Browsing by Author "Dirik, D."

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Amniocentesis Results of Van and Surrounding Provinces Between 2018 and 2020: a Tertiary Center Experience
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Küçükbaş, G.N.; Dirik, D.; Karaaslan, O.; Karaman, E.; Kolusari, A.; Aymelek, H.S.; Şahin, H.G.
Amniocentesis is one of the safest procedures of prenatal diagnosis. This study aimed to show amniocentesis indications, rate of successful amniocyte culture, complications and outcomes of these pregnancies undergoing prenatal diagnosis in eastern part of Turkey, especially Van province and its nearby. Between 2018 and 2020, 253 patients were referred to our center for amniocentesis and 120 patients giving consent were enrolled from Van and its surrounding provinces. The most frequent indication was high risk in prenatal screening tests whereas the highest chromosomal abnormality was found in fetuses with abnormal ultrasonographic findings. Overall, 11.6% of fetuses had chromosomal anomaly. The most abundant chromosomal abnormality was Trisomy 21, followed by trisomy 18 and 13. Except one case with amniotic leakage no complications were found. Eleven pregnancies were terminated whereas one fetus was born with Turner syndrome and two pregnancies resulted with stillbirth. In conclusion, fetuses with abnormal ultrasound screening had higher chromosome anomaly diagnosed by amniocentesis and compatible with the literature, amniocentesis is a safe and successful method of prenatal diagnosis of chromosomal abnormalities. Van and its surrounding provinces showed a high rate of chromosomal anomaly when prenatal diagnosis was done. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effect of Infliximab on Oxidative Stress in Ovarian Tissue in the Rat of Ovarian Hypersrimulation Syndrome
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Dirik, D.; Kömüroğlu, A.U.
Ovarian hyperstimulation syndrome (OHSS) is a complication that occurs during assisted reproductive techniques. In this study, our aim is to study the effect of Infliximab (IFX) on oxidative stress in ovarian tissue in a rat model of ovarian hyperstimulation syndrome. A total of 32 immature female rats were divided into four groups rando mly: Control, OHSS, OHSS+IFX, and IFX group. OHSS and OHSS+IFX groups were administered 30 IU pregnant mare serum gonadotropin/day on days 22-25 of life and 30 IU hCG on day 26. Plus, intraperitoneal IFX was administered half an hour before hCG administration to the OHSS+IFX group. On the 26th day, solely 7 mg/kg IFX was administered to the IFX group. 48 hours after administration of hCG administration, the rats were sacrificed and their ovarian tissues were sampled. The levels of MDA, AOPP, TSG as well as catalase activity were measured in these ovarian tissues. Ovarian tissue MDA and AOPP levels of the OHSS group were determined to be significantly higher compared to the control and OHSS-IFX groups. Ovarian tissue catalase activity and TSG level of the control group was significantly higher compared to the OHSS and OHSS-IFX groups. It was determined that although ovarian tissue catalase activity and TSG level in the OHSS-IFX group were higher compared to the OHSS group but it was not significant. The results revealed that IFX could prevent oxidative stress in ovarian tissue induced by O HSS. These effects may be mediated by the anti-inflammatory and antioxidant properties of IFX. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Epidemiology and Clinical Features of Preeclampsia
(Nova Science Publishers, Inc., 2020) Karaman, E.; Dirik, D.; Karaaslan, O.; Rapisarda, A.M.C.; Fichera, M.; Karaman, Y.
Preeclampsia is one of most important hypertensive disorders of pregnancy. It is characterized by the new onset of hypertension and proteinuria, or of hypertension and significant end-organ dysfunction with or without proteinuria, in the last half of gestation or postpartum. It complicates about 2-8% of gestations and it is a well-known cause of maternal-perinatal morbidity and mortality. The risk factors for development of preeclampsia include genetic factors, sperm exposure, maternal smoking, pre-existing medical conditions (such as hypertension, diabetes mellitus, chronic kidney disease and anti-phospholipid syndrome), and miscellaneous ones such as nulliparity, older maternal age and obesity. The clinical presentation of preeclampsia is varied. The main symptoms are headache, visual symptoms (including blindness), epigastric pain or nausea and vomiting. Preeclampsia is classified as mild and severe based on the degree of hypertension, laboratory and clinical findings. The most severe form is the development of eclampsia and HELLP syndrome. © 2020 by Nova Science Publishers, Inc. All rights reserved.
Evaluation of Peripartum Hysterectomy; Ten Years of Experience of a Tertiary Center
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Dirik, D.; Karaman, E.; Okyay, T.Y.; Kucukbas, G.N.; Karaaslan, O.; Alkiş, I.; Kolusari, A.
The objective of this study is to assess the 10-year incidence of peripartum hysterectomy that was performed in the province of Van, Turkey, as well as its clinical results. In this study, we retrospectively examined all patients who underwent peripartum hysterectomy, which was performed at Van Yuzuncu Yil University Dursun Odabas Medical Center between 2010 and 2020. 99 patients who underwent hysterectomy due to severe bleeding, which could not be stopped despite conservative tre atments within 24 hours following the delivery, were included in the study. The overall rate of peripartum hysterectomy was 99 of 22242 or 4.4 per 1,000 deliveries. The mean maternal age was 31.98 ± 5.41 years. The most common indications for peripartum hysterectomy are placental adhesion disorders (70.7%), uterine atony (25.2%), and uterine rupture (4%). Ultimately, the most common indication for peripartum hysterectomy is placental adhesion disorders. The rise in the number of cesarean section might have increased the incidence of placental adhesion disorders. Thus, patients should be provided with healthcare in centers that have adequate equipment and staff. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Maternal Serum Xenin-25 Levels in Gestational Diabetes Mellitus
(Verduci Editore s.r.l, 2023) Kucukbas, G.N.; Komuroglu, A.U.; Dirik, D.; Korpe, B.; Kose, C.; Karaaslan, O.; Sahin, H.G.
OBJECTIVE: Xenin-25 is a polypeptide having an insulinotropic effect via increasing the insulin-releasing action of glucose-dependent insulinotropic polypeptide (GIP) and promoting beta cell survival and proliferation. We aimed to assess serum xenin-25 levels in euglycemic pregnancies vs. pregnancies complicated with gestational diabetes mellitus (GDM). PATIENTS AND METHODS: Forty pregnancies complicated with GDM and 40 healthy pregnancies with gestational age between 24 and 28 weeks were included. Following eight hours of fasting, blood samples were drawn from the participants, and subsequently, 75 g of glucose was administered orally. Blood was drawn again 120 minutes after the glucose challenge. Serum xenin-25 levels were detected by ELISA. Statistical analysis was performed, and p<0.05 was considered statistically significant. RESULTS: There was no significant difference in maternal age, gestational age, BMI, fasting glucose, and insulin levels between the groups. Both fasting and 120th-minute xenin-25 levels were significantly higher in the GDM group when compared to the control group (p<0.05). Both the fasting and 120th-minute serum xenin-25 levels were significantly higher in women with GDM compared to healthy pregnant women. CONCLUSIONS: High levels of xenin-25 were associated with gestational diabetes, and xenin-25 might be a potential marker for detecting GDM in the future. © 2023 Verduci Editore s.r.l. All rights reserved.
Ovarian Torsion During Pregnancy: a Case of Malignant Ovarian Cancer
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Hacıoğlu, L.; Karaman, E.; Dirik, D.; Karaaslan, O.; Kolusarı, A.; Şahin, H.G.; Gül, A.
Ovarian torsion is an acute and emergency condition during pregnancy. It is caused mainly by the benign cystic mass in the ovary. However, ovarian cancer may be seen as a cause which is very rare during pregnancy. Here, we aim to present a case of pregnant women with ovarian torsion and diagnosed with malignant ovarian tumor. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Pathogenesis of Placenta Accreta Spectrum
(Springer International Publishing, 2022) Karaman, E.; Dirik, D.; Karaaslan, O.
This chapter covers the underlying mechanisms and pathological processes that leads to the development of placenta accreta. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.
Posterior Reversible Encephalopathy Syndrome in Eclamptic Patients: Five Years Experience of a Tertiary Center
(Wiley-blackwell, 2014) Kurdoglu, Z.; Sayin, R.; Cetin, O.; Dirik, D.; Karaagac, N.
Premenarchal Ovarian Torsion: Ten Years of Experience of a Tertiary Center
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Dirik, D.; Beger, B.; Okyay, T.Y.; Soysal, L.; Karaman, E.
Ovarian torsion is a surgical emergency, as it could lead to tissue necrosis and loss of fertility in the long term when diagnosis and intervention are delayed. In this study, the effectiveness of sonographic ovarian appearance in the decision of surgery and the clinical value of ovarian size in the diagnosis of torsion were investigated in premenarchal girls whose diagnosis of ovarian torsion was surgically verified. A retrospective cohort study design was utilized. Demographic characteristics, physical examination find ings, laboratory findings, ultrasonography findings, operation records, pathology reports of 20 premenarchal girls who were admitted to Van Yuzuncu Yil University Medical Faculty Emergency Service between 2010-2020 and who were surgically confirmed to have torsion scanned and recorded. The cases included in the study were divided into two groups: nine patients with normal ovarian torsion (group1) and eleven patients with mass or cystic ovarian torsion (group2). Regarding the duration passed between admissio n to the emergency department and undergoing surgery, the time was shorter in group 2 compared to group 1 (13.54 ± 6.02 hours and 77.0 ± 101.86 hours respectively; p=0.053). Conservative surgical treatment was realized in all patients in Group 1 (9/9; 100%) and 7 patients in Group 2 (7/11; 63.6%); patients in Group 2 underwent cystectomy. Furthermore, oophorectomy was performed on 4 patients in Group 2. In terms of the torsion side, right-sided torsion predominance was detected in the ovary in both groups (6 patients (66.6%) in Group 1 and 7 patients (63.6%) in Group 2. Ovarian volume and Doppler flow could be considered as a potential predictive variable for ovarian torsion. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Rare Case of Uterine Rupture Diagnosed in the Late Postpartum Period
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Karaaslan, O.; Kolusari, A.; Kolusari, P.; Dirik, D.; Sakinci, M.; Karaman, E.
Obstetric hemorrhages are still the most common cause of maternal mortality worldwide (1). Uterine rupture, which could be included among the causes of postpartum bleeding, results in serious mortality and morbidity. Although scarless uterine rupture is extremely rare, it might be seen with an approximate frequency of 1/5700-1/20000 in pregnancies (2-5). In general, it is diagnosed and treated in the early postpartum period as it usually presents symptoms at this very stage. A case of uterine rupture that was diagnosed and treated on the 28th postpartum day was discussed in this case. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Role of Paroxysmal Nocturnal Hemoglobinuria in Idiopathic Habitual Abortion
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Dirik, Y.; Ekinci, Ö.; Kara, O.; Dirik, D.; Doğan, A.; Demir, C.
Paroxysmal nocturnal hemoglobinuria (PNH) which is an acquired clonal hematopoietic stem cell disease, usually presents with intravascular hemolysis, thrombosis and bone marrow failure. Hereditary and acquired thrombophilia are known to play significant role in the etiology of patients with habitual abortion (HA). PNH, which is a cause of acquired thrombophilia, may have a role in the etiology of HA. In the present study, we investigated the presence of PNH clone among the patients with a history of HA. 150 patients were enrolled in the study group, diagnosed with habitual abortus of unknown etiology and 150 healthy women with no history of habitual abortus as a control group. The age range for both groups was 18–55 years. The PNH clone was screened by the FLAER (fluorescein-labeled proaerolysin) method. The PNH clone was positive in five (3.3%) patients in the study group. Four of the PNH clone positive patie nts were found to have a very low clone positivity level (0.05%, 0.24%, 0.12%, 0.21%), while one had a high level (30%). PNH clone positivity results in the study group indicate that PNH should be investigated in cases of idiopathic HA, as one patient required treatment. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Role of Paroxysmal Nocturnal Hemoglobinuria in Idiopathic Habitual Abortion
(Pergamon-elsevier Science Ltd, 2017) Dirik, Y.; Ekinci, O.; Kara, O.; Dirik, D.; Dogan, A.; Demir, C.