Browsing by Author "Dirik, Yaren"

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Can Ascites and Serum Analyses Differentiate Delta From Hbv Infection in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
(Carbone Editore, 2021) Aydin, Mesut; Ozer, Serhat; Aytemiz, Enver; Dirik, Yaren; Dulger, Ahmet C.
Aim: We tried in this work to define laboratory differences in ascites and serum of cirrhotic patients with HBV or Delta infection Material and Methods: We conducted a retrospective study in a large hospital experienced in hepatology by including 46 patients with HBV and HDV between January 2018 and September 2020. Data of age and gender-matched 24 patients with HBV and 22 patients with HBV/HDV having SBP were analyzed. Results: White blood cell, neutrophil counts, serum glucose, serum albumin, serum globulin, serum ascites-albumin gradient and serum albumin-globulin gradient levels were similar. Conclusion: Cirrhotic patients with HDV infection had lower platelet and serum fibrinogen and higher INR levels than those with HBV infection.
Can We Reduce Oxidative Stress With Liver Transplantation
(Soc Medical Biochemists Serbia, 2021) Aydin, Mesut; Dirik, Yaren; Demir, Canan; Tolunay, Harun; Demir, Halit
Background: The aim of this study was to determine the levels of lipid peroxidation (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in the blood serum of patients with cirrhosis and liver transplantation. Methods: In this study, serum malondialdehyde acid (MDA) levels, superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) activities were measured spectrophotometrically and compared to the results of the healthy control group. Results: SOD, CAT and GSH activities were significantly decreased in the patient groups compared to the healthy control group (p<0.05). MDA levels were significantly higher in the patient group compared to the healthy control group (p <0.05). Conclusions: In conclusion, this study demonstrated that oxidative stress may play an important role in the development of liver cirrhosis and in liver transplantation. This study is the first one to show how MDA, SOD, CAT and GSH levels change in liver cirrhosis and liver transplantation, while further studies are essential to investigate antioxidant enzymes and oxidative stress status in patients with cirrhosis and liver transplantation.
Covıd-19 ve Düşük Ürik Asit Seviyeleri
(2021) Dülger, Ahmet Cumhur; Aydın, Mesut; Dirik, Yaren; Tolunay, Harun Egemen; Gül, Alev
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An Interesting Cause of Hyperandrogenemic Hirsutism
(Hindawi Ltd, 2014) Atmaca, Murat; Seven, Ismet; Ucler, Rjfki; Alay, Murat; Barut, Veysi; Dirik, Yaren; Sezgin, Yasin
Mild clinical signs of hyperandrogenism such as hirsutism may appear during the menopausal transition as part of the normal aging process, but the development of frank virilization suggests a specific source of androgen excess. We report a case of a 68-yearold woman with signs of virilization that had started 6 months before. Clinical analyses revealed high levels of serum testosterone for a postmenopausal woman. Pelvic MRI and abdomen CT showed no evidence of ovarian and adrenal tumor. Postmenopausal hyperandrogenism can be the result of numerous etiologies ranging from normal physiologic changes to ovarian or rarely adrenal tumors. Our patient was found to have iatrogenic hyperandrogenism. This condition is rarely reported cause of virilization.
Kolon Divertiküler Hastalığı Olan Hastalarda Çölyak Hastalığı Sıklığı
(2021) Tuncel, Elif Tugba; Dulger, Ahmet Cumhur; Ozer, Serhat; Aydin, Mesut; Dirik, Yaren
Maç: Çölyak hastalığı, pozitif HLA haplotipleri DQ2 ve DQ8 olan deneklerde buğdaya aşırı duyarlılığın neden olduğu bir ince bağırsak malabsorpsiyon sendromudur. Kolonun divertiküler hastalığı, daha çok 40 yaş üstü erişkinlerde görülen kolonun sakküler dilatasyonlarıdır. Bu çalışmada, çölyak hastalığı' nın kolonun divertiküler hastalığı için koruyucu olup olmadığını araştırdık. Gereç ve Yöntem: Ocak-Ekim 2018 arasındaki 7 aylık dönemde 114 (57 kadın; ortalama yaş 58 ± 4.1 yıl) kolonun divertiküler hastalığı hastalığı tanısı olan hasta çalışmaya alındı. Yaşa uygun kontrol grubu (100 denek; 50 kadın; ortalama yaş 59 ± 3.4 yıl) kolonun divertiküler hastalığı olmayan deneklerden seçildi. Bulgular: Kolonun divertiküler hastalığı tanısı olan denekler arasında sadece bir tanesinde serolojik olarak çölyak hastalığı için pozitif tespit edildi (Doku Transglutaminaz - TTG IgA ve G). Dispepsili kontrol deneklerinde, deneklerin% 2.8'inde çölyak antikor pozitifliği tespit edildi. TTG Ig A seropozitifliği açısından gruplar arasında güçlü bir fark vardı (sırasıyla p =0.032). Sonuç: Sonuçlar, kolonun divertiküler hastalığı ve çölyak hastalığı arasında ters bir ilişki olduğunu göstermektedir. Bu veriler, çölyak antikorları varlığının kolon divertiküler hastalığı gelişimini önleyici bir role sahip olabileceğini desteklemektedir. Sunulan bulgunun mekanizması hala belirsizdir. Daha fazla araştırmaya ihtiyaç vardır.
Life-Threatening Hypophosphatemia And/Or Phosphate Depletion in a Patient With Acute Lymphoblastic Leukemia: a Rare Case Report
(W B Saunders Co-elsevier inc, 2014) Soyoral, Yasemin; Aslan, Mehmet; Ebinc, Senar; Dirik, Yaren; Demir, Cengiz
Acute severe hypophosphatemia can be life threatening and is associated with mortality and impaired cardiac and respiratory function. Several conditions including decreased absorption or increased urinary phosphate excretion, shifts from the extracellular to intracellular compartments, and phosphate consumption by rapidly proliferating cells are known to induce moderate to severe acute hypophosphatemia. Although hypophosphatemia and/or phosphate depletion in patients with acute or chronic myeloid leukemia have been reported in the literature, hypophosphatemia due to acute lymphoblastic leukemia (ALL) is very rare. We report a case of history of ALL complicated by life-threatening hypophosphatemia manifesting as generalized muscle weakness, fatigue, acute shortness of breath, and difficulty in standing up and walking for 3 days. Serum inorganic phosphate levels were consistently low (0.06 mmol/L). The patient was hospitalized and thought to have a relapsed ALL. Anticancer agents and oral phosphate (660 mg twice daily) were administered. On the second day of treatment, the patient began to improve, and the patient gradually fully recovered within 5 days. We suggested that this hypophosphatemia was induced by a shift of phosphorus into leukemic cells that rapidly replicated in the tissues and excessive cellular phosphate consumption by rapidly proliferating cells. Serum phosphate levels should always be monitored, especially in suspected life-threatening manifestation in relapsed ALL.
A Rare Presentation of Transfusional Hemochromatosis: Hypogonadotropic Hypogonadism
(Hindawi Ltd, 2015) Ucler, Rifki; Kara, Erdal; Atmaca, Murat; Olmez, Sehmus; Alay, Murat; Dirik, Yaren; Bora, Aydin
Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading to cellular damage and organ dysfunction. beta-thalassemia major is one of the causes of secondary hemochromatosis due to regular transfusional treatment for maintaining adequate levels of hemoglobin. Hypogonadism is one of the potential complications of hemochromatosis, usually seen in patients with a severe iron overload, and it shows an association with diabetes and cirrhosis in adult patients. We describe a patient with mild transfusional hemochromatosis due to beta-thalassemia major, presenting with central hypogonadism in the absence of cirrhosis or diabetes. Our case showed an atypical presentation with hypogonadotropic hypogonadism without severe hyperferritinemia, cirrhosis, or diabetes. With this case, we aim to raise awareness of hypogonadotropic hypogonadism in patients with intensive transfused thalassemia major even if not severe hemochromatosis so that hypogonadism related complications, such as osteoporosis, anergia, weakness, sexual dysfunction, and infertility, could be more effectively managed in these patients.