Browsing by Author "Dinc, Mehmet Emre"

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Mean Platelet Volume, Red Cell Distribution Width, and Neutrophil-To Ratio Before and After Surgery in Patients With Carotid Body Tumors
(Lippincott Williams & Wilkins, 2017) Bozan, Nazim; Kocak, Omer Faruk; Dinc, Mehmet Emre; Demir, Canser Yilmaz; Turan, Mahfuz; Kiroglu, Ahmet Faruk
Objective: Carotid body tumors (CBTs) are rare hypervascular benign tumors that originate from the paraganglia at the carotid bifurcation. The red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and mean platelet volume (MPV) may serve as markers in inflammatory, cardiovascular, and neoplastic diseases. However, their prognostic value in CBTs is unknown. The purpose of this study was to assess the leukocyte count, MPV, RDW, and NLR before and after surgery in patients with CBTs. Methods: This retrospective trial included data from 80 patients with CBTs and 65 age-matched healthy controls. The leukocyte, neutrophil, lymphocyte and platelet counts, RDW, and MPV were extracted and NLR was calculated from the complete blood count results of participants. Results: The leukocyte and neutrophil counts as well as RDW levels were significantly increased in patients with CBTs compared with healthy controls (P = 0.005, P = 0.003, and P = 0.026; respectively). Patients with CBTs had lower lymphocytes counts (P = 0.241) and higher NLRs (P = 0.054); however, the difference was statistically insignificant. Moreover, no statistically significant difference was detected between groups in terms of platelet counts and MPV levels. Furthermore, the leukocyte count, platelet numbers, MPV, RDW, and NLR levels in patients with CBTs were not statistically significant after surgery (all; P> 0.05). Conclusion: This is the first study that documents the increased RDW levels and leukocyte count in patients with CBTs. The combined use of RDW and the leukocyte count along with other clinical assessments can be used as a biomarker for CBTs. Further clinical trials with larger cases series are required to determine the actual predictive roles of these systemic biomarkers.
Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed With Chronic Otitis Media and Their Association With Surgical Treatment Outcomes
(Aves, 2017) Bozan, Nazim; Dinc, Mehmet Emre; Demir, Halit; Yalinkilic, Abdulaziz; Gonullu, Edip; Turan, Mahfuz; Kiroglu, Ahmet Faruk
OBJECTIVE: To determine the serum iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), magnesium (Mg), cobalt (Co), and lead (Pb) levels in patients with chronic otitis media (COM) and to evaluate the association of the serum levels of these elements with treatment outcomes. MATERIALS and METHODS: Thirty-one healthy volunteers and 31 patients with COM were prospectively included in this study. Serum levels of Fe, Zn, Mn, Mg, Cu, Co, and Pb were determined by an atomic absorption UNICAM-929 spectrophotometer. RESULTS: Serum Co, Pb, and Fe levels were significantly increased (p<0.001) and serum Cu, Zn, Mg, and Mn levels were significantly reduced in patients with COM compared with controls (p<0.001). Serum Co and Mn levels were significantly decreased (p<0.001 and p<0.005, respectively) and serum Cu levels were significantly increased after surgery (p<0.005). The other evaluated blood chemicals and heavy metals did not exhibit significant differences (p>0.05). CONCLUSION: Significant alterations in the serum chemical composition of patients with COM were observed. Moreover, with surgical treatment, serum levels of some of these chemicals were significantly altered. Further prospective studies are warranted to elucidate the exact association of these alterations in the etiopathogenesis of COM.
Thiol/Disulfide Homeostasis as a Novel Indicator of Oxidative Stress in Obstructive Sleep Apnea Patients
(Wiley, 2017) Dinc, Mehmet Emre; Ozdemir, Cengiz; Ayan, Nilhan Nurlu; Bozan, Nazim; Ulusoy, Seckin; Koca, Cemile; Erel, Ozcan
Objectives: The aim of the present study was to assess thiol/disulfide (SS) homeostasis as a novel indicator of oxidative stress in patients with obstructive sleep apnea (OSA) and to investigate the effect of continuous positive airway pressure (CPAP) therapy on oxidative parameters. Study Design: Prospective clinical study. Methods: A total of 104 subjects, 44 in an OSA group and 60 in two control groups (control simple snoring group, control OSA group) were included. The levels of parameters were measured using the Erel and Neselioglu method in patients with moderate or severe OSA before and after CPAP therapy. Results: The serum native thiol (SH) and total SH levels as well as the % SH/total SH ratio were significantly lower (P < 0.05) in OSA patients compared to controls, and the SS level and % SS/SH and % SS/total SH ratios were significantly higher (P < 0.05). After CPAP therapy, the native SH level and % SH/total SH ratio were significantly higher (P < 0.05) than before CPAP therapy, and the SS level and % SS/SH and % SS/total SH ratios were significantly lower (P < 0.05). Significant negative correlations were evident between the apnea/hypopnea index (AHI) and the native SH level and % SH/total SH ratio (P < 0.05) before CPAP therapy; and significant positive correlations were seen between the AHI and the % SS/SH and % SS/total SH ratios but not with the SS level. Conclusion: We found that oxidative stress was increased and CPAP therapy had a positive effect in patients with moderate or severe OSA.