Browsing by Author "Dere, Gokturk"

Now showing 1 - 2 of 2

Assessment of Hla-A, Hla-Dr, and Hla-Dq Alleles in Patients With Pemphigus Vulgaris From Eastern of Turkey
(Wiley, 2020) Dere, Gokturk; Yavuz, Ibrahim Halil; Ozaydin Yavuz, Goknur; Bayram, Yasemin; Gunes Bilgili, Serap; Ozturk, Murat
Background Pemphigus vulgaris (PV) is a chronic progressive autoimmune bullous disease caused by the interaction of pathogenic factors, genetic, and environmental factors. HLA alleles, which are considered as protective factors against disease or predisposing factors, may be different in various populations and ethnic groups. Aims The purpose of this study is to examine the HLA-A, HLA-DR, and HLA-DQ alleles in patients that are diagnosed with PV in and around eastern of Turkey and to determine the alleles that create predisposition to disease or protect against the disease. Patients/Methods Thirty patients diagnosed as PV with clinical, histopathological, and immunofluorescence findings and 30 healthy subjects were included in this study. The HLA-A, HLA-DR, and HLA-DQ typology in the DNA samples that were obtained from the blood samples of the groups was performed by using the PCR-SSP low-resolution gene panels. Results The HLA-A*03 allele was found to be significantly higher in patient group than the control group (P-value: .020). HLA-DRB1*04 and HLA-DRB1*14 alleles in PV patients were found to be significantly higher than the control group (P-value = .000). Conclusion It was concluded that the HLA-DRB1*03, HLADQB1*02, and HLA-DQB1*06 alleles in and around eastern of Turkey showed protective effects against pemphigus vulgaris. It was also concluded that the HLA-A*03, HLA-DRB1*04, HLA-DRB1*14, HLA-DRB4, HLA-DQB1*03, and HLA-DQB1*05 alleles could cause predisposition to the disease.
Tandoor Heat Related Symmetric Squamous Cell Carcinoma: Case Report
(derman Medical Publ, 2013) Ozkol, Hatice Uce; Calka, Omer; Dere, Gokturk; Bayram, Irfan
Skin squamous cell carsinoma (sSCC) is a malignant tumor of keratinizing epidermal cells. It is the second leading cause of death after melanoma. The risk factors for SCC include older age, male sex, sun exposure, precancerous lesion and immunosuppression. Other etiological factors responsible in the development of cutaneous SCC in some societies include chronic exposure to thermal radiation. Tandoor is used specifically in the eastern and southeastern regions of Turkey for made bread. Hands and face are subjected to a temperature of approximate 450 degrees C for a lengthy period while using the tandoor. In this paper we presented a 71 years old female patient with squamous cell carcinoma in her both wrists. She was exposed to tandoor heat for approximately 40 years. We think the continuous and repetitive high-temperature might have significantly contributed to development of the neoplasia in our patient. Tandoor heat related bilateral SCC in our present case report appears to be first reported in literature.