Browsing by Author "Doǧan, A."

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Anatomical and Histological Investigations on the Effects of Stratification Substrates on Final Take and Quality of Grafted Vines
(TUBITAK, 2000) Cangi, R.; Balta, F.; Doǧan, A.
This experiment was carried out to determine the effects of water, sawdust and pumice as stratification substrates on the success of callusing, final take and quality of grafted vines of the Hafizali and Ercis, grape cultivars grafted on Kober 5BB rootstock. The anatomical and histological development of the graft union was investigated at 21, 28, 35 and 42 days after grafting in all combinations. As for the results of the anatomical and histological investigations, it was observed that the cambial continuity between graft components in all combinations was mostly established in 21 days, and completed in 28-35 days in water and sawdust. Although water and sawdust were found to be better than pumice, water is recommended as the optimum stratification substrate.
Comprehensive Analysis of FLT3-Mutated Patients with Acute Myeloid Leukemia with Updated 2022 European LeukemiaNet Recommendations: Insights from the Turkish AML Registry Project
(BioMed Central Ltd, 2025) Pınar, I.E.; Celik, S.; Polat, M.G.; Karatas, A.F.; Doǧan, A.; Iltar, U.; Cengiz Seval, G.
Background: This study aimed to evaluate the prognostic significance and clinical impact of the revised 2022 European LeukemiaNet (ELN) classification for acute myeloid leukemia (AML), focusing particularly on patients harboring fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations. Methods: A retrospective, multicenter observational study was conducted by the Turkish Society of Hematology-Acute Leukemias Working Group, analyzing 312 adult patients newly diagnosed with AML from January 2012 to December 2022. Patients with acute promyelocytic leukemia were excluded. FLT3-ITD mutations were detected using polymerase chain reaction and, when available, next-generation sequencing. Patients were classified according to the 2017 ELN risk stratification, and FLT3-ITD-positive cases were reclassified based on the updated 2022 ELN criteria. Endpoints were complete remission (CR), disease-free survival (DFS), and overall survival (OS). Results: FLT3-ITD mutations were identified in 54 (17.3%) patients. According to the 2022 ELN classification, 29 patients previously categorized as the favorable (n = 6) or adverse-risk (n = 23) groups were reclassified into the intermediate-risk group, highlighting the substantial impact of removing the FLT3-ITD allelic ratio from risk stratification. With a median follow-up of 31.8 months, OS significantly differed among the 2017 ELN favorable-, intermediate-, and adverse-risk categories (not reached, 21.6 months, and 9.5 months, respectively, p < 0.001). FLT3-ITD-positive patients demonstrated significantly inferior DFS (p = 0.038) and OS (p = 0.009) compared to FLT3-ITD-negative patients. In patients achieving first CR, allogeneic hematopoietic stem cell transplantation (HSCT) improved OS in intermediate-risk (p = 0.003), showed a trend in adverse-risk (p = 0.098), and no benefit in favorable-risk (p = 0.351). Among reclassified FLT3-ITD-positive patients, survival outcomes aligned closely with the original intermediate-risk group defined by the 2017 ELN, supporting the rationale behind the ELN revision. Conclusions: Our findings validate the prognostic utility of the revised 2022 ELN guidelines, especially regarding FLT3-ITD-positive AML, emphasizing that the exclusion of the FLT3-ITD allelic ratio yields a more biologically consistent risk categorization. Furthermore, the data support tailored ELN-based risk stratification for older AML patients. Given the modest benefit of HSCT in adverse-risk patients, future refinements should further stratify this group to address their unmet therapeutic needs and enhance survival outcomes. Trial registration: The study was registered at ClinicalTrials.gov (NCT05979675). © 2025 Elsevier B.V., All rights reserved.
Electroacupuncture in the Treatment of a Ganglion of the Wrist - a Case Report
(2006) Tekeoǧlu, I.; Doǧan, A.
A ganglion is a cystic swelling that occurs most commonly in women. Recurrence is possible after conservative or surgical treatment. A novel method of therapy, electroacupuncture stimulation, was performed in a 53 year old woman with a large, recurrent dorsal wrist ganglion. After treatment it rapidly disappeared and there was no recurrence during the one year follow-up period. Although the mechanism is obscure, it is our impression that electroacupuncture may have a local action on such cysts in addition to needle drainage.
A Giant Cervical Osteochondroma
(TIP ARASTIRMALARI DERNEGI, 2005) Kiymaz, N.; Doǧan, A.; Yilmaz, N.; Mumcu, Ç.
A giant solitary osteochondroma in 17-year-old-boy was reported. Osteocondromas usually involves the long bones, scapulae, pelvic bones and seldom occurs in the axial skeleton. A 17-year-old boy presented with a swelling at the rear of the neck and an advanced degree of limitation in the movements of his neck. A hard mass sized approximately 7x8 cm was revealed in this region. Cervical x-ray and CT revealed the mass involving the sixth cervical vertebrae. Giant cervical osteochondroma operated and the mass was successfully excised. Osteochondromas that consists the largest portion of benign bone tumors at the spine is seldom. Therefore we are introducing a osteochondroma case located at the lower cervical region where an advance degree of limitation in neck movements that displays no any neurological symptoms and that reaches a very wide mass in size, and which is assumed as unusual.
Histopathology and Oxidative Stress in the Liver of Chalcalburnus Tarichi Living in Lake Van, Turkey
(Zhengzhou University, 2014) Kaptaner, B.; Kankaya, E.; Doǧan, A.; Çelik, I.
To assess the environmental quality in the Lake Van, Chalcalburnus tarichi, the only vertebrate and an endemic carp species of this lake basin, samples were collected from the lake, and their livers were examined histologically for this purpose. Histological alterations were recorded and evaluated semi-quantitatively based on the liver lesion categories and their severities. According to the results, five of a total of forty samples displayed normal (healthy) liver architecture, but the others displayed various histopathological alterations, including hepatocyte vacuolization, fatty degeneration, increase in melanomacrophage centers, necrosis, infiltration, congestion, fibrosis, single cell necrosis, bile duct alterations, glycogen depletion and nuclear pleomorphism. Liver index values were calculated and found to be changed between 2 and 50 (≤4 for fish with normal livers (FwNL) and ≥8-50 for fish with histopathological livers (FwHL). We also investigated oxidative stress biomarkers, lipid peroxidation (LPO) and antioxidant enzymes (superoxide dismutase (SOD) and catalase (CAT)) in FwHL as compared with FwNL. LPO and CAT were found to be significantly higher in FwHL, indicating increased oxidative stress. The results revealed that the observed histological and biochemical alterations in the livers of C. tarichi reflect the effects of environmental stressors present in the lake water causing pollution.
Pigmented Villonodular Synovitis Within Baker's Cyst: the Role of Mr-Arthrography
(Elsevier BV, 2003) Harman, M.; Arslan, H.; Doǧan, A.; Özen, S.; Ipeksoy, Ü.
We report a case of pigmented villonodular synovitis (PVNS) within Baker's cyst in a 55-year-old man who admitted to hospital with palpable popliteal mass. The mass was examined with ultrasonography (US), magnetic resonance imaging (MRI) and magnetic resonance arthrography (MRA). MRA was the best modality in the demonstration of the connection of the lesion with the joint space. In this study, we emphasized on the importance of the MRA in the PVNS within Baker's cyst. To the best our knowledge, this is the first report that illustrates the MRA characteristics of a PVNS within Baker's cyst. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Real-World Outcomes and Prognostic Factors in Primary Mediastinal B-Cell Lymphoma: A Multicenter Study of 157 Patients
(Springer Science and Business Media Deutschland GmbH, 2025) Kucukyurt, S.; Koca, O.; Terzi Demirsoy, E.; Akin, S.; Doǧan, A.; Gören, D.; Yiğitbaşı, A.
Primary mediastinal B-cell lymphoma (PMBCL) is a rare and distinct subtype of non-Hodgkin lymphoma. No consensus exists on optimal frontline treatment, and the use of R-CHOP ± radiotherapy (RT) and DA-EPOCH-R ± RT remains common, yet comparative real-world data are limited. In our multicenter retrospective study, we analyzed PMBCL patients, stratified by the first-line therapy (R-CHOP-21 ± RT or DA-EPOCH-R ± RT). Primary outcomes were complete response (CR) rate, progression-free survival (PFS), and overall survival (OS), alongside assessment of treatment-related toxicities and prognostic factors for PFS and OS. We included 157 patients [R-CHOP ± RT group (n = 80) and DA-EPOCH-R ± RT group (n = 77)] with a median age of 31 years, of whom 68.2% were female. CR rates were similar for R-CHOP ± RT (75%) and DA-EPOCH-R ± RT (76.6%). RT use was higher in the R-CHOP group (41.2% vs. 19.5%, p = 0.002). DA-EPOCH-R had significantly higher toxicity (29.9% vs. 16.2%, p = 0.033). The median follow-up of the entire cohort was 29 months with 2-year PFS and OS rates of 73.9% and 83.6%, respectively. Also, PFS and OS did not differ between regimens. In patients achieving CR with R-CHOP, RT omission did not impact survival. Multivariate analysis identified older age, poor performance status, superior vena cava syndrome and splenic involvement as independent OS predictors, while pericardial effusion, splenic involvement and hemoglobin < 10.5 g/dL were linked to inferior PFS. R-CHOP-21 ± RT and DA-EPOCH-R ± RT provide comparable efficacy in PMBCL. Due to the higher toxicity of DA-EPOCH-R, for those achieving CR following R-CHOP, selective RT omission may be a reasonable alternative. Established and disease-specific prognostic factors should guide individualized treatment strategies. © 2025 Elsevier B.V., All rights reserved.
The Value of Flexion Mri Acquisition in Detection of Meniscal Tears
(TIP ARASTIRMALARI DERNEGI, 2010) Gündüz, A.M.; Arslan, H.; Avcu, S.; Etlik, O.; Doǧan, A.; Ünal, O.
Aim: The efficiency of MRI of the flexed knee was studied concerning meniscal lesion staging, existence of tears and meniscocapsulary separation (MCS). Method: In our study with 50 cases, saggital TSE Pd/T2W sequences were acquired in flexion position in addition to routine MRI sequences in neutral position. Subtle or apparent tears and MCSs observed on neutral position acquisitions (NPA) were also evaluated with knee in flexion acquisitions (KFA) in order to evaluate additional diagnostic findings. Statistical evaluation was performed using Chi-square and reliability of medical diagnostic tests. Result: There was no statistically significant difference between NPA and KFA concerning meniscal lesion grading (p>0.05). There was no statistically significant difference between NPA and KFA concerning tears due to signal increase extending to the joint surface. On the other hand, KFA contributed in tears due to MCSs (28,6%). Conclusion: KFA is an applicable method in closed system MR devices, does not disrupt patient comfort and is not time consuming. Using this method, additional information can be acquired with high contrast resolution images. KFA seems to be a superior method to NPA in patients with suspected meniscal tears and especially in cases of MCS. Further studies with extended number of patients will increase the reliability of the results.