaş hayvancılık işletmelerinin yapısal özellikleri ve sosyo-ekonomik durumlarının ortaya konulması amaçlanmıştır. Bu amaçla 96 işletmede anket çalışması yapılmıştır. İşletme sahiplerinin tamamına yakını (%97.9) erkek olarak belirlenmiş ve yaş grubunun (%52.1) 41-60 yaş aralığında olduğu saptanmıştır. Önemli oranda (%33.3) ilkokul mezunu olan yetiştiricilerin %41.7'sinin 26 yıl ve üzerinde tecrübeye sahip olduğu bulunmuştur. İşletmelerin tamamına yakını (%89.6) meralardan faydalanmakta ve sürülerin meraya çoğunlukla (%82.3) Nisan ayında çıktıkları, Ekim ayında ise döndükleri saptanmıştır. Yetiştiricilerin önemli bir kısmı (%74.0) ücretli çoban temini yöntemini kullanmaktadır. Doğumların başlangıcı en fazla Şubat (%51.1) ayında olmakta ve çoğunlukla (%41.7) Nisan ayında tümüyle bitmektedir. Hayvanların damızlık amacıyla sürüde kullanım süresi; koyun (%79.2), koç (%77.1), keçi (%80.2) ve tekelerde (%80.2) önemli oranda 5-7 yaş olarak tespit edilmiştir. İşletmelerin %99'unda aşılama yapıldığı ve büyük oranda (%86.4) brucella, enterotoksemi ve çiçek aşılarının hepsinin yapıldığı bulunmuştur. Hakkâri ilindeki işletme sahiplerinin %95.8'i yetiştirici örgütlerine üye olduğunu bildirirken bilgi kaynağı olarak çoğunlukla aile büyükleri (%59.4) ve tarım müdürlükleri (%34.4) olarak bulunmuştur. Sonuç olarak Hakkâri ili Merkez, Çukurca, Derecik, Şemdinli ve Yüksekova'da genç nüfusun küçükbaş hayvancılığa özendirilmesi, yetiştirici birliğinin çiftçi eğitimlerinde daha çok etkin olması ve sürü büyüklüklerinin artırılması sorunların çözümünde önemli olacaktır.
Temporary Changes in Neutrophil-To Platelet-To Ratios, and Mean Platelet Volume Reflecting the Inflammatory Process After Radioiodine Therapy
(Lippincott Williams & Wilkins, 2016) Demir, Yusuf; Ucler, Rifki; Surucu, Erdem; Turan, Mahfuz; Balli, Zekeriya; Sengoz, Tarik
ObjectiveData on the effects of radioiodine (RAI) therapy on systemic inflammation are very limited. The aim of this study is to explore alterations of subclinical systemic inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), after RAI therapy in patients with differentiated thyroid carcinoma (DTC).Materials and methodsWe evaluated 57 DTC patients treated with RAI (RAI group), 37 DTC patients not treated with RAI (non-RAI control group), and 37 age-matched healthy individuals (healthy control group). NLR, PLR, and MPV levels were compared among the study groups; these were also examined after RAI in the RAI group.ResultsInitially, NLR was significantly higher in the RAI group than in the healthy controls. NLR and PLR increased significantly and MPV decreased significantly 2 months after RAI therapy (P=0.021, 0.001, and 0.008, respectively). Although NLR and PLR levels decreased, they were still high compared with the preoperative values. MPV returned to normal levels at 6 months. These parameters did not change significantly in the non-RAI control group.ConclusionThis is the first study to evaluate changes in NLR, PLR, and MPV after RAI therapy. Our findings suggest that NLR, PLR, and MPV changes indicate systemic inflammation that occurs after RAI therapy because of thyroid remnant tissue ablation.