Browsing by Author "Dilek, Imdat"

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Assessment of Malnutrition in Adult Acute Leukemia Cases
(Asian Pacific Organization Cancer Prevention, 2010) Turedi, Ali; Demir, Cengiz; Dilek, Imdat
Introduction: This study examined malnutrition in acute leukemia cases, and its association to the treatment. Methods: 54 cases, consisting of 40 patients with acute myeloblastic leukemia (AML) and 14 patients with acute lymphoblastic leukemia (ALL) were included to the study, where further 34 healthy subjects were also recruited. Body mass index (BMI), triceps skin-fold thickness (TST), mid-arm circumference (MAC) and biochemistry tests were used for the assessment tools of malnutrition. Results: When classified according to BMI, prevalence of malnutrition was 18.5% in all cases, 18% in newly-diagnosed cases, 20% in patients with remission and 16% without remission, and 5.8% in control group. No statistically significant difference was found between groups (p=0.47). Prevalence of malnutrition according to TST and MAC was not difference in patient and control group (p=0.048), (p=0.37). Patients with malnutrition according to BMI had also significant malnutrition according to TST and MAC measurements (p < 0.001). Conclusions: Prevalence of malnutrition was seen at higher percentage in adult acute leukemia cases, which was increased during the course of treatment, and TST measurement was better in establishing malnutrition.
Brucellosis Concomitant With Acute Leukemia
(All india inst Medical Sciences, 2007) Bay, Ali; Oner, Ahmet Faik; Dogan, Murat; Acikgoz, Mehmet; Dilek, Imdat
We present two patients with brucellosis concomitant with acute leukemia. Co-existence of acute leukemia with brucellosis which may have similar symptoms, have not been reported earlier. The first case presented with generalized arthralgia, fever, paleness, and pancytopenia. The second patient had mild leucopenia and thrombocytopenia. She presented with fever. We carried out the chemotherapy for both ALL and brucellosis simultaneously. While the first patient's fever disappeared within 3 days, the second patient's fever had continued on subfebril level for five days and then disappeared. We achieved the remission in both patients and no reactivation was observed during the follow-up period.
Hematological Complications in 787 Cases of Acute Brucellosis in Eastern Turkey
(Tubitak Scientific & Technological Research Council Turkey, 2008) Dilek, Imdat; Durmus, Ahmet; Karahocagil, M. Kasim; Akdeniz, Hayrettin; Karsen, Hasan; Baran, Ali Irfan; Evirgen, Oemer
Aim: In this paper, we present the hematological findings of 787 cases diagnosed with acute brucellosis. Materials and Methods: Records of the cases seen between 1994 and 2006 were retrospectively investigated regarding hematological changes. Results: Three hundred sixty-five (46%) patients were male and 422 (54%) were female. Mean age was 32 (range: 11-78 years). Mean hematological values were as follows: Hb 12 g/dl (4-19), Htc 36% (12-56), leukocyte 6.9 x 10(9)/L. (0.5-25) and platelets 213 x 10(9)/L (9-617). According to differential counts, 34% and 14% of patients had mononuclear cell and neutrophil dominance, respectively. Fifty-six percent of patients were found to have anemia, alone or in combination with leukopenia or thrombocytopenia. Fourteen percent of patients had thrombocytopenia, 12% leukopenia, 5% pancytopenia, 4% leukopenia + thrombocytopenia, 0.5% acute hemolysis, and 0.1% disseminated intravascular coagulation. Restoration of thrombocytopenia and leukopenia and improvement in clinical situation were seen within one week and recovery of anemia occurred within 3-4 weeks. Conclusions: Hematological complications such as anemia and leukopenia are more frequently seen in acute brucellosis cases. However, acute brucellosis should also be considered in the differential diagnosis in the presence of other hematological abnormalities such as severe thrombocytopenia, pancytopenia, acute hemolytic anemia, and disseminated intravascular coagulation.
Natural Coagulation Inhibitors and Active Protein C Resistance in Preeclampsia
(Hospital Clinicas, Univ Sao Paulo, 2010) Demir, Cengiz; Dilek, Imdat
INTRODUCTION: The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia. OBJECTIVES: The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R) in preeclampsia. PATIENTS AND METHODS: We studied 70 women with preeclampsia recruited consecutively and 70 healthy pregnant and 70 nonpregnant women as controls. Plasma protein C (PC), free protein S (fPS), antithrombin III (ATIII) and APC-R were evaluated. RESULTS: ATIII values were found to be significantly lower in preeclamptic patients than in the control groups (p < 0.001). Nevertheless, there was no significant difference between the healthy pregnant and nonpregnant women groups (p = 0.141). The fPS values of the preeclamptic and healthy pregnant groups were lower than that of the nonpregnant group (p < 0.001), and the fPS value of the preeclamptic pregnant women was lower than that of healthy pregnant women (p < 0.001). The PC value of the preeclamptic pregnant women was lower than that of the control groups (p < 0.001). The PC value of the healthy pregnant women was lower than that of the nonpregnant women (p < 0.001). The mean APC activity values were lower in the preeclamptic patients than that of the control groups (p < 0.001, p < 0.001). The APC-R positivity rates of the preeclamptic groups were higher than that of the control groups (p < 0.001). CONCLUSIONS: This study demonstrated that ATIII, fPS, PC values and APC resistance were lower and APC-R positivity was higher in preeclamptic women than in normal pregnant and nonpregnant women.
Nutritional Status and Immune Functions in Maintenance Hemodialysis Patients
(Hindawi Ltd, 2006) Sayarlioglu, Hayriye; Erkoc, Reha; Demir, Cengiz; Dogan, Ekrem; Sayarlioglu, Mehmet; Oner, Ahmet Faik; Dilek, Imdat
Epidemiological studies suggest various kinds of immune dysregulation in hemodialysis (HD) patients. The aim of this study was to investigate the relationship between immune functions and nutritional status of HD patients. We studied 54 patients with ESRD on chronic HD, included 34 females and 20 males with mean age 46.6 +/- 16.3 (18-77) years. We measured the height and dry weight of all patients. The BMI was calculated by dividing weight (kg) by height squared (m(2)). In all patients serum urea, creatinine, albumin, iron, cholesterol, triglyceride, CRP, IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. In this study, a positive correlation between albumin, cholesterol, and triglyceride levels as nutritional parameters and immune functions in terms of total and subtype lymphocyte counts was observed. Further prospective studies are needed to determine the clinical importance of this finding and the appropriate means of measurement and effects of nutrition on immune function in hemodialysis patients. Copyright (c) 2006 Hayriye Sayarlioglu et al.
Serum Ferritin Levels in Pregnancy
(Galenos Publ House, 2011) Demir, Cengiz; Kocaman, Cemal Ertan; Dilek, Imdat
Objective: Iron deficiency is often seen in pregnancy. However, the prevalence of iron deficiency in this group shows both national and regional differences. This study was carried out to determine the prevalence of iron deficiency in pregnant women living in the Van region. Material and Methods: We evaluated 700 pregnant women who were grouped according to age, duration of pregnancy and number of births. Iron deficiency was regarded as ferritin levels of <12 mu g/L. Results: Median ferritin levels of all pregnant women were 27.04 +/- 1.18 mu g/L (range: 1.5-248 mu g/L). Iron deficiency was observed in 40% of cases. Median ferritin levels were 35.69 +/- 2.42, 30.40 +/- 2.47 and 18.74 +/- 1.34 mu g/L in the first, second and third trimester, respectively. Rates of iron deficiency according to trimesters were 26%, 33.5% and 53% respectively. Conclusion: Ferritin levels were significantly low in pregnant women over 25 years of age, in those who had more than three pregnancy and in those who were over five months pregnant.
Therapeutic Response To Plasmapheresis in Four Cases With Obsessive-Compulsive Disorder and Tic Disorder Triggered by Streptococcal Infections
(Turkiye Sinir ve Ruh Sagligi dernegi, 2007) Besiroglu, Luetfullah; Agargun, Mehemet Yuecel; Oezbebit, Oezguer; Soezen, Mehmet; Dilek, Imdat; Guelec, Mustafa
The acronym PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) has been assigned to a subgroup of patients experiencing pediatric onset obsessive-compulsive symptoms and tics as a result of autoimmune response to group A B-hemolytic streptococcal infection. It has been hypothesized that an immune process initiated by infection affects the basal ganglia and causes neuropsychiatric symptoms. In cases with severe neuropsychiatric symptoms, the use of treatment strategies that interrupt the autoimmune process responsible for the pathogenesis of PANDAS, such as therapeutic plasmapheresis or intravenous immunoglobulin, has been proposed. In this paper we discuss the effect of plasmapheresis treatment in 4 adult cases of obsessive-compulsive disorder and tic disorder triggered by streptococcal infections.