Browsing by Author "Dogan, A."

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Calcaneal Brown Tumor With Primary Hyperparathyroidism Caused by Parathyroid Carcinoma: an Atypical Localization
(2004) Dogan, A.; Algün, E.; Kisli, E.; Harman, M.; Kösem, M.; Tosun, N.
Brown tumors are one of the characteristics of primary hyperparathyroidism, although, in some cases, they are noted with secondary hyperparathyroidism as well. The authors present a case of a 50-year-old woman with primary hyperparathyroidism caused by parathyroid carcinoma with an unusual location of a brown tumor in the calcaneus. She first presented with pain and swelling over the heel and ankle, and the diagnosis was suspected by radiographs. Biopsy of the calcaneal lesion confirmed a brown tumor. After the parathyroid lesion was removed surgically, her symptoms were relived. The calcaneal lesion was treated with immobilization of the foot.
A Case of Myasthenia Gravis Developing From Chronic Myeloid Leukemia With Imatinib Use: a Case Report
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Ekinci, O.; Demircioglu, S.; Demir, C.
Changes in Seed Mineral Matter Contents of Rose Hip Species Grown Naturally in Turkey
(int Soc Horticultural Science, 2015) Dogan, A.; Celik, F.; Gundogdu, M.; Kazankaya, A.; Sensoy, R. I. Gazioglu
Recently, the fruits and seeds of rose hip have an increasing potential for human nutrition and industrial aspects. Moreover, the rose hip seeds can be used as animal feed. In the present study, the seed mineral contents of different rose hip species (R. canina L., R. dumalis var. boissieri, R. iberica, R. heckeliana subsp. vanheurckiana and R. pulverulenta) were determined. The nitrogen (N), phosphorous (P) and potassium (K) contents of the investigated species varied from 19,039 to 28,076 ppm, from 553 to 1080 ppm, and from 1142 to 2945 ppm, respectively. The nickel (Ni), lead (Pb), and sulphur (S) contents of the investigated species ranged from 13.5 to 190.2 ppm, from 0.35 to 4.35 ppm, from 609.5 to 1152.5 ppm, respectively. Moreover, sodium (Na), iron (Fe), manganese (Mn), zinc (Zn), copper (Cu), magnesium (Mg), and calcium (Ca) contents were also determined. The mineral contents of the investigated species ranked from the highest to lowest as N>K>P>S>Mg>Ca>Na>Fe>Zn>Ni>Mn>Cu>Pb.
Characteristics of Pomegranate Genotypes Grown in Cukurca-Hakkari Region of Turkey
(int Soc Horticultural Science, 2015) Kazankaya, A.; Ozatak, O. F.; Dogan, A.; Sensoy, R. I. Gazioglu; Gundogdu, M.; Encu, T.
Pomegranate (Punica granatum L.) is an important fruit species in Turkey having rich diversity for pomegranate. In the present study, the fruit and tree characteristics of pomegranate genotypes grown in Cukurca-Hakkari region of Turkey were determined. In the result of this work carried out on the chosen 20 genotypes, some data can be summarized as: fruit weight ranged from 92.91 to 176.00 g; vitamin C content ranged from 30 to 50 mg/100 g; soluble solid content varied from 10.5 to 18 degrees Brix; total seed weight ranged from 52.75 to 92.50 g. The tastes of fruit were determined as sour, mildly sour, and sweet. Nine genotypes among the studied ones were found to be promising based on their superior characteristics.
Clinical and Pathological Characteristics of Non-Hodgkin Lymphoma Patients in Eastern Turkey: a Single-Center Study
(Pergamon-elsevier Science Ltd, 2018) Dogan, N. Yildirim; Erkurt, M.; Dogan, A.; Ekinci, O.; Kuku, I.; Kaya, E.
Clinical Features and Responses To Eculizumab of Paroxysmal Nocturnal Hemoglobinuria Patients: a Single-Center Experience
(Pergamon-elsevier Science Ltd, 2018) Ekinci, O.; Dogan, A.; Demircioglu, S.; Sonmez, G.; Demir, C.
Complement-Mediated Hemolytic Uremic Syndrome: a Case Report
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Ekinci, O.; Demircioglu, S.; Aydemir, O.; Gocuncu, S.; Demir, C.
Decreased Bone Mineral Density and Related Parameters in Severe Hemophilia a Patients: a Case-Control Study
(Pergamon-elsevier Science Ltd, 2018) Ekinci, O.; Demircioglu, S.; Dogan, A.; Demir, C.
Disseminated Intravascular Coagulation: a Single Center Experience
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Ekinci, O.; Candar, O.; Dogan, A.; Esen, R.; Demir, C.
We aimed to evaluate the clinical and demographic data of adult patients diagnosed with acute disseminated intravascular coagulation (DIC) who had been referred to the hematology unit by other clinics, as well as to evaluate the effect of clinical and laboratory parameters on patient survival. Materials and Methods: The records of 87 adult patients admitted to the Department of Hematology of Yuzuncu Yil University Faculty of Medicine between January 2013 and May 2017 and diagnosed with acute DIC were retrospectively examined. Of the patients participating in the study, 64 (73.6%) were female and 23 (26.4%) were male. Regarding the distribution of etiology in patients with acute DIC, the most common etiology, at 49.3%, was obstectic pathologies. Acute DIC was more frequent in women and younger adults (p = 0.001). Patients with trauma had the highest mortality rate (p = 0.001). Patients diagnosed with acute DIC who died as a result were older, and mortality was higher in males (p < 0.001 for both). Comparing ISTH scores, patients with acute DIC had significantly higher mortality (p = 0.028). In this study, a majority of the patients diagnosed with acute DIC were young and female. De spite their high incidence of acute DIC however, the mortality rate for young female patients was low. The mortality rate was higher in elderly and male patients, although intensive treatment was administered following diagnosis of acute DIC. We believe that early diagnosis and appropriate treatment are of critical importance for patients thought to have acute DIC, regardless of underlying condition. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Distribution of Abo and Rh Blood Groups and Seroprevalence of Hbsag, Anti-Hcv, Anti-Hiv and Syphilis in Healthy Donors: a Single Center Experience
(Pergamon-elsevier Science Ltd, 2017) Ekinci, O.; Kara, O.; Dogan, A.; Demircioglu, S.; Demir, C.
Effect of Helicobacter Pylori Infection on the First-Line Treatment Outcomes in Patients With Immune Thrombocytopenic Purpura
(Verduci Editore s.r.l, 2022) Dogan, A.; Ekinci, O.; Ebinc, S.
OBJECTIVE: Helicobacter pylori (H. pylori) eradication therapy is known to increase the platelet count, but in immune thrombocytopenic purpura (ITP), the effect of H. pylori infection on the response to treatment is not clear. This study aims to determine whether the response to the first-line treatment is affected by the states of H. pylori-positivity and -negativity in ITP patients. PATIENTS AND METHODS: Adult newly diagnosed or chronic ITP patients who had not received eradication therapy for H. pylori infection were included. Characteristics of the patients, presence and severity of bleeding, initial platelet count, administered treatments, and treatment response rates were inspected. RESULTS: Of 119 total patients, 66 (55.5%) were female, 32 (26.9%) were H. pylori-positive, 87 (73.1%) were H. pylori-negative. H. pylori-positive and H. pylori- negative groups were not significantly different in terms of age (p=0.127), gender (p=0.078), diagnosis status (p=0.094) and the distribution of bleeding symptoms (p=0.712). The most common treatment was standard-dose steroid in both groups (62.5% vs. 68.9%, p=0.524). Rates of complete response, partial response, no response were comparable for the two groups (respectively, 75% vs. 73.6%, and 18.8% vs. 19.5%, and 6.2% vs. 6.9%), and there was no significant difference between the groups (p=0.283). CONCLUSIONS: It can be stated, according to the present study, that in ITP patients in whom treatment is indicated, the response to the firstline treatment without the administration of H. pylori eradication therapy is similar between H. pylori-positive and H. pylori-negative patients. © 2022 Verduci Editore s.r.l. All rights reserved.
Exploring the Protective Effects of Chinar (Platanus Orientalis L.) Leaf on Testes Damage Induced by Ethanol in Rat Model
(Pakistan Agricultural Scientists Forum, 2024) Yaman, T.; Dogan, A.; Keles, O. F.; Donmez, F.; Battal, A.; Anuk, O. O.
The aim of this study was to investigate the protective effects of an infusion obtained from dried Chinar (Platanus orientalis L.; PO) leaves against ethanol (EtOH)-induced damage in rat testes. Thirty male Wistar rats were randomly and equally divided into 5 groups, as the Control, EtOH 20%, EtOH 20% + Silymarin (10 mg/kg/day), EtOH 20% + PO20 mg/mL infusion, and EtOH 20% + PO -60 mg/mL infusion. Histopathologically, treatment with PO -60 leaf infusion resulted in improvements in EtOH-induced damage in the testes by inhibiting the depletion of germ cells and loss of spermatozoa. Immunohistochemically, an increase in the expression of endothelial nitric oxide synthase (eNOS) and caspase-3 was observed in the EtOH group. Treatment with the PO extract markedly reduced the EtOH-induced expression of eNOS and caspase-3 in the EtOH 20% + PO -60 group. According to the biochemical results, both of the PO infusion treatments caused a decrease in the malondialdehyde levels compared to the EtOH group. On the other hand, the glutathione contents in the treatment groups were significantly higher than ethanol group. Fluctuations in antioxidant defense enzyme activities were determined. PO leaf might have a protective role against EtOH-induced testicular damage in rats by inducing apoptosis via the upregulation of eNOS expression and preventing lipid peroxidation.
Fruit Properties of Rose Hip Species Grown in Lake Van Basin (Eastern Anatolia Region)
(Asian Network for Scientific Information, 2006) Dogan, A.; Kazankaya, A.
In this study, some chemical and technological fruit attributes of rose hip species grown in the Lake Van Basin (Eastern Anatolia Region) were studied. Attributes such as fruit and stone length, width (mm) and weight (g), fruit flesh ratio (%), the water-soluble extracts (%), pH, titretable acidity (%) and dry matter content (%) were evaluated. Evaluated fruit attributes of the rose hip genotypes were significantly different from each others (p<0.05). Fruit weights were between 1.50 and 3.74 g. Rosa dumalis (Rd) has the heaviest average fruit weight of 3.11 g. However, this genotype has the lightest flesh ratio (57.2%) because of the highest stone weight. Fruit shape index were between 1.06 and 2.12. The rose hip samples had a range of 11-25% for water-soluble extract, 3.95-4.57 for pH, 0.35-1.14 for titretable acidity and 34.34-66.70 for dry matter content. Rosa foitida and Rosa pisiformis has the highest water-soluble extract of 20.54 and 20.33, respectively. Variations in water-soluble extract are of great importance. Chemical and technological values of the investigated rose hip species showed a similarity to that studied from other native rose hip populations earlier. © 2006 Asian Network for Scientific Information.
Hemophagocytic Lymphohistiocytosis Associated With Acute Hepatitis a Disease
(Pergamon-elsevier Science Ltd, 2018) Dogan, A.; Demircioglu, S.; Ekinci, O.; Zorlu, D.; Kayran, M.; Kara, O.; Demir, C.
Histopathological and Biochemical Alterations in the Adrenal Gland of Male Rats Exposed To Bisphenol F
(Pleiades Publishing inc, 2024) Kaptaner, B.; Dogan, A.; Yilmaz, C.; Aykut, H.; Dogan, E.; Babat, C. Fidan; Donmez, F.
Bisphenol F (BPF) is a bisphenol A derivative that is widely used in the manufacturing of industrial and consumer products. The presented study was conducted to explore the adverse effects of BPF on the adrenal glands of rats. Toward this aim, twenty-eight male albino Wistar rats were randomly divided into four groups, each containing seven individuals. The animals were administered a vehicle (control) or BPF at 3 different doses comprising 20, 100, and 500 mg/kg of body weight (bw) via oral gavage for 28 days. Next, the effects of BPF on the gland were evaluated in terms of histopathological alterations, serum adrenocorticotropic hormone (ACTH) and cortisol levels, and the contents of reduced glutathione (GSH) and malondialdehyde (MDA). The zona fasciculata of the adrenal cortex showed prominent histopathological lesions such as vacuolar degeneration and necrotic degeneration in the experimental groups. BPF caused noticeable elevations in the serum ACTH and cortisol levels. Moreover, decreases in levels of GSH and increments in the contents of MDA were determined, indicating oxidative stress. In conclusion, BPF showed toxic effects on the adrenal gland that may result in disruptions in its vital functions in the body. The results herein suggest that attention should be paid to the utilization of BPF in manufacturing processes due to its harmful effects and risks to the health of organisms.
Horse Mushroom (Agaricus Arvensis Schaeff.) Prevents Oxidative Stress in Carbon Tetrachloride Toxicity
(Elsevier, 2020) Dogan, A.; Ilhan, M.; Battal, A.
Environmental pollutants cause severe oxidative stress and lipid peroxidation. Oxidative stress generates free radicals (FRs) such as peroxyl radicals, superoxide radicals, hydroxyl radicals, etc. These FRs suppress in vivo and in vitro antioxidant defense systems in living systems. Bioactive compounds present in mushrooms have been reported to increase the activity of antioxidant enzymes and suppress the formation of possible FR sources. Agaricus arvensis is a macrofungus known as horse mushroom. Some studies report the antioxidant activity of A. arvensis. For instance, administration of the extract obtained from A. arvensis had regulative effects in liver enzymes and antioxidant parameters in kidney, liver, and brain tissues in CCl4-administered rats. A similar study showed that A. arvensis extract reduced erythrocyte fragility, and it regulated many hematological parameters in CCl4-administered rats. Therefore, the present study aimed to collect some data about oxidative stress, FRs, antioxidant activity, and mechanism of A. arvensis. © 2021 Elsevier Inc. All rights reserved.
Hplc Analysis of Blackberry Fruits for Organic Acid and Sugar Contents
(int Soc Horticultural Science, 2015) Sensoy, I. Gazioglu; Gundogdu, M.; Sensoy, S.; Celik, F.; Dogan, A.
Blackberry has an important potential in fruit species because it is commonly used in both the fresh and processing market. In the present study, the organic acid (citric acid, malic acid, succinic acid, and fumaric acid) and sugar (fructose, glucose, and sucrose) contents of the blackberry genotypes grown in Van province of Turkey were determined. Organic acid and sugars are among the criteria in fruit maturation as well as they are effective in several physiological events. The citric acid was the predominant organic acid in the studied blackberry genotypes and ranged from 5.690 to 12.019 g/kg. The citric acid was followed by malic acid which varied from 1.412 to 6.346 g/kg. While the genotype 65ED02 had the highest total organic acid content (20.827 g/kg), the genotype 65ER01 had the lowest total organic acid content (8.469 g/kg). Fructose was the predominant sugar in the studied blackberry genotypes and ranged from 11.272 to 25.241 g/kg. While the genotype 65ED01 had the highest total sugar content 44.399 g/kg), the genotype 65GV01 had the lowest total sugar content (22.117 g/kg).
Hplc Determination of Sugar Contents Based on Harvest Season in Almonds
(Chemical Publishing Co., 2007) Balta, M.F.; Yörük, I.H.; Dogan, A.; Erez, M.E.; Battal, P.
This study presents in comparison with harvest seasons sugar contents in 18 promising almond selections [Prunus dulcis (Mill.) D.A. Webb.] from Balikesir (western Anatolia, Turkey). Their majority had kernel weight over one gram since large kernel is a desired fruit characteristics for almond breeding efforts. Nuts of almond genotypes were collected at two seasons based on their harvest times. The harvest seasons were late August for 8 promising genotypes and early September for other 8 genotypes. Sugar contents were detected by HPLC Selections harvested in late August and early September averagely contained 2.19-2.31 g/100 g sucrose, 0.68-0.92 g/100 g maltose, 2.09-1.82 g/100 g glucose and 4.08-3.41 g/100 g fructose. Sugar contents of selections did not differ by harvest season statistically. Whereas, significant differences were found among selections for each harvest season. In addition, the mean sugar was fructose in 12 genotypes, sucrose in 4 genotypes and glucose in one genotype.
Hplc Determination of Sugar Contents Based on Harvest Season in Almonds [Prunus Dulcis (Mill.) D.a.!webb.]
(Asian Journal of Chemistry, 2007) Balta, M. Fikret; Yoeruek, I. H.; Dogan, A.; Erez, M. E.; Battal, P.
This study presents in comparison with harvest seasons sugar contents in 18 promising almond selections [Prunus dulcis (Mill.) D.A. Webb.] from Balikesir (western Anatolia, Turkey). Their majority had kernel weight over one gram since large kernel is a desired fruit characteristics for almond breeding efforts. Nuts of almond genotypes were collected at two seasons based on their harvest times. The harvest seasons were late August for 8 promising genotypes and early September for other 8 genotypes. Sugar contents were detected by HPLC. Selections harvested in late August and early September averagely contained 2.19-2.31 g/100 g sucrose, 0.68-0.92 g/100 g maltose, 2.09-1.82 g/100 g glucose and 4.08-3.41 g/100 g fructose. Sugar contents of selections did not differ by harvest season statistically. Whereas, significant differences were found among selections for each harvest season. In addition, the mean sugar was fructose in 12 genotypes, sucrose in 4 genotypes and glucose in one genotype.
Investigation of the Effects of Three Different Generations of Fluoroquinolone Derivatives on Antioxidant and Immunotoxic Enzyme Levels in Different Rat Tissues
(Taylor and Francis Ltd., 2022) Donmez, F.; Dogan, A.
Fluoroquinolones (FQs) are synthetic and broad-spectrum antimicrobial drugs derived from nalidixic acid. FQs are used against SARS-CoV-2 in our country, and for the treatment of some urinary tract diseases, gastrointestinal diseases, respiratory tract diseases, sexually transmitted diseases, and dermatological diseases. The present study investigated the effect of 1-,7-,14-day treatments of three different FQ derivatives; ciprofloxacin (CIP) 80 mg/kg/day, levofloxacin (LVX) 40 mg/kg/day, and moxifloxacin (MXF) 40 mg/kg/day, on biochemical parameters, lipid peroxidation, antioxidant enzymes, and immunotoxicity. 72 Wistar albino male rats were distributed to four groups including 18 rats in each group and were sacrificed on three different time points. The 14-day treatment of MXF significantly reduced the levels of aspartate aminotransferase (AST), glucose, reduced glutathione (GSH), malondialdehyde (MDA), catalase (CAT), myeloperoxidase (MPO), adenosine deaminase (ADA), and glutathione peroxidase (GPx). Furthermore, 14-day treatment of LVX increased liver [GSH, MPO, ADA, superoxide dismutase (SOD)], and GSH (erythrocyte) levels; whereas it significantly reduced the levels of AST, TG (triglycerides) and associated parameters levels in all the tissues (MDA), erythrocytes, and liver (MPO, CAT, SOD, GPx). After 14-day treatment of CIP; the erythrocyte levels of GSH, MPO, GPx, and CAT significantly decreased; whereas the levels of glucose, creatinine, MPO (liver), and GST (kidney and erythrocyte) significantly increased. It has been concluded that FQ derivatives used in this experiment did not display any correlation in terms of the efficacies in the different time points and tissues. Thus, it is recommended to use such FQ derivatives considering the duration of use and target tissue. © 2021 Informa UK Limited, trading as Taylor & Francis Group.