Browsing by Author "Dogan, E."

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Comparison of Three Different Docetaxel and Cisplatin Plus Fluorouracil (Dcf) as First-Line Therapy for Advanced Gastric Cancer: a Retrospective Analysis of the Two Institution
(Elsevier Sci Ltd, 2013) Inal, A.; Koca, D.; Kaplan, M. A.; Kucukoner, M.; Urakci, Z.; Dogan, E.; Isikdogan, A.
A Histological and Histochemical Study on the Gallbladder of the Alburnus Tarichi (Güldenstädt, 1814) (Cyprinidae)
(Universidad de la Frontera, 2020) Kaptaner, B.; Aykut, H.; Dogan, E.
In the current study, the histological structure of the gallbladder of Alburnus tarichi (Güldenstädt, 1814) was investigated. Hematoxylin and eosin were used to stain the histological sections for routine examinations, in addition to using periodic acid Schiff (PAS) for the neutral mucins, aldehyde fuchsin (AF) for the sulphated mucins, and Alcian blue (AB; pH: 2.5) for the acidic mucins. In addition, proliferating cell nuclear antigen (PCNA) immune-staining was performed for the detection of dividing cells among the epithelium. The gallbladder of A. tarichi was composed of mucosa, muscularis, and serosa or adventitia layers. The mucosa covering the wavy pleomorphic folds was made up of tall columnar epithelium and a lamina propria. The apical surface of the epithelial cells was lined by continuous short microvilli. On the epithelium, the luminal surface was remarkably stained with PAS, AF, and AB. Slight to moderate staining was observed on the epithelial cells in the apical zone with PAS. The cytoplasm of epithelial cells were stained in a slight manner with AF. No goblet cells were observed among the epithelium. According to the PCNA immune-staining, some epithelial cells were observed to proliferate. The lamina propria consisted of loose connective tissue that contained fibrocytes, collagen and elastic fibers, capillaries, and small blood vessels. The muscularis layer displayed muscle fibers that were circular, smooth, and surrounded by collagen fibers. The subserosal and serosal or adventitial layers had typical morphology to those of other fish and vertebrates. © Universidad de la Frontera. All rights reserved.
Histopathological and Biochemical Alterations in the Adrenal Gland of Male Rats Exposed To Bisphenol F
(Pleiades Publishing inc, 2024) Kaptaner, B.; Dogan, A.; Yilmaz, C.; Aykut, H.; Dogan, E.; Babat, C. Fidan; Donmez, F.
Bisphenol F (BPF) is a bisphenol A derivative that is widely used in the manufacturing of industrial and consumer products. The presented study was conducted to explore the adverse effects of BPF on the adrenal glands of rats. Toward this aim, twenty-eight male albino Wistar rats were randomly divided into four groups, each containing seven individuals. The animals were administered a vehicle (control) or BPF at 3 different doses comprising 20, 100, and 500 mg/kg of body weight (bw) via oral gavage for 28 days. Next, the effects of BPF on the gland were evaluated in terms of histopathological alterations, serum adrenocorticotropic hormone (ACTH) and cortisol levels, and the contents of reduced glutathione (GSH) and malondialdehyde (MDA). The zona fasciculata of the adrenal cortex showed prominent histopathological lesions such as vacuolar degeneration and necrotic degeneration in the experimental groups. BPF caused noticeable elevations in the serum ACTH and cortisol levels. Moreover, decreases in levels of GSH and increments in the contents of MDA were determined, indicating oxidative stress. In conclusion, BPF showed toxic effects on the adrenal gland that may result in disruptions in its vital functions in the body. The results herein suggest that attention should be paid to the utilization of BPF in manufacturing processes due to its harmful effects and risks to the health of organisms.
Hyperkalemia Occurring in a Patient With Psoriatic Arthritis Following Indomethacin Use
(2005) Sayarlioglu, H.; Atmaca, H.; Unalacak, M.; Dogan, E.; Erkoc, R.
Objective: To report a case of hyperkalemia possibly due to indomethacin use. Case Summary: A 52-year-old white woman with psoriatic arthritis for 16 years and diabetes mellitus for 3 years was admitted to the university hospital due to swelling and pain of wrists, elbows, knees and ankles for the last one month. The patient had been receiving methotrexate irregularly, but discontinued it 3 months ago. Physical examination and laboratory evaluations were compatible with diagnosis of exacerbation of psoriatic arthritis and type 2 diabetes mellitus. Two days after initiation of indomethacin and methotrexate, hyperkalemia developed with increase of blood urea nitrogen and decrease of creatinine clearance. Indomethacin was discontinued, and this resulted in normalization of laboratory findings between day 5 and 10 after discontinuation. Conclusion: The development of hyperkalemia caused by indomethacin is probably unusual, but it is important because indomethacin is a commonly used medication. This potentially serious complication can be prevented by careful attention to renal function and potassium balance in patients receiving indomethacin and other nonsteroidal anti-inflammatory drugs (NSAIDs), especially in patients with type 2 diabetes mellitus or preexisting renal disease.
A Modified Dcf Regimen as Primary Treatment for Patients With Metastatic Gastric Cancer
(Imprimatur Publications, 2013) Koca, D.; Dogan, E.; Yardim, H.; Duzen, O.; Karaca, S.
Purpose: To retrospectively assess the efficacy and toxity of a modified docetaxel, cisplatin, fluorouracil (mDCF) regimen as primary treatment in patients with metastatic gastric cancer (MGC). Methods: mDCF included folinic acid 400 mg/m(2) (day 1) + 5-fluorouracil (5-FU) 400 mg/m2 i.v. bolus (day 1) + 5-FU 2400 mg/m2 46-h infusion (days 1 and 2) + docetaxel 60 mg/m2 (day 1) + cisplatin 50 mg/m2 (day 1) and was administered once every two weeks in MGC patients. Results: Eighty-nine patients (median age 59 years, range 31-79) were enrolled. The median number of courses was 6 (range 2-12), and the total number was 492. The median follow-up duration was 8.6 months (range 2-14). Three (3.3%) patients showed complete response, 21 (23.6%) partial response, 36 (40.4%) stable disease, and progression was observed in 29 (32.6%) patients. The median progression-free survival (PFS) rate was 7 months (95% CI 5.7-8.2), and the median overall survival (OS) rate was 11 months (95% CI 9.7-12.2). The most common toxicity was neutropenia, which was observed in 52 (58.4%) patients. Conclusion: mDCF with reduced drug doses, given every two weeks, is a rather efficient regimen for MGC patients.
The Relationship Between Lipoprotein (A) Levels and Microvascular Complications in Patients With Type 2 Diabetes Mellitus
(Oriental Scientific Publ Co, 2010) Dogan, E.; Mavis, O.; Turan, N.; Demir, H.; Ilhan, M.
Lipoprotein (a) is known to have thrombotic and atherogenic features. Considering thrombotic and atherogenic features of Lp (a), the present study was planned to investigate the significance of lipoprotein (a) as a risk factor for the development of microvascular and macrovascular complications of diabetes. A total of 71 subjects were included in the study. In order to assess nephropathy, 24-hour urine samples were collected and microalbuminuria levels were measured. Ophthalmologists evaluated presence of retinopathy by eye-ground examination. Neuropathy was detected via anamnesis, physical examination, and electroneuromyography. Thirty-six percent of the patients had nephropathy, 26% had retinopathy and 22% had neuropathy. There were no significant difference between Lp (a) levels and vascular complications (P > 0.05). There were no statistically significant differences between Lp (a) and micro-or macrovascular complications in patients with type 2 diabetes.