Browsing by Author "Dilek, I."

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Abo and Rh Blood Groups Frequency in Men and Women Living in Eastern Turkey
(2006) Dilek, I.; Demir, C.; Bay, A.; Akdeniz, H.; Öner, A.F.
Objective: ABO and Rh blood groups which are basic for determination of blood compatibility consist of the most important tests of blood center. In this study, we aimed to find out the rates of ABO and Rh blood groups in male and female donors in our region. Therefore, donors attending to our blood center within the last five years were investigated taken into account their gender. Methods: Blood groups were examined by gel-centrifugation or tube agglutination methods. Results: Out of totally 33.193 individuals, 14.716 were female (44.3%) and 18.477 males (55.7%), and average age was 34 (range 20-60 years old). Taken into account the whole donors, A blood type was found as 43.8%, O blood type 30.8%, B blood type 16.2% and AB blood type 8.6% in rate. With respect to blood type frequency in genders group A was in the rate of 44.1% and 43.6%, group O 31% and 30.5%, group B 16.3% and 16.1% and group AB 8.6% and 9.8% in women and men, respectively. The Rh positivity rate into totally whole donors was 85.5%, being 86.0% in men and 84.8% in women. Conclusion: ABO and Rh blood groups rates were very near to each other in women and men, and also the average rate was very similar to averages in Turkey.
Acute Myeloblastic Leukemia-Associated Marfan Syndrome and Davidoff-Dyke Syndrome: a Case Report
(2008) Demir, C.; Bay, A.; Dilek, I.; Öner, A.F.
We present herein a 23-year-old man with acute myeloblastic leukemia (AML) associated with Davidoff-Dyke-Masson syndrome (DDMS) and Marfan syndrome (MS). The diagnosis of DDMS was based on findings including left facial asymmetry, left hemiparesis, mental retardation, right cerebral hemiatrophy, dilatation of the ipsilateral lateral ventricle and calvarial thickening. The diagnosis of MS was based on clinical findings including tall stature, myopia, retinitis pigmentosa, blue scleras, scoliosis, pectus excavatum, arachnodactyly and low ratio of upper/lower body segment. The patient developed hepatosplenomegaly, gingival hypertrophy and pancytopenia. Peripheral blood film and bone marrow examination showed that most of nucleated cells were blasts; immunophenotype of those cells showed CD11+, CD13+, CD14+, CD33+ and HLA-DR+. These findings confirmed the diagnosis of AML (FAB-M5). After induction chemotherapy, remission was obtained. To the best of our knowledge, our case is the third report of AML in MS syndrome, while AML associated with DDMS and MS has not been previously reported in the literature.
Assessing the Efficacy and Safety of Feiba in the Treatment of Fx Deficient Patients
(Wiley-blackwell, 2008) Dilek, I.; Oner, A.; Gursel, T.; Buyukavci, M.; Salcioglu, Z.; Ozatli, D.
Cerebral Hemiatrophy Associated With Hematological and Developmental Disorders
(2004) Ünal, Ö.; Çaksen, H.; Kiymaz, N.; Dilek, I.; Kayan, M.; Anlar, Ö.
The etiology of cerebral hemiatrophy may be congenital or acquired. Trauma, infection, vascular abnormality, ischemic and hemorrhagic conditions may be the etiologic factors in acquired type. There is limited information about its association with other disorders in the literature. We presented three new cases of cerebral hemiatrophy associated with some hematological and developmental disorders. Cerebral hemiatrophy was associated with thalassemia major in a 10-year-old girl, acute myeloblastic leukemia and Marfan syndrome in a 23-year-old man, and craniosynostosis in a 1-year-old boy. To the best of our knowledge, thalassemia major, myeloblastic leukemia, Marfan syndrome and craniosynostosis have not been reported in cerebral hemiatrophy in the literature. © 2004, IOS Press. All rights reserved.
Distribution of Blood and Blood Components, Indications and Early Complications of Transfusion
(TIP ARASTIRMALARI DERNEGI, 2010) Efe, S.; Demir, C.; Dilek, I.
Aim: It is aimed in this study to determine blood and blood component's transfusion indications, component using rate, early transfusion complications and the distribution of complications according to the blood component. Method: In this study, recipient's name, surname, age, gender, blood component, the clinic where transfusion have done, transfusion indications, whether or not transfusion history and complication, the amount and type of blood component, product waiting period in the blood center, vital findings before and after transfusion. Result: Percentage of transfused products was as follows: whole blood (50%), erytrocyte suspension (26%), fresh frozen plasma (19.8%) and platelet suspension (4.2%). Utilization rate of blood and blood components by service type was as follows: 30.8% in internal medicine, 11.9% in general surgery, 16.8% in obstetrics and gynecology, 15.3% in department of child health and disease and 25.2% in other service. Acute complication was observed in 3% of patients. 1.8% of them was developed acute febrile nonhemolytic transfusion reaction. Urticaria was observed in 0.95% of cases. Hypocalsemia in 2 patients (0.1%), hypotension in 2 patients (0.1%) using ACE inhibitory, hypertension in one patients (0.05%) and hypercalsemia in one patient (0.05%) after transfusion were observed in patients. Conclusion: Full blood utilization rates are high but it's close to Turkey average. Transfusion-related acute reaction rates were similar literature rates. It has suggested that information work should be increased to increase the use of component and to protect patients from unnecessary risk.
Effects of High-Dose Methylprednisolone Therapy on Lymphocyte Subtypes in Patients With Acute Immune Thrombocytopenic Purpura
(2005) Öner, A.F.; Bay, A.; Kuru, M.; Üner, A.; Arslan, Ş.; Dilek, I.
The aim of this study was to determine the effect of high-dose methylprednisolone (HDMP) on lymphocyte subtypes, CD4/CD8 ratio and clinical efficacy of the treatment in children with acute immune thrombocytopenic purpura (ITP). The study consisted of 21 children (aged between 1.5-14 years) with ITP treated with HDMP for 7 days. Absolute lymphocyte count, CD4+ and CD8+ T lymphocyte levels were examined on peripheral blood and CD4/CD8 ratio was calculated before and after HMTP treatment (on 0 and 8th days) in all subjects. There was no statistically significant difference for age and sex between the study and the control group. A significant reduction was observed in the percentage of CD4+ lymphocyte (39.0 ± 7.5% vs 29.3 ± 8.1%, p= 0.001), CD8+ lymphocyte (27.1 ± 7.2% vs 23.7 ± 8.3%, p= 0.03), CD4+/CD8+ (1.5 ± 0.5 vs 1.3 ± 0.4, p= 0.02) and the absolute number of CD4+ lymphocyte count (1694.99 ± 1019 vs 1199.12 ± 612, p= 0.038). These findings indicated that HDMP treatment may cause a decrease in the percentage of CD4+ and CD8+ T-lymphocyte and ratio of CD4+/CD8+ lymphocyte in patients with acute ITP. We suggest that the effectiveness of steroids may depended upon the suppression of CD4 T-lymphocyte and sequential monitoring of circulating lymphocyte subtypes may be used to predict the clinical effects of steroid treatment.
Efficacy of Intravenous Anti-D Therapy in Childhood Chronic Idiopathic Thrombocytopenic Purpura
(2006) Bay, A.; Öner, A.F.; Doǧan, M.; Açikgöz, M.; Dilek, I.
In this study we examined eleven patients with chronic immune thrombocytopenic purpura (ITP) who received anti D retrospectively. All of the cases have Rh+ blood group and non-splenectomized. Anti D was given 30μg/kg/dose on 0, 1, 7, 14, 21, 28 days by intravenous infusion in one hour. Three of them (27%) had complete response, three of them (27%) had partial response, three of them (27%) had minor response, and two of them (18%) didn't response. On following, only one patient who responded initially, had high trombocyte count over 1 year. The other patient's trombocyte counts were decreased to the initial level within 1-3 months after the treatment. We did not observe any important side effect. In conclusion, anti D should be considered as a therapeutic option for childhood chronic ITP.
Hcv Infection in Lymphoproliferative Disorders [1] (Multiple Letters)
(2004) Zavos, C.; Kountouras, J.; Chatzopoulos, D.; Dilek, I.; Demir, C.; Akdeniz, H.
Head and Neck Granulocytic Sarcoma With Acute Myeloid Leukemia: Three Rare Cases
(Medquest Communications LLC, 2001) Çankaya, H.; Ugras, S.; Dilek, I.
We conducted a retrospective review of pathology files and hospital records and identified three unusual presentations of granulocytic sarcoma associated with acute myeloid leukemia (AML) of the head and neck. At least one mass was observed on the skin of all three patients. A 17-year-old boy had masses in each temporal region that were accompanied by bilateral facial paralysis. He was administered chemotherapy and radiotherapy, but he died of infection secondary to a second relapse 29 months after the initial diagnosis. A 17-year-old girl had a tumor in the right parotid area. She received chemotherapy, but she died of infection and bleeding 2 months after the initial diagnosis, A 33-year-old man had numerous tumors widely disseminated over his skin. He received chemotherapy and was in remission 12 months after the initial diagnosis, but he eventually relapsed and died. Granulocytic sarcoma can be localized in unexpected regions, including the head and neck. This tumor is very often misdiagnosed as a malignant lymphoma, which leads to delayed treatment and a poor outcome. Therefore, clinical and histopathologic findings should be evaluated before any diagnosis of malignant tymphoma is pronounced. Immunohistochemical stains should also be performed on patients with suspected granulocytic sarcoma, and aggressive chemotherapy or immunotherapy should be administered. We believe that high-dose chemotherapy can improve survival rates in granulocytic sarcoma associated with AML.
Hepatitis C Virus Positivity in Patients With Neoplastic Lymphoproliferative Disorders
(2004) Dilek, I.; Durmuş, A.; Akdeniz, H.; Topal, C.; Demir, C.; Topcu, N.
Several studies have suggested that infection with hepatitis C virus (HCV), that is a hepatotropic and neoplastic virus, has a role in the aetiology of neoplastic lymphoproliferative disorders. The results of some studies, however, failed to establish such an association in the aetiology of these disorders. In this study, hepatitis C virus (HCV) antibodies were searched in 116 patients with lymphoproliferative disorders (LPD) by a third-generation macro ELISA technique. Fifty two of the patients had been suffering from non-Hodgkin's lymphoma (NHL), 38 from Hodgkin's disease (HD), 15 from chronic lymphocytic leukaemia (CLL), 6 from Waldenstrψm macroglobulinaemia (WM) and 5 from multiple myeloma (MM). Voluntary blood donors were taken as a control group. The results showed that anti-HCV positivity in all cases was significantly higher than the control group (8.6% vs 0.8%). The rates of anti-HCV positivity were 33.3%, 5.7%, 7.8%, 6.6% and 20% respectively in WM, NHL, HD, CLL and MM cases. In conclusion, the findings of our study demonstrate the probable role of HCV infection in the development of neoplastic LPD in our region.
Inflammatory Pseudotumor of the Lung Associated With Anemia: a Case Report and Review of the Literature
(2000) Yalcinkaya,; Demirtas, I.; Ayakta, H.; Akpolat, N.; Dilek, I.; Dilek, D.H.
Inflammatory pseudotumor of the lung is a benign tumor which is rarely seen. A mass in the left lung was observed in the chest roentgenogram of an 8 year-old boy while investigating for anemia. Preoperative investigations could not render the exact diagnosis. Pneumonectomy was required in exploratris thoracotomy. Histopathologic diagnosis was fibrohistiocytic type of inflammatory pseudotumor. Four months after the operation, anemia was cured without any further treatment.
A Patient With Acute Myeloid Leukemia Who Presented With Peritonitis While on Continuous Ambulatory Peritoneal Dialysis
(2012) Soyoral, Y.U.; Begenik, H.; Esen, R.; Dilek, I.; Dulger, A.C.; Demirtas, L.; Erkoc, R.
Peritonitis is a common complication in patients on continuous ambulatory peritoneal dialysis. In some cases peritoneal fluid is unremarkable. In these instances, one must evaluate for other causes of gastrointestinal pathology or a myriad of other causes. We report an unusual case of acute myeloid leukemia who presented with peritonitis in a continuous ambulatory peritoneal dialysis patient.
Relationship Between Leptin Levels and Body Indexes in Patients With Haematologic Malignancy
(2001) Mete, R.; Dilek, I.; Algün, E.; Erkoç, R.; Ayakta, H.; Topal, C.; Aksoy, H.
Leptin is a recently found hormone regulating body weight. In human obesity, this weight-regulating hormone level is in a positive correlation with FMI (fat mass index) and BMI (body mass index). In this study, we aimed to investigate the relation between serum leptin levels and BMI, PF (percentage fat), LMI (lean mass index), FMI and some other parameters of patients with haematologic malignant diseases. Fourty-four patients with haematologic malignant diseases and 25 healthy control group were taken into the study. In the comparison, there were no significant between the PF and FMI values of both groups, while the mean BMI and LMI values of the control group were significantly higher than that of the patient group. There was a positive correlation between leptin levels and BMI and FMI among parameters studied in our control group, whereas we couldn't demonstrate any such correlation in patient group. We estimate that the alteration may be due to disturbances in the feed back mechanism developing in patient with haematologic malignancy.
Seropositivity Rates of Hbsag, Anti-Hcv, Anti-Hiv and Vdrl in Blood Donors in Eastern Turkey
(2007) Dilek, I.; Demir, C.; Bay, A.; Akdeniz, H.; Öner, A.F.
Infections caused by hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency viruses (HIV) remain the leading most important health problems worldwide. Screening tests such as HBsAs, anti-HCV, anti-HIV and VDRL are mandatory tests to look at before transfusion of blood or blood components. In this study, donors who applied to our Blood Center in a nine-year period were retrospectively evaluated with respect to HBsAs, anti-HCV, anti-HIV and syphilis seroprevalence. HBsAg, anti-HCV and anti-HIV were examined by microparticle ELISA system, and syphilis antibodies were screened by a syphilis test device. Of the total 39,002 individuals, 16,601 (42%) were females and 22,401 (58%) were males. HBsAg positivity was found in 2.55%, anti-HCV in 0.17%, anti-HIV in 0.036%, and VDRL in 0.057% of overall donors. As a result, HBsAg, anti-HCV, anti-HIV and VDRL seropositivity rates in donors living in our region were found lower than those in many regions of Turkey. Nevertheless, because there is no screening method to reduce the risk resulting from transfusion to zero, it appears that it is essential to adopt strict criteria in the selection of donors and to avoid unnecessary transfusion. © Turkish Society of Hematology.
The Susceptibility of Autoxidation of Erythrocytes During Storage of Blood: Effects of Melatonin and Propofol
(Amer Assoc Clinical Chemistry, 2008) Sekeroglu, M. R.; Huyut, Z.; Dulger, H. H.; Dilek, I.